Abstract：
:Predominantly, carbon atoms of various species function as acceptors of noncovalent interactions when they are part of a π-system. Here, we report on the discovery of a halogen bond involving the isocyano carbon lone pair. The co-crystallization or mechanochemical liquid-assisted grinding of model mesityl isocyanide with four iodoperfluorobenezenes leads to a series of halogen-bonded adducts with isocyanides. The obtained adducts were characterized by single-crystal and powder X-ray diffraction, solid-state IR and 13C NMR spectroscopies, and also by thermogravimetric analysis. The formation of the halogen bond with the isocyano group leads to a strong reduction of the isocyanide odor (3- to 46-fold gas phase concentration decrease). This manipulation makes isocyanides more suitable for laboratory storage and usage while preserving their reactivity, which is found to be similar between the adducts and the parent isocyanide in some common transformations, such as ligation to metal centers and the multi-component Ugi reaction.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Mikherdov AS,Novikov AS,Boyarskiy VP,Kukushkin VYdoi
10.1038/s41467-020-16748-xsubject
Has Abstractpub_date
2020-06-10 00:00:00pages
2921issue
1issn
2041-1723pii
10.1038/s41467-020-16748-xjournal_volume
11pub_type
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