Biomimetic mineralization of metal-organic frameworks as protective coatings for biomacromolecules.

abstract：:Current mitigation efforts and existing future commitments are inadequate to accomplish the Paris Agreement temperature goals. In light of this, research and debate are intensifying on the possibilities of additionally employing proposed climate geoengineering technologies, either through atmospheric carbon dioxide re...

journal_title：Nature communications

authors： Lawrence MG,Schäfer S,Muri H,Scott V,Oschlies A,Vaughan NE,Boucher O,Schmidt H,Haywood J,Scheffran J

更新日期：2018-09-13 00:00:00

abstract：:In melanoma, therapies with inhibitors to oncogenic BRAFV600E are highly effective but responses are often short-lived due to the emergence of drug-resistant tumor subpopulations. We describe here a mechanism of acquired drug resistance through the tumor microenvironment, which is mediated by human tumor-associated B ...

journal_title：Nature communications

authors： Somasundaram R,Zhang G,Fukunaga-Kalabis M,Perego M,Krepler C,Xu X,Wagner C,Hristova D,Zhang J,Tian T,Wei Z,Liu Q,Garg K,Griss J,Hards R,Maurer M,Hafner C,Mayerhöfer M,Karanikas G,Jalili A,Bauer-Pohl V,Weihsengru

更新日期：2017-09-19 00:00:00

abstract：:Hydrogen, the simplest element in the universe, has a surprisingly complex phase diagram. Because of applications to planetary science, inertial confinement fusion and fundamental physics, its high-pressure properties have been the subject of intense study over the past two decades. While sophisticated static experime...

journal_title：Nature communications

authors： Davis P,Döppner T,Rygg JR,Fortmann C,Divol L,Pak A,Fletcher L,Becker A,Holst B,Sperling P,Redmer R,Desjarlais MP,Celliers P,Collins GW,Landen OL,Falcone RW,Glenzer SH

更新日期：2016-04-15 00:00:00

abstract：:The cellular and molecular basis of stromal cell recruitment, activation and crosstalk in carcinomas is poorly understood, limiting the development of targeted anti-stromal therapies. In mouse models of triple negative breast cancer (TNBC), Hedgehog ligand produced by neoplastic cells reprograms cancer-associated fibr...

journal_title：Nature communications

authors： Cazet AS,Hui MN,Elsworth BL,Wu SZ,Roden D,Chan CL,Skhinas JN,Collot R,Yang J,Harvey K,Johan MZ,Cooper C,Nair R,Herrmann D,McFarland A,Deng N,Ruiz-Borrego M,Rojo F,Trigo JM,Bezares S,Caballero R,Lim E,Timpson P

更新日期：2018-07-24 00:00:00

abstract：:Acid catalysis by hydronium ions is ubiquitous in aqueous-phase organic reactions. Here we show that hydronium ion catalysis, exemplified by intramolecular dehydration of cyclohexanol, is markedly influenced by steric constraints, yielding turnover rates that increase by up to two orders of magnitude in tight confines...

journal_title：Nature communications

authors： Shi H,Eckstein S,Vjunov A,Camaioni DM,Lercher JA

更新日期：2017-05-25 00:00:00

abstract：:Vibrio cholerae, responsible for acute gastroenteritis secretes a large multifunctional-autoprocessing repeat-in-toxin (MARTX) toxin linked to evasion of host immune system, facilitating colonization of small intestine. Unlike other effector domains of the multifunctional toxin that target cytoskeleton, the function o...

journal_title：Nature communications

authors： Agarwal S,Kim H,Chan RB,Agarwal S,Williamson R,Cho W,Paolo GD,Satchell KJ

更新日期：2015-10-26 00:00:00

abstract：:Calcium ions (Ca(2+)) function as universal second messengers in eukaryotic cells, including immune cells. Ca(2+) is crucial for peripheral T-lymphocyte activation and effector functions, and influences thymocyte selection and motility in the developing thymus. However, the role of Ca(2+) signalling in early T-lymphoc...

journal_title：Nature communications

authors： Ouyang K,Leandro Gomez-Amaro R,Stachura DL,Tang H,Peng X,Fang X,Traver D,Evans SM,Chen J

更新日期：2014-09-12 00:00:00

abstract：:The bacteria-derived clustered regularly interspaced short palindromic repeat (CRISPR)-Cas systems are powerful tools for genome engineering. Recently, in addition to Cas protein engineering, the improvement of guide RNAs are also performed, contributing to broadening the research area of CRISPR-Cas9 systems. Here we ...

journal_title：Nature communications

authors： Kweon J,Jang AH,Kim DE,Yang JW,Yoon M,Rim Shin H,Kim JS,Kim Y

更新日期：2017-11-23 00:00:00

abstract：:The transcriptional regulatory network (TRN) of Bacillus subtilis coordinates cellular functions of fundamental interest, including metabolism, biofilm formation, and sporulation. Here, we use unsupervised machine learning to modularize the transcriptome and quantitatively describe regulatory activity under diverse co...

journal_title：Nature communications

authors： Rychel K,Sastry AV,Palsson BO

更新日期：2020-12-11 00:00:00

abstract：:Bright sources of indistinguishable single photons are strongly needed for the scalability of quantum information processing. Semiconductor quantum dots are promising systems to build such sources. Several works demonstrated emission of indistinguishable photons while others proposed various approaches to efficiently ...

journal_title：Nature communications

authors： Gazzano O,Michaelis de Vasconcellos S,Arnold C,Nowak A,Galopin E,Sagnes I,Lanco L,Lemaître A,Senellart P

更新日期：2013-01-01 00:00:00

abstract：:Atmospheric iron affects the global carbon cycle by modulating ocean biogeochemistry through the deposition of soluble iron to the ocean. Iron emitted by anthropogenic (fossil fuel) combustion is a source of soluble iron that is currently considered less important than other soluble iron sources, such as mineral dust ...

journal_title：Nature communications

authors： Matsui H,Mahowald NM,Moteki N,Hamilton DS,Ohata S,Yoshida A,Koike M,Scanza RA,Flanner MG

更新日期：2018-04-23 00:00:00

abstract：:Symmetry-breaking phase transitions are an example of non-equilibrium processes that require real-time treatment, a major challenge in strongly coupled systems without long-lived quasiparticles. Holographic duality provides such an approach by mapping strongly coupled field theories in D dimensions into weakly coupled...

journal_title：Nature communications

authors： Sonner J,Del Campo A,Zurek WH

更新日期：2015-06-23 00:00:00

abstract：:The high-frequency dynamics of mode-coupled magnetic vortices have generated great interest for spintronic technologies, such as spin-torque nano-oscillators. While the spectroscopic characteristics of vortex oscillators have been reported, direct imaging of driven coupled magnetic quasi-particles is essential to the ...

journal_title：Nature communications

authors： Pulecio JF,Warnicke P,Pollard SD,Arena DA,Zhu Y

更新日期：2014-04-30 00:00:00

abstract：:The bacterial type III secretion system, or injectisome, is a syringe shaped nanomachine essential for the virulence of many disease causing Gram-negative bacteria. At the core of the injectisome structure is the needle complex, a continuous channel formed by the highly oligomerized inner and outer membrane hollow rin...

journal_title：Nature communications

authors： Hu J,Worrall LJ,Hong C,Vuckovic M,Atkinson CE,Caveney N,Yu Z,Strynadka NCJ

更新日期：2018-09-21 00:00:00

abstract：:One of the most dramatic events in river environments is the natural diversion, or avulsion, of a channel across its floodplain. Though rarely witnessed, avulsions can cause massive floods, and over geologic time they create most of the fluvial stratigraphic record. Avulsions exhibit behavior ranging from reoccupying ...

journal_title：Nature communications

authors： Valenza JM,Edmonds DA,Hwang T,Roy S

更新日期：2020-04-30 00:00:00

abstract：:Determination of the atomic structure of inorganic single-walled nanotubes with complex stoichiometry remains elusive due to the too many atomic coordinates to be fitted with respect to X-ray diffractograms inherently exhibiting rather broad features. Here we introduce a methodology to reduce the number of fitted vari...

journal_title：Nature communications

authors： Monet G,Amara MS,Rouzière S,Paineau E,Chai Z,Elliott JD,Poli E,Liu LM,Teobaldi G,Launois P

更新日期：2018-05-23 00:00:00

abstract：:Brain-computer interfaces (BCI) are used in stroke rehabilitation to translate brain signals into intended movements of the paralyzed limb. However, the efficacy and mechanisms of BCI-based therapies remain unclear. Here we show that BCI coupled to functional electrical stimulation (FES) elicits significant, clinicall...

journal_title：Nature communications

authors： Biasiucci A,Leeb R,Iturrate I,Perdikis S,Al-Khodairy A,Corbet T,Schnider A,Schmidlin T,Zhang H,Bassolino M,Viceic D,Vuadens P,Guggisberg AG,Millán JDR

更新日期：2018-06-20 00:00:00

abstract：:Human metapneumovirus (hMPV) is a frequent cause of bronchiolitis in young children. Its F glycoprotein mediates virus-cell membrane fusion and is the primary target of neutralizing antibodies. The inability to produce recombinant hMPV F glycoprotein in the metastable pre-fusion conformation has hindered structural an...

journal_title：Nature communications

authors： Battles MB,Más V,Olmedillas E,Cano O,Vázquez M,Rodríguez L,Melero JA,McLellan JS

更新日期：2017-11-16 00:00:00

abstract：:Lanthanide compounds show much higher energy barriers to magnetic relaxation than 3d-block compounds, and this has led to speculation that they could be used in molecular spintronic devices. Prototype molecular spin valves and molecular transistors have been reported, with remarkable experiments showing the influence ...

journal_title：Nature communications

authors： Moreno Pineda E,Chilton NF,Marx R,Dörfel M,Sells DO,Neugebauer P,Jiang SD,Collison D,van Slageren J,McInnes EJ,Winpenny RE

更新日期：2014-10-13 00:00:00

abstract：:Cellular microRNAs (miRNAs) have been shown to regulate hepatitis C virus (HCV) replication, yet a systematic interrogation of the repertoire of miRNAs impacting HCV life cycle is lacking. Here we apply integrative functional genomics strategies to elucidate global HCV-miRNA interactions. Through genome-wide miRNA mim...

journal_title：Nature communications

authors： Li Q,Lowey B,Sodroski C,Krishnamurthy S,Alao H,Cha H,Chiu S,El-Diwany R,Ghany MG,Liang TJ

更新日期：2017-11-27 00:00:00

abstract：:Adaptive behavior requires integrating prior with current information to anticipate upcoming events. Brain structures related to this computation should bring relevant signals from the recent past into the present. Here we report that rats can integrate the most recent prior information with sensory information, there...

journal_title：Nature communications

authors： Nogueira R,Abolafia JM,Drugowitsch J,Balaguer-Ballester E,Sanchez-Vives MV,Moreno-Bote R

更新日期：2017-03-24 00:00:00

abstract：:Singlet oxygen has won a great deal of attention to catalysis and biological studies due to its strong oxidizing properties. However, the photosensitizers which require for the generation of singlet oxygen remain inadequate because of their lack of long-wavelength absorption, weak hydrophilicity, and poor biocompatibi...

journal_title：Nature communications

authors： Gao R,Mei X,Yan D,Liang R,Wei M

更新日期：2018-07-18 00:00:00

abstract：:Physical properties of multi-orbital materials depend not only on the strength of the effective interactions among the valence electrons but also on their type. Strong correlations are caused by either Mott physics that captures the Coulomb repulsion among charges, or Hund physics that aligns the spins in different or...

journal_title：Nature communications

authors： Deng X,Stadler KM,Haule K,Weichselbaum A,von Delft J,Kotliar G

更新日期：2019-06-20 00:00:00

abstract：:Gamma-ray 'glows' are long duration (seconds to tens of minutes) X-ray and gamma-ray emission coming from thunderclouds. Measurements suggest the presence of relativistic runaway electron avalanches (RREA), the same process underlying terrestrial gamma-ray flashes. Here we demonstrate that glows are relatively a commo...

journal_title：Nature communications

authors： Kelley NA,Smith DM,Dwyer JR,Splitt M,Lazarus S,Martinez-McKinney F,Hazelton B,Grefenstette B,Lowell A,Rassoul HK

更新日期：2015-08-12 00:00:00

abstract：:Huntington's Disease (HD) is a neurodegenerative disease caused by poly-glutamine expansion in the Htt protein, resulting in Htt misfolding and cell death. Expression of the cellular protein folding and pro-survival machinery by heat shock transcription factor 1 (HSF1) ameliorates biochemical and neurobiological defec...

journal_title：Nature communications

authors： Gomez-Pastor R,Burchfiel ET,Neef DW,Jaeger AM,Cabiscol E,McKinstry SU,Doss A,Aballay A,Lo DC,Akimov SS,Ross CA,Eroglu C,Thiele DJ

更新日期：2017-02-13 00:00:00

abstract：:The spindle assembly checkpoint (SAC) arrests cells in mitosis by sensing unattached kinetochores, until all chromosomes are bi-oriented by spindle microtubules. Kinetochore accumulation of the SAC component Mad1-Mad2 is crucial for SAC activation. However, the mechanism by which Mad1-Mad2 accumulation at kinetochores...

journal_title：Nature communications

authors： Zhou H,Wang T,Zheng T,Teng J,Chen J

更新日期：2016-01-08 00:00:00

abstract：:The power conversion efficiency of hybrid solid-state solar cells has more than doubled from 7 to 15% over the past year. This is largely as a result of the incorporation of organometallic trihalide perovskite absorbers into these devices. But, as promising as this development is, long-term operational stability is ju...

journal_title：Nature communications

authors： Leijtens T,Eperon GE,Pathak S,Abate A,Lee MM,Snaith HJ

更新日期：2013-01-01 00:00:00

abstract：:When immersed into water, most solids develop a surface charge, which is neutralized by an accumulation of dissolved counterions at the interface. Although the density distribution of counterions perpendicular to the interface obeys well-established theories, little is known about counterions' lateral organization at ...

journal_title：Nature communications

authors： Ricci M,Spijker P,Voïtchovsky K

更新日期：2014-07-16 00:00:00

abstract：:The HIRA histone chaperone complex deposits the histone variant H3.3 onto chromatin in a DNA synthesis-independent manner. It comprises three identified subunits, HIRA, UBN1 and CABIN1, however the functional oligomerization state of the complex has not been investigated. Here we use biochemical and crystallographic a...

journal_title：Nature communications

authors： Ray-Gallet D,Ricketts MD,Sato Y,Gupta K,Boyarchuk E,Senda T,Marmorstein R,Almouzni G

更新日期：2018-08-06 00:00:00

abstract：:The ability to identify cause-effect relations is an essential component of the scientific method. The identification of causal relations is generally accomplished through statistical trials where alternative hypotheses are tested against each other. Traditionally, such trials have been based on classical statistics. ...

journal_title：Nature communications

authors： Chiribella G,Ebler D

更新日期：2019-04-01 00:00:00