Fusion guide RNAs for orthogonal gene manipulation with Cas9 and Cpf1.

abstract：:Innate immune signaling through the NLRP3 inflammasome is activated by multiple diabetes-related stressors, but whether targeting the inflammasome is beneficial for diabetes is still unclear. Nucleoside reverse-transcriptase inhibitors (NRTI), drugs approved to treat HIV-1 and hepatitis B infections, also block inflam...

journal_title：Nature communications

authors： Ambati J,Magagnoli J,Leung H,Wang SB,Andrews CA,Fu D,Pandey A,Sahu S,Narendran S,Hirahara S,Fukuda S,Sun J,Pandya L,Ambati M,Pereira F,Varshney A,Cummings T,Hardin JW,Edun B,Bennett CL,Ambati K,Fowler BJ,Kerur

更新日期：2020-09-23 00:00:00

abstract：:The complex transport processes contributing to sintering are not yet fully understood, partially because in-situ observations of sintering in three dimensions (3D) are very difficult. Here we report a novel experiment in which monocrystalline copper spheres are first marked with microscopic boreholes drilled using a ...

journal_title：Nature communications

authors： Grupp R,Nöthe M,Kieback B,Banhart J

更新日期：2011-01-01 00:00:00

abstract：:Microfluidic multipoles (MFMs) have been realized experimentally and hold promise for "open-space" biological and chemical surface processing. Whereas convective flow can readily be predicted using hydraulic-electrical analogies, the design of advanced microfluidic multipole is constrained by the lack of simple, accur...

journal_title：Nature communications

authors： Goyette PA,Boulais É,Normandeau F,Laberge G,Juncker D,Gervais T

更新日期：2019-04-16 00:00:00

abstract：:Folding processes play a crucial role in the development of function in biomacromolecules. Recreating this feature on synthetic systems would not only allow understanding and reproducing biological functions but also developing new functions. This has inspired the development of conformationally ordered synthetic olig...

journal_title：Nature communications

authors： Carini M,Ruiz MP,Usabiaga I,Fernández JA,Cocinero EJ,Melle-Franco M,Diez-Perez I,Mateo-Alonso A

更新日期：2017-05-18 00:00:00

abstract：:The Human Proteome Organization (HUPO) launched the Human Proteome Project (HPP) in 2010, creating an international framework for global collaboration, data sharing, quality assurance and enhancing accurate annotation of the genome-encoded proteome. During the subsequent decade, the HPP established collaborations, dev...

journal_title：Nature communications

authors： Adhikari S,Nice EC,Deutsch EW,Lane L,Omenn GS,Pennington SR,Paik YK,Overall CM,Corrales FJ,Cristea IM,Van Eyk JE,Uhlén M,Lindskog C,Chan DW,Bairoch A,Waddington JC,Justice JL,LaBaer J,Rodriguez H,He F,Kostrzewa M

更新日期：2020-10-16 00:00:00

abstract：:Poly-(ADP-ribose) polymerase inhibitors (PARPi) selectively kill breast and ovarian cancers with defects in homologous recombination (HR) caused by BRCA1/2 mutations. There is also clinical evidence for the utility of PARPi in breast and ovarian cancers without BRCA mutations, but the underlying mechanism is not clear...

journal_title：Nature communications

authors： Peng Y,Liao Q,Tan W,Peng C,Hu Z,Chen Y,Li Z,Li J,Zhen B,Zhu W,Li X,Yao Y,Song Q,Liu C,Qi X,He F,Pei H

更新日期：2019-03-15 00:00:00

abstract：:Much of the global annual mean temperature change over Quaternary glacial cycles can be attributed to slow ice sheet and greenhouse gas feedbacks, but analysis of the short-term response to orbital forcings has the potential to reveal key relationships in the climate system. In particular, obliquity and precession bot...

journal_title：Nature communications

authors： Erb MP,Jackson CS,Broccoli AJ,Lea DW,Valdes PJ,Crucifix M,DiNezio PN

更新日期：2018-04-10 00:00:00

abstract：:Signalling pathways that control endothelial cell (EC) permeability, leukocyte adhesion and inflammation are pivotal for atherosclerosis initiation and progression. Here we demonstrate that the Sterile-20-like mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4), which has been implicated in inflammation, ...

journal_title：Nature communications

authors： Roth Flach RJ,Skoura A,Matevossian A,Danai LV,Zheng W,Cortes C,Bhattacharya SK,Aouadi M,Hagan N,Yawe JC,Vangala P,Menendez LG,Cooper MP,Fitzgibbons TP,Buckbinder L,Czech MP

更新日期：2015-12-21 00:00:00

abstract：:Proper regulation of energy storage in adipose tissue is crucial for maintaining insulin sensitivity and molecules contributing to this process have not been fully revealed. Here we show that type II transmembrane protein tenomodulin (TNMD) is upregulated in adipose tissue of insulin-resistant versus insulin-sensitive...

journal_title：Nature communications

authors： Senol-Cosar O,Flach RJ,DiStefano M,Chawla A,Nicoloro S,Straubhaar J,Hardy OT,Noh HL,Kim JK,Wabitsch M,Scherer PE,Czech MP

更新日期：2016-02-16 00:00:00

abstract：:Secondary multidrug transporters use ion concentration gradients to energize the removal from cells of various antibiotics. The Escherichia coli multidrug transporter MdfA exchanges a single proton with a single monovalent cationic drug molecule. This stoichiometry renders the efflux of divalent cationic drugs energet...

journal_title：Nature communications

authors： Fluman N,Adler J,Rotenberg SA,Brown MH,Bibi E

更新日期：2014-08-08 00:00:00

abstract：:Semiconductor III-V photonic crystal (PC) laser is regarded as a promising ultra-compact light source with unique advantages of ultralow energy consumption and small footprint for the next generation of Si-based on-chip optical interconnects. However, the significant material dissimilarities between III-V materials an...

journal_title：Nature communications

authors： Zhou T,Tang M,Xiang G,Xiang B,Hark S,Martin M,Baron T,Pan S,Park JS,Liu Z,Chen S,Zhang Z,Liu H

更新日期：2020-02-20 00:00:00

abstract：:Underlying cellular responses is a transcriptional regulatory network (TRN) that modulates gene expression. A useful description of the TRN would decompose the transcriptome into targeted effects of individual transcriptional regulators. Here, we apply unsupervised machine learning to a diverse compendium of over 250 ...

journal_title：Nature communications

authors： Sastry AV,Gao Y,Szubin R,Hefner Y,Xu S,Kim D,Choudhary KS,Yang L,King ZA,Palsson BO

更新日期：2019-12-04 00:00:00

abstract：:The laboratory mouse serves as an important model system for studying gene, brain and behavioural interactions. Powerful methods of gene targeting have helped to decipher gene-function associations in human diseases. Yet, the laboratory mouse, obtained after decades of human-driven artificial selection, inbreeding, an...

journal_title：Nature communications

authors： Chalfin L,Dayan M,Levy DR,Austad SN,Miller RA,Iraqi FA,Dulac C,Kimchi T

更新日期：2014-08-05 00:00:00

abstract：:Alkali metal vapors enable access to single electron systems, suitable for demonstrating fundamental light-matter interactions and promising for quantum logic operations, storage and sensing. However, progress is hampered by the need for robust and repeatable control over the atomic vapor density and over the associat...

journal_title：Nature communications

authors： Rusimova KR,Slavov D,Pradaux-Caggiano F,Collins JT,Gordeev SN,Carbery DR,Wadsworth WJ,Mosley PJ,Valev VK

更新日期：2019-05-24 00:00:00

abstract：:Immune checkpoint blockers (ICB) have become pivotal therapies in the clinical armamentarium against metastatic melanoma (MMel). Given the frequency of immune related adverse events and increasing use of ICB, predictors of response to CTLA-4 and/or PD-1 blockade represent unmet clinical needs. Using a systems biology-...

journal_title：Nature communications

authors： Jacquelot N,Roberti MP,Enot DP,Rusakiewicz S,Ternès N,Jegou S,Woods DM,Sodré AL,Hansen M,Meirow Y,Sade-Feldman M,Burra A,Kwek SS,Flament C,Messaoudene M,Duong CPM,Chen L,Kwon BS,Anderson AC,Kuchroo VK,Weide B,Au

更新日期：2017-09-19 00:00:00

abstract：:Graphyne allotropes of carbon are fascinating materials, and their electronic properties are predicted to rival those of the "wonder material" graphene. One allotrope of graphyne, having rectangular symmetry rather than hexagonal, stands out as particularly attractive, namely 6,6,12-graphyne. It is currently an insurm...

journal_title：Nature communications

authors： Kilde MD,Murray AH,Andersen CL,Storm FE,Schmidt K,Kadziola A,Mikkelsen KV,Hampel F,Hammerich O,Tykwinski RR,Nielsen MB

更新日期：2019-08-16 00:00:00

abstract：:Graphene is an ideal medium for long-distance spin communication in future spintronic technologies. So far, the prospect is limited by the smaller sizes of exfoliated graphene flakes and lower spin transport properties of large-area chemical vapour-deposited (CVD) graphene. Here we demonstrate a high spintronic perfor...

journal_title：Nature communications

authors： Kamalakar MV,Groenveld C,Dankert A,Dash SP

更新日期：2015-04-10 00:00:00

abstract：:The mammary epithelium comprises two primary cellular lineages, but the degree of heterogeneity within these compartments and their lineage relationships during development remain an open question. Here we report single-cell RNA profiling of mouse mammary epithelial cells spanning four developmental stages in the post...

journal_title：Nature communications

authors： Pal B,Chen Y,Vaillant F,Jamieson P,Gordon L,Rios AC,Wilcox S,Fu N,Liu KH,Jackling FC,Davis MJ,Lindeman GJ,Smyth GK,Visvader JE

更新日期：2017-11-20 00:00:00

abstract：:It is vital to design effective nitrogen fixation systems that operate under mild conditions, and to this end we recently reported an example of the catalytic formation of ammonia using a dinitrogen-bridged dimolybdenum complex bearing a pincer ligand, where up to twenty three equivalents of ammonia were produced base...

journal_title：Nature communications

authors： Tanaka H,Arashiba K,Kuriyama S,Sasada A,Nakajima K,Yoshizawa K,Nishibayashi Y

更新日期：2014-04-28 00:00:00

abstract：:Voltage control of magnetism in ferromagnetic semiconductor has emerged as an appealing solution to significantly reduce the power dissipation and variability beyond current CMOS technology. However, it has been proven to be very challenging to achieve a candidate with high Curie temperature (Tc), controllable ferroma...

journal_title：Nature communications

authors： Nie T,Tang J,Kou X,Gen Y,Lee S,Zhu X,He Q,Chang LT,Murata K,Fan Y,Wang KL

更新日期：2016-10-20 00:00:00

abstract：:Face recognition is highly proficient in humans and other social primates; it emerges in infancy, but the development of the neural mechanisms supporting this behaviour is largely unknown. We use blood-volume functional MRI to monitor longitudinally the responsiveness to faces, scrambled faces, and objects in macaque ...

journal_title：Nature communications

authors： Livingstone MS,Vincent JL,Arcaro MJ,Srihasam K,Schade PF,Savage T

更新日期：2017-03-31 00:00:00

abstract：:MAVS and MITA are essential adaptor proteins mediating innate antiviral immune responses against RNA and DNA viruses, respectively. Here we show that RNF115 plays dual roles in response to RNA or DNA virus infections by catalyzing distinct types of ubiquitination of MAVS and MITA at different phases of viral infection...

journal_title：Nature communications

authors： Zhang ZD,Xiong TC,Yao SQ,Wei MC,Chen M,Lin D,Zhong B

更新日期：2020-11-02 00:00:00

abstract：:Genetic factors contribute to the risk of thrombotic diseases. Recent genome wide association studies have identified genetic loci including SLC44A2 which may regulate thrombosis. Here we show that Slc44a2 controls platelet activation and thrombosis by regulating mitochondrial energetics. We find that Slc44a2 null mic...

journal_title：Nature communications

authors： Bennett JA,Mastrangelo MA,Ture SK,Smith CO,Loelius SG,Berg RA,Shi X,Burke RM,Spinelli SL,Cameron SJ,Carey TE,Brookes PS,Gerszten RE,Sabater-Lleal M,de Vries PS,Huffman JE,Smith NL,Morrell CN,Lowenstein CJ

更新日期：2020-07-13 00:00:00

abstract：:Monitoring the Earth's stress state plays a role in our understanding of an earthquake's mechanism and in the distribution of hazards. Crustal deformation due to the July 2019 earthquake sequence in Ridgecrest (California) that culminated in a preceding quake of magnitude (M) 6.4 and a subsequent M7.1 quake caused str...

journal_title：Nature communications

authors： Nanjo KZ

更新日期：2020-06-17 00:00:00

abstract：:Rapid and accurate clinical diagnosis remains challenging. A component of diagnosis tool development is the design of effective classification models with Mass spectrometry (MS) data. Some Machine Learning approaches have been investigated but these models require time-consuming preprocessing steps to remove artifacts...

journal_title：Nature communications

authors： Seddiki K,Saudemont P,Precioso F,Ogrinc N,Wisztorski M,Salzet M,Fournier I,Droit A

更新日期：2020-11-05 00:00:00

abstract：:Efficient crop improvement depends on the application of accurate genetic information contained in diverse germplasm resources. Here we report a reference-grade genome of wild soybean accession W05, with a final assembled genome size of 1013.2 Mb and a contig N50 of 3.3 Mb. The analytical power of the W05 genome is de...

journal_title：Nature communications

authors： Xie M,Chung CY,Li MW,Wong FL,Wang X,Liu A,Wang Z,Leung AK,Wong TH,Tong SW,Xiao Z,Fan K,Ng MS,Qi X,Yang L,Deng T,He L,Chen L,Fu A,Ding Q,He J,Chung G,Isobe S,Tanabata T,Valliyodan B,Nguyen HT,Cannon SB

更新日期：2019-03-14 00:00:00

abstract：:Photo-activated resin composites are widely used in industry and medicine. Despite extensive chemical characterisation, the micro-scale pattern of resin matrix reactive group conversion between filler particles is not fully understood. Using an advanced synchrotron-based wide-field IR imaging system and state-of-the-a...

journal_title：Nature communications

authors： Sirovica S,Solheim JH,Skoda MWA,Hirschmugl CJ,Mattson EC,Aboualizadeh E,Guo Y,Chen X,Kohler A,Romanyk DL,Rosendahl SM,Morsch S,Martin RA,Addison O

更新日期：2020-04-15 00:00:00

abstract：:Bipolaron states, in which two electrons or two holes occupy a single molecule or conjugated polymer segment, are typically considered to be negligible in organic semiconductor devices due to Coulomb repulsion between the two charges. Here we use charge modulation spectroscopy to reveal a bipolaron sheet density >1010...

journal_title：Nature communications

authors： Dhanker R,Gray CL,Mukhopadhyay S,Nunez S,Cheng CY,Sokolov AN,Giebink NC

更新日期：2017-12-21 00:00:00

abstract：:Magnetized plasma interactions are ubiquitous in astrophysical and laboratory plasmas. Various physical effects have been shown to be important within colliding plasma flows influenced by opposing magnetic fields, however, experimental verification of the mechanisms within the interaction region has remained elusive. ...

journal_title：Nature communications

authors： Tubman ER,Joglekar AS,Bott AFA,Borghesi M,Coleman B,Cooper G,Danson CN,Durey P,Foster JM,Graham P,Gregori G,Gumbrell ET,Hill MP,Hodge T,Kar S,Kingham RJ,Read M,Ridgers CP,Skidmore J,Spindloe C,Thomas AGR,Treadwe

更新日期：2021-01-12 00:00:00

abstract：:Malaria is a major public health problem that is actively being addressed in a global eradication campaign. Increased population mobility through international air travel has elevated the risk of re-introducing parasites to elimination areas and dispersing drug-resistant parasites to new regions. A simple genetic mark...

journal_title：Nature communications

authors： Preston MD,Campino S,Assefa SA,Echeverry DF,Ocholla H,Amambua-Ngwa A,Stewart LB,Conway DJ,Borrmann S,Michon P,Zongo I,Ouédraogo JB,Djimde AA,Doumbo OK,Nosten F,Pain A,Bousema T,Drakeley CJ,Fairhurst RM,Sutherland CJ

更新日期：2014-06-13 00:00:00