Structural resolution of inorganic nanotubes with complex stoichiometry.

abstract：:Transposable elements constitute a substantial portion of eukaryotic genomes and contribute to genomic variation, function, and evolution. Miniature inverted-repeat transposable elements (MITEs), as DNA transposons, are widely distributed in plant and animal genomes. Previous studies have suggested that retrotransposo...

journal_title：Nature communications

authors： Shen J,Liu J,Xie K,Xing F,Xiong F,Xiao J,Li X,Xiong L

更新日期：2017-03-03 00:00:00

abstract：:With the rapidly growing global air traffic, the impacts of the black carbon (BC) in the aviation exhaust on climate, environment and public health are likely rising. The particle number and size distribution are crucial metrics for toxicological analysis and aerosol-cloud interactions. Here, a size-resolved BC partic...

journal_title：Nature communications

authors： Zhang X,Chen X,Wang J

更新日期：2019-02-01 00:00:00

abstract：:Due to the high versatility of chiral cyanohydrins, the catalytic asymmetric cyanation reaction of carbonyl compounds has attracted widespread interest. However, efficient protocols that function at a preparative scale with low catalyst loading are still rare. Here, asymmetric counteranion-directed Lewis acid organoca...

journal_title：Nature communications

authors： Zhang Z,Bae HY,Guin J,Rabalakos C,van Gemmeren M,Leutzsch M,Klussmann M,List B

更新日期：2016-08-17 00:00:00

abstract：:The human pathogen Helicobacter pylori displays extensive genetic diversity. While H. pylori is known to evolve during infection, population dynamics inside the gastric environment have not been extensively investigated. Here we obtained gastric biopsies from multiple stomach regions of 16 H. pylori-infected adults, a...

journal_title：Nature communications

authors： Ailloud F,Didelot X,Woltemate S,Pfaffinger G,Overmann J,Bader RC,Schulz C,Malfertheiner P,Suerbaum S

更新日期：2019-05-22 00:00:00

abstract：:Despite centuries of research, much about the barbarian migrations that took place between the fourth and sixth centuries in Europe remains hotly debated. To better understand this key era that marks the dawn of modern European societies, we obtained ancient genomic DNA from 63 samples from two cemeteries (from Hungar...

journal_title：Nature communications

authors： Amorim CEG,Vai S,Posth C,Modi A,Koncz I,Hakenbeck S,La Rocca MC,Mende B,Bobo D,Pohl W,Baricco LP,Bedini E,Francalacci P,Giostra C,Vida T,Winger D,von Freeden U,Ghirotto S,Lari M,Barbujani G,Krause J,Caramelli D

更新日期：2018-09-11 00:00:00

abstract：:Genomic changes observed across treatment may result from either clonal evolution or geographically disparate sampling of heterogeneous tumors. Here we use computational modeling based on analysis of fifteen primary breast tumors and find that apparent clonal change between two tumor samples can frequently be explaine...

journal_title：Nature communications

authors： Caswell-Jin JL,McNamara K,Reiter JG,Sun R,Hu Z,Ma Z,Ding J,Suarez CJ,Tilk S,Raghavendra A,Forte V,Chin SF,Bardwell H,Provenzano E,Caldas C,Lang J,West R,Tripathy D,Press MF,Curtis C

更新日期：2019-02-08 00:00:00

abstract：:How do descending inputs from the brain control leg motor circuits to change how an animal walks? Conceptually, descending neurons are thought to function either as command-type neurons, in which a single type of descending neuron exerts a high-level control to elicit a coordinated change in motor output, or through a...

journal_title：Nature communications

authors： Feng K,Sen R,Minegishi R,Dübbert M,Bockemühl T,Büschges A,Dickson BJ

更新日期：2020-12-02 00:00:00

abstract：:Ultra-long metal nanowires and their facile fabrication have been long sought after as they promise to offer substantial improvements of performance in numerous applications. However, ultra-long metal ultrafine/nanowires are beyond the capability of current manufacturing techniques, which impose limitations on their s...

journal_title：Nature communications

authors： Hwang I,Guan Z,Cao C,Tang W,Chui CO,Li X

更新日期：2020-11-23 00:00:00

abstract：:Deep learning algorithms have been successfully used in medical image classification. In the next stage, the technology of acquiring explainable knowledge from medical images is highly desired. Here we show that deep learning algorithm enables automated acquisition of explainable features from diagnostic annotation-fr...

journal_title：Nature communications

authors： Yamamoto Y,Tsuzuki T,Akatsuka J,Ueki M,Morikawa H,Numata Y,Takahara T,Tsuyuki T,Tsutsumi K,Nakazawa R,Shimizu A,Maeda I,Tsuchiya S,Kanno H,Kondo Y,Fukumoto M,Tamiya G,Ueda N,Kimura G

更新日期：2019-12-18 00:00:00

abstract：:Geometric phase, associated with holonomy transformation in quantum state space, is an important quantum-mechanical effect. Besides fundamental interest, this effect has practical applications, among which geometric quantum computation is a paradigm, where quantum logic operations are realized through geometric phase ...

journal_title：Nature communications

authors： Song C,Zheng SB,Zhang P,Xu K,Zhang L,Guo Q,Liu W,Xu D,Deng H,Huang K,Zheng D,Zhu X,Wang H

更新日期：2017-10-20 00:00:00

abstract：:Many bacteria and most archaea possess a crystalline protein surface layer (S-layer), which surrounds their growing and topologically complicated outer surface. Constructing a macromolecular structure of this scale generally requires localized enzymatic machinery, but a regulatory framework for S-layer assembly has no...

journal_title：Nature communications

authors： Comerci CJ,Herrmann J,Yoon J,Jabbarpour F,Zhou X,Nomellini JF,Smit J,Shapiro L,Wakatsuki S,Moerner WE

更新日期：2019-06-21 00:00:00

abstract：:Semaphorins and their transmembrane receptors, Plexins, are key regulators of axon guidance and development of neuronal connectivity. B-type Plexins respond to Class IV semaphorins and mediate a variety of developmental functions. Here we report that the expression of Plexin-B2 and its high-affinity ligand, Sema4C, pe...

journal_title：Nature communications

authors： Paldy E,Simonetti M,Worzfeld T,Bali KK,Vicuña L,Offermanns S,Kuner R

更新日期：2017-08-02 00:00:00

abstract：:Chemoproteomics is a key technology to characterize the mode of action of drugs, as it directly identifies the protein targets of bioactive compounds and aids in the development of optimized small-molecule compounds. Current approaches cannot identify the protein targets of a compound and also detect the interaction s...

journal_title：Nature communications

authors： Piazza I,Beaton N,Bruderer R,Knobloch T,Barbisan C,Chandat L,Sudau A,Siepe I,Rinner O,de Souza N,Picotti P,Reiter L

更新日期：2020-08-21 00:00:00

abstract：:Adoptive immunotherapy using chimeric antigen receptor (CAR) expressing T cells targeting the CD19 B lineage receptor has demonstrated marked success in relapsed pre-B-cell acute lymphoblastic leukaemia (ALL). Persisting CAR-T cells generate sustained pressure against CD19 that may drive unique mechanisms of resistanc...

journal_title：Nature communications

authors： Jacoby E,Nguyen SM,Fountaine TJ,Welp K,Gryder B,Qin H,Yang Y,Chien CD,Seif AE,Lei H,Song YK,Khan J,Lee DW,Mackall CL,Gardner RA,Jensen MC,Shern JF,Fry TJ

更新日期：2016-07-27 00:00:00

abstract：:Ufuk Günesdogan was incorrectly associated with Center for Genetic Analysis of Behaviour, National Institute for Physiological Sciences, 5-1 Higashiyama Myodaiji, Okazaki, Aichi 444-8787, Japan and Toshihiro Kobayashi was incorrectly associated with Department of Developmental Biology, University of Göttingen, Götting...

journal_title：Nature communications

authors： Hackett JA,Huang Y,Günesdogan U,Gretarsson KA,Kobayashi T,Surani MA

更新日期：2018-12-11 00:00:00

abstract：:Synapse formation is triggered through trans-synaptic interaction between pairs of pre- and postsynaptic adhesion molecules, the specificity of which depends on splice inserts known as 'splice-insert signaling codes'. Receptor protein tyrosine phosphatase δ (PTPδ) can bidirectionally induce pre- and postsynaptic diffe...

journal_title：Nature communications

authors： Yamagata A,Yoshida T,Sato Y,Goto-Ito S,Uemura T,Maeda A,Shiroshima T,Iwasawa-Okamoto S,Mori H,Mishina M,Fukai S

更新日期：2015-04-24 00:00:00

abstract：:Because monoclonal antibodies (mAbs) have exceptional specificity and favorable pharmacology, substantial efforts have been made to functionalize them, either with potent cytotoxins, biologics, radionuclides, or fluorescent groups for therapeutic benefit and/or use as theranostic agents. To exploit our recently discov...

journal_title：Nature communications

authors： Bzymek KP,Puckett JW,Zer C,Xie J,Ma Y,King JD,Goodstein LH,Avery KN,Colcher D,Singh G,Horne DA,Williams JC

更新日期：2018-04-20 00:00:00

abstract：:The myogenic regulatory factor MRF4 is highly expressed in adult skeletal muscle but its function is unknown. Here we show that Mrf4 knockdown in adult muscle induces hypertrophy and prevents denervation-induced atrophy. This effect is accompanied by increased protein synthesis and widespread activation of muscle-spec...

journal_title：Nature communications

authors： Moretti I,Ciciliot S,Dyar KA,Abraham R,Murgia M,Agatea L,Akimoto T,Bicciato S,Forcato M,Pierre P,Uhlenhaut NH,Rigby PW,Carvajal JJ,Blaauw B,Calabria E,Schiaffino S

更新日期：2016-08-03 00:00:00

abstract：:Membrane-bound pyrophosphatases (M-PPases), which couple proton/sodium ion transport to pyrophosphate synthesis/hydrolysis, are important in abiotic stress resistance and in the infectivity of protozoan parasites. Here, three M-PPase structures in different catalytic states show that closure of the substrate-binding p...

journal_title：Nature communications

authors： Li KM,Wilkinson C,Kellosalo J,Tsai JY,Kajander T,Jeuken LJ,Sun YJ,Goldman A

更新日期：2016-12-06 00:00:00

abstract：:Autoantibodies have been associated with autoimmune diseases. However, studies have identified autoantibodies in healthy donors (HD) who do not develop autoimmune disorders. Here we provide evidence of a network of immunoglobulin G (IgG) autoantibodies targeting G protein-coupled receptors (GPCR) in HD compared to pat...

journal_title：Nature communications

authors： Cabral-Marques O,Marques A,Giil LM,De Vito R,Rademacher J,Günther J,Lange T,Humrich JY,Klapa S,Schinke S,Schimke LF,Marschner G,Pitann S,Adler S,Dechend R,Müller DN,Braicu I,Sehouli J,Schulze-Forster K,Trippel T,S

更新日期：2018-12-06 00:00:00

abstract：:Chronic bacterial infections on medical devices, including catheter-associated urinary tract infections (CAUTI), are associated with bacterial biofilm communities that are refractory to antibiotic therapy and resistant to host immunity. Previously, we have shown that Pseudomonas aeruginosa can cause CAUTI by forming a...

journal_title：Nature communications

authors： Cole SJ,Hall CL,Schniederberend M,Farrow Iii JM,Goodson JR,Pesci EC,Kazmierczak BI,Lee VT

更新日期：2018-10-25 00:00:00

abstract：:Interaction between light and matter results in new quantum states whose energetics can modify chemical kinetics. In the regime of ensemble vibrational strong coupling (VSC), a macroscopic number [Formula: see text] of molecular transitions couple to each resonant cavity mode, yielding two hybrid light-matter (polarit...

journal_title：Nature communications

authors： Campos-Gonzalez-Angulo JA,Ribeiro RF,Yuen-Zhou J

更新日期：2019-10-15 00:00:00

abstract：:Genetic ablation of endothelial focal adhesion kinase (FAK) can inhibit pathological angiogenesis, suggesting that loss of endothelial FAK is sufficient to reduce neovascularization. Here we show that reduced stromal FAK expression in FAK-heterozygous mice unexpectedly enhances both B16F0 and CMT19T tumour growth and ...

journal_title：Nature communications

authors： Kostourou V,Lechertier T,Reynolds LE,Lees DM,Baker M,Jones DT,Tavora B,Ramjaun AR,Birdsey GM,Robinson SD,Parsons M,Randi AM,Hart IR,Hodivala-Dilke K

更新日期：2013-01-01 00:00:00

abstract：:Bystander activation of memory T cells occurs in the absence of cognate antigen during infections that elicit strong systemic inflammatory responses, which subsequently affect host immune responses. Here we report that memory T cell bystander activation is not limited to induction by systemic inflammation. We initiall...

journal_title：Nature communications

authors： Maurice NJ,McElrath MJ,Andersen-Nissen E,Frahm N,Prlic M

更新日期：2019-11-01 00:00:00

abstract：:Submarine channels are ubiquitous on the seafloor and their inception and evolution is a result of dynamic interaction between turbidity currents and the evolving seafloor. However, the morphodynamic links between channel inception and flow dynamics have not yet been monitored in experiments and only in one instance o...

journal_title：Nature communications

authors： de Leeuw J,Eggenhuisen JT,Cartigny MJ

更新日期：2016-03-21 00:00:00

abstract：:Adaptive optics by direct imaging of the wavefront distortions of a laser-induced guide star has long been used in astronomy, and more recently in microscopy to compensate for aberrations in transparent specimens. Here we extend this approach to tissues that strongly scatter visible light by exploiting the reduced sca...

journal_title：Nature communications

authors： Wang K,Sun W,Richie CT,Harvey BK,Betzig E,Ji N

更新日期：2015-06-15 00:00:00

abstract：:Ever since the discovery of dye self-assemblies in nature, there have been tremendous efforts to exploit biomimetic supramolecular assemblies for tailored artificial photon processing materials. This feature necessarily has resulted in an increasing demand for understanding exciton dynamics in the dye self-assemblies....

journal_title：Nature communications

authors： Sung J,Kim P,Fimmel B,Würthner F,Kim D

更新日期：2015-10-23 00:00:00

abstract：:Device applications of graphene such as ultrafast transistors and photodetectors benefit from the combination of both high-quality p- and n-doped components prepared in a large-scale manner with spatial control and seamless connection. Here we develop a well-controlled chemical vapour deposition process for direct gro...

journal_title：Nature communications

authors： Yan K,Wu D,Peng H,Jin L,Fu Q,Bao X,Liu Z

更新日期：2012-01-01 00:00:00

abstract：:The construction of enzyme-inspired artificial catalysts with enzyme-like active sites and microenvironment remains a great challenge. Herein, we report a single-atomic-site Co catalyst supported by carbon doped boron nitride (BCN) with locally polarized B-N bonds (Co SAs/BCN) to simulate the reductive dehalogenases. ...

journal_title：Nature communications

authors： Min Y,Zhou X,Chen JJ,Chen W,Zhou F,Wang Z,Yang J,Xiong C,Wang Y,Li F,Yu HQ,Wu Y

更新日期：2021-01-12 00:00:00

abstract：:The complex of yeast cytochrome c peroxidase and cytochrome c is a paradigm of the biological electron transfer (ET). Building on seven decades of research, two different models have been proposed to explain its functional redox activity. One postulates that the intermolecular ET occurs only in the dominant, high-affi...

journal_title：Nature communications

authors： Van de Water K,Sterckx YG,Volkov AN

更新日期：2015-05-06 00:00:00