Abstract:
:Intestinal microfold cells are the primary pathway for translocation of secretory IgA (SIgA)-pathogen complexes to gut-associated lymphoid tissue. Uptake of SIgA/commensals complexes is important for priming adaptive immunity in the mucosa. This study aims to explore the effect of SIgA retrograde transport of immune complexes in Crohn's disease (CD). Here we report a significant increase of SIgA transport in CD patients with NOD2-mutation compared to CD patients without NOD2 mutation and/or healthy individuals. NOD2 has an effect in the IgA transport through human and mouse M cells by downregulating Dectin-1 and Siglec-5 expression, two receptors involved in retrograde transport. These findings define a mechanism of NOD2-mediated regulation of mucosal responses to intestinal microbiota, which is involved in CD intestinal inflammation and dysbiosis.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Rochereau N,Roblin X,Michaud E,Gayet R,Chanut B,Jospin F,Corthésy B,Paul Sdoi
10.1038/s41467-020-20348-0subject
Has Abstractpub_date
2021-01-11 00:00:00pages
261issue
1issn
2041-1723pii
10.1038/s41467-020-20348-0journal_volume
12pub_type
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