Efficient near-infrared up-conversion photoluminescence in carbon nanotubes.

abstract：:Loss of protein and organelle quality control secondary to reduced autophagy is a hallmark of aging. However, the physiologic and molecular regulation of autophagy in long-lived organisms remains incompletely understood. Here we show that the Kruppel-like family of transcription factors are important regulators of aut...

journal_title：Nature communications

authors： Hsieh PN,Zhou G,Yuan Y,Zhang R,Prosdocimo DA,Sangwung P,Borton AH,Boriushkin E,Hamik A,Fujioka H,Fealy CE,Kirwan JP,Peters M,Lu Y,Liao X,Ramírez-Bergeron D,Feng Z,Jain MK

更新日期：2017-10-13 00:00:00

abstract：:In the human hematopoietic system, rare self-renewing multipotent long-term hematopoietic stem cells (LT-HSCs) are responsible for the lifelong production of mature blood cells and are the rational target for clinical regenerative therapies. However, the heterogeneity in the hematopoietic stem cell compartment and var...

journal_title：Nature communications

authors： Wagenblast E,Azkanaz M,Smith SA,Shakib L,McLeod JL,Krivdova G,Araújo J,Shultz LD,Gan OI,Dick JE,Lechman ER

更新日期：2019-10-18 00:00:00

abstract：:Microfluidics by soft lithography has proven to be of key importance for biophysics and life science research. While being based on replicating structures of a master mold using benchtop devices, design modifications are time consuming and require sophisticated cleanroom equipment. Here, we introduce virtual fluidic c...

journal_title：Nature communications

authors： Panhwar MH,Czerwinski F,Dabbiru VAS,Komaragiri Y,Fregin B,Biedenweg D,Nestler P,Pires RH,Otto O

更新日期：2020-05-04 00:00:00

abstract：:The emerging monolayer transition metal dichalcogenides have provided an unprecedented material platform for miniaturized opto-electronic devices with integrated functionalities. Although excitonic light-matter interactions associated with their direct bandgaps have received tremendous research efforts, wavefront engi...

journal_title：Nature communications

authors： Qin F,Liu B,Zhu L,Lei J,Fang W,Hu D,Zhu Y,Ma W,Wang B,Shi T,Cao Y,Guan BO,Qiu CW,Lu Y,Li X

更新日期：2021-01-04 00:00:00

abstract：:Pladienolide, herboxidiene and spliceostatin have been identified as splicing modulators that target SF3B1 in the SF3b subcomplex. Here we report that PHF5A, another component of this subcomplex, is also targeted by these compounds. Mutations in PHF5A-Y36, SF3B1-K1071, SF3B1-R1074 and SF3B1-V1078 confer resistance to ...

journal_title：Nature communications

authors： Teng T,Tsai JH,Puyang X,Seiler M,Peng S,Prajapati S,Aird D,Buonamici S,Caleb B,Chan B,Corson L,Feala J,Fekkes P,Gerard B,Karr C,Korpal M,Liu X,T Lowe J,Mizui Y,Palacino J,Park E,Smith PG,Subramanian V,Wu ZJ

更新日期：2017-05-25 00:00:00

abstract：:In contrast to processive molecular motors, skeletal myosins form a large motor ensemble for contraction of muscles against high loads. Despite numerous information on the molecular properties of skeletal myosin, its ensemble effects on collective force generation have not been rigorously clarified. Here we show 4 nm ...

journal_title：Nature communications

authors： Kaya M,Tani Y,Washio T,Hisada T,Higuchi H

更新日期：2017-07-06 00:00:00

abstract：:Metagenomic sequencing has greatly improved our ability to profile the composition of environmental and host-associated microbial communities. However, the dependency of most methods on reference genomes, which are currently unavailable for a substantial fraction of microbial species, introduces estimation biases. We ...

journal_title：Nature communications

authors： Milanese A,Mende DR,Paoli L,Salazar G,Ruscheweyh HJ,Cuenca M,Hingamp P,Alves R,Costea PI,Coelho LP,Schmidt TSB,Almeida A,Mitchell AL,Finn RD,Huerta-Cepas J,Bork P,Zeller G,Sunagawa S

更新日期：2019-03-04 00:00:00

abstract：:Multiple myeloma (MM) progression and myeloma-associated bone disease (MBD) are highly dependent on bone marrow mesenchymal stromal cells (MSCs). MM-MSCs exhibit abnormal transcriptomes, suggesting the involvement of epigenetic mechanisms governing their tumor-promoting functions and prolonged osteoblast suppression. ...

journal_title：Nature communications

authors： Garcia-Gomez A,Li T,de la Calle-Fabregat C,Rodríguez-Ubreva J,Ciudad L,Català-Moll F,Godoy-Tena G,Martín-Sánchez M,San-Segundo L,Muntión S,Morales X,Ortiz-de-Solórzano C,Oyarzabal J,San José-Enériz E,Esteller M,Agirre X,P

更新日期：2021-01-18 00:00:00

abstract：:Hydrosilylation of allenes is the addition of a hydrogen atom and a silyl group to a carbon-carbon double bond of an allene molecule and represents a straightforward and atom-economical approach to prepare synthetically versatile allylsilanes and vinylsilanes. However, this reaction generally produces six possible iso...

journal_title：Nature communications

authors： Wang C,Teo WJ,Ge S

更新日期：2017-12-22 00:00:00

abstract：:The potential of the folic acid biosynthesis pathway as a target for the development of antibiotics has been clinically validated. However, many pathogens have developed resistance to these antibiotics, prompting a re-evaluation of potential drug targets within the pathway. The ydaH gene of Alcanivorax borkumensis enc...

journal_title：Nature communications

authors： Bolla JR,Su CC,Delmar JA,Radhakrishnan A,Kumar N,Chou TH,Long F,Rajashankar KR,Yu EW

更新日期：2015-04-20 00:00:00

abstract：:In high magnetic fields, two-dimensional electron systems can form a number of phases in which interelectron repulsion plays the central role, since the kinetic energy is frozen out by Landau quantization. These phases include the well-known liquids of the fractional quantum Hall effect, as well as solid phases with b...

journal_title：Nature communications

authors： Hatke AT,Liu Y,Magill BA,Moon BH,Engel LW,Shayegan M,Pfeiffer LN,West KW,Baldwin KW

更新日期：2014-06-20 00:00:00

abstract：:Zea mays is an important genetic model for elucidating transcriptional networks. Uncertainties about the complete structure of mRNA transcripts limit the progress of research in this system. Here, using single-molecule sequencing technology, we produce 111,151 transcripts from 6 tissues capturing ∼70% of the genes ann...

journal_title：Nature communications

authors： Wang B,Tseng E,Regulski M,Clark TA,Hon T,Jiao Y,Lu Z,Olson A,Stein JC,Ware D

更新日期：2016-06-24 00:00:00

abstract：:The spindle assembly checkpoint (SAC) arrests cells in mitosis by sensing unattached kinetochores, until all chromosomes are bi-oriented by spindle microtubules. Kinetochore accumulation of the SAC component Mad1-Mad2 is crucial for SAC activation. However, the mechanism by which Mad1-Mad2 accumulation at kinetochores...

journal_title：Nature communications

authors： Zhou H,Wang T,Zheng T,Teng J,Chen J

更新日期：2016-01-08 00:00:00

abstract：:The Fanconi anaemia (FA) pathway is important for the repair of DNA interstrand crosslinks (ICL). The FANCD2-FANCI complex is central to the pathway, and localizes to ICLs dependent on its monoubiquitination. It has remained elusive whether the complex is recruited before or after the critical monoubiquitination. Here...

journal_title：Nature communications

authors： Liang CC,Li Z,Lopez-Martinez D,Nicholson WV,Vénien-Bryan C,Cohn MA

更新日期：2016-07-13 00:00:00

abstract：:Ultrafast materials science promises optical control of physical properties of solids. Continuous-wave circularly polarized laser driving was predicted to induce a light-matter coupled state with an energy gap and a quantum Hall effect, coined Floquet topological insulator. Whereas the envisioned Floquet topological i...

journal_title：Nature communications

authors： Sentef MA,Claassen M,Kemper AF,Moritz B,Oka T,Freericks JK,Devereaux TP

更新日期：2015-05-11 00:00:00

abstract：:Storage of anthropogenic CO2 in geological formations relies on a caprock as the primary seal preventing buoyant super-critical CO2 escaping. Although natural CO2 reservoirs demonstrate that CO2 may be stored safely for millions of years, uncertainty remains in predicting how caprocks will react with CO2-bearing brine...

journal_title：Nature communications

authors： Kampman N,Busch A,Bertier P,Snippe J,Hangx S,Pipich V,Di Z,Rother G,Harrington JF,Evans JP,Maskell A,Chapman HJ,Bickle MJ

更新日期：2016-07-28 00:00:00

abstract：:Streptomycetes are notable for their complex life cycle and production of most clinically important antibiotics. A key factor that controls entry into development and the onset of antibiotic production is the 68-residue protein, BldC. BldC is a putative DNA-binding protein related to MerR regulators, but lacks coiled-...

journal_title：Nature communications

authors： Schumacher MA,den Hengst CD,Bush MJ,Le TBK,Tran NT,Chandra G,Zeng W,Travis B,Brennan RG,Buttner MJ

更新日期：2018-03-19 00:00:00

abstract：:Sedimentary rocks are the archives of environmental conditions and ancient planetary surface processes that led to their formation. Reconstructions of Earth's past surface behaviour from the physical sedimentary record remain controversial, however, in part because we lack a quantitative framework to deconvolve intern...

journal_title：Nature communications

authors： Ganti V,Lamb MP,McElroy B

更新日期：2014-02-28 00:00:00

abstract：:Conjugated polymeric molecules have been heralded as promising electrode materials for the next-generation energy-storage technologies owing to their chemical flexibility at the molecular level, environmental benefit, and cost advantage. However, before any practical implementation takes place, the low capacity, poor ...

journal_title：Nature communications

authors： Lei Z,Yang Q,Xu Y,Guo S,Sun W,Liu H,Lv LP,Zhang Y,Wang Y

更新日期：2018-02-08 00:00:00

abstract：:Maintenance of genome integrity via repair of DNA damage is a key biological process required to suppress diseases, including Fanconi anemia (FA). We generated loss-of-function human haploid cells for FA complementation group C (FANCC), a gene encoding a component of the FA core complex, and used genome-wide CRISPR li...

journal_title：Nature communications

authors： Moder M,Velimezi G,Owusu M,Mazouzi A,Wiedner M,Ferreira da Silva J,Robinson-Garcia L,Schischlik F,Slavkovsky R,Kralovics R,Schuster M,Bock C,Ideker T,Jackson SP,Menche J,Loizou JI

更新日期：2017-11-01 00:00:00

abstract：:Plasmodium vivax is the leading cause of human malaria in Asia and Latin America but is absent from most of central Africa due to the near fixation of a mutation that inhibits the expression of its receptor, the Duffy antigen, on human erythrocytes. The emergence of this protective allele is not understood because P. ...

journal_title：Nature communications

authors： Liu W,Li Y,Shaw KS,Learn GH,Plenderleith LJ,Malenke JA,Sundararaman SA,Ramirez MA,Crystal PA,Smith AG,Bibollet-Ruche F,Ayouba A,Locatelli S,Esteban A,Mouacha F,Guichet E,Butel C,Ahuka-Mundeke S,Inogwabini BI,Ndjango

更新日期：2014-01-01 00:00:00

abstract：:Traditionally, molecular assembly pathways for viruses are inferred from high resolution structures of purified stable intermediates, low resolution images of cell sections and genetic approaches. Here, we directly visualise an unsuspected 'single shelled' intermediate for a mammalian orthoreovirus in cryo-preserved i...

journal_title：Nature communications

authors： Sutton G,Sun D,Fu X,Kotecha A,Hecksel CW,Clare DK,Zhang P,Stuart DI,Boyce M

更新日期：2020-09-07 00:00:00

abstract：:Allergic asthma is a leading chronic disease associated with airway hyperreactivity (AHR). Type-2 innate lymphoid cells (ILC2s) are a potent source of T-helper 2 (Th2) cytokines that promote AHR and lung inflammation. As the programmed cell death protein-1 (PD-1) inhibitory axis regulates a variety of immune responses...

journal_title：Nature communications

authors： Helou DG,Shafiei-Jahani P,Lo R,Howard E,Hurrell BP,Galle-Treger L,Painter JD,Lewis G,Soroosh P,Sharpe AH,Akbari O

更新日期：2020-08-10 00:00:00

abstract：:How genomic and transcriptomic alterations affect the functional proteome in lung cancer is not fully understood. Here, we integrate DNA copy number, somatic mutations, RNA-sequencing, and expression proteomics in a cohort of 108 squamous cell lung cancer (SCC) patients. We identify three proteomic subtypes, two of wh...

journal_title：Nature communications

authors： Stewart PA,Welsh EA,Slebos RJC,Fang B,Izumi V,Chambers M,Zhang G,Cen L,Pettersson F,Zhang Y,Chen Z,Cheng CH,Thapa R,Thompson Z,Fellows KM,Francis JM,Saller JJ,Mesa T,Zhang C,Yoder S,DeNicola GM,Beg AA,Boyle TA

更新日期：2019-08-08 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature communications

authors： Zheng J,Fan R,Wu H,Yao H,Yan Y,Liu J,Ran L,Sun Z,Yi L,Dang L,Gan P,Zheng P,Yang T,Zhang Y,Tang T,Wang Y

更新日期：2020-07-27 00:00:00

abstract：:Proteins and nucleic acids are sequence-regulated macromolecules with various properties originating from their perfectly sequenced primary structures. However, the sequence regulation of synthetic polymers, particularly vinyl polymers, has not been achieved and is one of the ultimate goals in polymer chemistry. In th...

journal_title：Nature communications

authors： Satoh K,Ozawa S,Mizutani M,Nagai K,Kamigaito M

更新日期：2010-04-12 00:00:00

abstract：:The design and assembly of artificial protocell consortia displaying dynamical behaviours and systems-based properties are emerging challenges in bottom-up synthetic biology. Cellular processes such as morphogenesis and differentiation rely in part on reaction-diffusion gradients, and the ability to mimic rudimentary ...

journal_title：Nature communications

authors： Tian L,Li M,Patil AJ,Drinkwater BW,Mann S

更新日期：2019-07-25 00:00:00

abstract：:Theory, simulations and experimental results have suggested an important role of internal friction in the kinetics of protein folding. Recent experiments on spectrin domains provided the first evidence for a pronounced contribution of internal friction in proteins that fold on the millisecond timescale. However, it ha...

journal_title：Nature communications

authors： Borgia A,Wensley BG,Soranno A,Nettels D,Borgia MB,Hoffmann A,Pfeil SH,Lipman EA,Clarke J,Schuler B

更新日期：2012-01-01 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature communications

authors： Weinert LA,Chaudhuri RR,Wang J,Peters SE,Corander J,Jombart T,Baig A,Howell KJ,Vehkala M,Välimäki N,Harris D,Chieu TTB,Van Vinh Chau N,Campbell J,Schultsz C,Parkhill J,Bentley SD,Langford PR,Rycroft AN,Wren BW,Far

更新日期：2019-11-22 00:00:00

abstract：:The mid-Pliocene Warm Period (mPWP) offers an opportunity to understand a warmer-than-present world and assess the predictive ability of numerical climate models. Environmental reconstruction and climate modelling are crucial for understanding the mPWP, and the synergy of these two, often disparate, fields has proven ...

journal_title：Nature communications

authors： Haywood AM,Dowsett HJ,Dolan AM

更新日期：2016-02-16 00:00:00