Parallel genome-wide screens identify synthetic viable interactions between the BLM helicase complex and Fanconi anemia.

abstract：:Electric gating can strongly modulate a wide variety of physical properties in semiconductors and insulators, such as significant changes of conductivity in silicon, appearance of superconductivity in SrTiO3, the paramagnet-ferromagnet transition in (In,Mn)As, and so on. The key to such modulation is charge accumulati...

journal_title：Nature communications

authors： Dushenko S,Hokazono M,Nakamura K,Ando Y,Shinjo T,Shiraishi M

更新日期：2018-08-07 00:00:00

abstract：:Gamma-ray 'glows' are long duration (seconds to tens of minutes) X-ray and gamma-ray emission coming from thunderclouds. Measurements suggest the presence of relativistic runaway electron avalanches (RREA), the same process underlying terrestrial gamma-ray flashes. Here we demonstrate that glows are relatively a commo...

journal_title：Nature communications

authors： Kelley NA,Smith DM,Dwyer JR,Splitt M,Lazarus S,Martinez-McKinney F,Hazelton B,Grefenstette B,Lowell A,Rassoul HK

更新日期：2015-08-12 00:00:00

abstract：:Cellular microRNAs (miRNAs) have been shown to regulate hepatitis C virus (HCV) replication, yet a systematic interrogation of the repertoire of miRNAs impacting HCV life cycle is lacking. Here we apply integrative functional genomics strategies to elucidate global HCV-miRNA interactions. Through genome-wide miRNA mim...

journal_title：Nature communications

authors： Li Q,Lowey B,Sodroski C,Krishnamurthy S,Alao H,Cha H,Chiu S,El-Diwany R,Ghany MG,Liang TJ

更新日期：2017-11-27 00:00:00

abstract：:The original version of this Article contained an error in the spelling of the author Dan Credgington, which was incorrectly given as Dan Credington. This has now been corrected in both the PDF and HTML versions of the Article. ...

journal_title：Nature communications

authors： Ban M,Zou Y,Rivett JPH,Yang Y,Thomas TH,Tan Y,Song T,Gao X,Credgington D,Deschler F,Sirringhaus H,Sun B

更新日期：2019-02-22 00:00:00

abstract：:Chronic cranial window (CCW) is an essential tool in enabling longitudinal imaging and manipulation of various brain activities in live animals. However, an active CCW capable of sensing the concealed in vivo environment while simultaneously providing longitudinal optical access to the brain is not currently available...

journal_title：Nature communications

authors： Li H,Dong B,Zhang X,Shu X,Chen X,Hai R,Czaplewski DA,Zhang HF,Sun C

更新日期：2019-09-19 00:00:00

abstract：:Metal-organic frameworks (MOFs) are well known for their tunable structure and porosity. Many studies have shown they are promising for various important applications, for which their performance can be further enhanced by encapsulating functional species, such as luminescent guest molecules, within the frameworks. Al...

journal_title：Nature communications

authors： Sun CY,Wang XL,Zhang X,Qin C,Li P,Su ZM,Zhu DX,Shan GG,Shao KZ,Wu H,Li J

更新日期：2013-01-01 00:00:00

abstract：:Astrocytic endfeet cover the entire cerebral vasculature and serve as exchange sites for ions, metabolites and energy substrates from the blood to the brain. They maintain endothelial tight junctions that form the blood-brain barrier (BBB) and release vasoactive molecules that regulate vascular tone. Malignant gliomas...

journal_title：Nature communications

authors： Watkins S,Robel S,Kimbrough IF,Robert SM,Ellis-Davies G,Sontheimer H

更新日期：2014-06-19 00:00:00

abstract：:CRISPR-Cas9 is a promising technology for genome editing. Here we use Cas9 nuclease-induced double-strand break DNA (DSB) at the UROS locus to model and correct congenital erythropoietic porphyria. We demonstrate that homology-directed repair is rare compared with NHEJ pathway leading to on-target indels and causing u...

journal_title：Nature communications

authors： Cullot G,Boutin J,Toutain J,Prat F,Pennamen P,Rooryck C,Teichmann M,Rousseau E,Lamrissi-Garcia I,Guyonnet-Duperat V,Bibeyran A,Lalanne M,Prouzet-Mauléon V,Turcq B,Ged C,Blouin JM,Richard E,Dabernat S,Moreau-Gaudry F,

更新日期：2019-03-08 00:00:00

abstract：:Plant metacaspases mediate programmed cell death in development, biotic and abiotic stresses, damage-induced immune response, and resistance to pathogen attack. Most metacaspases require Ca2+ for their activation and substrate processing. However, the Ca2+-dependent activation mechanism remains elusive. Here we report...

journal_title：Nature communications

authors： Zhu P,Yu XH,Wang C,Zhang Q,Liu W,McSweeney S,Shanklin J,Lam E,Liu Q

更新日期：2020-05-07 00:00:00

abstract：:On-surface chemical reactions hold the potential for manufacturing nanoscale structures directly onto surfaces by linking carbon atoms in a single-step reaction. To fabricate more complex and functionalized structures, the control of the on-surface chemical reactions must be developed significantly. Here, we present a...

journal_title：Nature communications

authors： Kawai S,Haapasilta V,Lindner BD,Tahara K,Spijker P,Buitendijk JA,Pawlak R,Meier T,Tobe Y,Foster AS,Meyer E

更新日期：2016-09-13 00:00:00

abstract：:Botulinum neurotoxins are known to have seven serotypes (BoNT/A-G). Here we report a new BoNT serotype, tentatively named BoNT/X, which has the lowest sequence identity with other BoNTs and is not recognized by antisera against known BoNTs. Similar to BoNT/B/D/F/G, BoNT/X cleaves vesicle-associated membrane proteins (...

journal_title：Nature communications

authors： Zhang S,Masuyer G,Zhang J,Shen Y,Lundin D,Henriksson L,Miyashita SI,Martínez-Carranza M,Dong M,Stenmark P

更新日期：2017-08-03 00:00:00

abstract：:In the original version of this Article, the legend in the upper panel of Figure 2 incorrectly read 'paternal imprinting' and should have read 'maternal imprinting'. This has been corrected in both the PDF and HTML versions of the Article. ...

journal_title：Nature communications

authors： Zeng Y,Amador C,Xia C,Marioni R,Sproul D,Walker RM,Morris SW,Bretherick A,Canela-Xandri O,Boutin TS,Clark DW,Campbell A,Rawlik K,Hayward C,Nagy R,Tenesa A,Porteous DJ,Wilson JF,Deary IJ,Evans KL,McIntosh AM,Nava

更新日期：2019-05-01 00:00:00

abstract：:Zika virus (ZIKV) is an emerging mosquito borne flavivirus and a major public health concern causing severe disease. Due to the presence of a lipid membrane and structural heterogeneity, attaining an atomic resolution structure is challenging, but important to understand virus assembly and life cycle mechanisms that o...

journal_title：Nature communications

authors： DiNunno NM,Goetschius DJ,Narayanan A,Majowicz SA,Moustafa I,Bator CM,Hafenstein SL,Jose J

更新日期：2020-10-02 00:00:00

abstract：:Synapse degeneration is an early and invariant feature of neurodegenerative diseases. Indeed, synapse loss occurs prior to neuronal degeneration and correlates with the symptom severity of these diseases. However, the molecular mechanisms that trigger synaptic loss remain poorly understood. Here we demonstrate that de...

journal_title：Nature communications

authors： Galli S,Lopes DM,Ammari R,Kopra J,Millar SE,Gibb A,Salinas PC

更新日期：2014-10-16 00:00:00

abstract：:SCRaMbLE (Synthetic Chromosome Rearrangement and Modification by LoxP-mediated Evolution) is a genome restructuring technique that can be used in synthetic genomes such as that of Sc2.0, the synthetic yeast genome, which contains hundreds to thousands of strategically positioned loxPsym sites. SCRaMbLE has been used t...

journal_title：Nature communications

authors： Shen MJ,Wu Y,Yang K,Li Y,Xu H,Zhang H,Li BZ,Li X,Xiao WH,Zhou X,Mitchell LA,Bader JS,Yuan Y,Boeke JD

更新日期：2018-05-22 00:00:00

abstract：:The intrinsically disordered scaffold proteins AFF1/4 and the transcription elongation factors ELL1/2 are core components of the super elongation complex required for HIV-1 proviral transcription. Here we report the 2.0-Å resolution crystal structure of the human ELL2 C-terminal domain bound to its 50-residue binding ...

journal_title：Nature communications

authors： Qi S,Li Z,Schulze-Gahmen U,Stjepanovic G,Zhou Q,Hurley JH

更新日期：2017-01-30 00:00:00

abstract：:Direct reprogramming of fibroblasts into cardiomyocytes by forced expression of cardiomyogenic factors, GMT (GATA4, Mef2C, Tbx5) or GHMT (GATA4, Hand2, Mef2C, Tbx5), has recently been demonstrated, suggesting a novel therapeutic strategy for cardiac repair. However, current approaches are inefficient. Here we demonstr...

journal_title：Nature communications

authors： Zhao Y,Londono P,Cao Y,Sharpe EJ,Proenza C,O'Rourke R,Jones KL,Jeong MY,Walker LA,Buttrick PM,McKinsey TA,Song K

更新日期：2015-09-10 00:00:00

abstract：:The resting-state human brain networks underlie fundamental cognitive functions and consist of complex interactions among brain regions. However, the level of complexity of the resting-state networks has not been quantified, which has prevented comprehensive descriptions of the brain activity as an integrative system....

journal_title：Nature communications

authors： Watanabe T,Hirose S,Wada H,Imai Y,Machida T,Shirouzu I,Konishi S,Miyashita Y,Masuda N

更新日期：2013-01-01 00:00:00

abstract：:Platinum nanoparticles (Pt NPs) are one of the most efficient cocatalysts in photocatalysis, and their size determines the activity and the selectivity of the catalytic reaction. Nevertheless, an in-depth understanding of the platinum's size effect in the carbon dioxide photocatalytic reduction is still lacking. Throu...

journal_title：Nature communications

authors： Dong C,Lian C,Hu S,Deng Z,Gong J,Li M,Liu H,Xing M,Zhang J

更新日期：2018-03-28 00:00:00

abstract：:Tissue injury and the healing response lead to the release of endogenous danger signals including Toll-like receptor (TLR) and interleukin-1 receptor, type 1 (IL-1R1) ligands, which modulate the immune microenvironment. Because TLRs and IL-1R1 have been shown to influence the repair process of various tissues, we expl...

journal_title：Nature communications

authors： Martino MM,Maruyama K,Kuhn GA,Satoh T,Takeuchi O,Müller R,Akira S

更新日期：2016-03-22 00:00:00

abstract：:The most explosive basaltic scoria cone eruption yet documented (>20 km high plumes) occurred at Sunset Crater (Arizona) ca. 1085 AD by undetermined eruptive mechanisms. We present melt inclusion analysis, including bubble contents by Raman spectroscopy, yielding high total CO2 (approaching 6000 ppm) and S (~2000 ppm)...

journal_title：Nature communications

authors： Allison CM,Roggensack K,Clarke AB

更新日期：2021-01-11 00:00:00

abstract：:EGFR is required for animal development, and dysregulation of EGFR is critically implicated in malignant transformation. However, the molecular mechanism underlying the regulation of EGFR expression remains poorly explored. Here we report that the zinc-finger protein ZNF516 is a transcription repressor. ZNF516 is phys...

journal_title：Nature communications

authors： Li L,Liu X,He L,Yang J,Pei F,Li W,Liu S,Chen Z,Xie G,Xu B,Ting X,Zhang Z,Jin T,Liu X,Zhang W,Yuan S,Yang Z,Wu C,Zhang Y,Yang X,Yi X,Liang J,Shang Y,Sun L

更新日期：2017-09-25 00:00:00

abstract：:The ever-increasing speed and resolution of modern microscopes make the storage and post-processing of images challenging and prevent thorough statistical analyses in developmental biology. Here, instead of deploying massive storage and computing power, we exploit the spherical geometry of zebrafish embryos by computi...

journal_title：Nature communications

authors： Schmid B,Shah G,Scherf N,Weber M,Thierbach K,Campos CP,Roeder I,Aanstad P,Huisken J

更新日期：2013-01-01 00:00:00

abstract：:Knowing which proteins and RNAs directly interact is essential for understanding cellular mechanisms. Unfortunately, discovering such interactions is costly and often unreliable. To overcome these limitations, we developed rec-YnH, a new yeast two and three-hybrid-based screening pipeline capable of detecting interact...

journal_title：Nature communications

authors： Yang JS,Garriga-Canut M,Link N,Carolis C,Broadbent K,Beltran-Sastre V,Serrano L,Maurer SP

更新日期：2018-09-14 00:00:00

abstract：:Memory consolidation requires a timely controlled interplay between the hippocampus, a brain region important for memory formation, and the cortex, a region recruited for memory storage. Here we show that memory consolidation is associated with specific epigenetic modifications on histone proteins that have a distinct...

journal_title：Nature communications

authors： Gräff J,Woldemichael BT,Berchtold D,Dewarrat G,Mansuy IM

更新日期：2012-01-01 00:00:00

abstract：:Generation and recombination of electrons and holes in organic solar cells occurs via charge transfer states located at the donor/acceptor interface. The energy of these charge transfer states is a crucial factor for the attainable open-circuit voltage and its correct determination is thus of utmost importance for a d...

journal_title：Nature communications

authors： List M,Sarkar T,Perkhun P,Ackermann J,Luo C,Würfel U

更新日期：2018-09-07 00:00:00

abstract：:Normalization is a common cortical computation widely observed in sensory perception, but its importance in perception of reward value and decision making remains largely unknown. We examined (1) whether normalized value signals occur in the orbitofrontal cortex (OFC) and (2) whether changes in behavioral task context...

journal_title：Nature communications

authors： Yamada H,Louie K,Tymula A,Glimcher PW

更新日期：2018-01-11 00:00:00

abstract：:Embedding tunable quantum emitters in a photonic bandgap structure enables control of dissipative and dispersive interactions between emitters and their photonic bath. Operation in the transmission band, outside the gap, allows for studying waveguide quantum electrodynamics in the slow-light regime. Alternatively, tun...

journal_title：Nature communications

authors： Mirhosseini M,Kim E,Ferreira VS,Kalaee M,Sipahigil A,Keller AJ,Painter O

更新日期：2018-09-12 00:00:00

abstract：:DNA-coated colloids hold great promise for self-assembly of programmed heterogeneous microstructures, provided they not only bind when cooled below their melting temperature, but also rearrange so that aggregated particles can anneal into the structure that minimizes the free energy. Unfortunately, DNA-coated colloids...

journal_title：Nature communications

authors： Wang Y,Wang Y,Zheng X,Ducrot É,Yodh JS,Weck M,Pine DJ

更新日期：2015-06-16 00:00:00

abstract：:A human cell contains hundreds to thousands of mitochondrial DNA (mtDNA) packaged into nucleoids. Currently, the segregation and allocation of nucleoids are thought to be passively determined by mitochondrial fusion and division. Here we provide evidence, using live-cell super-resolution imaging, that nucleoids can be...

journal_title：Nature communications

authors： Qin J,Guo Y,Xue B,Shi P,Chen Y,Su QP,Hao H,Zhao S,Wu C,Yu L,Li D,Sun Y

更新日期：2020-09-08 00:00:00