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Identification of a pocket factor that is critical to Zika virus assembly.

Abstract：

:Zika virus (ZIKV) is an emerging mosquito borne flavivirus and a major public health concern causing severe disease. Due to the presence of a lipid membrane and structural heterogeneity, attaining an atomic resolution structure is challenging, but important to understand virus assembly and life cycle mechanisms that offer distinct targets for therapeutic intervention. We here use subvolume refinement to achieve a 3.4 Å resolution structure and identify two distinct lipid moieties. The first arises from the inner leaflet and is coordinated by hydrophobic residues of the M and E transmembrane helices that form a binding pocket not previously characterized. The second lipid arises from the outer leaflet coordinate between two E protein helices. Structure-based mutagenesis identifies critical hydrophobic interactions and their effect on the virus life cycle. Results show that lipids play an essential role in the ZIKV assembly pathway revealing a potential target of lipid based antiviral drug development.

journal_name

Nat Commun

journal_title

Nature communications

authors

DiNunno NM,Goetschius DJ,Narayanan A,Majowicz SA,Moustafa I,Bator CM,Hafenstein SL,Jose J

doi

10.1038/s41467-020-18747-4

subject

Has Abstract

pub_date

2020-10-02 00:00:00

pages

4953

issue

1

issn

2041-1723

pii

10.1038/s41467-020-18747-4

journal_volume

11

pub_type

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