Proteogenomic landscape of squamous cell lung cancer.

abstract：:The original version of this Article contained an error in the last sentence of the second paragraph of the 'Atmospheric rarefaction effects' section of the Results, which incorrectly read 'The other one emulates the rarefied, CO2-rich Martian atmosphere (μ♂ = 1.3 × 10-5 N s m-2) at 6.9 mbar and 210 K, which gives ρ♂ ...

journal_title：Nature communications

authors： Di Renzo M,Urzay J

更新日期：2018-05-21 00:00:00

abstract：:Gross chromosomal rearrangements (GCRs), such as translocations, deletions or inversions, are often generated by illegitimate repair between two DNA breakages at regions with nucleotide sequences that might potentially adopt a non-B DNA conformation. We previously established a plasmid-based model system that recapitu...

journal_title：Nature communications

authors： Inagaki H,Ohye T,Kogo H,Tsutsumi M,Kato T,Tong M,Emanuel BS,Kurahashi H

更新日期：2013-01-01 00:00:00

abstract：:Lipids and amphiphilic block copolymers spontaneously self-assemble in water to form a plethora of micelles and vesicles. They are typically fluidic in nature and often mechanically weak for applications such as drug delivery and gene therapeutics. Mechanical properties of polymeric materials could be improved by form...

journal_title：Nature communications

authors： Wang W,Qi H,Zhou T,Mei S,Han L,Higuchi T,Jinnai H,Li CY

更新日期：2016-02-03 00:00:00

abstract：:The diversity reflected by >100 different neural cell types fundamentally contributes to brain function and a central idea is that neuronal identity can be inferred from genetic information. Recent large-scale transcriptomic assays seem to confirm this hypothesis, but a lack of morphological information has limited th...

journal_title：Nature communications

authors： Que L,Lukacsovich D,Luo W,Földy C

更新日期：2021-01-04 00:00:00

abstract：:FeV(O)(OH) species have long been proposed to play a key role in a wide range of biomimetic and enzymatic oxidations, including as intermediates in arene dihydroxylation catalyzed by Rieske oxygenases. However, the inability to accumulate these intermediates in solution has thus far prevented their spectroscopic and c...

journal_title：Nature communications

authors： Borrell M,Andris E,Navrátil R,Roithová J,Costas M

更新日期：2019-02-22 00:00:00

abstract：:Dimensionality reduction is often used to visualize complex expression profiling data. Here, we use the Uniform Manifold Approximation and Projection (UMAP) method on published transcript profiles of 1484 single gene deletions of Saccharomyces cerevisiae. Proximity in low-dimensional UMAP space identifies groups of ge...

journal_title：Nature communications

authors： Dorrity MW,Saunders LM,Queitsch C,Fields S,Trapnell C

更新日期：2020-03-24 00:00:00

abstract：:Some two-dimensional liquid systems are theoretically predicted to have an anomalous phase transition due to unique intermolecular interactions, for example the first-order transition between two-dimensional high-density water and low-density amorphous ice. However, it has never been experimentally observed, to the be...

journal_title：Nature communications

authors： Li W,Kong L,Feng B,Fu H,Li H,Zeng XC,Wu K,Chen L

更新日期：2018-01-15 00:00:00

abstract：:The original version of this Article was missing the ORCID ID of Professor Nicola Pugno.Also in the original version of this Article, the third to last sentence of the fourth paragraph of the Results incorrectly read 'However, the stepwise addition of CNTs increases the self-entanglement and thereby the compressive st...

journal_title：Nature communications

authors： Schütt F,Signetti S,Krüger H,Röder S,Smazna D,Kaps S,Gorb SN,Mishra YK,Pugno NM,Adelung R

更新日期：2018-01-09 00:00:00

abstract：:Transcription errors occur in all living cells; however, it is unknown how these errors affect cellular health. To answer this question, we monitor yeast cells that are genetically engineered to display error-prone transcription. We discover that these cells suffer from a profound loss in proteostasis, which sensitize...

journal_title：Nature communications

authors： Vermulst M,Denney AS,Lang MJ,Hung CW,Moore S,Moseley MA,Thompson JW,Madden V,Gauer J,Wolfe KJ,Summers DW,Schleit J,Sutphin GL,Haroon S,Holczbauer A,Caine J,Jorgenson J,Cyr D,Kaeberlein M,Strathern JN,Duncan MC,E

更新日期：2015-08-25 00:00:00

abstract：:Intramolecular photostabilization via triple-state quenching was recently revived as a tool to impart synthetic organic fluorophores with 'self-healing' properties. To date, utilization of such fluorophore derivatives is rare due to their elaborate multi-step synthesis. Here we present a general strategy to covalently...

journal_title：Nature communications

authors： van der Velde JH,Oelerich J,Huang J,Smit JH,Aminian Jazi A,Galiani S,Kolmakov K,Guoridis G,Eggeling C,Herrmann A,Roelfes G,Cordes T

更新日期：2016-01-11 00:00:00

abstract：:We have sequenced 463 presenting cases of myeloma entered into the UK Myeloma XI study using whole exome sequencing. Here we identify mutations induced as a consequence of misdirected AID in the partner oncogenes of IGH translocations, which are activating and associated with impaired clinical outcome. An APOBEC mutat...

journal_title：Nature communications

authors： Walker BA,Wardell CP,Murison A,Boyle EM,Begum DB,Dahir NM,Proszek PZ,Melchor L,Pawlyn C,Kaiser MF,Johnson DC,Qiang YW,Jones JR,Cairns DA,Gregory WM,Owen RG,Cook G,Drayson MT,Jackson GH,Davies FE,Morgan GJ

更新日期：2015-04-23 00:00:00

abstract：:Congenital Zika syndrome (CZS) causes early brain development impairment by affecting neural progenitor cells (NPCs). Here, we analyze NPCs from three pairs of dizygotic twins discordant for CZS. We compare by RNA-Seq the NPCs derived from CZS-affected and CZS-unaffected twins. Prior to Zika virus (ZIKV) infection the...

journal_title：Nature communications

authors： Caires-Júnior LC,Goulart E,Melo US,Araujo BHS,Alvizi L,Soares-Schanoski A,de Oliveira DF,Kobayashi GS,Griesi-Oliveira K,Musso CM,Amaral MS,daSilva LF,Astray RM,Suárez-Patiño SF,Ventini DC,Gomes da Silva S,Yamamoto GL,Ez

更新日期：2018-02-02 00:00:00

abstract：:The performance of conjugated polymer devices is largely dictated by charge transport processes. However, it is difficult to obtain a clear relationship between conjugated polymer structures and charge transport properties, due to the complexity of the structure and the dispersive nature of charge transport in conjuga...

journal_title：Nature communications

authors： Jiang Y,McNeill J

更新日期：2018-10-17 00:00:00

abstract：:The insulin/IGF-1 signalling pathway is a key regulator of metabolism and the rate of ageing. We previously documented that systemic inactivation of phosphoinositide 3-kinase (PI3K) p110α, the principal PI3K isoform that positively regulates insulin signalling, results in a beneficial metabolic effect in aged mice. He...

journal_title：Nature communications

authors： Araiz C,Yan A,Bettedi L,Samuelson I,Virtue S,McGavigan AK,Dani C,Vidal-Puig A,Foukas LC

更新日期：2019-04-04 00:00:00

abstract：:Increased vascular permeability contributes to many diseases, including acute respiratory distress syndrome, cancer and inflammation. Most past work on vascular barrier function has focused on soluble regulators, such as tumour-necrosis factor-α. Here we show that lung vascular permeability is controlled mechanically ...

journal_title：Nature communications

authors： Mammoto A,Mammoto T,Kanapathipillai M,Wing Yung C,Jiang E,Jiang A,Lofgren K,Gee EP,Ingber DE

更新日期：2013-01-01 00:00:00

abstract：:Despite tremendous importance in catalysis, the design of oxide-metal interface has been hampered by the limited understanding of the nature of interfacial sites and the oxide-metal interaction (OMI). Through construction of well-defined Cu2O/Pt, Cu2O/Ag and Cu2O/Au interfaces, we find that Cu2O nanostructures (NSs) o...

journal_title：Nature communications

authors： Huang W,Liu Q,Zhou Z,Li Y,Ling Y,Wang Y,Tu Y,Wang B,Zhou X,Deng D,Yang B,Yang Y,Liu Z,Bao X,Yang F

更新日期：2020-05-08 00:00:00

abstract：:Quantum dots (QDs) are an excellent single-photon source that can be combined with a spin quantum memory. Many quantum technologies require increased control over the characteristics of emitted photons. A powerful approach is to trigger coherent Raman photons from QDs with a Λ energy-level system, such as the spin sin...

journal_title：Nature communications

authors： Pursley BC,Carter SG,Yakes MK,Bracker AS,Gammon D

更新日期：2018-01-09 00:00:00

abstract：:The nucleotidyl cyclase toxin ExoY is one of the virulence factors injected by the Pseudomonas aeruginosa type III secretion system into host cells. Inside cells, it is activated by an unknown eukaryotic cofactor to synthesize various cyclic nucleotide monophosphates. ExoY-like adenylate cyclases are also found in Mul...

journal_title：Nature communications

authors： Belyy A,Raoux-Barbot D,Saveanu C,Namane A,Ogryzko V,Worpenberg L,David V,Henriot V,Fellous S,Merrifield C,Assayag E,Ladant D,Renault L,Mechold U

更新日期：2016-12-05 00:00:00

abstract：:Constitutive activation of Wnt/β-catenin inhibits oligodendrocyte myelination. Tcf7l2/Tcf4, a β-catenin transcriptional partner, is required for oligodendrocyte differentiation. How Tcf7l2 modifies β-catenin signalling and controls myelination remains elusive. Here we define a stage-specific Tcf7l2-regulated transcrip...

journal_title：Nature communications

authors： Zhao C,Deng Y,Liu L,Yu K,Zhang L,Wang H,He X,Wang J,Lu C,Wu LN,Weng Q,Mao M,Li J,van Es JH,Xin M,Parry L,Goldman SA,Clevers H,Lu QR

更新日期：2016-03-09 00:00:00

abstract：:Following microbial pathogen invasion, one of the main challenges for the host is to rapidly control pathogen spreading to avoid vital tissue damage. Here we report that an effector CD8(+) T-cell population that expresses the marker NK1.1 undergoes delayed contraction and sustains early anti-microbial protection. NK1....

journal_title：Nature communications

authors： Ruiz AL,Soudja SM,Deceneux C,Lauvau G,Marie JC

更新日期：2014-10-06 00:00:00

abstract：:Nanocarrier administration has primarily been restricted to intermittent bolus injections with limited available options for sustained delivery in vivo. Here, we demonstrate that cylinder-to-sphere transitions of self-assembled filomicelle (FM) scaffolds can be employed for sustained delivery of monodisperse micellar ...

journal_title：Nature communications

authors： Karabin NB,Allen S,Kwon HK,Bobbala S,Firlar E,Shokuhfar T,Shull KR,Scott EA

更新日期：2018-02-12 00:00:00

abstract：:Ligand-induced receptor dimerization has traditionally been viewed as the key event in transmembrane signalling by epidermal growth factor receptors (EGFRs). Here we show that the Caenorhabditis elegans EGFR orthologue LET-23 is constitutively dimeric, yet responds to its ligand LIN-3 without changing oligomerization ...

journal_title：Nature communications

authors： Freed DM,Alvarado D,Lemmon MA

更新日期：2015-06-10 00:00:00

abstract：:While plasmonic designs have dominated recent trends in structural color, schemes using localized surface plasmon resonances and surface plasmon polaritons that simultaneously achieve high color vibrancy at ultrahigh resolution have been elusive because of tradeoffs between size and performance. Herein we demonstrate ...

journal_title：Nature communications

authors： Lee JS,Park JY,Kim YH,Jeon S,Ouellette O,Sargent EH,Kim DH,Hyun JK

更新日期：2019-10-21 00:00:00

abstract：:The evolution of the seawater oxygen isotopic composition (δ18O) through geological time remains controversial. Yet, the past δ18Oseawater is key to assess past seawater temperatures, providing insights into past climate change and life evolution. Here we provide a new and unprecedentedly precise δ18O value of -1.33 ±...

journal_title：Nature communications

authors： Hodel F,Macouin M,Trindade RIF,Triantafyllou A,Ganne J,Chavagnac V,Berger J,Rospabé M,Destrigneville C,Carlut J,Ennih N,Agrinier P

更新日期：2018-04-13 00:00:00

abstract：:Lysosomes are the major degradative compartments within cells, harbouring a wide variety of hydrolytic enzymes within their lumen. Release of lysosomal hydrolases from lysosomes into the cell cytoplasm results in cell death. Here we report that damaged lysosomes undergo autophagic turnover. Using a light-induced lysos...

journal_title：Nature communications

authors： Hung YH,Chen LM,Yang JY,Yang WY

更新日期：2013-01-01 00:00:00

abstract：:Glucagon is released from pancreatic α-cells to activate pathways that raise blood glucose. Its secretion is regulated by α-cell-intrinsic glucose sensing and paracrine control through insulin and somatostatin. To understand the inadequately high glucagon levels that contribute to hyperglycemia in type-2 diabetes (T2D...

journal_title：Nature communications

authors： Omar-Hmeadi M,Lund PE,Gandasi NR,Tengholm A,Barg S

更新日期：2020-04-20 00:00:00

abstract：:Biologists have long been fascinated by the amazing diversity of animal colour patterns. Despite much interest, the underlying evolutionary and developmental mechanisms contributing to their rich variety remain largely unknown, especially the vivid and complex colour patterns seen in vertebrates. Here, we show that co...

journal_title：Nature communications

authors： Miyazawa S,Okamoto M,Kondo S

更新日期：2010-09-07 00:00:00

abstract：:Gemcitabine is the first-line treatment for locally advanced and metastatic gallbladder cancer (GBC), but poor gemcitabine response is universal. Here, we utilize a genome-wide CRISPR screen to identify that loss of ELP5 reduces the gemcitabine-induced apoptosis in GBC cells in a P53-dependent manner through the Elong...

journal_title：Nature communications

authors： Xu S,Zhan M,Jiang C,He M,Yang L,Shen H,Huang S,Huang X,Lin R,Shi Y,Liu Q,Chen W,Mohan M,Wang J

更新日期：2019-12-02 00:00:00

abstract：:The laboratory mouse serves as an important model system for studying gene, brain and behavioural interactions. Powerful methods of gene targeting have helped to decipher gene-function associations in human diseases. Yet, the laboratory mouse, obtained after decades of human-driven artificial selection, inbreeding, an...

journal_title：Nature communications

authors： Chalfin L,Dayan M,Levy DR,Austad SN,Miller RA,Iraqi FA,Dulac C,Kimchi T

更新日期：2014-08-05 00:00:00

abstract：:Ice-shelf channels are long curvilinear tracts of thin ice found on Antarctic ice shelves. Many of them originate near the grounding line, but their formation mechanisms remain poorly understood. Here we use ice-penetrating radar data from Roi Baudouin Ice Shelf, East Antarctica, to infer that the morphology of severa...

journal_title：Nature communications

authors： Drews R,Pattyn F,Hewitt IJ,Ng FSL,Berger S,Matsuoka K,Helm V,Bergeot N,Favier L,Neckel N

更新日期：2017-05-09 00:00:00