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CHML promotes liver cancer metastasis by facilitating Rab14 recycle.

Abstract：

:Metastasis-associated recurrence is the major cause of poor prognosis in hepatocellular carcinoma (HCC), however, the underlying mechanisms remain largely elusive. In this study, we report that expression of choroideremia-like (CHML) is increased in HCC, associated with poor survival, early recurrence and more satellite nodules in HCC patients. CHML promotes migration, invasion and metastasis of HCC cells, in a Rab14-dependent manner. Mechanism study reveals that CHML facilitates constant recycling of Rab14 by escorting Rab14 to the membrane. Furthermore, we identify several metastasis regulators as cargoes carried by Rab14-positive vesicles, including Mucin13 and CD44, which may contribute to metastasis-promoting effects of CHML. Altogether, our data establish CHML as a potential promoter of HCC metastasis, and the CHML-Rab14 axis may be a promising therapeutic target for HCC.

journal_name

Nat Commun

journal_title

Nature communications

authors

Chen TW,Yin FF,Yuan YM,Guan DX,Zhang E,Zhang FK,Jiang H,Ma N,Wang JJ,Ni QZ,Qiu L,Feng J,Zhang XL,Bao Y,Wang K,Cheng SQ,Wang XF,Wang X,Li JJ,Xie D

doi

10.1038/s41467-019-10364-0

subject

Has Abstract

pub_date

2019-06-07 00:00:00

pages

2510

issue

1

issn

2041-1723

pii

10.1038/s41467-019-10364-0

journal_volume

10

pub_type

杂志文章

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