当前位置： SCI文献检索 > Nature Communications期刊下所有文献 > A kinome-wide screen identifies a CDKL5-SOX9 regulatory axis in epithelial cell death and kidney injury.

A kinome-wide screen identifies a CDKL5-SOX9 regulatory axis in epithelial cell death and kidney injury.

Abstract：

:Renal tubular epithelial cells (RTECs) perform the essential function of maintaining the constancy of body fluid composition and volume. Toxic, inflammatory, or hypoxic-insults to RTECs can cause systemic fluid imbalance, electrolyte abnormalities and metabolic waste accumulation- manifesting as acute kidney injury (AKI), a common disorder associated with adverse long-term sequelae and high mortality. Here we report the results of a kinome-wide RNAi screen for cellular pathways involved in AKI-associated RTEC-dysfunction and cell death. Our screen and validation studies reveal an essential role of Cdkl5-kinase in RTEC cell death. In mouse models, genetic or pharmacological Cdkl5 inhibition mitigates nephrotoxic and ischemia-associated AKI. We propose that Cdkl5 is a stress-responsive kinase that promotes renal injury in part through phosphorylation-dependent suppression of pro-survival transcription regulator Sox9. These findings reveal a surprising non-neuronal function of Cdkl5, identify a pathogenic Cdkl5-Sox9 axis in epithelial cell-death, and support CDKL5 antagonism as a therapeutic approach for AKI.

journal_name

Nat Commun

journal_title

Nature communications

authors

Kim JY,Bai Y,Jayne LA,Hector RD,Persaud AK,Ong SS,Rojesh S,Raj R,Feng MJHH,Chung S,Cianciolo RE,Christman JW,Campbell MJ,Gardner DS,Baker SD,Sparreboom A,Govindarajan R,Singh H,Chen T,Poi M,Susztak K,Cobb SR,P

doi

10.1038/s41467-020-15638-6

subject

Has Abstract

pub_date

2020-04-21 00:00:00

pages

1924

issue

1

issn

2041-1723

pii

10.1038/s41467-020-15638-6

journal_volume

11

pub_type

杂志文章

相关文献

Nature Communications文献大全
  • Highly multiplexed imaging of single cells using a high-throughput cyclic immunofluorescence method.

    abstract：:Single-cell analysis reveals aspects of cellular physiology not evident from population-based studies, particularly in the case of highly multiplexed methods such as mass cytometry (CyTOF) able to correlate the levels of multiple signalling, differentiation and cell fate markers. Immunofluorescence (IF) microscopy add...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms9390

    authors： Lin JR,Fallahi-Sichani M,Sorger PK

    更新日期：2015-09-24 00:00:00

  • High-throughput preparation of radioprotective polymers via Hantzsch's reaction for in vivo X-ray damage determination.

    abstract：:Radioprotectors for acute injuries caused by large doses of ionizing radiation are vital to national security, public health and future development of humankind. Here, we develop a strategy to explore safe and efficient radioprotectors by combining Hantzsch's reaction, high-throughput methods and polymer chemistry. A ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-20027-0

    authors： Liu G,Zeng Y,Lv T,Mao T,Wei Y,Jia S,Gou Y,Tao L

    更新日期：2020-12-04 00:00:00

  • Molecular transport through large-diameter DNA nanopores.

    abstract：:DNA-based nanopores are synthetic biomolecular membrane pores, whose geometry and chemical functionality can be tuned using the tools of DNA nanotechnology, making them promising molecular devices for applications in single-molecule biosensing and synthetic biology. Here we introduce a large DNA membrane channel with ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms12787

    authors： Krishnan S,Ziegler D,Arnaut V,Martin TG,Kapsner K,Henneberg K,Bausch AR,Dietz H,Simmel FC

    更新日期：2016-09-23 00:00:00

  • Citizen science provides a reliable and scalable tool to track disease-carrying mosquitoes.

    abstract：:Recent outbreaks of Zika, chikungunya and dengue highlight the importance of better understanding the spread of disease-carrying mosquitoes across multiple spatio-temporal scales. Traditional surveillance tools are limited by jurisdictional boundaries and cost constraints. Here we show how a scalable citizen science s...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-017-00914-9

    authors： Palmer JRB,Oltra A,Collantes F,Delgado JA,Lucientes J,Delacour S,Bengoa M,Eritja R,Bartumeus F

    更新日期：2017-10-24 00:00:00

  • Potential regime shift in decreased sea ice production after the Mertz Glacier calving.

    abstract：:Variability in dense shelf water formation can potentially impact Antarctic Bottom Water (AABW) production, a vital component of the global climate system. In East Antarctica, the George V Land polynya system (142-150°E) is structured by the local 'icescape', promoting sea ice formation that is driven by the offshore ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms1820

    authors： Tamura T,Williams GD,Fraser AD,Ohshima KI

    更新日期：2012-05-08 00:00:00

  • Resolving Dirac electrons with broadband high-resolution NMR.

    abstract：:Detecting the metallic Dirac electronic states on the surface of Topological Insulators (TIs) is critical for the study of important surface quantum properties (SQPs), such as Majorana zero modes, where simultaneous probing of the bulk and edge electron states is required. However, there is a particular shortage of ex...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-14838-4

    authors： Papawassiliou W,Jaworski A,Pell AJ,Jang JH,Kim Y,Lee SC,Kim HJ,Alwahedi Y,Alhassan S,Subrati A,Fardis M,Karagianni M,Panopoulos N,Dolinšek J,Papavassiliou G

    更新日期：2020-03-09 00:00:00

  • VAMP7 regulates constitutive membrane incorporation of the cold-activated channel TRPM8.

    abstract：:The cation channel TRPM8 plays a central role in the somatosensory system, as a key sensor of innocuously cold temperatures and cooling agents. Although increased functional expression of TRPM8 has been implicated in various forms of pathological cold hypersensitivity, little is known about the cellular and molecular ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms10489

    authors： Ghosh D,Pinto S,Danglot L,Vandewauw I,Segal A,Van Ranst N,Benoit M,Janssens A,Vennekens R,Vanden Berghe P,Galli T,Vriens J,Voets T

    更新日期：2016-02-04 00:00:00

  • Implications of improved representations of plant respiration in a changing climate.

    abstract：:Land-atmosphere exchanges influence atmospheric CO2. Emphasis has been on describing photosynthetic CO2 uptake, but less on respiration losses. New global datasets describe upper canopy dark respiration (R d) and temperature dependencies. This allows characterisation of baseline R d, instantaneous temperature response...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-017-01774-z

    authors： Huntingford C,Atkin OK,Martinez-de la Torre A,Mercado LM,Heskel MA,Harper AB,Bloomfield KJ,O'Sullivan OS,Reich PB,Wythers KR,Butler EE,Chen M,Griffin KL,Meir P,Tjoelker MG,Turnbull MH,Sitch S,Wiltshire A,Malhi Y

    更新日期：2017-11-17 00:00:00

  • Midwinter Arctic leads form and dissipate low clouds.

    abstract：:Leads are a key feature of the Arctic ice pack during the winter owing to their substantial contribution to the surface energy balance. According to the present understanding, enhanced heat and moisture fluxes from high lead concentrations tend to produce more boundary layer clouds. However, described here in our comp...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-14074-5

    authors： Li X,Krueger SK,Strong C,Mace GG,Benson S

    更新日期：2020-01-10 00:00:00

  • Author Correction: Metal-coordinated sub-10 nm membranes for water purification.

    abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title：Nature communications

    pub_type： 已发布勘误

    doi：10.1038/s41467-020-14339-4

    authors： You X,Wu H,Zhang R,Su Y,Cao L,Yu Q,Yuan J,Xiao K,He M,Jiang Z

    更新日期：2020-01-24 00:00:00

  • Receptor-binding loops in alphacoronavirus adaptation and evolution.

    abstract：:RNA viruses are characterized by a high mutation rate, a buffer against environmental change. Nevertheless, the means by which random mutation improves viral fitness is not well characterized. Here we report the X-ray crystal structure of the receptor-binding domain (RBD) of the human coronavirus, HCoV-229E, in comple...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-017-01706-x

    authors： Wong AHM,Tomlinson ACA,Zhou D,Satkunarajah M,Chen K,Sharon C,Desforges M,Talbot PJ,Rini JM

    更新日期：2017-11-23 00:00:00

  • The role of spin in the degradation of organic photovoltaics.

    abstract：:Stability is now a critical factor in the commercialization of organic photovoltaic (OPV) devices. Both extrinsic stability to oxygen and water and intrinsic stability to light and heat in inert conditions must be achieved. Triplet states are known to be problematic in both cases, leading to singlet oxygen production ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-20601-6

    authors： Ramirez I,Privitera A,Karuthedath S,Jungbluth A,Benduhn J,Sperlich A,Spoltore D,Vandewal K,Laquai F,Riede M

    更新日期：2021-01-20 00:00:00

  • Structure of the human plasma membrane Ca2+-ATPase 1 in complex with its obligatory subunit neuroplastin.

    abstract：:Plasma membrane Ca2+-ATPases (PMCAs) are key regulators of global Ca2+ homeostasis and local intracellular Ca2+ dynamics. Recently, Neuroplastin (NPTN) and basigin were identified as previously unrecognized obligatory subunits of PMCAs that dramatically increase the efficiency of PMCA-mediated Ca2+ clearance. Here, we...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-06075-7

    authors： Gong D,Chi X,Ren K,Huang G,Zhou G,Yan N,Lei J,Zhou Q

    更新日期：2018-09-06 00:00:00

  • Laminin regulates PDGFRβ(+) cell stemness and muscle development.

    abstract：:Muscle-resident PDGFRβ(+) cells, which include pericytes and PW1(+) interstitial cells (PICs), play a dual role in muscular dystrophy. They can either undergo myogenesis to promote muscle regeneration or differentiate into adipocytes and other cells to compromise regeneration. How the differentiation and fate determin...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms11415

    authors： Yao Y,Norris EH,Mason CE,Strickland S

    更新日期：2016-05-03 00:00:00

  • Heterovalent cation substitutional doping for quantum dot homojunction solar cells.

    abstract：:Colloidal quantum dots have emerged as a material platform for low-cost high-performance optoelectronics. At the heart of optoelectronic devices lies the formation of a junction, which requires the intimate contact of n-type and p-type semiconductors. Doping in bulk semiconductors has been largely deployed for many de...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms3981

    authors： Stavrinadis A,Rath AK,de Arquer FP,Diedenhofen SL,Magén C,Martinez L,So D,Konstantatos G

    更新日期：2013-01-01 00:00:00

  • Controlling spin current polarization through non-collinear antiferromagnetism.

    abstract：:The interconversion of charge and spin currents via spin-Hall effect is essential for spintronics. Energy-efficient and deterministic switching of magnetization can be achieved when spin polarizations of these spin currents are collinear with the magnetization. However, symmetry conditions generally restrict spin pola...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-17999-4

    authors： Nan T,Quintela CX,Irwin J,Gurung G,Shao DF,Gibbons J,Campbell N,Song K,Choi S-,Guo L,Johnson RD,Manuel P,Chopdekar RV,Hallsteinsen I,Tybell T,Ryan PJ,Kim J-,Choi Y,Radaelli PG,Ralph DC,Tsymbal EY,Rzchowski MS,

    更新日期：2020-09-16 00:00:00

  • RAN translation at C9orf72-associated repeat expansions is selectively enhanced by the integrated stress response.

    abstract：:Repeat-associated non-AUG (RAN) translation allows for unconventional initiation at disease-causing repeat expansions. As RAN translation contributes to pathogenesis in multiple neurodegenerative disorders, determining its mechanistic underpinnings may inform therapeutic development. Here we analyze RAN translation at...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-017-02200-0

    authors： Green KM,Glineburg MR,Kearse MG,Flores BN,Linsalata AE,Fedak SJ,Goldstrohm AC,Barmada SJ,Todd PK

    更新日期：2017-12-08 00:00:00

  • Bidirectional prefrontal-hippocampal dynamics organize information transfer during sleep in humans.

    abstract：:How are memories transferred from short-term to long-term storage? Systems-level memory consolidation is thought to be dependent on the coordinated interplay of cortical slow waves, thalamo-cortical sleep spindles and hippocampal ripple oscillations. However, it is currently unclear how the selective interaction of th...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-11444-x

    authors： Helfrich RF,Lendner JD,Mander BA,Guillen H,Paff M,Mnatsakanyan L,Vadera S,Walker MP,Lin JJ,Knight RT

    更新日期：2019-08-08 00:00:00

  • Polarization of M2 macrophages requires Lamtor1 that integrates cytokine and amino-acid signals.

    abstract：:Macrophages play crucial roles in host defence and tissue homoeostasis, processes in which both environmental stimuli and intracellularly generated metabolites influence activation of macrophages. Activated macrophages are classified into M1 and M2 macrophages. It remains unclear how intracellular nutrition sufficienc...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms13130

    authors： Kimura T,Nada S,Takegahara N,Okuno T,Nojima S,Kang S,Ito D,Morimoto K,Hosokawa T,Hayama Y,Mitsui Y,Sakurai N,Sarashina-Kida H,Nishide M,Maeda Y,Takamatsu H,Okuzaki D,Yamada M,Okada M,Kumanogoh A

    更新日期：2016-10-12 00:00:00

  • Time-compressed preplay of anticipated events in human primary visual cortex.

    abstract：:Perception is guided by the anticipation of future events. It has been hypothesized that this process may be implemented by pattern completion in early visual cortex, in which a stimulus sequence is recreated after only a subset of the visual input is provided. Here we test this hypothesis using ultra-fast functional ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms15276

    authors： Ekman M,Kok P,de Lange FP

    更新日期：2017-05-23 00:00:00

  • An excitatory ventral hippocampus to lateral septum circuit that suppresses feeding.

    abstract：:Previous research has focused on feeding circuits residing in the hindbrain and midbrain that govern homeostatic or hedonic control of food intake. However, the feeding circuits controlling emotional or cognitive aspects of food intake are largely unknown. Here we use chemical genetics and optogenetic techniques to di...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms10188

    authors： Sweeney P,Yang Y

    更新日期：2015-12-15 00:00:00

  • Author Correction: Molecular basis for the inhibition of the methyl-lysine binding function of 53BP1 by TIRR.

    abstract：:The original version of this Article contained an error in the author affiliations. Xiaochun Yu was incorrectly associated with College of Life Sciences, Hebei University, Baoding 071000 Hebei, China.This has now been corrected in both the PDF and HTML versions of the Article. ...

    journal_title：Nature communications

    pub_type： 杂志文章,已发布勘误

    doi：10.1038/s41467-018-08086-w

    authors： Wang J,Yuan Z,Cui Y,Xie R,Yang G,Kassab MA,Wang M,Ma Y,Wu C,Yu X,Liu X

    更新日期：2019-01-08 00:00:00

  • Targeting mutant p53-expressing tumours with a T cell receptor-like antibody specific for a wild-type antigen.

    abstract：:Accumulation of mutant p53 proteins is frequently found in a wide range of cancers. While conventional antibodies fail to target intracellular proteins, proteosomal degradation results in the presentation of p53-derived peptides on the tumour cell surface by class I molecules of the major histocompatibility complex (M...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-13305-z

    authors： Low L,Goh A,Koh J,Lim S,Wang CI

    更新日期：2019-11-26 00:00:00

  • Synthetic antibodies against BRIL as universal fiducial marks for single-particle cryoEM structure determination of membrane proteins.

    abstract：:We propose the concept of universal fiducials based on a set of pre-made semi-synthetic antibodies (sABs) generated by customized phage display selections against the fusion protein BRIL, an engineered variant of apocytochrome b562a. These sABs can bind to BRIL fused either into the loops or termini of different GPCRs...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-15363-0

    authors： Mukherjee S,Erramilli SK,Ammirati M,Alvarez FJD,Fennell KF,Purdy MD,Skrobek BM,Radziwon K,Coukos J,Kang Y,Dutka P,Gao X,Qiu X,Yeager M,Eric Xu H,Han S,Kossiakoff AA

    更新日期：2020-03-27 00:00:00

  • A pan-cancer analysis of synonymous mutations.

    abstract：:Synonymous mutations have been viewed as silent mutations, since they only affect the DNA and mRNA, but not the amino acid sequence of the resulting protein. Nonetheless, recent studies suggest their significant impact on splicing, RNA stability, RNA folding, translation or co-translational protein folding. Hence, we ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-10489-2

    authors： Sharma Y,Miladi M,Dukare S,Boulay K,Caudron-Herger M,Groß M,Backofen R,Diederichs S

    更新日期：2019-06-12 00:00:00

  • Quantifying cerebral contributions to pain beyond nociception.

    abstract：:Cerebral processes contribute to pain beyond the level of nociceptive input and mediate psychological and behavioural influences. However, cerebral contributions beyond nociception are not yet well characterized, leading to a predominant focus on nociception when studying pain and developing interventions. Here we use...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms14211

    authors： Woo CW,Schmidt L,Krishnan A,Jepma M,Roy M,Lindquist MA,Atlas LY,Wager TD

    更新日期：2017-02-14 00:00:00

  • Estimating sources and sinks of malaria parasites in Madagascar.

    abstract：:In areas where malaria epidemiology is spatially and temporally heterogeneous, human-mediated parasite importation can result in non-locally acquired clinical cases and outbreaks in low-transmission areas. Using mobility estimates derived from the mobile phone data and spatial malaria prevalence data, we identify trav...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-06290-2

    authors： Ihantamalala FA,Herbreteau V,Rakotoarimanana FMJ,Rakotondramanga JM,Cauchemez S,Rahoilijaona B,Pennober G,Buckee CO,Rogier C,Metcalf CJE,Wesolowski A

    更新日期：2018-09-25 00:00:00

  • Edge and confinement effects allow in situ measurement of size and thickness of liquid-exfoliated nanosheets.

    abstract：:Two-dimensional nanomaterials such as MoS2 are of great interest both because of their novel physical properties and their applications potential. Liquid exfoliation, an important production method, is limited by our inability to quickly and easily measure nanosheet size, thickness or concentration. Here we demonstrat...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms5576

    authors： Backes C,Smith RJ,McEvoy N,Berner NC,McCloskey D,Nerl HC,O'Neill A,King PJ,Higgins T,Hanlon D,Scheuschner N,Maultzsch J,Houben L,Duesberg GS,Donegan JF,Nicolosi V,Coleman JN

    更新日期：2014-08-07 00:00:00

  • A bacterial checkpoint protein for ribosome assembly moonlights as an essential metabolite-proofreading enzyme.

    abstract：:In eukaryotes, adventitious oxidation of erythrose-4-phosphate, an intermediate of the pentose phosphate pathway (PPP), generates 4-phosphoerythronate (4PE), which inhibits 6-phosphogluconate dehydrogenase. 4PE is detoxified by metabolite-proofreading phosphatases such as yeast Pho13. Here, we report that a similar fu...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-09508-z

    authors： Sachla AJ,Helmann JD

    更新日期：2019-04-04 00:00:00

  • Size-dependent kinetics during non-equilibrium lithiation of nano-sized zinc ferrite.

    abstract：:Spinel transition metal oxides (TMOs) have emerged as promising anode materials for lithium-ion batteries. It has been shown that reducing their particle size to nanoscale dimensions benefits overall electrochemical performance. Here, we use in situ transmission electron microscopy to probe the lithiation behavior of ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-07831-5

    authors： Li J,Meng Q,Zhang Y,Peng L,Yu G,Marschilok AC,Wu L,Su D,Takeuchi KJ,Takeuchi ES,Zhu Y,Stach EA

    更新日期：2019-01-09 00:00:00