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Estimating sources and sinks of malaria parasites in Madagascar.

Abstract：

:In areas where malaria epidemiology is spatially and temporally heterogeneous, human-mediated parasite importation can result in non-locally acquired clinical cases and outbreaks in low-transmission areas. Using mobility estimates derived from the mobile phone data and spatial malaria prevalence data, we identify travel routes relevant to malaria transmission in Madagascar. We find that the primary hubs of parasite importation are in a spatially connected area of the central highlands. Surprisingly, sources of these imported infections are not spatially clustered. We then related these source locations directly to clinical cases in the low-transmission area of the capital. We find that in the capital, a major sink, the primary sources of infection are along the more populated coastal areas, although these sources are seasonally variable. Our results have implications for targeting interventions at source locations to achieve local or national malaria control goals.

journal_name

Nat Commun

journal_title

Nature communications

authors

Ihantamalala FA,Herbreteau V,Rakotoarimanana FMJ,Rakotondramanga JM,Cauchemez S,Rahoilijaona B,Pennober G,Buckee CO,Rogier C,Metcalf CJE,Wesolowski A

doi

10.1038/s41467-018-06290-2

subject

Has Abstract

pub_date

2018-09-25 00:00:00

pages

3897

issue

1

issn

2041-1723

pii

10.1038/s41467-018-06290-2

journal_volume

9

pub_type

杂志文章

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