Abstract:
:Radioprotectors for acute injuries caused by large doses of ionizing radiation are vital to national security, public health and future development of humankind. Here, we develop a strategy to explore safe and efficient radioprotectors by combining Hantzsch's reaction, high-throughput methods and polymer chemistry. A water-soluble polymer with low-cytotoxicity and an excellent anti-radiation capability has been achieved. In in vivo experiments, this polymer is even better than amifostine, which is the only approved radioprotector for clinical applications, in effectively protecting zebrafish embryos from fatally large doses of ionizing radiation (80 Gy X-ray). A mechanistic study also reveals that the radioprotective ability of this polymer originates from its ability to efficiently prevent DNA damage due to high doses of radiation. This is an initial attempt to explore polymer radioprotectors via a multi-component reaction. It allows exploiting functional polymers and provides the underlying insights to guide the design of radioprotective polymers.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Liu G,Zeng Y,Lv T,Mao T,Wei Y,Jia S,Gou Y,Tao Ldoi
10.1038/s41467-020-20027-0subject
Has Abstractpub_date
2020-12-04 00:00:00pages
6214issue
1issn
2041-1723pii
10.1038/s41467-020-20027-0journal_volume
11pub_type
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