Field theory for recurrent mobility.

abstract：:The signaling diversity of GABAergic interneurons to post-synaptic neurons is crucial to generate the functional heterogeneity that characterizes brain circuits. Whether this diversity applies to other brain cells, such as the glial cells astrocytes, remains unexplored. Using optogenetics and two-photon functional ima...

journal_title：Nature communications

authors： Mariotti L,Losi G,Lia A,Melone M,Chiavegato A,Gómez-Gonzalo M,Sessolo M,Bovetti S,Forli A,Zonta M,Requie LM,Marcon I,Pugliese A,Viollet C,Bettler B,Fellin T,Conti F,Carmignoto G

更新日期：2018-01-08 00:00:00

abstract：:Self-assembly of small molecules in water to form nanofibres, besides generating sophisticated biomaterials, promises a simple system inside cells for regulating cellular processes. But lack of a convenient approach for studying the self-assembly of small molecules inside cells hinders the development of such systems....

journal_title：Nature communications

authors： Gao Y,Shi J,Yuan D,Xu B

更新日期：2012-01-01 00:00:00

abstract：:Ni/Fe oxyhydroxides are the best performing Earth-abundant electrocatalysts for water oxidation. However, the origin of their remarkable performance is not well understood. Herein, we employ spectroelectrochemical techniques to analyse the kinetics of water oxidation on a series of Ni/Fe oxyhydroxide films: FeOOH, FeO...

journal_title：Nature communications

authors： Francàs L,Corby S,Selim S,Lee D,Mesa CA,Godin R,Pastor E,Stephens IEL,Choi KS,Durrant JR

更新日期：2019-11-15 00:00:00

abstract：:Bone mineral density is known to be a heritable, polygenic trait whereas genetic variants contributing to lean mass variation remain largely unknown. We estimated the shared SNP heritability and performed a bivariate GWAS meta-analysis of total-body lean mass (TB-LM) and total-body less head bone mineral density (TBLH...

journal_title：Nature communications

authors： Medina-Gomez C,Kemp JP,Dimou NL,Kreiner E,Chesi A,Zemel BS,Bønnelykke K,Boer CG,Ahluwalia TS,Bisgaard H,Evangelou E,Heppe DHM,Bonewald LF,Gorski JP,Ghanbari M,Demissie S,Duque G,Maurano MT,Kiel DP,Hsu YH,C J van d

更新日期：2017-07-25 00:00:00

abstract：:Somatic mutations in the RNase IIIb domain of DICER1 arise in cancer and disrupt the cleavage of 5' pre-miRNA arms. Here, we characterize an unstudied, recurrent, mutation (S1344L) in the DICER1 RNase IIIa domain in tumors from The Cancer Genome Atlas (TCGA) project and MSK-IMPACT profiling. RNase IIIa/b hotspots are ...

journal_title：Nature communications

authors： Vedanayagam J,Chatila WK,Aksoy BA,Majumdar S,Skanderup AJ,Demir E,Schultz N,Sander C,Lai EC

更新日期：2019-08-15 00:00:00

abstract：:Scintillation based X-ray detection has received great attention for its application in a wide range of areas from security to healthcare. Here, we report highly efficient X-ray scintillators with state-of-the-art performance based on an organic metal halide, ethylenebis-triphenylphosphonium manganese (II) bromide ((C...

journal_title：Nature communications

authors： Xu LJ,Lin X,He Q,Worku M,Ma B

更新日期：2020-08-28 00:00:00

abstract：:SMC (structural maintenance of chromosomes) family members play essential roles in chromosome condensation, sister chromatid cohesion and DNA repair. It remains unclear how SMCs structure chromosomes and how their mechanochemical cycle regulates their interactions with DNA. Here we used single-molecule fluorescence mi...

journal_title：Nature communications

authors： Kim H,Loparo JJ

更新日期：2016-01-04 00:00:00

abstract：:A primary function of the midbrain stimulus selection network is to compute the highest-priority location for attention and gaze. Here we report the contribution of a specific cholinergic circuit to this computation. We functionally disconnected the tegmental cholinergic nucleus isthmi pars parvocellularis (Ipc) from ...

journal_title：Nature communications

authors： Asadollahi A,Knudsen EI

更新日期：2016-11-17 00:00:00

abstract：:For the large-scale sustainable implementation of polymer electrolyte membrane fuel cells in vehicles, high-performance electrocatalysts with low platinum consumption are desirable for use as cathode material during the oxygen reduction reaction in fuel cells. Here we report a carbon black-supported cost-effective, ef...

journal_title：Nature communications

authors： Liu J,Jiao M,Lu L,Barkholtz HM,Li Y,Wang Y,Jiang L,Wu Z,Liu DJ,Zhuang L,Ma C,Zeng J,Zhang B,Su D,Song P,Xing W,Xu W,Wang Y,Jiang Z,Sun G

更新日期：2017-07-24 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature communications

authors： Mattesen TB,Rasmussen MH,Sandoval J,Ongen H,Árnadóttir SS,Gladov J,Martinez-Cardus A,de Moura MC,Madsen AH,Laurberg S,Dermitzakis ET,Esteller M,Andersen CL,Bramsen JB

更新日期：2020-06-03 00:00:00

abstract：:The gut-derived orexigenic peptide hormone ghrelin enhances neuronal firing in the substantia nigra pars compacta, where dopaminergic neurons modulate the function of the nigrostriatal system for motor coordination. Here we describe a novel mechanism by which ghrelin enhances firing of nigral dopaminergic neurons by i...

journal_title：Nature communications

authors： Shi L,Bian X,Qu Z,Ma Z,Zhou Y,Wang K,Jiang H,Xie J

更新日期：2013-01-01 00:00:00

abstract：:Determining whether recurrent but rare cancer mutations are bona fide driver mutations remains a bottleneck in cancer research. Here we present the most comprehensive analysis of murine leukemia virus-driven lymphomagenesis produced to date, sequencing 700,000 mutations from >500 malignancies collected at time points ...

journal_title：Nature communications

authors： Webster P,Dawes JC,Dewchand H,Takacs K,Iadarola B,Bolt BJ,Caceres JJ,Kaczor J,Dharmalingam G,Dore M,Game L,Adejumo T,Elliott J,Naresh K,Karimi M,Rekopoulou K,Tan G,Paccanaro A,Uren AG

更新日期：2018-07-09 00:00:00

abstract：:No method exists to measure large-scale translation of genes in uncultured organisms in microbiomes. To overcome this limitation, we develop MetaRibo-Seq, a method for simultaneous ribosome profiling of tens to hundreds of organisms in microbiome samples. MetaRibo-Seq was benchmarked against gold-standard Ribo-Seq in ...

journal_title：Nature communications

authors： Fremin BJ,Sberro H,Bhatt AS

更新日期：2020-06-29 00:00:00

abstract：:Gene-targeted animal models that are generated by injecting Cas9 and sgRNAs into zygotes are often accompanied by undesired double-strand break (DSB)-induced byproducts and random biallelic targeting due to uncontrollable Cas9 targeting activity. Here, we establish a parental allele-specific gene-targeting (Past-CRISP...

journal_title：Nature communications

authors： Li Y,Weng Y,Bai D,Jia Y,Liu Y,Zhang Y,Kou X,Zhao Y,Ruan J,Chen J,Yin J,Wang H,Teng X,Wang Z,Liu W,Gao S

更新日期：2020-09-14 00:00:00

abstract：:The electron deficiency and strong bonding capacity of boron have led to a vast variety of molecular structures in chemistry and materials science. Here we report the observation of highly symmetric cobalt-centered boron drum-like structures of CoB16(-), characterized by photoelectron spectroscopy and ab initio calcul...

journal_title：Nature communications

authors： Popov IA,Jian T,Lopez GV,Boldyrev AI,Wang LS

更新日期：2015-10-12 00:00:00

abstract：:Van der Waals materials exhibit intriguing structural, electronic, and photonic properties. Electron energy loss spectroscopy within scanning transmission electron microscopy allows for nanoscale mapping of such properties. However, its detection is typically limited to energy losses in the eV range-too large for prob...

journal_title：Nature communications

authors： Govyadinov AA,Konečná A,Chuvilin A,Vélez S,Dolado I,Nikitin AY,Lopatin S,Casanova F,Hueso LE,Aizpurua J,Hillenbrand R

更新日期：2017-07-21 00:00:00

abstract：:Decision-making is often accompanied by a degree of confidence on whether a choice is correct. Decision uncertainty, or lack in confidence, may lead to change-of-mind. Studies have identified the behavioural characteristics associated with decision confidence or change-of-mind, and their neural correlates. Although se...

journal_title：Nature communications

authors： Atiya NAA,Rañó I,Prasad G,Wong-Lin K

更新日期：2019-05-23 00:00:00

abstract：:Diverse entry inhibitors targeting the gp120 subunit of the HIV-1 envelope (Env) trimer have been developed including BMS-626529, also called temsavir, a prodrug version of which is currently in phase III clinical trials. Here we report the characterization of a panel of small-molecule inhibitors including BMS-818251,...

journal_title：Nature communications

authors： Lai YT,Wang T,O'Dell S,Louder MK,Schön A,Cheung CSF,Chuang GY,Druz A,Lin B,McKee K,Peng D,Yang Y,Zhang B,Herschhorn A,Sodroski J,Bailer RT,Doria-Rose NA,Mascola JR,Langley DR,Kwong PD

更新日期：2019-01-03 00:00:00

abstract：:Liquid sensors composed of ionic liquids are rising as alternatives to solid semiconductors for flexible and self-healing electronics. However, the fluidic nature may give rise to leakage problems in cases of accidental damages. Here, we proposed a liquid sensor based on a binary ionic liquid system, in which a flowin...

journal_title：Nature communications

authors： Gao N,He Y,Tao X,Xu XQ,Wu X,Wang Y

更新日期：2019-02-01 00:00:00

abstract：:Nitrogen fixation by cyanobacteria supplies critical bioavailable nitrogen to marine ecosystems worldwide; however, field and lab data have demonstrated it to be limited by iron, phosphorus and/or CO2. To address unknown future interactions among these factors, we grew the nitrogen-fixing cyanobacterium Trichodesmium ...

journal_title：Nature communications

authors： Walworth NG,Fu FX,Webb EA,Saito MA,Moran D,Mcllvin MR,Lee MD,Hutchins DA

更新日期：2016-06-27 00:00:00

abstract：:Topological defects in matter behave collectively to form highly non-trivial structures called topological textures that are characterised by conserved quantities such as the winding number. Here we show that an epitaxial ferroelectric square nanoplate of bismuth ferrite subjected to a large strain gradient (as much a...

journal_title：Nature communications

authors： Kim KE,Jeong S,Chu K,Lee JH,Kim GY,Xue F,Koo TY,Chen LQ,Choi SY,Ramesh R,Yang CH

更新日期：2018-01-26 00:00:00

abstract：:A logical qubit is a two-dimensional subspace of a higher dimensional system, chosen such that it is possible to detect and correct the occurrence of certain errors. Manipulation of the encoded information generally requires arbitrary and precise control over the entire system. Whether based on multiple physical qubit...

journal_title：Nature communications

authors： Heeres RW,Reinhold P,Ofek N,Frunzio L,Jiang L,Devoret MH,Schoelkopf RJ

更新日期：2017-07-21 00:00:00

abstract：:Lorlatinib (PF-06463922) is a next-generation small-molecule inhibitor of the orphan receptor tyrosine kinase c-ros oncogene 1 (ROS1), which has a kinase domain that is physiologically related to anaplastic lymphoma kinase (ALK), and is undergoing Phase I/II clinical trial investigations for non-small cell lung cancer...

journal_title：Nature communications

authors： Collier TL,Normandin MD,Stephenson NA,Livni E,Liang SH,Wooten DW,Esfahani SA,Stabin MG,Mahmood U,Chen J,Wang W,Maresca K,Waterhouse RN,El Fakhri G,Richardson P,Vasdev N

更新日期：2017-06-08 00:00:00

abstract：:Enantioenriched 1,4-dienes are versatile building blocks in asymmetric synthesis, therefore their efficient synthesis directly from chemical feedstock is highly sought after. Here, we show an enantioselective cross-hydroalkenylation of cyclic 1,3-diene and hetero-substituted terminal olefin by using a chiral [NHC-Ni(a...

journal_title：Nature communications

authors： Chen Y,Dang L,Ho CY

更新日期：2020-05-08 00:00:00

abstract：:Imaging compound action potentials (CAPs) in peripheral nerves could help avoid side effects in neuromodulation by selective stimulation of identified fascicles. Existing methods have low resolution, limited imaging depth, or are invasive. Fast neural electrical impedance tomography (EIT) allows fascicular CAP imaging...

journal_title：Nature communications

authors： Ravagli E,Mastitskaya S,Thompson N,Iacoviello F,Shearing PR,Perkins J,Gourine AV,Aristovich K,Holder D

更新日期：2020-12-07 00:00:00

abstract：:Aerosol-cloud interactions constitute the largest source of uncertainty in global radiative forcing estimates, hampering our understanding of climate evolution. Recent empirical evidence suggests surface tension depression by organic aerosol to significantly influence the formation of cloud droplets, and hence cloud o...

journal_title：Nature communications

authors： Lowe SJ,Partridge DG,Davies JF,Wilson KR,Topping D,Riipinen I

更新日期：2019-11-18 00:00:00

abstract：:Calcareous microplankton shells form the dominant components of ancient and modern pelagic sea-floor carbonates and are widely used in palaeoenvironmental reconstructions. The efficacy of these applications, however, is dependent upon minimal geochemical alteration during diagenesis, but these modifying processes are ...

journal_title：Nature communications

authors： Wendler JE,Bown P

更新日期：2013-01-01 00:00:00

abstract：:Sliding clamps encircle DNA and tether polymerases and other factors to the genomic template. However, the molecular mechanism of clamp sliding on DNA is unknown. Using crystallography, NMR and molecular dynamics simulations, here we show that the human clamp PCNA recognizes DNA through a double patch of basic residue...

journal_title：Nature communications

authors： De March M,Merino N,Barrera-Vilarmau S,Crehuet R,Onesti S,Blanco FJ,De Biasio A

更新日期：2017-01-10 00:00:00

abstract：:Transcription preinitiation complex assembly on the promoters of protein encoding genes is nucleated in vivo by TFIID composed of the TATA-box Binding Protein (TBP) and 13 TBP-associate factors (Tafs) providing regulatory and chromatin binding functions. Here we present the cryo-electron microscopy structure of promot...

journal_title：Nature communications

authors： Kolesnikova O,Ben-Shem A,Luo J,Ranish J,Schultz P,Papai G

更新日期：2018-11-07 00:00:00

abstract：:Metabolism is coordinated among tissues and organs via neuronal signals. Levels of circulating amino acids (AAs), which are elevated in obesity, activate the intracellular target of rapamycin complex-1 (mTORC1)/S6kinase (S6K) pathway in the liver. Here we demonstrate that hepatic AA/mTORC1/S6K signalling modulates sys...

journal_title：Nature communications

authors： Uno K,Yamada T,Ishigaki Y,Imai J,Hasegawa Y,Sawada S,Kaneko K,Ono H,Asano T,Oka Y,Katagiri H

更新日期：2015-08-13 00:00:00