Abstract:
:Enantioenriched 1,4-dienes are versatile building blocks in asymmetric synthesis, therefore their efficient synthesis directly from chemical feedstock is highly sought after. Here, we show an enantioselective cross-hydroalkenylation of cyclic 1,3-diene and hetero-substituted terminal olefin by using a chiral [NHC-Ni(allyl)]BArF catalyst. Using a structurally flexible chiral C2 NHC-Ni design is key to access a broad scope of chiral 1,4-diene 3 or 3' with high enantioselectivity. This study also offers insights on how to regulate chiral C2 NHC-Ni(II) 1,3-allylic shift on cyclic diene 1 and to build sterically more hindered endocyclic chiral allylic structures on demand.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Chen Y,Dang L,Ho CYdoi
10.1038/s41467-020-16139-2subject
Has Abstractpub_date
2020-05-08 00:00:00pages
2269issue
1issn
2041-1723pii
10.1038/s41467-020-16139-2journal_volume
11pub_type
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