SNHG5 promotes colorectal cancer cell survival by counteracting STAU1-mediated mRNA destabilization.

abstract：:Here we benchmark device-to-device variation in field-effect transistors (FETs) based on monolayer MoS2 and WS2 films grown using metal-organic chemical vapor deposition process. Our study involves 230 MoS2 FETs and 160 WS2 FETs with channel lengths ranging from 5 μm down to 100 nm. We use statistical measures to eval...

journal_title：Nature communications

authors： Sebastian A,Pendurthi R,Choudhury TH,Redwing JM,Das S

更新日期：2021-01-29 00:00:00

abstract：:MADS-domain transcription factors have been shown to act as key repressors or activators of the transition to flowering and as master regulators of reproductive organ identities. Despite their important roles in plant development, the origin of several MADS-box subfamilies has remained enigmatic so far. Here we demons...

journal_title：Nature communications

authors： Ruelens P,de Maagd RA,Proost S,Theißen G,Geuten K,Kaufmann K

更新日期：2013-01-01 00:00:00

abstract：:Clonal expansions occur in the persistent HIV reservoir as shown by the duplication of proviral integration sites. However, the source of the proliferation of HIV-infected cells remains unclear. Here, we analyze the TCR repertoire of single HIV-infected cells harboring translation-competent proviruses in longitudinal ...

journal_title：Nature communications

authors： Gantner P,Pagliuzza A,Pardons M,Ramgopal M,Routy JP,Fromentin R,Chomont N

更新日期：2020-08-14 00:00:00

abstract：:Scenarios that limit global warming to below 2 °C by 2100 assume significant land-use change to support large-scale carbon dioxide (CO2) removal from the atmosphere by afforestation/reforestation, avoided deforestation, and Biomass Energy with Carbon Capture and Storage (BECCS). The more ambitious mitigation scenarios...

journal_title：Nature communications

authors： Harper AB,Powell T,Cox PM,House J,Huntingford C,Lenton TM,Sitch S,Burke E,Chadburn SE,Collins WJ,Comyn-Platt E,Daioglou V,Doelman JC,Hayman G,Robertson E,van Vuuren D,Wiltshire A,Webber CP,Bastos A,Boysen L,Ciais

更新日期：2018-08-07 00:00:00

abstract：:Obesity develops when energy intake exceeds energy expenditure. Promoting brown adipose tissue formation and function increases energy expenditure and hence may counteract obesity. Berberine (BBR) is a compound derived from the Chinese medicinal plant Coptis chinensis. Here we show that BBR increases energy expenditur...

journal_title：Nature communications

authors： Zhang Z,Zhang H,Li B,Meng X,Wang J,Zhang Y,Yao S,Ma Q,Jin L,Yang J,Wang W,Ning G

更新日期：2014-11-25 00:00:00

abstract：:Bell correlations are a foundational demonstration of how quantum entanglement contradicts the classical notion of local realism. Rigorous validation of quantum nonlocality have only been achieved between solid-state electron spins, internal states of trapped atoms, and photon polarisations, all weakly coupling to gra...

journal_title：Nature communications

authors： Shin DK,Henson BM,Hodgman SS,Wasak T,Chwedeńczuk J,Truscott AG

更新日期：2019-10-01 00:00:00

abstract：:Ice-shelf channels are long curvilinear tracts of thin ice found on Antarctic ice shelves. Many of them originate near the grounding line, but their formation mechanisms remain poorly understood. Here we use ice-penetrating radar data from Roi Baudouin Ice Shelf, East Antarctica, to infer that the morphology of severa...

journal_title：Nature communications

authors： Drews R,Pattyn F,Hewitt IJ,Ng FSL,Berger S,Matsuoka K,Helm V,Bergeot N,Favier L,Neckel N

更新日期：2017-05-09 00:00:00

abstract：:Members of the Herpesviridae, including the medically important alphaherpesvirus varicella-zoster virus (VZV), induce fusion of the virion envelope with cell membranes during entry, and between cells to form polykaryocytes in infected tissues. The conserved glycoproteins, gB, gH and gL, are the core functional protein...

journal_title：Nature communications

authors： Oliver SL,Xing Y,Chen DH,Roh SH,Pintilie GD,Bushnell DA,Sommer MH,Yang E,Carfi A,Chiu W,Arvin AM

更新日期：2020-08-18 00:00:00

abstract：:A diversity of self-propelled chemical motors, based on Marangoni propulsive forces, has been developed in recent years. However, most motors are non-functional due to poor performance, a lack of control, and the use of toxic materials. To overcome these limitations, we have developed multifunctional and biodegradable...

journal_title：Nature communications

authors： Pena-Francesch A,Giltinan J,Sitti M

更新日期：2019-07-18 00:00:00

abstract：:The development of integrated photonics and lab-on-a-chip platforms for environmental and biomedical diagnostics demands ultraviolet electroluminescent materials with high mechanical, chemical and environmental stability and almost complete compatibility with existing silicon technology. Here we report the realization...

journal_title：Nature communications

authors： Brovelli S,Chiodini N,Lorenzi R,Lauria A,Romagnoli M,Paleari A

更新日期：2012-02-21 00:00:00

abstract：:Bone mineral density is known to be a heritable, polygenic trait whereas genetic variants contributing to lean mass variation remain largely unknown. We estimated the shared SNP heritability and performed a bivariate GWAS meta-analysis of total-body lean mass (TB-LM) and total-body less head bone mineral density (TBLH...

journal_title：Nature communications

authors： Medina-Gomez C,Kemp JP,Dimou NL,Kreiner E,Chesi A,Zemel BS,Bønnelykke K,Boer CG,Ahluwalia TS,Bisgaard H,Evangelou E,Heppe DHM,Bonewald LF,Gorski JP,Ghanbari M,Demissie S,Duque G,Maurano MT,Kiel DP,Hsu YH,C J van d

更新日期：2017-07-25 00:00:00

abstract：:Recent studies show that the D'' layer, just above the Earth's core-mantle boundary, is composed of MgSiO3 post-perovskite and has significant lateral inhomogeneity. Here we consider the D'' diversity as related to the single-crystal elasticity of the post-perovskite phase. We measure the single-crystal elasticity of ...

journal_title：Nature communications

authors： Yoneda A,Fukui H,Xu F,Nakatsuka A,Yoshiasa A,Seto Y,Ono K,Tsutsui S,Uchiyama H,Baron AQ

更新日期：2014-03-27 00:00:00

abstract：:Several CRISPR-Cas9 orthologues have been used for genome editing. Here, we present the smallest Cas9 orthologue characterized to date, derived from Campylobacter jejuni (CjCas9), for efficient genome editing in vivo. After determining protospacer-adjacent motif (PAM) sequences and optimizing single-guide RNA (sgRNA) ...

journal_title：Nature communications

authors： Kim E,Koo T,Park SW,Kim D,Kim K,Cho HY,Song DW,Lee KJ,Jung MH,Kim S,Kim JH,Kim JH,Kim JS

更新日期：2017-02-21 00:00:00

abstract：:Enhancement of optical emission on plasmonic nanostructures is intrinsically limited by the distance between the emitter and nanostructure surface, owing to a tightly-confined and exponentially-decaying electromagnetic field. This fundamental limitation prevents efficient application of plasmonic fluorescence enhancem...

journal_title：Nature communications

authors： Kumar S,Park H,Cho H,Siddique RH,Narasimhan V,Yang D,Choo H

更新日期：2020-06-10 00:00:00

abstract：:Daily-life foldable items, such as popup tents, the curved origami sculptures exhibited in the Museum of Modern Art of New York, overstrained bicycle wheels, released bilayered microrings and strained cyclic macromolecules, are made of rings buckled or folded in tridimensional saddle shapes. Surprisingly, despite thei...

journal_title：Nature communications

authors： Mouthuy PO,Coulombier M,Pardoen T,Raskin JP,Jonas AM

更新日期：2012-01-01 00:00:00

abstract：:Quantum dots (QDs) are an excellent single-photon source that can be combined with a spin quantum memory. Many quantum technologies require increased control over the characteristics of emitted photons. A powerful approach is to trigger coherent Raman photons from QDs with a Λ energy-level system, such as the spin sin...

journal_title：Nature communications

authors： Pursley BC,Carter SG,Yakes MK,Bracker AS,Gammon D

更新日期：2018-01-09 00:00:00

abstract：:Antibody cocktails represent a promising approach to prevent SARS-CoV-2 escape. The determinants for selecting antibody combinations and the mechanism that antibody cocktails prevent viral escape remain unclear. We compared the critical residues in the receptor-binding domain (RBD) used by multiple neutralizing antibo...

journal_title：Nature communications

authors： Ku Z,Xie X,Davidson E,Ye X,Su H,Menachery VD,Li Y,Yuan Z,Zhang X,Muruato AE,I Escuer AG,Tyrell B,Doolan K,Doranz BJ,Wrapp D,Bates PF,McLellan JS,Weiss SR,Zhang N,Shi PY,An Z

更新日期：2021-01-20 00:00:00

abstract：:Circadian rhythms are a nearly universal feature of living organisms and affect almost every biological process. Our innate preference for mornings or evenings is determined by the phase of our circadian rhythms. We conduct a genome-wide association analysis of self-reported morningness, followed by analyses of biolog...

journal_title：Nature communications

authors： Hu Y,Shmygelska A,Tran D,Eriksson N,Tung JY,Hinds DA

更新日期：2016-02-02 00:00:00

abstract：:The predicted 80 open reading frames (ORFs) of herpes simplex virus 1 (HSV-1) have been intensively studied for decades. Here, we unravel the complete viral transcriptome and translatome during lytic infection with base-pair resolution by computational integration of multi-omics data. We identify a total of 201 transc...

journal_title：Nature communications

authors： Whisnant AW,Jürges CS,Hennig T,Wyler E,Prusty B,Rutkowski AJ,L'hernault A,Djakovic L,Göbel M,Döring K,Menegatti J,Antrobus R,Matheson NJ,Künzig FWH,Mastrobuoni G,Bielow C,Kempa S,Liang C,Dandekar T,Zimmer R,Landth

更新日期：2020-04-27 00:00:00

abstract：:Nitric oxide (NO) has important functions in biology and atmospheric chemistry as a toxin, signaling molecule, ozone depleting agent and the precursor of the greenhouse gas nitrous oxide (N2O). Although NO is a potent oxidant, and was available on Earth earlier than oxygen, it is unclear whether NO can be used by micr...

journal_title：Nature communications

authors： Hu Z,Wessels HJCT,van Alen T,Jetten MSM,Kartal B

更新日期：2019-03-20 00:00:00

abstract：:The Mycobacterium tuberculosis (Mtb) electron transport chain (ETC) has received significant attention as a drug target, however its vulnerability may be affected by its flexibility in response to disruption. Here we determine the effect of the ETC inhibitors bedaquiline, Q203 and clofazimine on the Mtb ETC, and the v...

journal_title：Nature communications

authors： Lamprecht DA,Finin PM,Rahman MA,Cumming BM,Russell SL,Jonnala SR,Adamson JH,Steyn AJ

更新日期：2016-08-10 00:00:00

abstract：:Ciliary membrane composition is controlled by transition zone (TZ) proteins such as RPGRIP1, RPGRIPL and NPHP4, which are vital for balanced coordination of diverse signalling systems like the Sonic hedgehog (Shh) pathway. Activation of this pathway involves Shh-induced ciliary accumulation of Smoothened (SMO), which ...

journal_title：Nature communications

authors： Schou KB,Mogensen JB,Morthorst SK,Nielsen BS,Aleliunaite A,Serra-Marques A,Fürstenberg N,Saunier S,Bizet AA,Veland IR,Akhmanova A,Christensen ST,Pedersen LB

更新日期：2017-01-30 00:00:00

abstract：:Intensive studies have recently been performed on graphene-based photodetectors, but most of them are based on field effect transistor structures containing mechanically exfoliated graphene, not suitable for practical large-scale device applications. Here we report high-efficient photodetector behaviours of chemical v...

journal_title：Nature communications

authors： Kim CO,Kim S,Shin DH,Kang SS,Kim JM,Jang CW,Joo SS,Lee JS,Kim JH,Choi SH,Hwang E

更新日期：2014-01-01 00:00:00

abstract：:Little is known about how archaeal viruses perturb the transcription machinery of their hosts. Here we provide the first example of an archaeo-viral transcription factor that directly targets the host RNA polymerase (RNAP) and efficiently represses its activity. ORF145 from the temperate Acidianus two-tailed virus (AT...

journal_title：Nature communications

authors： Sheppard C,Blombach F,Belsom A,Schulz S,Daviter T,Smollett K,Mahieu E,Erdmann S,Tinnefeld P,Garrett R,Grohmann D,Rappsilber J,Werner F

更新日期：2016-11-24 00:00:00

abstract：:A disturbance of reactive oxygen species (ROS) homeostasis may cause the pathogenesis of many diseases. Inspired by natural photosynthesis, this work proposes a photo-driven H2-evolving liposomal nanoplatform (Lip NP) that comprises an upconversion nanoparticle (UCNP) that is conjugated with gold nanoparticles (AuNPs)...

journal_title：Nature communications

authors： Wan WL,Tian B,Lin YJ,Korupalli C,Lu MY,Cui Q,Wan D,Chang Y,Sung HW

更新日期：2020-01-27 00:00:00

abstract：:Rearrangement reactions have attracted considerable interest over the past decades due to their high bond-forming efficiency and atom economy in the construction of complex organic architectures. In contrast to the well-established [3,3]-rearrangement, [1,3] O-to-C rearrangement has been far less vigorously investigat...

journal_title：Nature communications

authors： Zhou B,Zhang YQ,Zhang K,Yang MY,Chen YB,Li Y,Peng Q,Zhu SF,Zhou QL,Ye LW

更新日期：2019-07-19 00:00:00

abstract：:Upgrading C1 chemicals (for example, CO, CO/H2, MeOH and CO2) with C-C bond formation is essential for the synthesis of bulk chemicals. In general, these industrially important processes (for example, Fischer Tropsch) proceed at drastic reaction conditions (>250 °C; high pressure) and suffer from low selectivity, whic...

journal_title：Nature communications

authors： Dong K,Elangovan S,Sang R,Spannenberg A,Jackstell R,Junge K,Li Y,Beller M

更新日期：2016-07-05 00:00:00

abstract：:Neurons communicate through chemical synapses and electrical synapses (gap junctions). Although these two types of synapses often coexist between neurons, little is known about whether they interact, and whether any interactions between them are important to controlling synaptic strength and circuit functions. By stud...

journal_title：Nature communications

authors： Liu P,Chen B,Mailler R,Wang ZW

更新日期：2017-03-20 00:00:00

abstract：:Rare genetic disorders (RGDs) often exhibit significant clinical variability among affected individuals, a disease characteristic termed variable expressivity. Recently, the aggregate effect of common variation, quantified as polygenic scores (PGSs), has emerged as an effective tool for predictions of disease risk and...

journal_title：Nature communications

authors： Oetjens MT,Kelly MA,Sturm AC,Martin CL,Ledbetter DH

更新日期：2019-10-25 00:00:00

abstract：:RNA viruses are characterized by a high mutation rate, a buffer against environmental change. Nevertheless, the means by which random mutation improves viral fitness is not well characterized. Here we report the X-ray crystal structure of the receptor-binding domain (RBD) of the human coronavirus, HCoV-229E, in comple...

journal_title：Nature communications

authors： Wong AHM,Tomlinson ACA,Zhou D,Satkunarajah M,Chen K,Sharon C,Desforges M,Talbot PJ,Rini JM

更新日期：2017-11-23 00:00:00