Abstract:
:Ice-shelf channels are long curvilinear tracts of thin ice found on Antarctic ice shelves. Many of them originate near the grounding line, but their formation mechanisms remain poorly understood. Here we use ice-penetrating radar data from Roi Baudouin Ice Shelf, East Antarctica, to infer that the morphology of several ice-shelf channels is seeded upstream of the grounding line by large basal obstacles indenting the ice from below. We interpret each obstacle as an esker ridge formed from sediments deposited by subglacial water conduits, and calculate that the eskers' size grows towards the grounding line where deposition rates are maximum. Relict features on the shelf indicate that these linked systems of subglacial conduits and ice-shelf channels have been changing over the past few centuries. Because ice-shelf channels are loci where intense melting occurs to thin an ice shelf, these findings expose a novel link between subglacial drainage, sedimentation and ice-shelf stability.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Drews R,Pattyn F,Hewitt IJ,Ng FSL,Berger S,Matsuoka K,Helm V,Bergeot N,Favier L,Neckel Ndoi
10.1038/ncomms15228subject
Has Abstractpub_date
2017-05-09 00:00:00pages
15228issn
2041-1723pii
ncomms15228journal_volume
8pub_type
杂志文章abstract::Remarkable breakthroughs have established the functionality of graphene and carbon nanotube transistors as replacements to silicon in conventional computing structures, and numerous spintronic logic gates have been presented. However, an efficient cascaded logic structure that exploits electron spin has not yet been d...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms15635
更新日期:2017-06-05 00:00:00
abstract::In all known examples of metal-ligand (M-L) δ and φ bonds, the metal orbitals are aligned to the ligand orbitals in a "head-to-head" or "side-to-head" fashion. Here, we report two fundamentally new types of M-L δ and φ interactions; "head-to-side" δ and "side-to-side" φ back-bonding, found in complexes of metallacyclo...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-15197-w
更新日期:2020-03-25 00:00:00
abstract::There has been much research on renewable energy-harvesting techniques. However, owing to increasing energy demands, significant energy-related issues remain to be solved. Efforts aimed at reducing the amount of energy loss in electric/electronic systems are essential for reducing energy consumption and protecting the...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-03893-7
更新日期:2018-04-12 00:00:00
abstract::Although snoring is common in the general population, its aetiology has been largely understudied. Here we report a genetic study on snoring (n ~ 408,000; snorers ~ 152,000) using data from the UK Biobank. We identify 42 genome-wide significant loci, with an SNP-based heritability estimate of ~10% on the liability sca...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-14625-1
更新日期:2020-02-14 00:00:00
abstract::Human metapneumovirus (hMPV) is a frequent cause of bronchiolitis in young children. Its F glycoprotein mediates virus-cell membrane fusion and is the primary target of neutralizing antibodies. The inability to produce recombinant hMPV F glycoprotein in the metastable pre-fusion conformation has hindered structural an...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-01708-9
更新日期:2017-11-16 00:00:00
abstract::Blends of electron-donating and -accepting organic semiconductors are widely used as photoactive materials in next-generation solar cells and photodetectors. The yield of free charges in these systems is often determined by the separation of interfacial electron-hole pairs, which is expected to depend on the ability o...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms11944
更新日期:2016-06-21 00:00:00
abstract::Understanding and reshaping cellular behaviors with synthetic gene networks requires the ability to sense and respond to changes in the intracellular environment. Intracellular proteins are involved in almost all cellular processes, and thus can provide important information about changes in cellular conditions such a...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-03984-5
更新日期:2018-05-14 00:00:00
abstract::Chronic lymphocytic leukaemia (CLL) is a clonal disorder of mature B cells. Most patients are characterised by an indolent disease course and an anergic phenotype of their leukaemia cells, which refers to a state of unresponsiveness to B cell receptor stimulation. Up to 10% of CLL patients transform from an indolent s...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-00830-y
更新日期:2017-10-02 00:00:00
abstract::Epigenetic regulation plays an important role in governing stem cell fate and tumorigenesis. Lost expression of a key DNA demethylation enzyme TET2 is associated with human cancers and has been linked to stem cell traits in vitro; however, whether and how TET2 regulates mammary stem cell fate and mammary tumorigenesis...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18129-w
更新日期:2020-09-15 00:00:00
abstract::HPV16 causes half of cervical cancers worldwide; for unknown reasons, most infections resolve within two years. Here, we analyze the viral genomes of 5,328 HPV16-positive case-control samples to investigate mutational signatures and the role of human APOBEC3-induced mutations in viral clearance and cervical carcinogen...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-14730-1
更新日期:2020-02-14 00:00:00
abstract::Metastasis is the primary cause for mortality in breast cancer. MicroRNAs, gene expression master regulators, constitute an attractive candidate to control metastasis. Here we show that breast cancer metastasis can be prevented by miR-96 or miR-182 treatment, and decipher the mechanism of action. We found that miR-96/...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms12868
更新日期:2016-09-19 00:00:00
abstract::Optogenetics has emerged as an alternative method for electrical control of the heart, where illumination is used to elicit a bioelectric response in tissue modified to express photosensitive proteins (opsins). This technology promises to enable evocation of spatiotemporally precise responses in targeted cells or tiss...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3370
更新日期:2013-01-01 00:00:00
abstract::The Mesoamerican and Caribbean (MAC) region is characterized by tropical cyclones (TCs), strong El Niño-Southern Oscillation events, and climate variability that bring unique hazards to socio-ecological systems. Here we report the first characterization of the isotopic evolution of a TC (Hurricane Otto, 2016) in the M...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-12062-3
更新日期:2019-09-20 00:00:00
abstract::Non-line-of-sight (NLOS) imaging recovers objects using diffusely reflected indirect light using transient illumination devices in combination with a computational inverse method. While capture systems capable of collecting light from the entire NLOS relay surface can be much more light efficient than single pixel poi...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-15157-4
更新日期:2020-04-02 00:00:00
abstract::Advanced colorectal cancer is one of the deadliest cancers, with a 5-year survival rate of only 12% for patients with the metastatic disease. Checkpoint inhibitors, such as the antibodies inhibiting the PD-1/PD-L1 axis, are among the most promising immunotherapies for patients with advanced colon cancer, but their dur...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms12499
更新日期:2016-08-17 00:00:00
abstract::A key mechanism of bacterial resistance to macrolide antibiotics is the dimethylation of a nucleotide in the large ribosomal subunit by erythromycin resistance methyltransferases. The majority of erm genes are expressed only when the antibiotic is present and the erythromycin resistance methyltransferase activity is c...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2984
更新日期:2013-01-01 00:00:00
abstract::The photon-like behavior of electrons in graphene causes unusual confinement properties that depend strongly on the geometry and strength of the surrounding potential. We report bottom-up synthesis of atomically-precise one-dimensional (1D) arrays of point charges on graphene that allow exploration of a new type of su...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-08371-2
更新日期:2019-01-29 00:00:00
abstract::Osteoderms are bones embedded within the dermis, and are common to select members of most major tetrapod lineages. The largest known animals that bear osteoderms are members of Titanosauria, a diverse clade of sauropod dinosaurs. Here we report on two titanosaur osteoderms recovered from the Upper Cretaceous Maevarano...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1578
更新日期:2011-11-29 00:00:00
abstract::Ataxia telangiectasia is caused by mutations in ATM and represents a paradigm for cancer predisposition and neurodegenerative syndromes linked to deficiencies in the DNA-damage response. The role of ATM as a key regulator of signalling following DNA double-strand breaks (DSBs) has been dissected in extraordinary detai...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4347
更新日期:2014-02-27 00:00:00
abstract::Cancer proteogenomics promises new insights into cancer biology and treatment efficacy by integrating genomics, transcriptomics and protein profiling including modifications by mass spectrometry (MS). A critical limitation is sample input requirements that exceed many sources of clinically important material. Here we ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-14381-2
更新日期:2020-01-27 00:00:00
abstract::Damage to the genome is implicated in the progression of cancer and stress-induced diseases. DNA lesions exist in low levels, and cannot be amplified by standard PCR because they are frequently strong blocks to polymerases. Here, we describe a method for PCR amplification of lesion-containing DNA in which the site and...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms9807
更新日期:2015-11-06 00:00:00
abstract::Microbiome-derived metabolites influence intestinal homeostasis and regulate graft-versus-host disease (GVHD), but the molecular mechanisms remain unknown. Here we show the metabolite sensor G-protein-coupled receptor 43 (GPR43) is important for attenuation of gastrointestinal GVHD in multiple clinically relevant muri...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-06048-w
更新日期:2018-09-10 00:00:00
abstract::Controlling the structure of catalysts at the atomic level provides an opportunity to establish detailed understanding of the catalytic form-to-function and realize new, non-equilibrium catalytic structures. Here, advanced thin-film deposition is used to control the atomic structure of La2/3Sr1/3MnO3, a well-known cat...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-06503-8
更新日期:2018-10-02 00:00:00
abstract::Fatty acids (FAs) are not only essential components of cellular energy storage and structure, but play crucial roles in signalling. Here we present a toolkit of photoswitchable FA analogues (FAAzos) that incorporate an azobenzene photoswitch along the FA chain. By modifying the FAAzos to resemble capsaicin, we prepare...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms8118
更新日期:2015-05-22 00:00:00
abstract::One of the fundamental design paradigms in organic photovoltaic device engineering is based on the idea that charge separation is an extrinsically driven process requiring an interface for exciton fission. This idea has driven an enormous materials science engineering effort focused on construction of domain sizes com...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms10629
更新日期:2016-02-25 00:00:00
abstract::CD8+ T cells provide a critical defence from pathogens at mucosal epithelia including the female reproductive tract (FRT). Mucosal immunisation is considered essential to initiate this response, however this is difficult to reconcile with evidence that antigen delivered to skin can recruit protective CD8+ T cells to m...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-09969-2
更新日期:2019-05-17 00:00:00
abstract::Locusts are one of the world's most destructive agricultural pests and represent a useful model system in entomology. Here we present a draft 6.5 Gb genome sequence of Locusta migratoria, which is the largest animal genome sequenced so far. Our findings indicate that the large genome size of L. migratoria is likely to...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3957
更新日期:2014-01-01 00:00:00
abstract::Variation in the geographic spread of fossil localities strongly biases inferences about the evolution of biodiversity, due to the ubiquitous scaling of species richness with area. This obscures answers to key questions, such as how tetrapods attained their tremendous extant diversity. Here, we address this problem by...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms15381
更新日期:2017-05-22 00:00:00
abstract::Age, as a threshold of floral competence acquisition, prevents precocious flowering when there is insufficient biomass, and ensures flowering independent of environmental conditions; however, the underlying regulatory mechanisms are largely unknown. In this study, silencing the expression of a nuclear factor gene, CmN...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-00812-0
更新日期:2017-10-10 00:00:00
abstract::Heterogeneous catalysis is an enabling technology that utilises transition metal nanoparticles (NPs) supported on oxides to promote chemical reactions. Structural mismatch at the NP-support interface generates lattice strain that could affect catalytic properties. However, detailed knowledge about strain in supported ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-05055-1
更新日期:2018-07-13 00:00:00