Actively evolving subglacial conduits and eskers initiate ice shelf channels at an Antarctic grounding line.

abstract：:Covalently locking interacting proteins in situ is an attractive strategy for addressing the challenge of identifying weak and transient protein interactions, yet it is demanding to execute chemical reactions in live systems in a biocompatible, specific, and autonomous manner. Harnessing proximity-enabled reactivity o...

journal_title：Nature communications

authors： Yang B,Tang S,Ma C,Li ST,Shao GC,Dang B,DeGrado WF,Dong MQ,Wang PG,Ding S,Wang L

更新日期：2017-12-21 00:00:00

abstract：:Targeted insertion of transgenes at pre-determined plant genomic safe harbors provides a desirable alternative to insertions at random sites achieved through conventional methods. Most existing cases of targeted gene insertion in plants have either relied on the presence of a selectable marker gene in the insertion ca...

journal_title：Nature communications

authors： Dong OX,Yu S,Jain R,Zhang N,Duong PQ,Butler C,Li Y,Lipzen A,Martin JA,Barry KW,Schmutz J,Tian L,Ronald PC

更新日期：2020-03-04 00:00:00

abstract：:The exploration of chemical space for new reactivity, reactions and molecules is limited by the need for separate work-up-separation steps searching for molecules rather than reactivity. Herein we present a system that can autonomously evaluate chemical reactivity within a network of 64 possible reaction combinations ...

journal_title：Nature communications

authors： Dragone V,Sans V,Henson AB,Granda JM,Cronin L

更新日期：2017-06-09 00:00:00

abstract：:Visualizing the rearrangement of atoms in a wide range of molecular and condensed-matter systems requires resolving picometre displacements on a 10-fs timescale, which is achievable using pump-probe diffraction, given short enough pulses. Here we demonstrate the compression of single-electron pulses with a de Broglie ...

journal_title：Nature communications

authors： Gliserin A,Walbran M,Krausz F,Baum P

更新日期：2015-10-27 00:00:00

abstract：:Transcription of eukaryotic protein-coding genes requires passage of RNA polymerase II (Pol II) through nucleosomes, but it is unclear how this is achieved. Here we report the cryo-EM structure of transcribing Saccharomyces cerevisiae Pol II engaged with a downstream nucleosome core particle at an overall resolution o...

journal_title：Nature communications

authors： Farnung L,Vos SM,Cramer P

更新日期：2018-12-21 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature communications

authors： Paulevé L,Kolčák J,Chatain T,Haar S

更新日期：2020-09-24 00:00:00

abstract：:Molecular spins have become key enablers for exploring magnetic interactions, quantum information processes and many-body effects in metals. Metal-organic molecules, in particular, let the spin state of the core metal ion to be modified according to its organic environment, allowing localized magnetic moments to emerg...

journal_title：Nature communications

authors： Atxabal A,Ribeiro M,Parui S,Urreta L,Sagasta E,Sun X,Llopis R,Casanova F,Hueso LE

更新日期：2016-12-12 00:00:00

abstract：:Type 2 diabetes mellitus (T2DM) is characterized by defects in both insulin sensitivity and glucose-stimulated insulin secretion (GSIS) and is often accompanied by obesity. In this study, we show that disruption of thioredoxin binding protein-2 (TBP-2, also called Txnip) in obese mice (ob/ob) dramatically improves hyp...

journal_title：Nature communications

authors： Yoshihara E,Fujimoto S,Inagaki N,Okawa K,Masaki S,Yodoi J,Masutani H

更新日期：2010-11-23 00:00:00

abstract：:Plasma membrane Ca2+-ATPases (PMCAs) are key regulators of global Ca2+ homeostasis and local intracellular Ca2+ dynamics. Recently, Neuroplastin (NPTN) and basigin were identified as previously unrecognized obligatory subunits of PMCAs that dramatically increase the efficiency of PMCA-mediated Ca2+ clearance. Here, we...

journal_title：Nature communications

authors： Gong D,Chi X,Ren K,Huang G,Zhou G,Yan N,Lei J,Zhou Q

更新日期：2018-09-06 00:00:00

abstract：:The yeast Saccharomyces cerevisiae has been an essential component of human civilization because of its long global history of use in food and beverage fermentation. However, the diversity and evolutionary history of the domesticated populations of the yeast remain elusive. We show here that China/Far East Asia is lik...

journal_title：Nature communications

authors： Duan SF,Han PJ,Wang QM,Liu WQ,Shi JY,Li K,Zhang XL,Bai FY

更新日期：2018-07-12 00:00:00

abstract：:Gap junction channels mediate intercellular signalling that is crucial in tissue development, homeostasis and pathologic states such as cardiac arrhythmias, cancer and trauma. To explore the mechanism by which Ca(2+) blocks intercellular communication during tissue injury, we determined the X-ray crystal structures of...

journal_title：Nature communications

authors： Bennett BC,Purdy MD,Baker KA,Acharya C,McIntire WE,Stevens RC,Zhang Q,Harris AL,Abagyan R,Yeager M

更新日期：2016-01-12 00:00:00

abstract：:Energy affects every single individual and entity in the world. Therefore, it is crucial to precisely quantify the "price of energy" and study how it evolves through time, through major political and social events, and through changes in energy and monetary policies. Here, we develop a predictive framework, an index t...

journal_title：Nature communications

authors： Baratsas SG,Niziolek AM,Onel O,Matthews LR,Floudas CA,Hallermann DR,Sorescu SM,Pistikopoulos EN

更新日期：2021-01-04 00:00:00

abstract：:Genome stability relies on proper coordination of mitosis and cytokinesis, where dynamic microtubules capture and faithfully segregate chromosomes into daughter cells. With a high-content RNAi imaging screen targeting more than 2,000 human lncRNAs, we identify numerous lncRNAs involved in key steps of cell division su...

journal_title：Nature communications

authors： Stojic L,Lun ATL,Mascalchi P,Ernst C,Redmond AM,Mangei J,Barr AR,Bousgouni V,Bakal C,Marioni JC,Odom DT,Gergely F

更新日期：2020-04-15 00:00:00

abstract：:Polycyclic aromatic hydrocarbons as well as other organic molecules appear among the most abundant observed species in interstellar space and are key molecules to understanding the prebiotic roots of life. However, their existence and abundance in space remain a puzzle. Here we present a new top-down route to form pol...

journal_title：Nature communications

authors： Merino P,Švec M,Martinez JI,Jelinek P,Lacovig P,Dalmiglio M,Lizzit S,Soukiassian P,Cernicharo J,Martin-Gago JA

更新日期：2014-01-01 00:00:00

abstract：:The analysis of whole-genome sequencing studies is challenging due to the large number of noncoding rare variants, our limited understanding of their functional effects, and the lack of natural units for testing. Here we propose a scan statistic framework, WGScan, to simultaneously detect the existence, and estimate t...

journal_title：Nature communications

authors： He Z,Xu B,Buxbaum J,Ionita-Laza I

更新日期：2019-07-09 00:00:00

abstract：:Epigenomic data sets provide critical information about the dynamic role of chromatin states in gene regulation, but a key question of how chromatin state segmentations vary under different conditions across the genome has remained unaddressed. Here we present ChromDiff, a group-wise chromatin state comparison method ...

journal_title：Nature communications

authors： Yen A,Kellis M

更新日期：2015-08-18 00:00:00

abstract：:Much of the global annual mean temperature change over Quaternary glacial cycles can be attributed to slow ice sheet and greenhouse gas feedbacks, but analysis of the short-term response to orbital forcings has the potential to reveal key relationships in the climate system. In particular, obliquity and precession bot...

journal_title：Nature communications

authors： Erb MP,Jackson CS,Broccoli AJ,Lea DW,Valdes PJ,Crucifix M,DiNezio PN

更新日期：2018-04-10 00:00:00

abstract：:Understanding the dynamics of ring polymers is a particularly challenging yet interesting problem in soft materials. Despite recent progress, a complete understanding of the nonequilibrium behavior of ring polymers has not yet been achieved. In this work, we directly observe the flow dynamics of DNA-based rings in sem...

journal_title：Nature communications

authors： Zhou Y,Hsiao KW,Regan KE,Kong D,McKenna GB,Robertson-Anderson RM,Schroeder CM

更新日期：2019-04-15 00:00:00

abstract：:CD24 is overexpressed in nearly 70% human cancers, whereas TP53 is the most frequently mutated tumour-suppressor gene that functions in a context-dependent manner. Here we show that both targeted mutation and short hairpin RNA (shRNA) silencing of CD24 retard the growth, progression and metastasis of prostate cancer. ...

journal_title：Nature communications

authors： Wang L,Liu R,Ye P,Wong C,Chen GY,Zhou P,Sakabe K,Zheng X,Wu W,Zhang P,Jiang T,Bassetti MF,Jube S,Sun Y,Zhang Y,Zheng P,Liu Y

更新日期：2015-01-20 00:00:00

abstract：:Ferroelectric domain walls constitute a completely new class of sheet-like functional material. Moreover, since domain walls are generally writable, erasable and mobile, they could be useful in functionally agile devices: for example, creating and moving conducting walls could make or break electrical connections in n...

journal_title：Nature communications

authors： McQuaid RGP,Campbell MP,Whatmore RW,Kumar A,Gregg JM

更新日期：2017-05-16 00:00:00

abstract：:Graphene nanoscrolls are Archimedean-type spirals formed by rolling single-layer graphene sheets. Their unique structure makes them conceptually interesting and understanding their formation gives important information on the manipulation and characteristics of various carbon nanostructures. Here we report a 100% effi...

journal_title：Nature communications

authors： Sharifi T,Gracia-Espino E,Barzegar HR,Jia X,Nitze F,Hu G,Nordblad P,Tai CW,Wågberg T

更新日期：2013-01-01 00:00:00

abstract：:Steroidal C19-hydroxylation is pivotal to the synthesis of naturally occurring bioactive C19-OH steroids and 19-norsteroidal pharmaceuticals. However, realizing this transformation is proved to be challenging through either chemical or biological synthesis. Herein, we report a highly efficient method to synthesize 19-...

journal_title：Nature communications

authors： Wang J,Zhang Y,Liu H,Shang Y,Zhou L,Wei P,Yin WB,Deng Z,Qu X,Zhou Q

更新日期：2019-07-29 00:00:00

abstract：:Unusual features of the vibrational density of states D(ω) of glasses allow one to rationalize their peculiar low-temperature properties. Simulational studies of D(ω) have been restricted to studying poorly annealed glasses that may not be relevant to experiments. Here we report on D(ω) of zero-temperature glasses wit...

journal_title：Nature communications

authors： Wang L,Ninarello A,Guan P,Berthier L,Szamel G,Flenner E

更新日期：2019-01-03 00:00:00

abstract：:Mountains are plant biodiversity hotspots considered particularly vulnerable to multiple environmental changes. Here, we quantify population changes and range-shift dynamics along elevational gradients over the last three decades for c. two-thirds of the orchid species of the European Alps. Local extinctions were more...

journal_title：Nature communications

authors： Geppert C,Perazza G,Wilson RJ,Bertolli A,Prosser F,Melchiori G,Marini L

更新日期：2020-11-17 00:00:00

abstract：:Variation in the geographic spread of fossil localities strongly biases inferences about the evolution of biodiversity, due to the ubiquitous scaling of species richness with area. This obscures answers to key questions, such as how tetrapods attained their tremendous extant diversity. Here, we address this problem by...

journal_title：Nature communications

authors： Close RA,Benson RBJ,Upchurch P,Butler RJ

更新日期：2017-05-22 00:00:00

abstract：:The role of microglia in spinal cord injury (SCI) remains poorly understood and is often confused with the response of macrophages. Here, we use specific transgenic mouse lines and depleting agents to understand the response of microglia after SCI. We find that microglia are highly dynamic and proliferate extensively ...

journal_title：Nature communications

authors： Bellver-Landete V,Bretheau F,Mailhot B,Vallières N,Lessard M,Janelle ME,Vernoux N,Tremblay MÈ,Fuehrmann T,Shoichet MS,Lacroix S

更新日期：2019-01-31 00:00:00

abstract：:The Aharonov-Bohm effect is one of the most intriguing phenomena in both classical and quantum physics, and associates with a number of important and fundamental issues in quantum mechanics. The Aharonov-Bohm effects of charged particles have been experimentally demonstrated and found applications in various fields. R...

journal_title：Nature communications

authors： Li E,Eggleton BJ,Fang K,Fan S

更新日期：2014-01-01 00:00:00

abstract：:Different thresholds of Wnt signalling are thought to drive stem cell maintenance, regeneration, differentiation and cancer. However, the principle that oncogenic Wnt signalling could be specifically targeted remains controversial. Here we examine the requirement of BCL9/9l, constituents of the Wnt-enhanceosome, for i...

journal_title：Nature communications

authors： Gay DM,Ridgway RA,Müller M,Hodder MC,Hedley A,Clark W,Leach JD,Jackstadt R,Nixon C,Huels DJ,Campbell AD,Bird TG,Sansom OJ

更新日期：2019-02-13 00:00:00

abstract：:Genetic studies of Neolithic and Bronze Age skeletons from Europe have provided evidence for strong population genetic changes at the beginning and the end of the Neolithic period. To further understand the implications of these in Southern Central Europe, we analyze 96 ancient genomes from Switzerland, Southern Germa...

journal_title：Nature communications

authors： Furtwängler A,Rohrlach AB,Lamnidis TC,Papac L,Neumann GU,Siebke I,Reiter E,Steuri N,Hald J,Denaire A,Schnitzler B,Wahl J,Ramstein M,Schuenemann VJ,Stockhammer PW,Hafner A,Lösch S,Haak W,Schiffels S,Krause J

更新日期：2020-04-20 00:00:00

abstract：:Transition metal catalyzed Sonogashira cross-coupling of terminal alkynes with aryl(vinyl) (pseudo)halides has been successfully extended to alkyl halides for the synthesis of functionalized internal alkynes. The direct alkynylation of remote unfunctionalized sp3 carbon by terminal alkynes remains difficult to realize...

journal_title：Nature communications

authors： Li Z,Torres-Ochoa RO,Wang Q,Zhu J

更新日期：2020-01-21 00:00:00