Abstract:
:A disturbance of reactive oxygen species (ROS) homeostasis may cause the pathogenesis of many diseases. Inspired by natural photosynthesis, this work proposes a photo-driven H2-evolving liposomal nanoplatform (Lip NP) that comprises an upconversion nanoparticle (UCNP) that is conjugated with gold nanoparticles (AuNPs) via a ROS-responsive linker, which is encapsulated inside the liposomal system in which the lipid bilayer embeds chlorophyll a (Chla). The UCNP functions as a transducer, converting NIR light into upconversion luminescence for simultaneous imaging and therapy in situ. Functioning as light-harvesting antennas, AuNPs are used to detect the local concentration of ROS for FRET biosensing, while the Chla activates the photosynthesis of H2 gas to scavenge local excess ROS. The results thus obtained indicate the potential of using the Lip NPs in the analysis of biological tissues, restoring their ROS homeostasis, possibly preventing the initiation and progression of diseases.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Wan WL,Tian B,Lin YJ,Korupalli C,Lu MY,Cui Q,Wan D,Chang Y,Sung HWdoi
10.1038/s41467-020-14413-xsubject
Has Abstractpub_date
2020-01-27 00:00:00pages
534issue
1issn
2041-1723pii
10.1038/s41467-020-14413-xjournal_volume
11pub_type
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