Attosecond interferometry with self-amplified spontaneous emission of a free-electron laser.

abstract：:Understanding how cellular functions emerge from the underlying molecular mechanisms is a key challenge in biology. This will require computational models, whose predictive power is expected to increase with coverage and precision of formulation. Genome-scale models revolutionised the metabolic field and made the firs...

journal_title：Nature communications

authors： Münzner U,Klipp E,Krantz M

更新日期：2019-03-21 00:00:00

abstract：:Epitaxial films may be released from growth substrates and transferred to structurally and chemically incompatible substrates, but epitaxial films of transition metal perovskite oxides have not been transferred to electroactive substrates for voltage control of their myriad functional properties. Here we demonstrate g...

journal_title：Nature communications

authors： Pesquera D,Khestanova E,Ghidini M,Zhang S,Rooney AP,Maccherozzi F,Riego P,Farokhipoor S,Kim J,Moya X,Vickers ME,Stelmashenko NA,Haigh SJ,Dhesi SS,Mathur ND

更新日期：2020-06-24 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature communications

authors： Weinert LA,Chaudhuri RR,Wang J,Peters SE,Corander J,Jombart T,Baig A,Howell KJ,Vehkala M,Välimäki N,Harris D,Chieu TTB,Van Vinh Chau N,Campbell J,Schultsz C,Parkhill J,Bentley SD,Langford PR,Rycroft AN,Wren BW,Far

更新日期：2019-11-22 00:00:00

abstract：:Blends of electron-donating and -accepting organic semiconductors are widely used as photoactive materials in next-generation solar cells and photodetectors. The yield of free charges in these systems is often determined by the separation of interfacial electron-hole pairs, which is expected to depend on the ability o...

journal_title：Nature communications

authors： Stolterfoht M,Armin A,Shoaee S,Kassal I,Burn P,Meredith P

更新日期：2016-06-21 00:00:00

abstract：:Diet is commonly assumed to affect the evolution of species, but few studies have directly tested its effect at macroevolutionary scales. Here we use Bayesian models of trait-dependent diversification and a comprehensive dietary database of all birds worldwide to assess speciation and extinction dynamics of avian diet...

journal_title：Nature communications

authors： Burin G,Kissling WD,Guimarães PR Jr,Şekercioğlu ÇH,Quental TB

更新日期：2016-04-07 00:00:00

abstract：:Poly-(ADP-ribose) polymerase inhibitors (PARPi) selectively kill breast and ovarian cancers with defects in homologous recombination (HR) caused by BRCA1/2 mutations. There is also clinical evidence for the utility of PARPi in breast and ovarian cancers without BRCA mutations, but the underlying mechanism is not clear...

journal_title：Nature communications

authors： Peng Y,Liao Q,Tan W,Peng C,Hu Z,Chen Y,Li Z,Li J,Zhen B,Zhu W,Li X,Yao Y,Song Q,Liu C,Qi X,He F,Pei H

更新日期：2019-03-15 00:00:00

abstract：:Long-term follow up studies from Ebola virus disease (EVD) survivors (EBOV_S) are lacking. Here, we evaluate immune and gene expression profiles in 35 Guinean EBOV_S from the last West African outbreak, a median of 23 months (IQR [18-25]) after discharge from treatment center. Compared with healthy donors, EBOV_S exhi...

journal_title：Nature communications

authors： Wiedemann A,Foucat E,Hocini H,Lefebvre C,Hejblum BP,Durand M,Krüger M,Keita AK,Ayouba A,Mély S,Fernandez JC,Touré A,Fourati S,Lévy-Marchal C,Raoul H,Delaporte E,Koivogui L,Thiébaut R,Lacabaratz C,Lévy Y,PostEboGui

更新日期：2020-07-24 00:00:00

abstract：:Impaired lung function is often caused by cigarette smoking, making it challenging to disentangle its role in lung cancer susceptibility. Investigation of the shared genetic basis of these phenotypes in the UK Biobank and International Lung Cancer Consortium (29,266 cases, 56,450 controls) shows that lung cancer is ge...

journal_title：Nature communications

authors： Kachuri L,Johansson M,Rashkin SR,Graff RE,Bossé Y,Manem V,Caporaso NE,Landi MT,Christiani DC,Vineis P,Liu G,Scelo G,Zaridze D,Shete SS,Albanes D,Aldrich MC,Tardón A,Rennert G,Chen C,Goodman GE,Doherty JA,Bickebö

更新日期：2020-01-07 00:00:00

abstract：:Sign epistasis is a central evolutionary constraint, but its causal factors remain difficult to predict. Here we use the notion of parameterised optima to explain epistasis within a signalling cascade, and test these predictions in Escherichia coli. We show that sign epistasis arises from the benefit of tuning phenoty...

journal_title：Nature communications

authors： Nghe P,Kogenaru M,Tans SJ

更新日期：2018-04-13 00:00:00

abstract：:To perform their computational function, genetic circuits change states through a symphony of genetic parts that turn regulator expression on and off. Debugging is frustrated by an inability to characterize parts in the context of the circuit and identify the origins of failures. Here, we take snapshots of a large gen...

journal_title：Nature communications

authors： Espah Borujeni A,Zhang J,Doosthosseini H,Nielsen AAK,Voigt CA

更新日期：2020-10-05 00:00:00

abstract：:The circular photogalvanic effect (CPGE) is the part of a photocurrent that switches depending on the sense of circular polarization of the incident light. It has been consistently observed in systems without inversion symmetry and depends on non-universal material details. Here we find that in a class of Weyl semimet...

journal_title：Nature communications

authors： de Juan F,Grushin AG,Morimoto T,Moore JE

更新日期：2017-07-06 00:00:00

abstract：:Single-atom catalysts have recently been applied in many applications such as CO oxidation. Experimental in situ investigations into this reaction, however, are limited. Hereby, we present a suite of operando/in situ spectroscopic experiments for structurally well-defined atomically dispersed Rh on phosphotungstic aci...

journal_title：Nature communications

authors： Hülsey MJ,Zhang B,Ma Z,Asakura H,Do DA,Chen W,Tanaka T,Zhang P,Wu Z,Yan N

更新日期：2019-03-22 00:00:00

abstract：:Berry phase associated with energy bands in crystals can lead to quantised observables like quantised dipole polarizations in one-dimensional topological insulators. Recent theories have generalised the concept of quantised dipoles to multipoles, resulting in the discovery of multipole topological insulators which exh...

journal_title：Nature communications

authors： Xue H,Ge Y,Sun HX,Wang Q,Jia D,Guan YJ,Yuan SQ,Chong Y,Zhang B

更新日期：2020-05-15 00:00:00

abstract：:Ubiquitylation of histone H2B at lysine residue 120 (H2BK120ub) is a prominent histone posttranslational modification (PTM) associated with the actively transcribed genome. Although H2BK120ub triggers several critical downstream histone modification pathways and changes in chromatin structure, less is known about the ...

journal_title：Nature communications

authors： Wojcik F,Dann GP,Beh LY,Debelouchina GT,Hofmann R,Muir TW

更新日期：2018-04-11 00:00:00

abstract：:Most seafloor hydrothermal circulation occurs far from the magmatic influence of mid-ocean ridges, driving large flows of water, heat and solutes through volcanic rock outcrops on ridge flanks. Here we create three-dimensional simulations of ridge-flank hydrothermal circulation, flowing between and through seamounts, ...

journal_title：Nature communications

authors： Winslow DM,Fisher AT

更新日期：2015-06-26 00:00:00

abstract：:Pulsars are rotating neutron stars emitting lighthouse-like beams. Owing to their unique properties, pulsars are a unique astrophysical tool to test general relativity, inform on matter in extreme conditions, and probe galactic magnetic fields. Understanding pulsar physics and emission mechanisms is critical to these ...

journal_title：Nature communications

authors： Gueroult R,Shi Y,Rax JM,Fisch NJ

更新日期：2019-07-19 00:00:00

abstract：:Intestinal intraepithelial T cells contribute to the regulation of inflammatory responses in the intestine; however, the molecular basis for their development and maintenance is unknown. The aryl hydrocarbon receptor complexes with the aryl hydrocarbon receptor nuclear translocator (ARNT) and senses environmental fact...

journal_title：Nature communications

authors： Nakajima K,Maekawa Y,Kataoka K,Ishifune C,Nishida J,Arimochi H,Kitamura A,Yoshimoto T,Tomita S,Nagahiro S,Yasutomo K

更新日期：2013-01-01 00:00:00

abstract：:Frameshift insertion/deletions (fs-indels) are an infrequent but highly immunogenic mutation subtype. Although fs-indels are degraded through the nonsense-mediated decay (NMD) pathway, we hypothesise that some fs-indels escape degradation and elicit anti-tumor immune responses. Using allele-specific expression analysi...

journal_title：Nature communications

authors： Litchfield K,Reading JL,Lim EL,Xu H,Liu P,Al-Bakir M,Wong YNS,Rowan A,Funt SA,Merghoub T,Perkins D,Lauss M,Svane IM,Jönsson G,Herrero J,Larkin J,Quezada SA,Hellmann MD,Turajlic S,Swanton C

更新日期：2020-07-30 00:00:00

abstract：:Colorectal cancer (CRC) transcriptional subtypes have been recently identified by gene expression profiling. Here we describe an analytical pipeline, microRNA master regulator analysis (MMRA), developed to search for microRNAs potentially driving CRC subtypes. Starting from a microRNA-mRNA tumour expression data set, ...

journal_title：Nature communications

authors： Cantini L,Isella C,Petti C,Picco G,Chiola S,Ficarra E,Caselle M,Medico E

更新日期：2015-11-17 00:00:00

abstract：:Quantum dots (QDs) are an excellent single-photon source that can be combined with a spin quantum memory. Many quantum technologies require increased control over the characteristics of emitted photons. A powerful approach is to trigger coherent Raman photons from QDs with a Λ energy-level system, such as the spin sin...

journal_title：Nature communications

authors： Pursley BC,Carter SG,Yakes MK,Bracker AS,Gammon D

更新日期：2018-01-09 00:00:00

abstract：:Classic, model-based theory of land-atmosphere interactions across the Sahel promote positive vegetation-rainfall feedbacks dominated by surface albedo mechanism. However, neither the proposed positive vegetation-rainfall feedback nor its underlying albedo mechanism has been convincingly demonstrated using observation...

journal_title：Nature communications

authors： Yu Y,Notaro M,Wang F,Mao J,Shi X,Wei Y

更新日期：2017-11-30 00:00:00

abstract：:The xeroderma pigmentosum C (XPC) complex initiates nucleotide excision repair by recognizing DNA lesions before recruiting downstream factors. How XPC detects structurally diverse lesions embedded within normal DNA is unknown. Here we present a crystal structure that captures the yeast XPC orthologue (Rad4) on a sing...

journal_title：Nature communications

authors： Chen X,Velmurugu Y,Zheng G,Park B,Shim Y,Kim Y,Liu L,Van Houten B,He C,Ansari A,Min JH

更新日期：2015-01-06 00:00:00

abstract：:Stem cell transplantation is a promising strategy for therapeutic cardiac regeneration, but current therapies are limited by inefficient interaction between potentially beneficial cells (either exogenously transplanted or endogenously recruited) and the injured tissue. Here we apply targeted nanomedicine to achieve in...

journal_title：Nature communications

authors： Cheng K,Shen D,Hensley MT,Middleton R,Sun B,Liu W,De Couto G,Marbán E

更新日期：2014-09-10 00:00:00

abstract：:CrAss-like phages are double-stranded DNA viruses that are prevalent in human gut microbiomes. Here, we analyze gut metagenomic data from mother-infant pairs and patients undergoing fecal microbiota transplantation to evaluate the patterns of acquisition, transmission and strain diversity of crAss-like phages. We find...

journal_title：Nature communications

authors： Siranosian BA,Tamburini FB,Sherlock G,Bhatt AS

更新日期：2020-01-15 00:00:00

abstract：:Geranyl-CoA carboxylase (GCC) is essential for the growth of Pseudomonas organisms with geranic acid as the sole carbon source. GCC has the same domain organization and shares strong sequence conservation with the related biotin-dependent carboxylases 3-methylcrotonyl-CoA carboxylase (MCC) and propionyl-CoA carboxylas...

journal_title：Nature communications

authors： Jurado AR,Huang CS,Zhang X,Zhou ZH,Tong L

更新日期：2015-11-23 00:00:00

abstract：:Cellobiohydrolase 1 from Trichoderma reesei (TrCel7A) processively hydrolyses cellulose into cellobiose. Although enzymatic techniques have been established as promising tools in biofuel production, a clear understanding of the motor's mechanistic action has yet to be revealed. Here, we develop an optical tweezers-bas...

journal_title：Nature communications

authors： Brady SK,Sreelatha S,Feng Y,Chundawat SP,Lang MJ

更新日期：2015-12-10 00:00:00

abstract：:The interplay between superconductivity and charge-density wave (CDW) in 2H-NbSe2 is not fully understood despite decades of study. Artificially introduced disorder can tip the delicate balance between two competing long-range orders, and reveal the underlying interactions that give rise to them. Here we introduce dis...

journal_title：Nature communications

authors： Cho K,Kończykowski M,Teknowijoyo S,Tanatar MA,Guss J,Gartin PB,Wilde JM,Kreyssig A,McQueeney RJ,Goldman AI,Mishra V,Hirschfeld PJ,Prozorov R

更新日期：2018-07-18 00:00:00

abstract：:Recent studies of thermal transport in nanomaterials have demonstrated the breakdown of Fourier's law through observations of ballistic transport. Despite its unique features, another instance of the breakdown of Fourier's law, hydrodynamic phonon transport, has drawn less attention because it has been observed only a...

journal_title：Nature communications

authors： Lee S,Broido D,Esfarjani K,Chen G

更新日期：2015-02-18 00:00:00

abstract：:Sensorimotor behaviors require processing of behaviorally relevant sensory cues and the ability to select appropriate responses from a vast behavioral repertoire. Modulation by the prefrontal cortex (PFC) is thought to be key for both processes, but the precise role of specific circuits remains unclear. We examined th...

journal_title：Nature communications

authors： Huda R,Sipe GO,Breton-Provencher V,Cruz KG,Pho GN,Adam E,Gunter LM,Sullins A,Wickersham IR,Sur M

更新日期：2020-11-26 00:00:00

abstract：:Owing to the advantages of integration and being magnet-free and light-weight, the switched-capacitor-convertor plays an increasing role compared to traditional transformer in some specific power supply systems. However, the high output impedance and switching loss largely reduces its power efficiency, due to imperfec...

journal_title：Nature communications

authors： Liu W,Wang Z,Wang G,Zeng Q,He W,Liu L,Wang X,Xi Y,Guo H,Hu C,Wang ZL

更新日期：2020-04-20 00:00:00