当前位置： SCI文献检索 > Nature Communications期刊下所有文献 > Distinct prefrontal top-down circuits differentially modulate sensorimotor behavior.

Distinct prefrontal top-down circuits differentially modulate sensorimotor behavior.

Abstract：

:Sensorimotor behaviors require processing of behaviorally relevant sensory cues and the ability to select appropriate responses from a vast behavioral repertoire. Modulation by the prefrontal cortex (PFC) is thought to be key for both processes, but the precise role of specific circuits remains unclear. We examined the sensorimotor function of anatomically distinct outputs from a subdivision of the mouse PFC, the anterior cingulate cortex (ACC). Using a visually guided two-choice behavioral paradigm with multiple cue-response mappings, we dissociated the sensory and motor response components of sensorimotor control. Projection-specific two-photon calcium imaging and optogenetic manipulations show that ACC outputs to the superior colliculus, a key midbrain structure for response selection, principally coordinate specific motor responses. Importantly, ACC outputs exert control by reducing the innate response bias of the superior colliculus. In contrast, ACC outputs to the visual cortex facilitate sensory processing of visual cues. Our results ascribe motor and sensory roles to ACC projections to the superior colliculus and the visual cortex and demonstrate for the first time a circuit motif for PFC function wherein anatomically non-overlapping output pathways coordinate complementary but distinct aspects of visual sensorimotor behavior.

journal_name

Nat Commun

journal_title

Nature communications

authors

Huda R,Sipe GO,Breton-Provencher V,Cruz KG,Pho GN,Adam E,Gunter LM,Sullins A,Wickersham IR,Sur M

doi

10.1038/s41467-020-19772-z

subject

Has Abstract

pub_date

2020-11-26 00:00:00

pages

6007

issue

1

issn

2041-1723

pii

10.1038/s41467-020-19772-z

journal_volume

11

pub_type

杂志文章

相关文献

Nature Communications文献大全
  • Ultrafast X-ray Auger probing of photoexcited molecular dynamics.

    abstract：:Molecules can efficiently and selectively convert light energy into other degrees of freedom. Disentangling the underlying ultrafast motion of electrons and nuclei of the photoexcited molecule presents a challenge to current spectroscopic approaches. Here we explore the photoexcited dynamics of molecules by an interac...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms5235

    authors： McFarland BK,Farrell JP,Miyabe S,Tarantelli F,Aguilar A,Berrah N,Bostedt C,Bozek JD,Bucksbaum PH,Castagna JC,Coffee RN,Cryan JP,Fang L,Feifel R,Gaffney KJ,Glownia JM,Martinez TJ,Mucke M,Murphy B,Natan A,Osipov T,

    更新日期：2014-06-23 00:00:00

  • Multi-level chirality in liquid crystals formed by achiral molecules.

    abstract：:Complex materials often exhibit a hierarchical structure with an intriguing mechanism responsible for the 'propagation' of order from the molecular to the nano- or micro-scale level. In particular, the chirality of biological molecules such as nucleic acids and amino acids is responsible for the helical structure of D...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-09862-y

    authors： Salamończyk M,Vaupotič N,Pociecha D,Walker R,Storey JMD,Imrie CT,Wang C,Zhu C,Gorecka E

    更新日期：2019-04-23 00:00:00

  • Asymmetric ephaptic inhibition between compartmentalized olfactory receptor neurons.

    abstract：:In the Drosophila antenna, different subtypes of olfactory receptor neurons (ORNs) housed in the same sensory hair (sensillum) can inhibit each other non-synaptically. However, the mechanisms underlying this underexplored form of lateral inhibition remain unclear. Here we use recordings from pairs of sensilla impaled ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-09346-z

    authors： Zhang Y,Tsang TK,Bushong EA,Chu LA,Chiang AS,Ellisman MH,Reingruber J,Su CY

    更新日期：2019-04-05 00:00:00

  • Dynamics of soliton self-injection locking in optical microresonators.

    abstract：:Soliton microcombs constitute chip-scale optical frequency combs, and have the potential to impact a myriad of applications from frequency synthesis and telecommunications to astronomy. The demonstration of soliton formation via self-injection locking of the pump laser to the microresonator has significantly relaxed t...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-20196-y

    authors： Voloshin AS,Kondratiev NM,Lihachev GV,Liu J,Lobanov VE,Dmitriev NY,Weng W,Kippenberg TJ,Bilenko IA

    更新日期：2021-01-11 00:00:00

  • Tug-of-war between actomyosin-driven antagonistic forces determines the positioning symmetry in cell-sized confinement.

    abstract：:Symmetric or asymmetric positioning of intracellular structures including the nucleus and mitotic spindle steers various biological processes such as cell migration, division, and embryogenesis. In typical animal cells, both a sparse actomyosin meshwork in the cytoplasm and a dense actomyosin cortex underneath the cel...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-16677-9

    authors： Sakamoto R,Tanabe M,Hiraiwa T,Suzuki K,Ishiwata S,Maeda YT,Miyazaki M

    更新日期：2020-06-15 00:00:00

  • An auto-inducible mechanism for ionic liquid resistance in microbial biofuel production.

    abstract：:Ionic liquids (ILs) are emerging as superior solvents for numerous industrial applications, including the pretreatment of biomass for the microbial production of biofuels. However, some of the most effective ILs used to solubilize cellulose inhibit microbial growth, decreasing efficiency in the overall process. Here w...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms4490

    authors： Ruegg TL,Kim EM,Simmons BA,Keasling JD,Singer SW,Lee TS,Thelen MP

    更新日期：2014-03-26 00:00:00

  • Shape-memory effects in molecular crystals.

    abstract：:Molecular crystals can be bent elastically by expansion or plastically by delamination into slabs that glide along slip planes. Here we report that upon bending, terephthalic acid crystals can undergo a mechanically induced phase transition without delamination and their overall crystal integrity is retained. Such pla...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-11612-z

    authors： Ahmed E,Karothu DP,Warren M,Naumov P

    更新日期：2019-08-19 00:00:00

  • DHX36 prevents the accumulation of translationally inactive mRNAs with G4-structures in untranslated regions.

    abstract：:Translation efficiency can be affected by mRNA stability and secondary structures, including G-quadruplex structures (G4s). The highly conserved DEAH-box helicase DHX36/RHAU resolves G4s on DNA and RNA in vitro, however a systems-wide analysis of DHX36 targets and function is lacking. We map globally DHX36 binding to ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-10432-5

    authors： Sauer M,Juranek SA,Marks J,De Magis A,Kazemier HG,Hilbig D,Benhalevy D,Wang X,Hafner M,Paeschke K

    更新日期：2019-06-03 00:00:00

  • A biochemical network controlling basal myosin oscillation.

    abstract：:The actomyosin cytoskeleton, a key stress-producing unit in epithelial cells, oscillates spontaneously in a wide variety of systems. Although much of the signal cascade regulating myosin activity has been characterized, the origin of such oscillatory behavior is still unclear. Here, we show that basal myosin II oscill...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-03574-5

    authors： Qin X,Hannezo E,Mangeat T,Liu C,Majumder P,Liu J,Choesmel-Cadamuro V,McDonald JA,Liu Y,Yi B,Wang X

    更新日期：2018-03-23 00:00:00

  • Mechanically interlocked functionalization of monoclonal antibodies.

    abstract：:Because monoclonal antibodies (mAbs) have exceptional specificity and favorable pharmacology, substantial efforts have been made to functionalize them, either with potent cytotoxins, biologics, radionuclides, or fluorescent groups for therapeutic benefit and/or use as theranostic agents. To exploit our recently discov...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-03976-5

    authors： Bzymek KP,Puckett JW,Zer C,Xie J,Ma Y,King JD,Goodstein LH,Avery KN,Colcher D,Singh G,Horne DA,Williams JC

    更新日期：2018-04-20 00:00:00

  • Hierarchical self-entangled carbon nanotube tube networks.

    abstract：:Three-dimensional (3D) assemblies based on carbon nanomaterials still lag behind their individual one-dimensional building blocks in terms of mechanical and electrical properties. Here we demonstrate a simple strategy for the fabrication of an open porous 3D self-organized double-hierarchical carbon nanotube tube stru...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-017-01324-7

    authors： Schütt F,Signetti S,Krüger H,Röder S,Smazna D,Kaps S,Gorb SN,Mishra YK,Pugno NM,Adelung R

    更新日期：2017-10-31 00:00:00

  • Prevailing oxic environments in the Pacific Ocean during the mid-Cretaceous Oceanic anoxic event 2.

    abstract：:The occurrence of Oceanic Anoxic Event 2 (OAE2) 94 million years ago is considered to be one of the largest carbon cycle perturbations in the Earth's history. The marked increase in the spatial extent of the anoxic conditions in the world's oceans associated with OAE2 resulted in the mass accumulation of organic-rich ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms1233

    authors： Takashima R,Nishi H,Yamanaka T,Tomosugi T,Fernando AG,Tanabe K,Moriya K,Kawabe F,Hayashi K

    更新日期：2011-01-01 00:00:00

  • Berberine activates thermogenesis in white and brown adipose tissue.

    abstract：:Obesity develops when energy intake exceeds energy expenditure. Promoting brown adipose tissue formation and function increases energy expenditure and hence may counteract obesity. Berberine (BBR) is a compound derived from the Chinese medicinal plant Coptis chinensis. Here we show that BBR increases energy expenditur...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms6493

    authors： Zhang Z,Zhang H,Li B,Meng X,Wang J,Zhang Y,Yao S,Ma Q,Jin L,Yang J,Wang W,Ning G

    更新日期：2014-11-25 00:00:00

  • GSNOR provides plant tolerance to iron toxicity via preventing iron-dependent nitrosative and oxidative cytotoxicity.

    abstract：:Iron (Fe) is essential for life, but in excess can cause oxidative cytotoxicity through the generation of Fe-catalyzed reactive oxygen species. It is yet unknown which genes and mechanisms can provide Fe-toxicity tolerance. Here, we identify S-nitrosoglutathione-reductase (GSNOR) variants underlying a major quantitati...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-11892-5

    authors： Li B,Sun L,Huang J,Göschl C,Shi W,Chory J,Busch W

    更新日期：2019-08-29 00:00:00

  • Planar Hall effect and anisotropic magnetoresistance in polar-polar interface of LaVO3-KTaO3 with strong spin-orbit coupling.

    abstract：:Among the perovskite oxide family, KTaO3 (KTO) has recently attracted considerable interest as a possible system for the realization of the Rashba effect. In this work, we report a novel conducting interface by placing KTO with another insulator, LaVO3 (LVO) and report planar Hall effect (PHE) and anisotropic magnetor...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-14689-z

    authors： Wadehra N,Tomar R,Varma RM,Gopal RK,Singh Y,Dattagupta S,Chakraverty S

    更新日期：2020-02-13 00:00:00

  • Mutations associated with neuropsychiatric conditions delineate functional brain connectivity dimensions contributing to autism and schizophrenia.

    abstract：:16p11.2 and 22q11.2 Copy Number Variants (CNVs) confer high risk for Autism Spectrum Disorder (ASD), schizophrenia (SZ), and Attention-Deficit-Hyperactivity-Disorder (ADHD), but their impact on functional connectivity (FC) remains unclear. Here we report an analysis of resting-state FC using magnetic resonance imaging...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-18997-2

    authors： Moreau CA,Urchs SGW,Kuldeep K,Orban P,Schramm C,Dumas G,Labbe A,Huguet G,Douard E,Quirion PO,Lin A,Kushan L,Grot S,Luck D,Mendrek A,Potvin S,Stip E,Bourgeron T,Evans AC,Bearden CE,Bellec P,Jacquemont S

    更新日期：2020-10-19 00:00:00

  • Human seizures couple across spatial scales through travelling wave dynamics.

    abstract：:Epilepsy-the propensity toward recurrent, unprovoked seizures-is a devastating disease affecting 65 million people worldwide. Understanding and treating this disease remains a challenge, as seizures manifest through mechanisms and features that span spatial and temporal scales. Here we address this challenge through t...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms14896

    authors： Martinet LE,Fiddyment G,Madsen JR,Eskandar EN,Truccolo W,Eden UT,Cash SS,Kramer MA

    更新日期：2017-04-04 00:00:00

  • Biotransformation of p-xylene into terephthalic acid by engineered Escherichia coli.

    abstract：:Terephthalic acid (TPA) is an important industrial chemical currently produced by energy intensive and potentially hazardous p-xylene (pX) oxidation process. Here we report the development of metabolically engineered Escherichia coli system for biological transformation of pX into TPA. The engineered E. coli strain ha...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms15689

    authors： Luo ZW,Lee SY

    更新日期：2017-05-31 00:00:00

  • Budding-like division of all-aqueous emulsion droplets modulated by networks of protein nanofibrils.

    abstract：:Networks of natural protein nanofibrils, such as cytoskeletal filaments, control the shape and the division of cells, yet mimicking this functionality in a synthetic setting has proved challenging. Here, we demonstrate that artificial networks of protein nanofibrils can induce controlled deformation and division of al...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-04510-3

    authors： Song Y,Michaels TCT,Ma Q,Liu Z,Yuan H,Takayama S,Knowles TPJ,Shum HC

    更新日期：2018-05-29 00:00:00

  • Membrane cholesterol access into a G-protein-coupled receptor.

    abstract：:Cholesterol is a key component of cell membranes with a proven modulatory role on the function and ligand-binding properties of G-protein-coupled receptors (GPCRs). Crystal structures of prototypical GPCRs such as the adenosine A2A receptor (A2AR) have confirmed that cholesterol finds stable binding sites at the recep...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms14505

    authors： Guixà-González R,Albasanz JL,Rodriguez-Espigares I,Pastor M,Sanz F,Martí-Solano M,Manna M,Martinez-Seara H,Hildebrand PW,Martín M,Selent J

    更新日期：2017-02-21 00:00:00

  • Combined chemical genetics and data-driven bioinformatics approach identifies receptor tyrosine kinase inhibitors as host-directed antimicrobials.

    abstract：:Antibiotic resistance poses rapidly increasing global problems in combatting multidrug-resistant (MDR) infectious diseases like MDR tuberculosis, prompting for novel approaches including host-directed therapies (HDT). Intracellular pathogens like Salmonellae and Mycobacterium tuberculosis (Mtb) exploit host pathways t...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-017-02777-6

    authors： Korbee CJ,Heemskerk MT,Kocev D,van Strijen E,Rabiee O,Franken KLMC,Wilson L,Savage NDL,Džeroski S,Haks MC,Ottenhoff THM

    更新日期：2018-01-24 00:00:00

  • Towards nanoprinting with metals on graphene.

    abstract：:Graphene and carbon nanotubes are envisaged as suitable materials for the fabrication of the new generation of nanoelectronics. The controlled patterning of such nanostructures with metal nanoparticles is conditioned by the transfer between a recipient and the surface to pattern. Electromigration under the impact of a...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms9071

    authors： Melinte G,Moldovan S,Hirlimann C,Liu X,Bégin-Colin S,Bégin D,Banhart F,Pham-Huu C,Ersen O

    更新日期：2015-08-28 00:00:00

  • Publisher Correction: Discovery of coding regions in the human genome by integrated proteogenomics analysis workflow.

    abstract：:In the original version of this Article, extraneous text not belonging to the Article was accidentally appended to the results section. This error has now been corrected in both the PDF and HTML versions of the Article. ...

    journal_title：Nature communications

    pub_type： 杂志文章,已发布勘误

    doi：10.1038/s41467-018-04279-5

    authors： Zhu Y,Orre LM,Johansson HJ,Huss M,Boekel J,Vesterlund M,Fernandez-Woodbridge A,Branca RMM,Lehtiö J

    更新日期：2018-05-08 00:00:00

  • TruePrime is a novel method for whole-genome amplification from single cells based on TthPrimPol.

    abstract：:Sequencing of a single-cell genome requires DNA amplification, a process prone to introducing bias and errors into the amplified genome. Here we introduce a novel multiple displacement amplification (MDA) method based on the unique DNA primase features of Thermus thermophilus (Tth) PrimPol. TthPrimPol displays a poten...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms13296

    authors： Picher ÁJ,Budeus B,Wafzig O,Krüger C,García-Gómez S,Martínez-Jiménez MI,Díaz-Talavera A,Weber D,Blanco L,Schneider A

    更新日期：2016-11-29 00:00:00

  • X-ray refinement significantly underestimates the level of microscopic heterogeneity in biomolecular crystals.

    abstract：:Biomolecular X-ray structures typically provide a static, time- and ensemble-averaged view of molecular ensembles in crystals. In the absence of rigid-body motions and lattice defects, B-factors are thought to accurately reflect the structural heterogeneity of such ensembles. In order to study the effects of averaging...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms4220

    authors： Kuzmanic A,Pannu NS,Zagrovic B

    更新日期：2014-01-01 00:00:00

  • Shifting transcriptional machinery is required for long-term memory maintenance and modification in Drosophila mushroom bodies.

    abstract：:Accumulating evidence suggests that transcriptional regulation is required for maintenance of long-term memories (LTMs). Here we characterize global transcriptional and epigenetic changes that occur during LTM storage in the Drosophila mushroom bodies (MBs), structures important for memory. Although LTM formation requ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms13471

    authors： Hirano Y,Ihara K,Masuda T,Yamamoto T,Iwata I,Takahashi A,Awata H,Nakamura N,Takakura M,Suzuki Y,Horiuchi J,Okuno H,Saitoe M

    更新日期：2016-11-14 00:00:00

  • Nonreciprocal reconfigurable microwave optomechanical circuit.

    abstract：:Nonreciprocal microwave devices are ubiquitous in radar and radio communication and indispensable in the readout chains of superconducting quantum circuits. Since they commonly rely on ferrite materials requiring large magnetic fields that make them bulky and lossy, there has been significant interest in magnetic-fiel...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-017-00447-1

    authors： Bernier NR,Tóth LD,Koottandavida A,Ioannou MA,Malz D,Nunnenkamp A,Feofanov AK,Kippenberg TJ

    更新日期：2017-09-19 00:00:00

  • Light-induced evaporative cooling of holes in the Hubbard model.

    abstract：:An elusive goal in the field of driven quantum matter is the induction of long-range order. Here, we propose a mechanism based on light-induced evaporative cooling of holes in a correlated fermionic system. Since the entropy of a filled narrow band grows rapidly with hole doping, the isentropic transfer of holes from ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-13557-9

    authors： Werner P,Eckstein M,Müller M,Refael G

    更新日期：2019-12-05 00:00:00

  • Discordant congenital Zika syndrome twins show differential in vitro viral susceptibility of neural progenitor cells.

    abstract：:Congenital Zika syndrome (CZS) causes early brain development impairment by affecting neural progenitor cells (NPCs). Here, we analyze NPCs from three pairs of dizygotic twins discordant for CZS. We compare by RNA-Seq the NPCs derived from CZS-affected and CZS-unaffected twins. Prior to Zika virus (ZIKV) infection the...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-017-02790-9

    authors： Caires-Júnior LC,Goulart E,Melo US,Araujo BHS,Alvizi L,Soares-Schanoski A,de Oliveira DF,Kobayashi GS,Griesi-Oliveira K,Musso CM,Amaral MS,daSilva LF,Astray RM,Suárez-Patiño SF,Ventini DC,Gomes da Silva S,Yamamoto GL,Ez

    更新日期：2018-02-02 00:00:00

  • A glycoprotein B-neutralizing antibody structure at 2.8 Å uncovers a critical domain for herpesvirus fusion initiation.

    abstract：:Members of the Herpesviridae, including the medically important alphaherpesvirus varicella-zoster virus (VZV), induce fusion of the virion envelope with cell membranes during entry, and between cells to form polykaryocytes in infected tissues. The conserved glycoproteins, gB, gH and gL, are the core functional protein...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-17911-0

    authors： Oliver SL,Xing Y,Chen DH,Roh SH,Pintilie GD,Bushnell DA,Sommer MH,Yang E,Carfi A,Chiu W,Arvin AM

    更新日期：2020-08-18 00:00:00