Abstract:
:Iron (Fe) is essential for life, but in excess can cause oxidative cytotoxicity through the generation of Fe-catalyzed reactive oxygen species. It is yet unknown which genes and mechanisms can provide Fe-toxicity tolerance. Here, we identify S-nitrosoglutathione-reductase (GSNOR) variants underlying a major quantitative locus for root tolerance to Fe-toxicity in Arabidopsis using genome-wide association studies and allelic complementation. These variants act largely through transcript level regulation. We further show that the elevated nitric oxide is essential for Fe-dependent redox toxicity. GSNOR maintains root meristem activity and prevents cell death via inhibiting Fe-dependent nitrosative and oxidative cytotoxicity. GSNOR is also required for root tolerance to Fe-toxicity throughout higher plants such as legumes and monocots, which exposes an opportunity to address crop production under high-Fe conditions using natural GSNOR variants. Overall, this study shows that genetic or chemical modulation of the nitric oxide pathway can broadly modify Fe-toxicity tolerance.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Li B,Sun L,Huang J,Göschl C,Shi W,Chory J,Busch Wdoi
10.1038/s41467-019-11892-5subject
Has Abstractpub_date
2019-08-29 00:00:00pages
3896issue
1issn
2041-1723pii
10.1038/s41467-019-11892-5journal_volume
10pub_type
杂志文章abstract::Semiconductor III-V photonic crystal (PC) laser is regarded as a promising ultra-compact light source with unique advantages of ultralow energy consumption and small footprint for the next generation of Si-based on-chip optical interconnects. However, the significant material dissimilarities between III-V materials an...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-14736-9
更新日期:2020-02-20 00:00:00
abstract::Knowledge of the RNA three-dimensional structure, either in isolation or as part of RNP complexes, is fundamental to understand the mechanism of numerous cellular processes. Because of its flexibility, RNA represents a challenge for crystallization, while the large size of cellular complexes brings solution-state NMR ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms8024
更新日期:2015-05-11 00:00:00
abstract::The coupling of compartmentalisation with molecular replication is thought to be crucial for the emergence of the first evolvable chemical systems. Minimal artificial replicators have been designed based on molecular recognition, inspired by the template copying of DNA, but none yet have been coupled to compartmentali...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-00177-4
更新日期:2017-08-10 00:00:00
abstract::Spin-orbit torque has recently been intensively investigated for the purposes of manipulating the magnetization in magnetic nano-devices and understanding fundamental physics. Therefore, the search for novel materials or material combinations that exhibit a strong enough spin-torque effect has become one of the top pr...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-06518-1
更新日期:2018-09-28 00:00:00
abstract::The transcription factor MafB is expressed by monocytes and macrophages. Efferocytosis (apoptotic cell uptake) by macrophages is important for inhibiting the development of autoimmune diseases, and is greatly reduced in Mafb-deficient macrophages. Here, we show the expression of the first protein in the classical comp...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-01711-0
更新日期:2017-11-22 00:00:00
abstract::Thin-film oxide heterostructures show great potential for use in spintronic memories, where electronic charge and spin are coupled to transport information. Here we use a La0.7Sr0.3MnO3 (LSMO)/PbZr0.2Ti0.8O3 (PZT) model system to explore how local variations in electronic and magnetic phases mediate this coupling. We ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms7735
更新日期:2015-04-16 00:00:00
abstract::Solar-driven electrochemical carbon dioxide (CO2) reduction is capable of producing value-added chemicals and represents a potential route to alleviate carbon footprint in the global environment. However, the ever-changing sunlight illumination presents a substantial impediment of maintaining high electrocatalytic eff...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-07380-x
更新日期:2018-11-27 00:00:00
abstract::Graphene has various potential applications owing to its unique electronic, optical, mechanical and chemical properties, which are primarily based on its two-dimensional nature. Graphene-based vertical devices can extend the investigations and potential applications range to three dimensions, while interfacial propert...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2935
更新日期:2013-01-01 00:00:00
abstract::Bacterial autotransporters comprise a 12-stranded membrane-embedded β-barrel domain, which must be folded in a process that entraps segments of an N-terminal passenger domain. This first stage of autotransporter folding determines whether subsequent translocation can deliver the N-terminal domain to its functional for...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms5239
更新日期:2014-06-26 00:00:00
abstract::Quantum fluctuations give rise to van der Waals and Casimir forces that dominate the interaction between electrically neutral objects at sub-micron separations. Under the trend of miniaturization, such quantum electrodynamical effects are expected to play an important role in micro- and nano-mechanical devices. Nevert...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2842
更新日期:2013-01-01 00:00:00
abstract::Crustal fluids exist near fault zones, but their relation to the processes that generate earthquakes, including slow-slip events, is unclear. Fault-zone fluids are characterized by low electrical resistivity. Here we investigate the time-dependent crustal resistivity in the rupture area of the 1999 Mw 7.6 Izmit earthq...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3116
更新日期:2013-01-01 00:00:00
abstract::Adult-type granulosa cell tumors of the ovary (aGCTs) are rare gynecologic malignancies that exhibit a high frequency of somatic FOXL2 c.C402G (p.Cys134Trp) mutation. Treatment of relapsed aGCT remains a significant clinical challenge. Here we show, using whole-exome and cancer gene panel sequencing of 79 aGCTs from t...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-04950-x
更新日期:2018-06-27 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Nature communications
pub_type: 已发布勘误
doi:10.1038/s41467-019-12107-7
更新日期:2019-09-05 00:00:00
abstract::Problematic microfossils dominate the palaeontological record between the Great Oxidation Event 2.4 billion years ago (Ga) and the last Palaeoproterozoic iron formations, deposited 500-600 million years later. These fossils are often associated with iron-rich sedimentary rocks, but their affinities, metabolism, and, h...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms14890
更新日期:2017-03-23 00:00:00
abstract::Perceptual decisions are accompanied by feelings of confidence that reflect the likelihood that the decision was correct. Here we aim to clarify the relationship between perception and confidence by studying the same perceptual task across three different confidence contexts. Human observers were asked to categorize t...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-15561-w
更新日期:2020-04-09 00:00:00
abstract::Natural killer (NK) cells are lymphocytes with important anti-tumour functions. Cytokine activation of NK cell glycolysis and oxidative phosphorylation (OXPHOS) are essential for robust NK cell responses. However, the mechanisms leading to this metabolic phenotype are unclear. Here we show that the transcription facto...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-04719-2
更新日期:2018-06-14 00:00:00
abstract::Continuum numerical modeling of dynamic crack propagation has been a great challenge over the past decade. This is particularly the case for anticracks in porous materials, as reported in sedimentary rocks, deep earthquakes, landslides, and snow avalanches, as material inter-penetration further complicates the problem...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-05181-w
更新日期:2018-08-03 00:00:00
abstract::Development of on-chip integrated carbon-based optoelectronic nanocircuits requires fast and non-invasive structural characterization of their building blocks. Recent advances in synthesis of single wall carbon nanotubes and graphene nanoribbons allow for their use as atomically precise building blocks. However, while...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-13728-8
更新日期:2020-01-03 00:00:00
abstract::Telomerase elongates the telomeric G-strand to prevent telomere shortening through conventional DNA replication. However, synthesis of the complementary C-strand by DNA polymerase α is also required to maintain telomere length. Polymerase α cannot perform this role without the ssDNA binding complex CST (CTC1-STN1-TEN1...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-05154-z
更新日期:2018-07-19 00:00:00
abstract::The term tunnel electroresistance (TER) denotes a fast, non-volatile, reversible resistance switching triggered by voltage pulses in ferroelectric tunnel junctions. It is explained by subtle mechanisms connected to the voltage-induced reversal of the ferroelectric polarization. Here we demonstrate that effects functio...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-14379-w
更新日期:2020-01-31 00:00:00
abstract::Anion-π interactions occur on the surface of π-acidic aromatic planes with positive quadrupole moments. Their ability to contribute to the binding and transport of anions has been demonstrated recently. However, their ability to stabilize anionic reactive intermediates and transition states remains essentially unexplo...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4911
更新日期:2014-05-21 00:00:00
abstract::Considering the rapid increase of CO2 emission, especially from power plants, there is a constant need for materials which can effectively eliminate post-combustion CO2 (the main component: CO2/N2 = 15/85). Here, we show the design and synthesis of a Cu(II) metal-organic framework (FJI-H14) with a high density of acti...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-01166-3
更新日期:2017-11-01 00:00:00
abstract::Standard units of measurement are required for the quantitative description of nature; however, few standard units have been established for genomics to date. Here, we have developed a synthetic DNA ladder that defines a quantitative standard unit that can measure DNA sequence abundance within a next-generation sequen...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-17445-5
更新日期:2020-07-17 00:00:00
abstract::Bryostatin is in clinical trials for Alzheimer's disease, cancer, and HIV/AIDS eradication. It binds to protein kinase C competitively with diacylglycerol, the endogenous protein kinase C regulator, and plant-derived phorbol esters, but each ligand induces different activities. Determination of the structural origin f...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-016-0015-8
更新日期:2017-02-23 00:00:00
abstract::5S rRNA is an indispensable component of cytoplasmic ribosomes in all species. The functions of 5S rRNA and the reasons for its evolutionary preservation as an independent molecule remain unclear. Here we used ribosome engineering to investigate whether 5S rRNA autonomy is critical for ribosome function and cell survi...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-16694-8
更新日期:2020-06-09 00:00:00
abstract::To function, biomolecules require sufficient specificity of interaction as well as stability to live in the cell while still being able to move. Thermodynamic stability of only a limited number of specific structures is important so as to prevent promiscuous interactions. The individual interactions in proteins, there...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19560-9
更新日期:2020-11-23 00:00:00
abstract::A transcriptional programme initiated by the proneural factors Neurog2 and Ascl1 controls successive steps of neurogenesis in the embryonic cerebral cortex. Previous work has shown that proneural factors also confer a migratory behaviour to cortical neurons by inducing the expression of the small GTP-binding proteins ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4405
更新日期:2014-02-27 00:00:00
abstract::RNAs contain post-transcriptional modifications, which fulfill a variety of functions in translation, secondary structure stabilization and cellular stress survival. Here, 2-methylthiocytidine (ms2C) is identified in tRNA of E. coli and P. aeruginosa using NAIL-MS (nucleic acid isotope labeling coupled mass spectromet...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-13565-9
更新日期:2019-12-06 00:00:00
abstract::X-linked lymphoproliferative syndrome type-2 (XLP-2) is a primary immunodeficiency disease attributed to XIAP mutation and is triggered by infection. Here, we show that mouse Xiap-/- regulatory T (Treg) cells and human XIAP-deficient Treg cells are defective in suppressive function. The Xiap-/- Treg cell defect is lin...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-02862-4
更新日期:2018-01-31 00:00:00
abstract::Platinum nanoparticles (Pt NPs) are one of the most efficient cocatalysts in photocatalysis, and their size determines the activity and the selectivity of the catalytic reaction. Nevertheless, an in-depth understanding of the platinum's size effect in the carbon dioxide photocatalytic reduction is still lacking. Throu...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-03666-2
更新日期:2018-03-28 00:00:00