Abstract:
:A transcriptional programme initiated by the proneural factors Neurog2 and Ascl1 controls successive steps of neurogenesis in the embryonic cerebral cortex. Previous work has shown that proneural factors also confer a migratory behaviour to cortical neurons by inducing the expression of the small GTP-binding proteins such as Rnd2 and Rnd3. However, the directionality of radial migration suggests that migrating neurons also respond to extracellular signal-regulated pathways. Here we show that the Plexin B2 receptor interacts physically and functionally with Rnd3 and stimulates RhoA activity in migrating cortical neurons. Plexin B2 competes with p190RhoGAP for binding to Rnd3, thus blocking the Rnd3-mediated inhibition of RhoA and also recruits RhoGEFs to directly stimulate RhoA activity. Thus, an interaction between the cell-extrinsic Plexin signalling pathway and the cell-intrinsic Ascl1-Rnd3 pathway determines the level of RhoA activity appropriate for cortical neuron migration.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Azzarelli R,Pacary E,Garg R,Garcez P,van den Berg D,Riou P,Ridley AJ,Friedel RH,Parsons M,Guillemot Fdoi
10.1038/ncomms4405subject
Has Abstractpub_date
2014-02-27 00:00:00pages
3405issn
2041-1723pii
ncomms4405journal_volume
5pub_type
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