Molecular dynamics simulations reveal ligand-controlled positioning of a peripheral protein complex in membranes.

abstract：:The prediction of implant behavior in vivo by the use of easy-to-perform in vitro methods is of great interest in biomaterials research. Simulated body fluids (SBFs) have been proposed and widely used to evaluate the bone-bonding ability of implant materials. In view of its limitations, we report here a rapid in vitro...

journal_title：Nature communications

authors： Zhao W,Michalik D,Ferguson S,Hofstetter W,Lemaître J,von Rechenberg B,Bowen P

更新日期：2019-05-02 00:00:00

abstract：:Confined samples of liquid crystals are characterized by a variety of topological defects and can be exposed to external constraints such as extreme confinements with nontrivial topology. Here we explore the intrinsic structure of smectic colloidal layers dictated by the interplay between entropy and an imposed extern...

journal_title：Nature communications

authors： Wittmann R,Cortes LBG,Löwen H,Aarts DGAL

更新日期：2021-01-27 00:00:00

abstract：:In conventional computers, wiring between transistors is required to enable the execution of Boolean logic functions. This has resulted in processors in which billions of transistors are physically interconnected, which limits integration densities, gives rise to huge power consumption and restricts processing speeds....

journal_title：Nature communications

authors： Mahboob I,Flurin E,Nishiguchi K,Fujiwara A,Yamaguchi H

更新日期：2011-02-15 00:00:00

abstract：:Ribosomal RNA (rRNA) is most highly expressed in rapidly growing bacteria and is drastically downregulated under stress conditions by the global transcriptional regulator DksA and the alarmone ppGpp. Here, we determined cryo-electron microscopy structures of the Escherichia coli RNA polymerase (RNAP) σ70 holoenzyme du...

journal_title：Nature communications

authors： Shin Y,Qayyum MZ,Pupov D,Esyunina D,Kulbachinskiy A,Murakami KS

更新日期：2021-01-22 00:00:00

abstract：:Serial X-ray crystallography allows macromolecular structure determination at both X-ray free electron lasers (XFELs) and, more recently, synchrotron sources. The time resolution for serial synchrotron crystallography experiments has been limited to millisecond timescales with monochromatic beams. The polychromatic, "...

journal_title：Nature communications

authors： Meents A,Wiedorn MO,Srajer V,Henning R,Sarrou I,Bergtholdt J,Barthelmess M,Reinke PYA,Dierksmeyer D,Tolstikova A,Schaible S,Messerschmidt M,Ogata CM,Kissick DJ,Taft MH,Manstein DJ,Lieske J,Oberthuer D,Fischetti RF,C

更新日期：2017-11-03 00:00:00

abstract：:The miniaturization of integrated optical circuits below the diffraction limit for high-speed manipulation of information is one of the cornerstones in plasmonics research. By coupling to surface plasmons supported on nanostructured metallic surfaces, light can be confined to the nanoscale, enabling the potential inte...

journal_title：Nature communications

authors： Raza S,Esfandyarpour M,Koh AL,Mortensen NA,Brongersma ML,Bozhevolnyi SI

更新日期：2016-12-16 00:00:00

abstract：:In eukaryotes, telomeres cap chromosome ends to maintain genomic stability. Failure to maintain telomeres leads to their progressive erosion and eventually triggers replicative senescence, a pathway that protects against unrestricted cell proliferation. However, the mechanisms underlying the variability and dynamics o...

journal_title：Nature communications

authors： Xu Z,Fallet E,Paoletti C,Fehrmann S,Charvin G,Teixeira MT

更新日期：2015-07-09 00:00:00

abstract：:Unlike microevolutionary processes, little is known about the genetic basis of macroevolutionary processes. One of these magnificent examples is the transition from non-avian dinosaurs to birds that has created numerous evolutionary innovations such as self-powered flight and its associated wings with flight feathers....

journal_title：Nature communications

authors： Seki R,Li C,Fang Q,Hayashi S,Egawa S,Hu J,Xu L,Pan H,Kondo M,Sato T,Matsubara H,Kamiyama N,Kitajima K,Saito D,Liu Y,Gilbert MT,Zhou Q,Xu X,Shiroishi T,Irie N,Tamura K,Zhang G

更新日期：2017-02-06 00:00:00

abstract：:The manipulation of magnetic ordering with applied electric fields is of pressing interest for new magnetoelectric devices and information storage applications. Recently, such magnetoelectric control was realized in multiferroics. However, their magnetoelectric switching is often accompanied by significant hysteresis,...

journal_title：Nature communications

authors： Oh YS,Artyukhin S,Yang JJ,Zapf V,Kim JW,Vanderbilt D,Cheong SW

更新日期：2014-01-01 00:00:00

abstract：:A skullcap found in the Salkhit Valley in northeast Mongolia is, to our knowledge, the only Pleistocene hominin fossil found in the country. It was initially described as an individual with possible archaic affinities, but its ancestry has been debated since the discovery. Here, we determine the age of the Salkhit sku...

journal_title：Nature communications

authors： Devièse T,Massilani D,Yi S,Comeskey D,Nagel S,Nickel B,Ribechini E,Lee J,Tseveendorj D,Gunchinsuren B,Meyer M,Pääbo S,Higham T

更新日期：2019-01-30 00:00:00

abstract：:Epitaxial films may be released from growth substrates and transferred to structurally and chemically incompatible substrates, but epitaxial films of transition metal perovskite oxides have not been transferred to electroactive substrates for voltage control of their myriad functional properties. Here we demonstrate g...

journal_title：Nature communications

authors： Pesquera D,Khestanova E,Ghidini M,Zhang S,Rooney AP,Maccherozzi F,Riego P,Farokhipoor S,Kim J,Moya X,Vickers ME,Stelmashenko NA,Haigh SJ,Dhesi SS,Mathur ND

更新日期：2020-06-24 00:00:00

abstract：:Widely recognized as a significant carbon sink, North American forests have experienced a history of recovery and are facing an uncertain future. This growing carbon sink is dictated by recovery from land-use change, with growth trajectory modified by environmental change. To address both processes, we compiled a fore...

journal_title：Nature communications

authors： Zhu K,Zhang J,Niu S,Chu C,Luo Y

更新日期：2018-07-13 00:00:00

abstract：:The growth of large-domain single crystalline graphene with the controllable number of layers is of central importance for large-scale integration of graphene devices. Here we report a new pathway to greatly reduce the graphene nucleation density from ~10(6) to 4 nuclei cm(-2), enabling the growth of giant single crys...

journal_title：Nature communications

authors： Zhou H,Yu WJ,Liu L,Cheng R,Chen Y,Huang X,Liu Y,Wang Y,Huang Y,Duan X

更新日期：2013-01-01 00:00:00

abstract：:The ability to fabricate nanoscale domains of uniform size in two-dimensional materials could potentially enable new applications in nanoelectronics and the development of innovative metamaterials. However, achieving even minimal control over the growth of two-dimensional lateral heterostructures at such extreme dimen...

journal_title：Nature communications

authors： Camilli L,Jørgensen JH,Tersoff J,Stoot AC,Balog R,Cassidy A,Sadowski JT,Bøggild P,Hornekær L

更新日期：2017-06-29 00:00:00

abstract：:Sirtuins regulate numerous important biological processes in mammals, including various age-associated pathophysiologies. However, whether sirtuins are critical to control ageing and longevity in mammals has been controversial. Recent studies have demonstrated critical roles of sirtuins in the brain, especially the hy...

journal_title：Nature communications

authors： Satoh A,Imai S

更新日期：2014-06-26 00:00:00

abstract：:Turning graphene magnetic is a promising challenge to make it an active material for spintronics. Predictions state that graphene structures with specific shapes can spontaneously develop magnetism driven by Coulomb repulsion of π-electrons, but its experimental verification is demanding. Here, we report on the observ...

journal_title：Nature communications

authors： Li J,Sanz S,Corso M,Choi DJ,Peña D,Frederiksen T,Pascual JI

更新日期：2019-01-14 00:00:00

abstract：:Since the formulation of the geometric phase by Berry, its relevance has been demonstrated in a large variety of physical systems. However, a geometric phase of the most fundamental spin-1/2 system, the electron spin, has not been observed directly and controlled independently from dynamical phases. Here we report exp...

journal_title：Nature communications

authors： Nagasawa F,Frustaglia D,Saarikoski H,Richter K,Nitta J

更新日期：2013-01-01 00:00:00

abstract：:The complex of yeast cytochrome c peroxidase and cytochrome c is a paradigm of the biological electron transfer (ET). Building on seven decades of research, two different models have been proposed to explain its functional redox activity. One postulates that the intermolecular ET occurs only in the dominant, high-affi...

journal_title：Nature communications

authors： Van de Water K,Sterckx YG,Volkov AN

更新日期：2015-05-06 00:00:00

abstract：:The growing realization of a looming biodiversity crisis has inspired considerable progress in the quest to link biodiversity, structure and ecosystem function. Here we construct a method that bridges low- and high-diversity approaches to food web theory by elucidating the connection between the stability of the basic...

journal_title：Nature communications

authors： Gellner G,McCann KS

更新日期：2016-04-12 00:00:00

abstract：:Rechargeable magnesium batteries are one of the most promising candidates for next-generation battery technologies. Despite recent significant progress in the development of efficient electrolytes, an on-going challenge for realization of rechargeable magnesium batteries remains to overcome the sluggish kinetics cause...

journal_title：Nature communications

authors： Li Z,Mu X,Zhao-Karger Z,Diemant T,Behm RJ,Kübel C,Fichtner M

更新日期：2018-11-30 00:00:00

abstract：:Redox-regulated effector systems that counteract oxidative stress are essential for all forms of life. Here we uncover a new paradigm for sensing oxidative stress centred on the hydrophobic core of a sensor protein. RsrA is an archetypal zinc-binding anti-sigma factor that responds to disulfide stress in the cytoplasm...

journal_title：Nature communications

authors： Rajasekar KV,Zdanowski K,Yan J,Hopper JT,Francis ML,Seepersad C,Sharp C,Pecqueur L,Werner JM,Robinson CV,Mohammed S,Potts JR,Kleanthous C

更新日期：2016-07-19 00:00:00

abstract：:The phosphorylation of eIF4E1 at serine 209 by MNK1 or MNK2 has been shown to initiate oncogenic mRNA translation, a process that favours cancer development and maintenance. Here, we interrogate the MNK-eIF4E axis in diffuse large B-cell lymphoma (DLBCL) and show a distinct distribution of MNK1 and MNK2 in germinal ce...

journal_title：Nature communications

authors： Landon AL,Muniandy PA,Shetty AC,Lehrmann E,Volpon L,Houng S,Zhang Y,Dai B,Peroutka R,Mazan-Mamczarz K,Steinhardt J,Mahurkar A,Becker KG,Borden KL,Gartenhaus RB

更新日期：2014-11-18 00:00:00

abstract：:Understanding the molecular parameters that regulate cross-species transmission and host adaptation of potential pathogens is crucial to control emerging infectious disease. Although microbial pathotype diversity is conventionally associated with gene gain or loss, the role of pathoadaptive nonsynonymous single-nucleo...

journal_title：Nature communications

authors： Yue M,Han X,De Masi L,Zhu C,Ma X,Zhang J,Wu R,Schmieder R,Kaushik RS,Fraser GP,Zhao S,McDermott PF,Weill FX,Mainil JG,Arze C,Fricke WF,Edwards RA,Brisson D,Zhang NR,Rankin SC,Schifferli DM

更新日期：2015-10-30 00:00:00

abstract：:Colloidal interactions in nematic liquid crystals can be described as interactions between elastic multipoles that depend on particle shape, topology, chirality, boundary conditions and induced topological defects. Here, we describe a nematic colloidal system consisting of mesostructures of gold capable of inducing el...

journal_title：Nature communications

authors： Yuan Y,Tasinkevych M,Smalyukh II

更新日期：2020-01-10 00:00:00

abstract：:Understanding the biomolecular interactions between graphene and human immune cells is a prerequisite for its utilization as a diagnostic or therapeutic tool. To characterize the complex interactions between graphene and immune cells, we propose an integrative analytical pipeline encompassing the evaluation of molecul...

journal_title：Nature communications

authors： Orecchioni M,Bedognetti D,Newman L,Fuoco C,Spada F,Hendrickx W,Marincola FM,Sgarrella F,Rodrigues AF,Ménard-Moyon C,Cesareni G,Kostarelos K,Bianco A,Delogu LG

更新日期：2017-10-24 00:00:00

abstract：:Macrophages regulate host responses to implants through their dynamic adhesion, release, and activation. Herein, we employ bisphosphonate (BP)-coated gold nanoparticle template (BNP) to direct the swift and convertible formation of Mg2+-functional Mg2+-BP nanoparticle (NP) on the BP-AuNP surface via reversible Mg2+-BP...

journal_title：Nature communications

authors： Kang H,Yang B,Zhang K,Pan Q,Yuan W,Li G,Bian L

更新日期：2019-04-12 00:00:00

abstract：:State-of-the-art techniques allow researchers to record large numbers of spike trains in parallel for many hours. With enough such data, we should be able to infer the connectivity among neurons. Here we develop a method for reconstructing neuronal circuitry by applying a generalized linear model (GLM) to spike cross-...

journal_title：Nature communications

authors： Kobayashi R,Kurita S,Kurth A,Kitano K,Mizuseki K,Diesmann M,Richmond BJ,Shinomoto S

更新日期：2019-10-02 00:00:00

abstract：:Reversible acetylation of α-tubulin is an evolutionarily conserved modification in microtubule networks. Despite its prevalence, the physiological function and regulation of microtubule acetylation remain poorly understood. Here we report that macrophages challenged by bacterial lipopolysaccharides (LPS) undergo exten...

journal_title：Nature communications

authors： Wang B,Rao YH,Inoue M,Hao R,Lai CH,Chen D,McDonald SL,Choi MC,Wang Q,Shinohara ML,Yao TP

更新日期：2014-03-17 00:00:00

abstract：:X-chromosome inactivation (XCI), i.e., the inactivation of one of the female X chromosomes, restores equal expression of X-chromosomal genes between females and males. However, ~10% of genes show variable degrees of escape from XCI between females, although little is known about the causes of variable XCI. Using a dis...

journal_title：Nature communications

authors： Luijk R,Wu H,Ward-Caviness CK,Hannon E,Carnero-Montoro E,Min JL,Mandaviya P,Müller-Nurasyid M,Mei H,van der Maarel SM,BIOS Consortium.,Relton C,Mill J,Waldenberger M,Bell JT,Jansen R,Zhernakova A,Franke L,'t Hoen PAC

更新日期：2018-09-14 00:00:00

abstract：:N-Methyl-D-aspartate receptors (NMDARs) play critical roles in the central nervous system. Their heterotetrameric composition generates subtypes with distinct functional properties and spatio-temporal distribution in the brain, raising the possibility for subtype-specific targeting by pharmacological means for treatme...

journal_title：Nature communications

authors： Wang JX,Irvine MW,Burnell ES,Sapkota K,Thatcher RJ,Li M,Simorowski N,Volianskis A,Collingridge GL,Monaghan DT,Jane DE,Furukawa H

更新日期：2020-01-22 00:00:00