Abstract:
:Natural killer (NK) cells are lymphocytes with important anti-tumour functions. Cytokine activation of NK cell glycolysis and oxidative phosphorylation (OXPHOS) are essential for robust NK cell responses. However, the mechanisms leading to this metabolic phenotype are unclear. Here we show that the transcription factor cMyc is essential for IL-2/IL-12-induced metabolic and functional responses in mice. cMyc protein levels are acutely regulated by amino acids; cMyc protein is lost rapidly when glutamine is withdrawn or when system L-amino acid transport is blocked. We identify SLC7A5 as the predominant system L-amino acid transporter in activated NK cells. Unlike other lymphocyte subsets, glutaminolysis and the tricarboxylic acid cycle do not sustain OXPHOS in activated NK cells. Glutamine withdrawal, but not the inhibition of glutaminolysis, results in the loss of cMyc protein, reduced cell growth and impaired NK cell responses. These data identify an essential role for amino acid-controlled cMyc for NK cell metabolism and function.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Loftus RM,Assmann N,Kedia-Mehta N,O'Brien KL,Garcia A,Gillespie C,Hukelmann JL,Oefner PJ,Lamond AI,Gardiner CM,Dettmer K,Cantrell DA,Sinclair LV,Finlay DKdoi
10.1038/s41467-018-04719-2subject
Has Abstractpub_date
2018-06-14 00:00:00pages
2341issue
1issn
2041-1723pii
10.1038/s41467-018-04719-2journal_volume
9pub_type
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