Membrane cholesterol access into a G-protein-coupled receptor.

abstract：:In the original version of the Supplementary Information file associated with this Article, Supplementary Fig. 18 panel b was inadvertently replaced with a duplicate of panel a. The error has now been fixed and the corrected version of the Supplementary Information PDF is available to download from the HTML version of...

journal_title：Nature communications

authors： Ahn JH,Lee HS,Lee JS,Lee YS,Park JL,Kim SY,Hwang JA,Kunkeaw N,Jung SY,Kim TJ,Lee KS,Jeon SH,Lee I,Johnson BH,Choi JH,Lee YS

更新日期：2018-12-19 00:00:00

abstract：:Nascent polypeptides can induce ribosome stalling, regulating downstream genes. Stalling of ErmBL peptide translation in the presence of the macrolide antibiotic erythromycin leads to resistance in Streptococcus sanguis. To reveal this stalling mechanism we obtained 3.6-Å-resolution cryo-EM structures of ErmBL-stalled...

journal_title：Nature communications

authors： Arenz S,Bock LV,Graf M,Innis CA,Beckmann R,Grubmüller H,Vaiana AC,Wilson DN

更新日期：2016-07-06 00:00:00

abstract：:Recently, ferroelectric tunnel junctions have attracted much attention due to their potential applications in non-destructive readout non-volatile memories. Using a semiconductor electrode has been proven effective to enhance the tunnelling electroresistance in ferroelectric tunnel junctions. Here we report a systemat...

journal_title：Nature communications

authors： Xi Z,Ruan J,Li C,Zheng C,Wen Z,Dai J,Li A,Wu D

更新日期：2017-05-17 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature communications

authors： Saremi NF,Supple MA,Byrne A,Cahill JA,Coutinho LL,Dalén L,Figueiró HV,Johnson WE,Milne HJ,O'Brien SJ,O'Connell B,Onorato DP,Riley SPD,Sikich JA,Stahler DR,Villela PMS,Vollmers C,Wayne RK,Eizirik E,Corbett-Detig RB,

更新日期：2019-11-21 00:00:00

abstract：:The cell cytosol is crowded with high concentrations of many different biomacromolecules, which is difficult to mimic in bottom-up synthetic cell research and limits the functionality of existing protocellular platforms. There is thus a clear need for a general, biocompatible, and accessible tool to more accurately em...

journal_title：Nature communications

authors： Altenburg WJ,Yewdall NA,Vervoort DFM,van Stevendaal MHME,Mason AF,van Hest JCM

更新日期：2020-12-08 00:00:00

abstract：:Quantum Hall edge channels offer an efficient and controllable platform to study quantum transport in one dimension. Such channels are a prospective tool for the efficient transfer of quantum information at the nanoscale, and play a vital role in exposing intriguing physics. Electric current along the edge carries ene...

journal_title：Nature communications

authors： Krähenmann T,Fischer SG,Röösli M,Ihn T,Reichl C,Wegscheider W,Ensslin K,Gefen Y,Meir Y

更新日期：2019-09-02 00:00:00

abstract：:In weakly spin-orbit coupled materials, the spin-selective nature of recombination can give rise to large magnetic-field effects, e.g. on the electro-luminescence of molecular semiconductors. Although silicon has weak spin-orbit coupling, observing spin-dependent recombination through magneto-electroluminescence is ch...

journal_title：Nature communications

authors： Chiodi F,Bayliss SL,Barast L,Débarre D,Bouchiat H,Friend RH,Chepelianskii AD

更新日期：2018-01-26 00:00:00

abstract：:Many volcanoes erupt compositionally homogeneous magmas over timescales ranging from decades to millennia. This monotonous activity is thought to reflect a high degree of chemical homogeneity in their magmatic systems, leading to predictable eruptive behaviour. We combine petrological analyses of erupted crystals with...

journal_title：Nature communications

authors： Stock MJ,Geist D,Neave DA,Gleeson MLM,Bernard B,Howard KA,Buisman I,Maclennan J

更新日期：2020-07-28 00:00:00

abstract：:EGFR is required for animal development, and dysregulation of EGFR is critically implicated in malignant transformation. However, the molecular mechanism underlying the regulation of EGFR expression remains poorly explored. Here we report that the zinc-finger protein ZNF516 is a transcription repressor. ZNF516 is phys...

journal_title：Nature communications

authors： Li L,Liu X,He L,Yang J,Pei F,Li W,Liu S,Chen Z,Xie G,Xu B,Ting X,Zhang Z,Jin T,Liu X,Zhang W,Yuan S,Yang Z,Wu C,Zhang Y,Yang X,Yi X,Liang J,Shang Y,Sun L

更新日期：2017-09-25 00:00:00

abstract：:Marine particles transport organic matter through the water column to the sediment where the organic matter can be buried. This pathway is one of the few natural removal mechanisms of CO2 from the atmosphere over geological time. Picophytoplankton, major primary producers in the ocean, have until recently been thought...

journal_title：Nature communications

authors： Tang T,Kisslinger K,Lee C

更新日期：2014-06-12 00:00:00

abstract：:Group O D-negative blood cells are universal donors in transfusion medicine and methods for converting other blood groups into this universal donor group have been researched. However, conversion of D-positive cells into D-negative is yet to be achieved, although conversion of group A or B cells into O cells has been ...

journal_title：Nature communications

authors： Kim YH,Kim HO,Baek EJ,Kurita R,Cha HJ,Nakamura Y,Kim H

更新日期：2015-06-16 00:00:00

abstract：:Grain boundaries have a major effect on the physical properties of two-dimensional layered materials. Therefore, it is important to develop simple, fast and sensitive characterization methods to visualize grain boundaries. Conventional Raman and photoluminescence methods have been used for detecting grain boundaries; ...

journal_title：Nature communications

authors： Karvonen L,Säynätjoki A,Huttunen MJ,Autere A,Amirsolaimani B,Li S,Norwood RA,Peyghambarian N,Lipsanen H,Eda G,Kieu K,Sun Z

更新日期：2017-06-05 00:00:00

abstract：:Yeast lacks dedicated photoreceptors; however, blue light still causes pronounced oscillations of the transcription factor Msn2 into and out of the nucleus. Here we show that this poorly understood phenomenon is initiated by a peroxisomal oxidase, which converts light into a hydrogen peroxide (H2O2) signal that is sen...

journal_title：Nature communications

authors： Bodvard K,Peeters K,Roger F,Romanov N,Igbaria A,Welkenhuysen N,Palais G,Reiter W,Toledano MB,Käll M,Molin M

更新日期：2017-03-24 00:00:00

abstract：:Berry phase associated with energy bands in crystals can lead to quantised observables like quantised dipole polarizations in one-dimensional topological insulators. Recent theories have generalised the concept of quantised dipoles to multipoles, resulting in the discovery of multipole topological insulators which exh...

journal_title：Nature communications

authors： Xue H,Ge Y,Sun HX,Wang Q,Jia D,Guan YJ,Yuan SQ,Chong Y,Zhang B

更新日期：2020-05-15 00:00:00

abstract：:Graphite dual-ion batteries represent a potential battery concept for large-scale stationary storage of electricity, especially when constructed free of lithium and other chemical elements with limited natural reserves. Owing to their non-rocking-chair operation mechanism, however, the practical deployment of graphite...

journal_title：Nature communications

authors： Kravchyk KV,Bhauriyal P,Piveteau L,Guntlin CP,Pathak B,Kovalenko MV

更新日期：2018-10-26 00:00:00

abstract：:Topological insulators represent a new quantum state of matter that are insulating in the bulk but metallic on the edge or surface. In the Dirac surface state, it is well-established that the electron spin is locked with the crystal momentum. Here we report a new phenomenon of the spin texture locking with the orbital...

journal_title：Nature communications

authors： Xie Z,He S,Chen C,Feng Y,Yi H,Liang A,Zhao L,Mou D,He J,Peng Y,Liu X,Liu Y,Liu G,Dong X,Yu L,Zhang J,Zhang S,Wang Z,Zhang F,Yang F,Peng Q,Wang X,Chen C,Xu Z,Zhou XJ

更新日期：2014-02-28 00:00:00

abstract：:MicroRNAs (miRNAs) associated with Argonaute proteins (AGOs) regulate gene expression in mammals. miRNA 3' ends are subject to frequent sequence modifications, which have been proposed to affect miRNA stability. However, the underlying mechanism is not well understood. Here, by genetic and biochemical studies as well ...

journal_title：Nature communications

authors： Yang A,Shao TJ,Bofill-De Ros X,Lian C,Villanueva P,Dai L,Gu S

更新日期：2020-06-02 00:00:00

abstract：:Human-pluripotent-stem-cell-derived kidney cells (hPSC-KCs) have important potential for disease modelling and regeneration. Whether the hPSC-KCs can reconstitute tissue-specific phenotypes is currently unknown. Here we show that hPSC-KCs self-organize into kidney organoids that functionally recapitulate tissue-specif...

journal_title：Nature communications

authors： Freedman BS,Brooks CR,Lam AQ,Fu H,Morizane R,Agrawal V,Saad AF,Li MK,Hughes MR,Werff RV,Peters DT,Lu J,Baccei A,Siedlecki AM,Valerius MT,Musunuru K,McNagny KM,Steinman TI,Zhou J,Lerou PH,Bonventre JV

更新日期：2015-10-23 00:00:00

abstract：:DNA can form diverse higher-order structures, whose details are greatly dependent on nucleotide sequence. G-rich sequences containing four or more repeats of three guanines are expected to form G-quadruplexes. Here we show that DNA sequences with GGGAGCG repeats found in the regulatory region of the PLEKHG3 gene are c...

journal_title：Nature communications

authors： Kocman V,Plavec J

更新日期：2014-12-15 00:00:00

abstract：:Cambodia harbours a variety of aboriginal (and presumably ancient) populations that have largely been ignored in studies of genetic diversity. Here we investigate the matrilineal gene pool of 1,054 Cambodians from 14 geographic populations. Using mitochondrial whole-genome sequencing, we identify eight new mitochondri...

journal_title：Nature communications

authors： Zhang X,Qi X,Yang Z,Serey B,Sovannary T,Bunnath L,Seang Aun H,Samnom H,Zhang H,Lin Q,van Oven M,Shi H,Su B

更新日期：2013-01-01 00:00:00

abstract：:Large-scale deep-coverage whole-genome sequencing (WGS) is now feasible and offers potential advantages for locus discovery. We perform WGS in 16,324 participants from four ancestries at mean depth >29X and analyze genotypes with four quantitative traits-plasma total cholesterol, low-density lipoprotein cholesterol (L...

journal_title：Nature communications

authors： Natarajan P,Peloso GM,Zekavat SM,Montasser M,Ganna A,Chaffin M,Khera AV,Zhou W,Bloom JM,Engreitz JM,Ernst J,O'Connell JR,Ruotsalainen SE,Alver M,Manichaikul A,Johnson WC,Perry JA,Poterba T,Seed C,Surakka IL,Esko T

更新日期：2018-08-23 00:00:00

abstract：:The potential of the folic acid biosynthesis pathway as a target for the development of antibiotics has been clinically validated. However, many pathogens have developed resistance to these antibiotics, prompting a re-evaluation of potential drug targets within the pathway. The ydaH gene of Alcanivorax borkumensis enc...

journal_title：Nature communications

authors： Bolla JR,Su CC,Delmar JA,Radhakrishnan A,Kumar N,Chou TH,Long F,Rajashankar KR,Yu EW

更新日期：2015-04-20 00:00:00

abstract：:Male pattern baldness (MPB) is a sex-limited, age-related, complex trait. We study MPB genetics in 205,327 European males from the UK Biobank. Here we show that MPB is strongly heritable and polygenic, with pedigree-heritability of 0.62 (SE = 0.03) estimated from close relatives, and SNP-heritability of 0.39 (SE = 0.0...

journal_title：Nature communications

authors： Yap CX,Sidorenko J,Wu Y,Kemper KE,Yang J,Wray NR,Robinson MR,Visscher PM

更新日期：2018-12-20 00:00:00

abstract：:Magnetic resonance imaging is an important technique for identifying different types of tissues in a body or spatial information about composite materials. Because temperature is a fundamental parameter reflecting the biological status of the body and individual tissues, it would be helpful to have temperature maps su...

journal_title：Nature communications

authors： Hankiewicz JH,Celinski Z,Stupic KF,Anderson NR,Camley RE

更新日期：2016-08-09 00:00:00

abstract：:Missense mutations in Valosin-Containing Protein (VCP) are linked to diverse degenerative diseases including IBMPFD, amyotrophic lateral sclerosis (ALS), muscular dystrophy and Parkinson's disease. Here, we characterize a VCP-binding co-factor (SVIP) that specifically recruits VCP to lysosomes. SVIP is essential for l...

journal_title：Nature communications

authors： Johnson AE,Orr BO,Fetter RD,Moughamian AJ,Primeaux LA,Geier EG,Yokoyama JS,Miller BL,Davis GW

更新日期：2021-01-21 00:00:00

abstract：:Do completely unpredictable events exist? Classical physics excludes fundamental randomness. Although quantum theory makes probabilistic predictions, this does not imply that nature is random, as randomness should be certified without relying on the complete structure of the theory being used. Bell tests approach the ...

journal_title：Nature communications

authors： Gallego R,Masanes L,De La Torre G,Dhara C,Aolita L,Acín A

更新日期：2013-01-01 00:00:00

abstract：:As influenza A viruses remain a major threat to human health worldwide, the discovery of broadly neutralizing monoclonal antibodies that recognize conserved epitopes would facilitate the development of antibody-based therapeutic strategies. Here we report that a VH4-4-encoded human mAb named 3E1 could neutralize H1 an...

journal_title：Nature communications

authors： Wang W,Sun X,Li Y,Su J,Ling Z,Zhang T,Wang F,Zhang H,Chen H,Ding J,Sun B

更新日期：2016-12-02 00:00:00

abstract：:Intensive studies have recently been performed on graphene-based photodetectors, but most of them are based on field effect transistor structures containing mechanically exfoliated graphene, not suitable for practical large-scale device applications. Here we report high-efficient photodetector behaviours of chemical v...

journal_title：Nature communications

authors： Kim CO,Kim S,Shin DH,Kang SS,Kim JM,Jang CW,Joo SS,Lee JS,Kim JH,Choi SH,Hwang E

更新日期：2014-01-01 00:00:00

abstract：:Current-induced magnetic domain wall (DW) motion is an important operating principle of spintronic devices. Injected current generates spin torques (STs) on the DWs in two ways. One is the spin transfer from magnetic domains to the walls by the current flowing in the magnet. Current flow in attached heavy metals also ...

journal_title：Nature communications

authors： Moon KW,Kim C,Yoon J,Choi JW,Kim DO,Song KM,Kim D,Chun BS,Hwang C

更新日期：2018-09-17 00:00:00

abstract：:Naturally heat-resistant coral populations hold significant potential for facilitating coral reef survival under rapid climate change. However, it remains poorly understood whether they can acclimatize to ocean warming when superimposed on their already thermally-extreme habitats. Furthermore, it is unknown whether th...

journal_title：Nature communications

authors： Schoepf V,Carrion SA,Pfeifer SM,Naugle M,Dugal L,Bruyn J,McCulloch MT

更新日期：2019-09-17 00:00:00