Discordant congenital Zika syndrome twins show differential in vitro viral susceptibility of neural progenitor cells.

abstract：:The continuum hypothesis states that both deterministic and stochastic processes contribute to the assembly of ecological communities. However, the contextual dependency of these processes remains an open question that imposes strong limitations on predictions of community responses to environmental change. Here we me...

journal_title：Nature communications

authors： Powell JR,Karunaratne S,Campbell CD,Yao H,Robinson L,Singh BK

更新日期：2015-10-05 00:00:00

abstract：:In Drosophila, a complex consisting of Calypso and ASX catalyzes H2A deubiquitination and has been reported to act as part of the Polycomb machinery in transcriptional silencing. The mammalian homologs of these proteins (BAP1 and ASXL1/2/3, respectively), are frequently mutated in various cancer types, yet their preci...

journal_title：Nature communications

authors： Campagne A,Lee MK,Zielinski D,Michaud A,Le Corre S,Dingli F,Chen H,Shahidian LZ,Vassilev I,Servant N,Loew D,Pasmant E,Postel-Vinay S,Wassef M,Margueron R

更新日期：2019-01-21 00:00:00

abstract：:Genomic and phenotypic analyses indicate extensive intra- as well as intertumoral heterogeneity in primary human malignant cell populations despite their clonal origin. Cellular DNA barcoding offers a powerful and unbiased alternative to track the number and size of multiple subclones within a single human tumour xeno...

journal_title：Nature communications

authors： Nguyen LV,Cox CL,Eirew P,Knapp DJ,Pellacani D,Kannan N,Carles A,Moksa M,Balani S,Shah S,Hirst M,Aparicio S,Eaves CJ

更新日期：2014-12-23 00:00:00

abstract：:Autophagy cargo recognition and clearance are essential for intracellular protein quality control. SQSTM1/p62 sequesters intracellular aberrant proteins and mediates cargo delivery for their selective autophagic degradation. The formation of p62 non-membrane-bound liquid compartments is critical for its function as a ...

journal_title：Nature communications

authors： Yang Y,Willis TL,Button RW,Strang CJ,Fu Y,Wen X,Grayson PRC,Evans T,Sipthorpe RJ,Roberts SL,Hu B,Zhang J,Lu B,Luo S

更新日期：2019-08-21 00:00:00

abstract：:Pineoblastoma is a rare pediatric cancer induced by germline mutations in the tumor suppressors RB1 or DICER1. Presence of leptomeningeal metastases is indicative of poor prognosis. Here we report that inactivation of Rb plus p53 via a WAP-Cre transgene, commonly used to target the mammary gland during pregnancy, indu...

journal_title：Nature communications

authors： Chung PED,Gendoo DMA,Ghanbari-Azarnier R,Liu JC,Jiang Z,Tsui J,Wang DY,Xiao X,Li B,Dubuc A,Shih D,Remke M,Ho B,Garzia L,Ben-David Y,Kang SG,Croul S,Haibe-Kains B,Huang A,Taylor MD,Zacksenhaus E

更新日期：2020-04-14 00:00:00

abstract：:Intricate biomineralization processes in molluscs engineer hierarchical structures with meso-, nano- and atomic architectures that give the final composite material exceptional mechanical strength and optical iridescence on the macroscale. This multiscale biological assembly inspires new synthetic routes to complex ma...

journal_title：Nature communications

authors： Hovden R,Wolf SE,Holtz ME,Marin F,Muller DA,Estroff LA

更新日期：2015-12-03 00:00:00

abstract：:Inspired by biological neural systems, neuromorphic devices may open up new computing paradigms to explore cognition, learning and limits of parallel computation. Here we report the demonstration of a synaptic transistor with SmNiO₃, a correlated electron system with insulator-metal transition temperature at 130°C in ...

journal_title：Nature communications

authors： Shi J,Ha SD,Zhou Y,Schoofs F,Ramanathan S

更新日期：2013-01-01 00:00:00

abstract：:The actin cytoskeleton is an active semi-flexible polymer network whose non-equilibrium properties coordinate both stable and contractile behaviors to maintain or change cell shape. While myosin motors drive the actin cytoskeleton out-of-equilibrium, the role of myosin-driven active stresses in the accumulation and di...

journal_title：Nature communications

authors： Seara DS,Yadav V,Linsmeier I,Tabatabai AP,Oakes PW,Tabei SMA,Banerjee S,Murrell MP

更新日期：2018-11-23 00:00:00

abstract：:One of the hallmark experiments of quantum transport is the observation of the quantized resistance in a point contact in GaAs/AlGaAs heterostructures. Being formed with split gate technology, these structures represent in an ideal manner equilibrium reservoirs which are connected only through a few electron mode chan...

journal_title：Nature communications

authors： Thierschmann H,Mulazimoglu E,Manca N,Goswami S,Klapwijk TM,Caviglia AD

更新日期：2018-06-11 00:00:00

abstract：:Genetic screens are powerful tools to identify the genes required for a given biological process. However, for technical reasons, comprehensive screens have been restricted to very few model organisms. Therefore, although deep sequencing is revealing the genes of ever more insect species, the functional studies predom...

journal_title：Nature communications

authors： Schmitt-Engel C,Schultheis D,Schwirz J,Ströhlein N,Troelenberg N,Majumdar U,Dao VA,Grossmann D,Richter T,Tech M,Dönitz J,Gerischer L,Theis M,Schild I,Trauner J,Koniszewski ND,Küster E,Kittelmann S,Hu Y,Lehmann S,S

更新日期：2015-07-28 00:00:00

abstract：:Ribosomal RNA (rRNA) is most highly expressed in rapidly growing bacteria and is drastically downregulated under stress conditions by the global transcriptional regulator DksA and the alarmone ppGpp. Here, we determined cryo-electron microscopy structures of the Escherichia coli RNA polymerase (RNAP) σ70 holoenzyme du...

journal_title：Nature communications

authors： Shin Y,Qayyum MZ,Pupov D,Esyunina D,Kulbachinskiy A,Murakami KS

更新日期：2021-01-22 00:00:00

abstract：:Human type 1 insulin-like growth factor receptor is a homodimeric receptor tyrosine kinase that signals into pathways directing normal cellular growth, differentiation and proliferation, with aberrant signalling implicated in cancer. Insulin-like growth factor binding is understood to relax conformational restraints w...

journal_title：Nature communications

authors： Xu Y,Kong GK,Menting JG,Margetts MB,Delaine CA,Jenkin LM,Kiselyov VV,De Meyts P,Forbes BE,Lawrence MC

更新日期：2018-02-26 00:00:00

abstract：:Radioprotectors for acute injuries caused by large doses of ionizing radiation are vital to national security, public health and future development of humankind. Here, we develop a strategy to explore safe and efficient radioprotectors by combining Hantzsch's reaction, high-throughput methods and polymer chemistry. A ...

journal_title：Nature communications

authors： Liu G,Zeng Y,Lv T,Mao T,Wei Y,Jia S,Gou Y,Tao L

更新日期：2020-12-04 00:00:00

abstract：:Understanding how rock-forming minerals transform under shock loading is critical for modeling collisions between planetary bodies, interpreting the significance of shock features in minerals and for using them as diagnostic indicators of impact conditions, such as shock pressure. To date, our understanding of the for...

journal_title：Nature communications

authors： Gleason AE,Bolme CA,Lee HJ,Nagler B,Galtier E,Kraus RG,Sandberg R,Yang W,Langenhorst F,Mao WL

更新日期：2017-11-14 00:00:00

abstract：:Deep subwavelength integration of high-definition plasmonic nanostructures is of key importance in the development of future optical nanocircuitry for high-speed communication, quantum computation and lab-on-a-chip applications. To date, the experimental realization of proposed extended plasmonic networks consisting o...

journal_title：Nature communications

authors： Huang JS,Callegari V,Geisler P,Brüning C,Kern J,Prangsma JC,Wu X,Feichtner T,Ziegler J,Weinmann P,Kamp M,Forchel A,Biagioni P,Sennhauser U,Hecht B

更新日期：2010-01-01 00:00:00

abstract：:The extraction of a clear and simple footprint of the structure of large, weighted and directed networks is a general problem that has relevance for many applications. An important example is seen in origin-destination matrices, which contain the complete information on commuting flows, but are difficult to analyze an...

journal_title：Nature communications

authors： Louail T,Lenormand M,Picornell M,García Cantú O,Herranz R,Frias-Martinez E,Ramasco JJ,Barthelemy M

更新日期：2015-01-21 00:00:00

abstract：:Cyanobacteria are model organisms for photosynthesis and are attractive for biotechnology applications. To aid investigation of genotype-phenotype relationships in cyanobacteria, we develop an inducible CRISPRi gene repression library in Synechocystis sp. PCC 6803, where we aim to target all genes for repression. We t...

journal_title：Nature communications

authors： Yao L,Shabestary K,Björk SM,Asplund-Samuelsson J,Joensson HN,Jahn M,Hudson EP

更新日期：2020-04-03 00:00:00

abstract：:Materials genomics represents a research mode for materials development, for which reliable methods for efficient materials construction are essential. Here we present a methodology for high-throughput construction of covalent organic frameworks (COFs) based on materials genomics strategy, in which a gene partition me...

journal_title：Nature communications

authors： Lan Y,Han X,Tong M,Huang H,Yang Q,Liu D,Zhao X,Zhong C

更新日期：2018-12-10 00:00:00

abstract：:Water structure has an essential role in biological assembly. Hydrophobic dewetting has been documented as a general mechanism for the assembly of hydrophobic surfaces; however, the association mechanism of hydrophilic interfaces remains mysterious and cannot be explained by simple continuum water models that ignore t...

journal_title：Nature communications

authors： Ahmad M,Gu W,Geyer T,Helms V

更新日期：2011-03-29 00:00:00

abstract：:The discovery of quantum spin-Hall (QSH) insulators has brought topology to the forefront of condensed matter physics. While a QSH state from spin-orbit coupling can be fully understood in terms of band theory, fascinating many-body effects are expected if it instead results from spontaneous symmetry breaking. Here, w...

journal_title：Nature communications

authors： Liu Y,Wang Z,Sato T,Hohenadler M,Wang C,Guo W,Assaad FF

更新日期：2019-06-14 00:00:00

abstract：:The application of nanoparticle drug formulations, such as nanoliposomal doxorubicin (Doxil), is increasingly integrated in clinical cancer care. Despite nanomedicine's remarkable potential and growth over the last three decades, its clinical benefits for cancer patients vary. Here we report a non-invasive quantitativ...

journal_title：Nature communications

authors： Pérez-Medina C,Abdel-Atti D,Tang J,Zhao Y,Fayad ZA,Lewis JS,Mulder WJM,Reiner T

更新日期：2016-06-20 00:00:00

abstract：:Simultaneous, enantiomer-specific identification of chiral molecules in multi-component mixtures is extremely challenging. Many established techniques for single-component analysis fail to provide selectivity in multi-component mixtures and lack sensitivity for dilute samples. Here we show how enantiomers may be diffe...

journal_title：Nature communications

authors： Fanood MM,Ram NB,Lehmann CS,Powis I,Janssen MH

更新日期：2015-06-24 00:00:00

abstract：:The Paris Agreement set a goal to keep global warming well below 2 °C and pursue efforts to limit it to 1.5 °C. Understanding how 0.5 °C less warming reduces impacts and risks is key for climate policies. Here, we show that both areal and population exposures to dangerous extreme precipitation events (e.g., once in 10...

journal_title：Nature communications

authors： Zhang W,Zhou T,Zou L,Zhang L,Chen X

更新日期：2018-08-08 00:00:00

abstract：:Protein tyrosine phosphatases regulate a myriad of essential subcellular signaling events, yet they remain difficult to study in their native biophysical context. Here we develop a minimally disruptive optical approach to control protein tyrosine phosphatase 1B (PTP1B)-an important regulator of receptor tyrosine kinas...

journal_title：Nature communications

authors： Hongdusit A,Zwart PH,Sankaran B,Fox JM

更新日期：2020-02-07 00:00:00

abstract：:Infrared light detection and sensing is deeply embedded in modern technology and human society and its development has always been benefitting from the discovery of various photoelectric materials. The rise of two-dimensional materials, thanks to their distinct electronic structures, extreme dimensional confinement an...

journal_title：Nature communications

authors： Yin J,Tan Z,Hong H,Wu J,Yuan H,Liu Y,Chen C,Tan C,Yao F,Li T,Chen Y,Liu Z,Liu K,Peng H

更新日期：2018-08-17 00:00:00

abstract：:The synergistic interaction among different components in complex catalysts is one of the crucial factors in determining catalytic performance. Here we report the interactions among the three components in controlling the catalytic performance of Cu-ZnO-ZrO2 (CZZ) catalyst for CO2 hydrogenation to methanol. The in sit...

journal_title：Nature communications

authors： Wang Y,Kattel S,Gao W,Li K,Liu P,Chen JG,Wang H

更新日期：2019-03-11 00:00:00

abstract：:A reliable method for recording evoked synaptic events in identified neurons in Caenorhabditis elegans would greatly accelerate our understanding of its nervous system at the molecular, cellular and network levels. Here we describe a method for recording synaptic currents and potentials from identified neurons in near...

journal_title：Nature communications

authors： Lindsay TH,Thiele TR,Lockery SR

更新日期：2011-01-01 00:00:00

abstract：:Social media has arguably shifted political agenda-setting power away from mainstream media onto politicians. Current U.S. President Trump's reliance on Twitter is unprecedented, but the underlying implications for agenda setting are poorly understood. Using the president as a case study, we present evidence suggestin...

journal_title：Nature communications

authors： Lewandowsky S,Jetter M,Ecker UKH

更新日期：2020-11-10 00:00:00

abstract：:Acute stroke causes complex, pathological, and systemic responses that have not been treatable by any single medication. In this study, using a murine transient middle cerebral artery occlusion stroke model, a novel therapeutic strategy is proposed, where blood replacement (BR) robustly reduces infarctions and improve...

journal_title：Nature communications

authors： Ren X,Hu H,Farooqi I,Simpkins JW

更新日期：2020-08-25 00:00:00

abstract：:Various quantum applications can be reduced to estimating expectation values, which are inevitably deviated by operational and environmental errors. Although errors can be tackled by quantum error correction, the overheads are far from being affordable for near-term technologies. To alleviate the detrimental effects o...

journal_title：Nature communications

authors： Zhang S,Lu Y,Zhang K,Chen W,Li Y,Zhang JN,Kim K

更新日期：2020-01-30 00:00:00