Kinetic gating mechanism of DNA damage recognition by Rad4/XPC.

abstract：:The nutritional environment to which animals are exposed in early life can lead to epigenetic changes in the genome that influence the risk of obesity in later life. Here, we demonstrate that the fibroblast growth factor-21 gene (Fgf21) is subject to peroxisome proliferator-activated receptor (PPAR) α-dependent DNA de...

journal_title：Nature communications

authors： Yuan X,Tsujimoto K,Hashimoto K,Kawahori K,Hanzawa N,Hamaguchi M,Seki T,Nawa M,Ehara T,Kitamura Y,Hatada I,Konishi M,Itoh N,Nakagawa Y,Shimano H,Takai-Igarashi T,Kamei Y,Ogawa Y

更新日期：2018-02-12 00:00:00

abstract：:Considering the synthetic value of introducing active alcoholic hydroxyl group, developing C-H functionalization of alcohols is of significance. Herein, we present a photochemical method that under visible light irradiation, selectfluor can effectively promote the oxidative cross-coupling between alcohols and heteroar...

journal_title：Nature communications

authors： Niu L,Liu J,Liang XA,Wang S,Lei A

更新日期：2019-01-28 00:00:00

abstract：:Merons are nontrivial topological spin textures highly relevant for many phenomena in solid state physics. Despite their importance, direct observation of such vortex quasiparticles is scarce and has been limited to a few complex materials. Here, we show the emergence of merons and antimerons in recently discovered tw...

journal_title：Nature communications

authors： Augustin M,Jenkins S,Evans RFL,Novoselov KS,Santos EJG

更新日期：2021-01-08 00:00:00

abstract：:SecB chaperones assist protein export by binding both unfolded proteins and the SecA motor. Certain SecB homologs can also control toxin-antitoxin (TA) systems known to modulate bacterial growth in response to stress. In such TA-chaperone (TAC) systems, SecB assists the folding and prevents degradation of the antitoxi...

journal_title：Nature communications

authors： Guillet V,Bordes P,Bon C,Marcoux J,Gervais V,Sala AJ,Dos Reis S,Slama N,Mares-Mejía I,Cirinesi AM,Maveyraud L,Genevaux P,Mourey L

更新日期：2019-02-15 00:00:00

abstract：:Conventional interferometers usually utilize beam splitters for wave splitting and recombination. These interferometers are widely used for precision measurement. Their sensitivity for phase measurement is limited by the shot noise, which can be suppressed with squeezed states of light. Here we study a new type of int...

journal_title：Nature communications

authors： Hudelist F,Kong J,Liu C,Jing J,Ou ZY,Zhang W

更新日期：2014-01-01 00:00:00

abstract：:The negative phase of the Interdecadal Pacific Oscillation (IPO), a dominant mode of multi-decadal variability of sea surface temperatures (SSTs) in the Pacific, contributed to the reduced rate of global surface temperature warming in the early 2000s. A proposed mechanism for IPO multidecadal variability indicates tha...

journal_title：Nature communications

authors： Meehl GA,Hu A,Teng H

更新日期：2016-06-02 00:00:00

abstract：:In melanoma, therapies with inhibitors to oncogenic BRAFV600E are highly effective but responses are often short-lived due to the emergence of drug-resistant tumor subpopulations. We describe here a mechanism of acquired drug resistance through the tumor microenvironment, which is mediated by human tumor-associated B ...

journal_title：Nature communications

authors： Somasundaram R,Zhang G,Fukunaga-Kalabis M,Perego M,Krepler C,Xu X,Wagner C,Hristova D,Zhang J,Tian T,Wei Z,Liu Q,Garg K,Griss J,Hards R,Maurer M,Hafner C,Mayerhöfer M,Karanikas G,Jalili A,Bauer-Pohl V,Weihsengru

更新日期：2017-09-19 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature communications

authors： Rees-Garbutt J,Chalkley O,Landon S,Purcell O,Marucci L,Grierson C

更新日期：2020-05-06 00:00:00

abstract：:Pair production can be triggered by high-intensity lasers via the Breit-Wheeler process. However, the straightforward laser-laser colliding for copious numbers of pair creation requires light intensities several orders of magnitude higher than possible with the ongoing laser facilities. Despite the numerous proposed a...

journal_title：Nature communications

authors： Zhu XL,Yu TP,Sheng ZM,Yin Y,Turcu IC,Pukhov A

更新日期：2016-12-14 00:00:00

abstract：:The rapidly increasing use of sensors throughout different research disciplines and the demand for more efficient devices with less power consumption depends critically on the emergence of new sensor materials and novel sensor concepts. Atomically thin transition metal dichalcogenides have a huge potential for sensor ...

journal_title：Nature communications

authors： Feierabend M,Berghäuser G,Knorr A,Malic E

更新日期：2017-03-15 00:00:00

abstract：:Lifestyle contributes to inter-individual variability in brain aging, but previous studies focused on the effects of single lifestyle variables. Here, we studied the combined and individual contributions of four lifestyle variables - alcohol consumption, smoking, physical activity, and social integration - to brain st...

journal_title：Nature communications

authors： Bittner N,Jockwitz C,Mühleisen TW,Hoffstaedter F,Eickhoff SB,Moebus S,Bayen UJ,Cichon S,Zilles K,Amunts K,Caspers S

更新日期：2019-02-06 00:00:00

abstract：:Gene-targeted animal models that are generated by injecting Cas9 and sgRNAs into zygotes are often accompanied by undesired double-strand break (DSB)-induced byproducts and random biallelic targeting due to uncontrollable Cas9 targeting activity. Here, we establish a parental allele-specific gene-targeting (Past-CRISP...

journal_title：Nature communications

authors： Li Y,Weng Y,Bai D,Jia Y,Liu Y,Zhang Y,Kou X,Zhao Y,Ruan J,Chen J,Yin J,Wang H,Teng X,Wang Z,Liu W,Gao S

更新日期：2020-09-14 00:00:00

abstract：:Topological insulators do not allow conduction in the bulk, yet they support edge modes that travel along the boundary only in one direction, determined by the carried electron spin, with inherent robustness to defects and disorder. Topological insulators have inspired analogues in photonics and optics, in which one-w...

journal_title：Nature communications

authors： Khanikaev AB,Fleury R,Mousavi SH,Alù A

更新日期：2015-10-06 00:00:00

abstract：:Mitochondrial quality control is essential in highly structured cells such as neurons and muscles. In skeletal muscle the mitochondrial fission proteins are reduced in different physiopathological conditions including ageing sarcopenia, cancer cachexia and chemotherapy-induced muscle wasting. However, whether mitochon...

journal_title：Nature communications

authors： Favaro G,Romanello V,Varanita T,Andrea Desbats M,Morbidoni V,Tezze C,Albiero M,Canato M,Gherardi G,De Stefani D,Mammucari C,Blaauw B,Boncompagni S,Protasi F,Reggiani C,Scorrano L,Salviati L,Sandri M

更新日期：2019-06-12 00:00:00

abstract：:SIRT1 is the most evolutionarily conserved mammalian sirtuin, and it plays a vital role in the regulation of metabolism, stress responses, genome stability, and ageing. As a stress sensor, SIRT1 deacetylase activity is significantly increased during stresses, but the molecular mechanisms are not yet fully clear. Here,...

journal_title：Nature communications

authors： Han C,Gu Y,Shan H,Mi W,Sun J,Shi M,Zhang X,Lu X,Han F,Gong Q,Yu W

更新日期：2017-11-14 00:00:00

abstract：:Engineering catalytic sites at the atomic level provides an opportunity to understand the catalyst's active sites, which is vital to the development of improved catalysts. Here we show a reliable and tunable polyoxometalate template-based synthetic strategy to atomically engineer metal doping sites onto metallic 1T-Mo...

journal_title：Nature communications

authors： Huang Y,Sun Y,Zheng X,Aoki T,Pattengale B,Huang J,He X,Bian W,Younan S,Williams N,Hu J,Ge J,Pu N,Yan X,Pan X,Zhang L,Wei Y,Gu J

更新日期：2019-02-28 00:00:00

abstract：:Post-transcriptional RNA modifications play a critical role in the pathogenesis of human mitochondrial disorders, but the mechanisms by which specific modifications affect mitochondrial protein synthesis remain poorly understood. Here we used a quantitative RNA sequencing approach to investigate, at nucleotide resolut...

journal_title：Nature communications

authors： Richter U,Evans ME,Clark WC,Marttinen P,Shoubridge EA,Suomalainen A,Wredenberg A,Wedell A,Pan T,Battersby BJ

更新日期：2018-09-27 00:00:00

abstract：:Cryptosporidiosis in an enteric infection caused by Cryptosporidium parasites and is a major cause of acute infant diarrhea in the developing world. A major bottleneck to research progress is the lack of methods to cryopreserve Cryptosporidium oocysts, thus requiring routine propagation in laboratory animals. Here, we...

journal_title：Nature communications

authors： Jaskiewicz JJ,Sandlin RD,Swei AA,Widmer G,Toner M,Tzipori S

更新日期：2018-07-23 00:00:00

abstract：:The worldwide biodiversity crisis has intensified the need to better understand how biodiversity and human disturbance are related. The 'intermediate disturbance hypothesis' suggests that disturbance regimes generate predictable non-linear patterns in species richness. Evidence often contradicts intermediate disturban...

journal_title：Nature communications

authors： Mayor SJ,Cahill JF Jr,He F,Sólymos P,Boutin S

更新日期：2012-01-01 00:00:00

abstract：:In LaAlO(3)/SrTiO(3) heterointerfaces, charge carriers migrate from the LaAlO(3) to the interface in an electronic reconstruction. Magnetism has been observed in LaAlO(3)/SrTiO(3), but its relationship to the interface conductivity is unknown. Here we show that reconstruction is necessary, but not sufficient, for the ...

journal_title：Nature communications

authors： Kalisky B,Bert JA,Klopfer BB,Bell C,Sato HK,Hosoda M,Hikita Y,Hwang HY,Moler KA

更新日期：2012-06-26 00:00:00

abstract：:Island systems generally have fewer species than continental areas due to their small size and geographical isolation. Low island diversity reduces the possibility of exportation of island lineages and island systems are not thought to have a major influence on the build-up of continental diversity. However, the view ...

journal_title：Nature communications

authors： Jønsson KA,Holt BG

更新日期：2015-10-05 00:00:00

abstract：:Angiogenesis is essential for tissue development, wound healing and tissue perfusion, with its dysregulation linked to tumorigenesis, rheumatoid arthritis and heart disease. Here we show that pro-angiogenic stimuli couple to NADPH oxidase-dependent generation of oxidants that catalyse an activating intermolecular-disu...

journal_title：Nature communications

authors： Burgoyne JR,Rudyk O,Cho HJ,Prysyazhna O,Hathaway N,Weeks A,Evans R,Ng T,Schröder K,Brandes RP,Shah AM,Eaton P

更新日期：2015-08-10 00:00:00

abstract：:One of the most dramatic events in river environments is the natural diversion, or avulsion, of a channel across its floodplain. Though rarely witnessed, avulsions can cause massive floods, and over geologic time they create most of the fluvial stratigraphic record. Avulsions exhibit behavior ranging from reoccupying ...

journal_title：Nature communications

authors： Valenza JM,Edmonds DA,Hwang T,Roy S

更新日期：2020-04-30 00:00:00

abstract：:Symmetric or asymmetric positioning of intracellular structures including the nucleus and mitotic spindle steers various biological processes such as cell migration, division, and embryogenesis. In typical animal cells, both a sparse actomyosin meshwork in the cytoplasm and a dense actomyosin cortex underneath the cel...

journal_title：Nature communications

authors： Sakamoto R,Tanabe M,Hiraiwa T,Suzuki K,Ishiwata S,Maeda YT,Miyazaki M

更新日期：2020-06-15 00:00:00

abstract：:Photocatalytic formation of hydrocarbons using solar energy via artificial photosynthesis is a highly desirable renewable-energy source for replacing conventional fossil fuels. Using an L-cysteine-based hydrothermal process, here we synthesize a carbon-doped SnS2 (SnS2-C) metal dichalcogenide nanostructure, which exhi...

journal_title：Nature communications

authors： Shown I,Samireddi S,Chang YC,Putikam R,Chang PH,Sabbah A,Fu FY,Chen WF,Wu CI,Yu TY,Chung PW,Lin MC,Chen LC,Chen KH

更新日期：2018-01-12 00:00:00

abstract：:The mathematics of gauge theories lies behind many of the most profound advances in physics in the past 200 years, from Maxwell's theory of electromagnetism to Einstein's theory of general relativity. More recently it has become clear that gauge theories also emerge in condensed matter, a prime example being the spin-...

journal_title：Nature communications

authors： Benton O,Jaubert LD,Yan H,Shannon N

更新日期：2016-05-26 00:00:00

abstract：:Calcareous microplankton shells form the dominant components of ancient and modern pelagic sea-floor carbonates and are widely used in palaeoenvironmental reconstructions. The efficacy of these applications, however, is dependent upon minimal geochemical alteration during diagenesis, but these modifying processes are ...

journal_title：Nature communications

authors： Wendler JE,Bown P

更新日期：2013-01-01 00:00:00

abstract：:Climate change is impacting fisheries worldwide with uncertain outcomes for food and nutritional security. Using management strategy evaluations for key US fisheries in the eastern Bering Sea we find that Ecosystem Based Fisheries Management (EBFM) measures forestall future declines under climate change over non-EBFM ...

journal_title：Nature communications

authors： Holsman KK,Haynie AC,Hollowed AB,Reum JCP,Aydin K,Hermann AJ,Cheng W,Faig A,Ianelli JN,Kearney KA,Punt AE

更新日期：2020-09-11 00:00:00

abstract：:Recent studies of thermal transport in nanomaterials have demonstrated the breakdown of Fourier's law through observations of ballistic transport. Despite its unique features, another instance of the breakdown of Fourier's law, hydrodynamic phonon transport, has drawn less attention because it has been observed only a...

journal_title：Nature communications

authors： Lee S,Broido D,Esfarjani K,Chen G

更新日期：2015-02-18 00:00:00

abstract：:All motile organisms use spatially distributed chemical features of their surroundings to guide their behaviors, but the neural mechanisms underlying such behaviors in mammals have been difficult to study, largely due to the technical challenges of controlling chemical concentrations in space and time during behaviora...

journal_title：Nature communications

authors： Radvansky BA,Dombeck DA

更新日期：2018-02-26 00:00:00