Abstract:
:The nutritional environment to which animals are exposed in early life can lead to epigenetic changes in the genome that influence the risk of obesity in later life. Here, we demonstrate that the fibroblast growth factor-21 gene (Fgf21) is subject to peroxisome proliferator-activated receptor (PPAR) α-dependent DNA demethylation in the liver during the postnatal period. Reductions in Fgf21 methylation can be enhanced via pharmacologic activation of PPARα during the suckling period. We also reveal that the DNA methylation status of Fgf21, once established in early life, is relatively stable and persists into adulthood. Reduced DNA methylation is associated with enhanced induction of hepatic FGF21 expression after PPARα activation, which may partly explain the attenuation of diet-induced obesity in adulthood. We propose that Fgf21 methylation represents a form of epigenetic memory that persists into adulthood, and it may have a role in the developmental programming of obesity.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Yuan X,Tsujimoto K,Hashimoto K,Kawahori K,Hanzawa N,Hamaguchi M,Seki T,Nawa M,Ehara T,Kitamura Y,Hatada I,Konishi M,Itoh N,Nakagawa Y,Shimano H,Takai-Igarashi T,Kamei Y,Ogawa Ydoi
10.1038/s41467-018-03038-wsubject
Has Abstractpub_date
2018-02-12 00:00:00pages
636issue
1issn
2041-1723pii
10.1038/s41467-018-03038-wjournal_volume
9pub_type
杂志文章abstract::Using time-domain thermoreflectance, the thermal conductivity and elastic properties of a sputter deposited LiCoO2 film, a common lithium-ion cathode material, are measured as a function of the degree of lithiation. Here we report that via in situ measurements during cycling, the thermal conductivity of a LiCoO2 catho...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms5035
更新日期:2014-06-03 00:00:00
abstract::Majority of disease-modifying therapeutic targets are restricted to the intracellular space and are therefore not druggable using existing biologic modalities. The ability to efficiently deliver macromolecules inside target cells or tissues would greatly expand the current landscape of therapeutic targets for future g...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-03390-x
更新日期:2018-03-06 00:00:00
abstract::Turn-on fluorescence imaging is routinely studied; however, turn-on chemiluminescence has been rarely explored for in vivo imaging. Herein, we report the design and validation of chemiluminescence probe ADLumin-1 as a turn-on probe for amyloid beta (Aβ) species. Two-photon imaging indicates that ADLumin-1 can efficien...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-17783-4
更新日期:2020-08-13 00:00:00
abstract::The diversity of life and its organization in networks of interacting species has been a long-standing theoretical puzzle for ecologists. Ever since May's provocative paper challenging whether 'large complex systems [are] stable' various hypotheses have been proposed to explain when stability should be the rule, not t...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms12457
更新日期:2016-08-24 00:00:00
abstract::Direct reciprocity is a mechanism for cooperation among humans. Many of our daily interactions are repeated. We interact repeatedly with our family, friends, colleagues, members of the local and even global community. In the theory of repeated games, it is a tacit assumption that the various games that a person plays ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-02721-8
更新日期:2018-02-07 00:00:00
abstract::Metastasis-associated recurrence is the major cause of poor prognosis in hepatocellular carcinoma (HCC), however, the underlying mechanisms remain largely elusive. In this study, we report that expression of choroideremia-like (CHML) is increased in HCC, associated with poor survival, early recurrence and more satelli...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-10364-0
更新日期:2019-06-07 00:00:00
abstract::The sensitivity of quantum magnetometer is challenged by control errors and, especially in the solid state, by their short coherence times. Refocusing techniques can overcome these limitations and improve the sensitivity to periodic fields, but they come at the cost of reduced bandwidth and cannot be applied to sense ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2375
更新日期:2013-01-01 00:00:00
abstract::Urban residential buildings make large contributions to energy consumption. Energy consumption per square meter is most widely used to measure energy efficiency in urban residential buildings. This study aims to explore whether it is an appropriate indicator. An extended STIRPAT model was used based on the survey data...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-12852-9
更新日期:2019-10-30 00:00:00
abstract::Proper regulation of energy storage in adipose tissue is crucial for maintaining insulin sensitivity and molecules contributing to this process have not been fully revealed. Here we show that type II transmembrane protein tenomodulin (TNMD) is upregulated in adipose tissue of insulin-resistant versus insulin-sensitive...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms10686
更新日期:2016-02-16 00:00:00
abstract::In the human hematopoietic system, rare self-renewing multipotent long-term hematopoietic stem cells (LT-HSCs) are responsible for the lifelong production of mature blood cells and are the rational target for clinical regenerative therapies. However, the heterogeneity in the hematopoietic stem cell compartment and var...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-12726-0
更新日期:2019-10-18 00:00:00
abstract::Electric fields can transform materials with respect to their structure and properties, enabling various applications ranging from batteries to spintronics. Recently electrolytic gating, which can generate large electric fields and voltage-driven ion transfer, has been identified as a powerful means to achieve electri...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-14631-3
更新日期:2020-02-14 00:00:00
abstract::Elemental phosphorus is attracting growing interest across fundamental and applied fields of research. However, atomistic simulations of phosphorus have remained an outstanding challenge. Here, we show that a universally applicable force field for phosphorus can be created by machine learning (ML) from a suitably chos...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19168-z
更新日期:2020-10-29 00:00:00
abstract::The large interest in chiral magnetic structures for realization of nanoscale magnetic storage or logic devices has necessitated methods which can quantify magnetic interactions at the atomic scale. To overcome the limitations of the typically used current-based sensing of atomic-scale exchange interactions, a force-b...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-15024-2
更新日期:2020-03-05 00:00:00
abstract::Immune checkpoint blockade therapies have extended patient survival across multiple cancer lineages, but there is a heated debate on whether cancer immunotherapy efficacy is different between male and female patients. We summarize the existing meta-analysis to show inconsistent conclusions for whether gender is associ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-15679-x
更新日期:2020-04-14 00:00:00
abstract::A planar slab of negative-index material works as a superlens with sub-diffraction-limited resolution, as propagating waves are focused and, moreover, evanescent waves are reconstructed in the image plane. Here we demonstrate a superlens for electric evanescent fields with low losses using perovskites in the mid-infra...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1249
更新日期:2011-01-01 00:00:00
abstract::Emerging quantum technologies require mastering thermal management, especially at the nanoscale. It is now accepted that thermal metamaterial-based phonon manipulation is possible, especially at sub-kelvin temperatures. In these extreme limits of low temperatures and dimensions, heat conduction enters a quantum regime...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-06791-0
更新日期:2018-10-16 00:00:00
abstract::Human Ebp1 is a member of the proliferation-associated 2G4 (PA2G4) family and plays an important role in cancer regulation. Ebp1 shares the methionine aminopeptidase (MetAP) fold and binds to mature 80S ribosomes for translational control. Here, we present a cryo-EM single particle analysis reconstruction of Ebp1 boun...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-14603-7
更新日期:2020-02-07 00:00:00
abstract::Although hexagonal boron nitride (h-BN) is a good candidate for gate-insulating materials by minimizing interaction from substrate, further applications to electronic devices with available two-dimensional semiconductors continue to be limited by flake size. While monolayer h-BN has been synthesized on Pt and Cu foil ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms9662
更新日期:2015-10-28 00:00:00
abstract::To cope with the global bacterial multidrug resistance, scientific communities have devoted significant efforts to develop novel antibiotics, particularly those with new modes of actions. Teixobactin, recently isolated from uncultured bacteria, is considered as a promising first-in-class drug candidate for clinical de...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms12394
更新日期:2016-08-03 00:00:00
abstract::Lungs resected for adenocarcinomas often harbour minute discrete foci of cytologically atypical pneumocyte proliferations designated as atypical adenomatous hyperplasia (AAH). Evidence suggests that AAH represents an initial step in the progression to adenocarcinoma in situ (AIS), minimally invasive adenocarcinoma (MI...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms9258
更新日期:2015-09-16 00:00:00
abstract::Various melting-related phenomena (like surface melting, size dependence of melting temperature, melting of few nm-size particles and overheating at a very fast heating rate) are of great fundamental and applied interest, although the corresponding theory is still lacking. Here we develop an advanced phase-field theor...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1275
更新日期:2011-01-01 00:00:00
abstract::Polycomb repressive complex 2 (PRC2) controls maintenance and lineage determination of stem cells by suppressing genes that regulate cellular differentiation and tissue development. However, the role of PRC2 in lineage-committed somatic cells is mostly unknown. Here we show that Eed deficiency in chondrocytes causes s...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms12047
更新日期:2016-06-22 00:00:00
abstract::Heterogeneous catalysis is an enabling technology that utilises transition metal nanoparticles (NPs) supported on oxides to promote chemical reactions. Structural mismatch at the NP-support interface generates lattice strain that could affect catalytic properties. However, detailed knowledge about strain in supported ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-05055-1
更新日期:2018-07-13 00:00:00
abstract::The immunosuppressive microenvironment that is shaped by hepatic metastatic pancreatic ductal adenocarcinoma (PDAC) is essential for tumor cell evasion of immune destruction. Neutrophils are important components of the metastatic tumor microenvironment and exhibit heterogeneity. However, the specific phenotypes, funct...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-20447-y
更新日期:2021-01-08 00:00:00
abstract::Nanostructured materials premise to revolutionize the label-free biosensing of analytes for clinical applications, leveraging the deeper interaction between materials and analytes with comparable size. However, when the characteristic dimension of the materials reduces to the nanoscale, the surface functionalization f...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-07723-8
更新日期:2018-12-10 00:00:00
abstract::Room-temperature infrared sub-band gap photoresponse in silicon is of interest for telecommunications, imaging and solid-state energy conversion. Attempts to induce infrared response in silicon largely centred on combining the modification of its electronic structure via controlled defect formation (for example, vacan...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4011
更新日期:2014-01-01 00:00:00
abstract::Replacing sluggish oxygen evolution reaction (OER) with hydrazine oxidation reaction (HzOR) to produce hydrogen has been considered as a more energy-efficient strategy than water splitting. However, the relatively high cell voltage in two-electrode system and the required external electric power hinder its scalable ap...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-15563-8
更新日期:2020-04-15 00:00:00
abstract::Acoustic sensors play an important role in many areas, such as homeland security, navigation, communication, health care and industry. However, the fundamental pressure detection limit hinders the performance of current acoustic sensing technologies. Here, through analytical, numerical and experimental studies, we sho...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms6247
更新日期:2014-10-15 00:00:00
abstract::Nanoporous frameworks are polymeric materials built from rigid molecules, which give rise to their nanoporous structures with applications in gas sorption and storage, catalysis and others. Conceptually new applications could emerge, should these beneficial properties be manipulated by external stimuli in a reversible...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4588
更新日期:2014-04-07 00:00:00
abstract::Thin-film oxide heterostructures show great potential for use in spintronic memories, where electronic charge and spin are coupled to transport information. Here we use a La0.7Sr0.3MnO3 (LSMO)/PbZr0.2Ti0.8O3 (PZT) model system to explore how local variations in electronic and magnetic phases mediate this coupling. We ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms7735
更新日期:2015-04-16 00:00:00