An olfactory virtual reality system for mice.

abstract：:Pattern-triggered immunity and effector-triggered immunity are two primary forms of innate immunity in land plants. The molecular components and connecting nodes of pattern-triggered immunity and effector-triggered immunity are not fully understood. Here, we report that the Arabidopsis calcium-dependent protein kinase...

journal_title：Nature communications

authors： Lu YJ,Li P,Shimono M,Corrion A,Higaki T,He SY,Day B

更新日期：2020-12-04 00:00:00

abstract：:Across phyla, body size is linked to climate. For example, rearing fruit flies at lower temperatures results in bigger body sizes than those observed at higher temperatures. The underlying molecular basis of this effect is poorly understood. Here we provide evidence that the temperature-dependent regulation of Drosoph...

journal_title：Nature communications

authors： Li Q,Gong Z

更新日期：2015-12-09 00:00:00

abstract：:Understanding human cooperation is of major interest across the natural and social sciences. But it is unclear to what extent cooperation is actually a general concept. Most research on cooperation has implicitly assumed that a person's behaviour in one cooperative context is related to their behaviour in other settin...

journal_title：Nature communications

authors： Peysakhovich A,Nowak MA,Rand DG

更新日期：2014-09-16 00:00:00

abstract：:Epitaxy is widely employed to create highly oriented crystalline films. A less appreciated, but nonetheless powerful means of creating such films is via topotactic transformation, in which a chemical reaction transforms a single crystal of one phase into a single crystal of a different phase, which inherits its orient...

journal_title：Nature communications

authors： Mairoser T,Mundy JA,Melville A,Hodash D,Cueva P,Held R,Glavic A,Schubert J,Muller DA,Schlom DG,Schmehl A

更新日期：2015-07-16 00:00:00

abstract：:Recent years have witnessed thriving progress of flexible and portable electronics, with very high demand for cost-effective and tailor-made multifunctional devices. Here, we report on an ingenious origami hierarchical sensor array (OHSA) written with a conductive ink. Thanks to origami as a controllable hierarchical ...

journal_title：Nature communications

authors： Zhang M,Sun JJ,Khatib M,Lin ZY,Chen ZH,Saliba W,Gharra A,Horev YD,Kloper V,Milyutin Y,Huynh TP,Brandon S,Shi G,Haick H

更新日期：2019-03-08 00:00:00

abstract：:The Paris Agreement set a goal to keep global warming well below 2 °C and pursue efforts to limit it to 1.5 °C. Understanding how 0.5 °C less warming reduces impacts and risks is key for climate policies. Here, we show that both areal and population exposures to dangerous extreme precipitation events (e.g., once in 10...

journal_title：Nature communications

authors： Zhang W,Zhou T,Zou L,Zhang L,Chen X

更新日期：2018-08-08 00:00:00

abstract：:Alike materials in the solid state, the phase diagram of type-II superconductors exhibit crystalline, amorphous, liquid and spatially inhomogeneous phases. The multitude of different phases of vortex matter has thence proven to act as almost ideal model system for the study of both the underlying properties of superco...

journal_title：Nature communications

authors： Reimann T,Mühlbauer S,Schulz M,Betz B,Kaestner A,Pipich V,Böni P,Grünzweig C

更新日期：2015-11-02 00:00:00

abstract：:Genomic alterations occurring during melanoma progression and the resulting genomic heterogeneity between metastatic deposits remain incompletely understood. Analyzing 86 metastatic melanoma deposits from 53 patients with whole-exome sequencing (WES), we show a low branch to trunk mutation ratio and little intermetast...

journal_title：Nature communications

authors： Birkeland E,Zhang S,Poduval D,Geisler J,Nakken S,Vodak D,Meza-Zepeda LA,Hovig E,Myklebost O,Knappskog S,Lønning PE

更新日期：2018-07-10 00:00:00

abstract：:Flexible, wearable sensing devices can yield important information about the underlying physiology of a human subject for applications in real-time health and fitness monitoring. Despite significant progress in the fabrication of flexible biosensors that naturally comply with the epidermis, most designs measure only a...

journal_title：Nature communications

authors： Imani S,Bandodkar AJ,Mohan AM,Kumar R,Yu S,Wang J,Mercier PP

更新日期：2016-05-23 00:00:00

abstract：:The possibility of measuring binding of small-molecule drugs to desired targets in live cells could provide a better understanding of drug action. However, current approaches mostly yield static data, require lysis or rely on indirect assays and thus often provide an incomplete understanding of drug action. Here, we p...

journal_title：Nature communications

authors： Dubach JM,Vinegoni C,Mazitschek R,Fumene Feruglio P,Cameron LA,Weissleder R

更新日期：2014-05-28 00:00:00

abstract：:The interior of the neuronal cell nucleus is a highly organized three-dimensional (3D) structure where regions of the genome that are linearly millions of bases apart establish sub-structures with specialized functions. To investigate neuronal chromatin organization and dynamics in vivo, we generated bitransgenic mice...

journal_title：Nature communications

authors： Ito S,Magalska A,Alcaraz-Iborra M,Lopez-Atalaya JP,Rovira V,Contreras-Moreira B,Lipinski M,Olivares R,Martinez-Hernandez J,Ruszczycki B,Lujan R,Geijo-Barrientos E,Wilczynski GM,Barco A

更新日期：2014-07-18 00:00:00

abstract：:Graphene has various potential applications owing to its unique electronic, optical, mechanical and chemical properties, which are primarily based on its two-dimensional nature. Graphene-based vertical devices can extend the investigations and potential applications range to three dimensions, while interfacial propert...

journal_title：Nature communications

authors： Chen JJ,Meng J,Zhou YB,Wu HC,Bie YQ,Liao ZM,Yu DP

更新日期：2013-01-01 00:00:00

abstract：:Hypoxic damage to the developing brain due to preterm birth causes many anatomical changes, including damage to the periventricular white matter. This results in the loss of glial cells, significant disruptions in myelination, and thereby cognitive and behavioral disabilities seen throughout life. Encouragingly, these...

journal_title：Nature communications

authors： Forbes TA,Goldstein EZ,Dupree JL,Jablonska B,Scafidi J,Adams KL,Imamura Y,Hashimoto-Torii K,Gallo V

更新日期：2020-02-19 00:00:00

abstract：:Cryo-electron microscopy can determine the structure of biological matter in vitrified liquids. However, structure alone is insufficient to understand the function of native and engineered biomolecules. So far, their mechanical properties have mainly been probed at room temperature using tens of pico-newton forces wit...

journal_title：Nature communications

authors： Pawlak R,Vilhena JG,Hinaut A,Meier T,Glatzel T,Baratoff A,Gnecco E,Pérez R,Meyer E

更新日期：2019-02-08 00:00:00

abstract：:Translationally controlled tumour protein (TCTP) is implicated in growth regulation and cancer. Recently, human TCTP has been suggested to play a role in the DNA damage response by forming a complex with ataxia telangiectasia-mutated (ATM) kinase . However, the exact nature of this interaction and its roles in vivo re...

journal_title：Nature communications

authors： Hong ST,Choi KW

更新日期：2013-01-01 00:00:00

abstract：:Synapse degeneration is an early and invariant feature of neurodegenerative diseases. Indeed, synapse loss occurs prior to neuronal degeneration and correlates with the symptom severity of these diseases. However, the molecular mechanisms that trigger synaptic loss remain poorly understood. Here we demonstrate that de...

journal_title：Nature communications

authors： Galli S,Lopes DM,Ammari R,Kopra J,Millar SE,Gibb A,Salinas PC

更新日期：2014-10-16 00:00:00

abstract：:Nonlinear spectroscopies are utilized extensively for selective measurements of chemical dynamics in the optical, infrared, and radio-frequency regimes. The development of these techniques for extreme ultraviolet (XUV) light sources facilitates measurements of electronic dynamics on attosecond timescales. Here, we elu...

journal_title：Nature communications

authors： Fidler AP,Camp SJ,Warrick ER,Bloch E,Marroux HJB,Neumark DM,Schafer KJ,Gaarde MB,Leone SR

更新日期：2019-03-27 00:00:00

abstract：:In retinitis pigmentosa, loss of cone photoreceptors leads to blindness, and preservation of cone function is a major therapeutic goal. However, cone loss is thought to occur as a secondary event resulting from degeneration of rod photoreceptors. Here we report a genome editing approach in which adeno-associated virus...

journal_title：Nature communications

authors： Yu W,Mookherjee S,Chaitankar V,Hiriyanna S,Kim JW,Brooks M,Ataeijannati Y,Sun X,Dong L,Li T,Swaroop A,Wu Z

更新日期：2017-03-14 00:00:00

abstract：:A Correction to this paper has been published: https://doi.org/10.1038/s41467-020-19868-6. ...

journal_title：Nature communications

authors： Heimbucher T,Hog J,Gupta P,Murphy CT

更新日期：2020-11-20 00:00:00

abstract：:Prolonged cell survival occurs through the expression of specific protein isoforms generated by alternate splicing of mRNA precursors in cancer cells. How alternate splicing regulates tumor development and resistance to targeted therapies in cancer remain poorly understood. Here we show that RNF113A, whose loss-of-fun...

journal_title：Nature communications

authors： Shostak K,Jiang Z,Charloteaux B,Mayer A,Habraken Y,Tharun L,Klein S,Xu X,Duong HQ,Vislovukh A,Close P,Florin A,Rambow F,Marine JC,Büttner R,Chariot A

更新日期：2020-03-09 00:00:00

abstract：:Ensuring that one gene's transcription does not inappropriately affect the expression of its neighbors is a fundamental challenge to gene regulation in a genomic context. In plants, which lack homologs of animal insulator proteins, the mechanisms that prevent transcriptional interference are not well understood. Here ...

journal_title：Nature communications

authors： Yu X,Martin PGP,Michaels SD

更新日期：2019-09-25 00:00:00

abstract：:Optogenetics enables manipulation of biological processes with light at high spatio-temporal resolution to control the behavior of cells, networks, or even whole animals. In contrast to the performance of excitatory rhodopsins, the effectiveness of inhibitory optogenetic tools is still insufficient. Here we report a t...

journal_title：Nature communications

authors： Bernal Sierra YA,Rost BR,Pofahl M,Fernandes AM,Kopton RA,Moser S,Holtkamp D,Masala N,Beed P,Tukker JJ,Oldani S,Bönigk W,Kohl P,Baier H,Schneider-Warme F,Hegemann P,Beck H,Seifert R,Schmitz D

更新日期：2018-11-05 00:00:00

abstract：:A specific bone vessel subtype, strongly positive for CD31 and endomucin (CD31hiEmcnhi), is identified as coupling angiogenesis and osteogenesis. The abundance of type CD31hiEmcnhi vessels decrease during ageing. Here we show that expression of the miR-497∼195 cluster is high in CD31hiEmcnhi endothelium but gradually ...

journal_title：Nature communications

authors： Yang M,Li CJ,Sun X,Guo Q,Xiao Y,Su T,Tu ML,Peng H,Lu Q,Liu Q,He HB,Jiang TJ,Lei MX,Wan M,Cao X,Luo XH

更新日期：2017-07-07 00:00:00

abstract：:Assembly of infectious influenza A viruses (IAV) is a complex process involving transport from the nucleus to the plasma membrane. Rab11A-containing recycling endosomes have been identified as a platform for intracellular transport of viral RNA (vRNA). Here, using high spatiotemporal resolution light-sheet microscopy ...

journal_title：Nature communications

authors： Bhagwat AR,Le Sage V,Nturibi E,Kulej K,Jones J,Guo M,Tae Kim E,Garcia BA,Weitzman MD,Shroff H,Lakdawala SS

更新日期：2020-01-07 00:00:00

abstract：:Methanol is a biotechnologically promising substitute for food and feed substrates since it can be produced renewably from electricity, water and CO2. Although progress has been made towards establishing Escherichia coli as a platform organism for methanol conversion via the energy efficient ribulose monophosphate (Ru...

journal_title：Nature communications

authors： Keller P,Noor E,Meyer F,Reiter MA,Anastassov S,Kiefer P,Vorholt JA

更新日期：2020-10-26 00:00:00

abstract：:The nasal cellular epigenome may serve as biomarker of airway disease and environmental response. Here we collect nasal swabs from the anterior nares of 547 children (mean-age 12.9 y), and measure DNA methylation (DNAm) with the Infinium MethylationEPIC BeadChip. We perform nasal Epigenome-Wide Association analyses (E...

journal_title：Nature communications

authors： Cardenas A,Sordillo JE,Rifas-Shiman SL,Chung W,Liang L,Coull BA,Hivert MF,Lai PS,Forno E,Celedón JC,Litonjua AA,Brennan KJ,DeMeo DL,Baccarelli AA,Oken E,Gold DR

更新日期：2019-07-12 00:00:00

abstract：:Hybridomas, fusions of primary mouse B cells and myelomas, are stable, rapidly-proliferating cell lines widely utilized for antibody screening and production. Antibody specificity of a hybridoma clone is determined by the immunoglobulin sequence of the primary B cell. Here we report a platform for rapid reprogramming ...

journal_title：Nature communications

authors： Pogson M,Parola C,Kelton WJ,Heuberger P,Reddy ST

更新日期：2016-08-17 00:00:00

abstract：:Trace elements diffuse negligible distances through the pristine crystal lattice in minerals: this is a fundamental assumption when using them to decipher geological processes. For example, the reliable use of the mineral zircon (ZrSiO4) as a U-Th-Pb geochronometer and trace element monitor requires minimal radiogenic...

journal_title：Nature communications

authors： Piazolo S,La Fontaine A,Trimby P,Harley S,Yang L,Armstrong R,Cairney JM

更新日期：2016-02-12 00:00:00

abstract：:Considerable interest has been devoted to converting mechanical energy into electricity using polymer nanofibres. In particular, piezoelectric nanofibres produced by electrospinning have shown remarkable mechanical energy-to-electricity conversion ability. However, there is little data for the acoustic-to-electric con...

journal_title：Nature communications

authors： Lang C,Fang J,Shao H,Ding X,Lin T

更新日期：2016-03-23 00:00:00

abstract：:Osteosarcoma is the most frequent primary bone tumor with poor prognosis. Through RNA-sequencing of 100,987 individual cells from 7 primary, 2 recurrent, and 2 lung metastatic osteosarcoma lesions, 11 major cell clusters are identified based on unbiased clustering of gene expression profiles and canonical markers. The...

journal_title：Nature communications

authors： Zhou Y,Yang D,Yang Q,Lv X,Huang W,Zhou Z,Wang Y,Zhang Z,Yuan T,Ding X,Tang L,Zhang J,Yin J,Huang Y,Yu W,Wang Y,Zhou C,Su Y,He A,Sun Y,Shen Z,Qian B,Meng W,Fei J,Yao Y,Pan X,Chen P,Hu H

更新日期：2020-12-10 00:00:00