Patterns of genomic evolution in advanced melanoma.

abstract：:Mapping neuroanatomy is a foundational goal towards understanding brain function. Electron microscopy (EM) has been the gold standard for connectivity analysis because nanoscale resolution is necessary to unambiguously resolve synapses. However, molecular information that specifies cell types is often lost in EM recon...

journal_title：Nature communications

authors： Shen FY,Harrington MM,Walker LA,Cheng HPJ,Boyden ES,Cai D

更新日期：2020-09-15 00:00:00

abstract：:Topologically nontrivial materials host protected edge states associated with the bulk band inversion through the bulk-edge correspondence. Manipulating such edge states is highly desired for developing new functions and devices practically using their dissipation-less nature and spin-momentum locking. Here we introdu...

journal_title：Nature communications

authors： Mitsuishi N,Sugita Y,Bahramy MS,Kamitani M,Sonobe T,Sakano M,Shimojima T,Takahashi H,Sakai H,Horiba K,Kumigashira H,Taguchi K,Miyamoto K,Okuda T,Ishiwata S,Motome Y,Ishizaka K

更新日期：2020-05-18 00:00:00

abstract：:Flexible, wearable sensing devices can yield important information about the underlying physiology of a human subject for applications in real-time health and fitness monitoring. Despite significant progress in the fabrication of flexible biosensors that naturally comply with the epidermis, most designs measure only a...

journal_title：Nature communications

authors： Imani S,Bandodkar AJ,Mohan AM,Kumar R,Yu S,Wang J,Mercier PP

更新日期：2016-05-23 00:00:00

abstract：:To fulfill its role in protein biogenesis, the endoplasmic reticulum (ER) depends on the Hsp70-type molecular chaperone BiP, which requires a constant ATP supply. However, the carrier that catalyzes ATP uptake into the ER was unknown. Here, we report that our screen of gene expression datasets for member(s) of the fam...

journal_title：Nature communications

authors： Klein MC,Zimmermann K,Schorr S,Landini M,Klemens PAW,Altensell J,Jung M,Krause E,Nguyen D,Helms V,Rettig J,Fecher-Trost C,Cavalié A,Hoth M,Bogeski I,Neuhaus HE,Zimmermann R,Lang S,Haferkamp I

更新日期：2018-08-28 00:00:00

abstract：:Human gut microbiome is a promising target for managing type 2 diabetes (T2D). Measures altering gut microbiota like oral intake of probiotics or berberine (BBR), a bacteriostatic agent, merit metabolic homoeostasis. We hence conducted a randomized, double-blind, placebo-controlled trial with newly diagnosed T2D patie...

journal_title：Nature communications

authors： Zhang Y,Gu Y,Ren H,Wang S,Zhong H,Zhao X,Ma J,Gu X,Xue Y,Huang S,Yang J,Chen L,Chen G,Qu S,Liang J,Qin L,Huang Q,Peng Y,Li Q,Wang X,Kong P,Hou G,Gao M,Shi Z,Li X,Qiu Y,Zou Y,Yang H,Wang J,Xu G,

更新日期：2020-10-06 00:00:00

abstract：:Systems allowing label-free molecular detection are expected to have enormous impact on biochemical sciences. Research focuses on materials and technologies based on exploiting localized surface plasmon resonances in metallic nanostructures. The reason for this focused attention is their suitability for single-molecul...

journal_title：Nature communications

authors： Maccaferri N,Gregorczyk KE,de Oliveira TV,Kataja M,van Dijken S,Pirzadeh Z,Dmitriev A,Åkerman J,Knez M,Vavassori P

更新日期：2015-02-02 00:00:00

abstract：:Protein integration into biological membranes is a vital cellular event for all organisms. We previously reported an integration factor in the inner membrane of Escherichia coli, named MPIase (membrane protein integrase). Here we show that in contrast to previously identified integration factors that are proteins, MPI...

journal_title：Nature communications

authors： Nishiyama K,Maeda M,Yanagisawa K,Nagase R,Komura H,Iwashita T,Yamagaki T,Kusumoto S,Tokuda H,Shimamoto K

更新日期：2012-01-01 00:00:00

abstract：:Recent discovery of the half quantized thermal Hall conductivity in [Formula: see text]-RuCl[Formula: see text], a candidate material for the Kitaev spin liquid, suggests the presence of a highly entangled quantum state in external magnetic fields. This field induced phase appears between the low field zig-zag magneti...

journal_title：Nature communications

authors： Lee HY,Kaneko R,Chern LE,Okubo T,Yamaji Y,Kawashima N,Kim YB

更新日期：2020-04-02 00:00:00

abstract：:The presence and absence of RNA modifications regulates RNA metabolism by modulating the binding of writer, reader, and eraser proteins. For 5-methylcytosine (m5C) however, it is largely unknown how it recruits or repels RNA-binding proteins. Here, we decipher the consequences of m5C deposition into the abundant non-c...

journal_title：Nature communications

authors： Sajini AA,Choudhury NR,Wagner RE,Bornelöv S,Selmi T,Spanos C,Dietmann S,Rappsilber J,Michlewski G,Frye M

更新日期：2019-06-11 00:00:00

abstract：:Forebrain neurons have weak intrinsic antioxidant defences compared with astrocytes, but the molecular basis and purpose of this is poorly understood. We show that early in mouse cortical neuronal development in vitro and in vivo, expression of the master-regulator of antioxidant genes, transcription factor NF-E2-rela...

journal_title：Nature communications

authors： Bell KF,Al-Mubarak B,Martel MA,McKay S,Wheelan N,Hasel P,Márkus NM,Baxter P,Deighton RF,Serio A,Bilican B,Chowdhry S,Meakin PJ,Ashford ML,Wyllie DJ,Scannevin RH,Chandran S,Hayes JD,Hardingham GE

更新日期：2015-05-13 00:00:00

abstract：:Crystalline solids are generally known as excellent heat conductors, amorphous materials or glasses as thermal insulators. It has thus come as a surprise that certain crystal structures defy this paradigm. A prominent example are type-I clathrates and other materials with guest-host structures. They sustain low-energy...

journal_title：Nature communications

authors： Ikeda MS,Euchner H,Yan X,Tomeš P,Prokofiev A,Prochaska L,Lientschnig G,Svagera R,Hartmann S,Gati E,Lang M,Paschen S

更新日期：2019-02-21 00:00:00

abstract：:Histone deacetylase inhibitors (HDACi) are approved for treating certain haematological malignancies, however, recent evidence also illustrates they are modulators of the immune system. In experimental models, HDACi are particularly potent against malignancies originating from the B-lymphocyte lineage. Here we examine...

journal_title：Nature communications

authors： Waibel M,Christiansen AJ,Hibbs ML,Shortt J,Jones SA,Simpson I,Light A,O'Donnell K,Morand EF,Tarlinton DM,Johnstone RW,Hawkins ED

更新日期：2015-04-27 00:00:00

abstract：:The environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) causes hepatic toxicity associated with prominent lipid accumulation in humans. Here, the authors report that the lysosomal copper transporter SLC46A3 is induced by TCDD and underlies the hepatic lipid accumulation in mice, potentially via effect...

journal_title：Nature communications

authors： Kim JH,Matsubara T,Lee J,Fenollar-Ferrer C,Han K,Kim D,Jia S,Chang CJ,Yang H,Nagano T,Krausz KW,Yim SH,Gonzalez FJ

更新日期：2021-01-12 00:00:00

abstract：:Eurasian continent has experienced cold winters over the past two decades in contrast with Arctic warming. Previous studies have suggested that the cold Eurasian winters are associated with Arctic sea-ice loss, while others attributed them to atmospheric internal variability. However, here we show that the Arctic and ...

journal_title：Nature communications

authors： Matsumura S,Kosaka Y

更新日期：2019-08-01 00:00:00

abstract：:Natural killer (NK) cells are cytotoxic innate lymphoid cells that are involved in immune defense. NK cell reactivity is controlled in part by MHC class I recognition by inhibitory receptors, but the underlying molecular mechanisms remain undefined. Using a mouse model of conditional deletion in NK cells, we show here...

journal_title：Nature communications

authors： Viant C,Fenis A,Chicanne G,Payrastre B,Ugolini S,Vivier E

更新日期：2014-10-30 00:00:00

abstract：:Grain boundaries have a major effect on the physical properties of two-dimensional layered materials. Therefore, it is important to develop simple, fast and sensitive characterization methods to visualize grain boundaries. Conventional Raman and photoluminescence methods have been used for detecting grain boundaries; ...

journal_title：Nature communications

authors： Karvonen L,Säynätjoki A,Huttunen MJ,Autere A,Amirsolaimani B,Li S,Norwood RA,Peyghambarian N,Lipsanen H,Eda G,Kieu K,Sun Z

更新日期：2017-06-05 00:00:00

abstract：:Nonlinear spectroscopies are utilized extensively for selective measurements of chemical dynamics in the optical, infrared, and radio-frequency regimes. The development of these techniques for extreme ultraviolet (XUV) light sources facilitates measurements of electronic dynamics on attosecond timescales. Here, we elu...

journal_title：Nature communications

authors： Fidler AP,Camp SJ,Warrick ER,Bloch E,Marroux HJB,Neumark DM,Schafer KJ,Gaarde MB,Leone SR

更新日期：2019-03-27 00:00:00

abstract：:The efficiency of an heat engine is traditionally defined as the ratio of its average output work over its average input heat. Its highest possible value was discovered by Carnot in 1824 and is a cornerstone concept in thermodynamics. It led to the discovery of the second law and to the definition of the Kelvin temper...

journal_title：Nature communications

authors： Verley G,Esposito M,Willaert T,Van den Broeck C

更新日期：2014-09-15 00:00:00

abstract：:Control over interactions with biomolecules holds the key to applications of graphene in biotechnology. One such application is nanopore sequencing, where a DNA molecule is electrophoretically driven through a graphene nanopore. Here we investigate how interactions of single-stranded DNA and a graphene membrane can be...

journal_title：Nature communications

authors： Shankla M,Aksimentiev A

更新日期：2014-10-09 00:00:00

abstract：:FAM46C is one of the most frequently mutated genes in multiple myeloma. Here, using a combination of in vitro and in vivo approaches, we demonstrate that FAM46C encodes an active non-canonical poly(A) polymerase which enhances mRNA stability and gene expression. Reintroduction of active FAM46C into multiple myeloma ce...

journal_title：Nature communications

authors： Mroczek S,Chlebowska J,Kuliński TM,Gewartowska O,Gruchota J,Cysewski D,Liudkovska V,Borsuk E,Nowis D,Dziembowski A

更新日期：2017-09-20 00:00:00

abstract：:Aortic dissection and intramural haematoma comprise an aortopathy involving separation of the aortic wall. Underlying mechanisms of the condition remain unclear. Here we show that granulocyte macrophage colony-stimulating factor (GM-CSF) is a triggering molecule for this condition. Transcription factor Krüppel-like fa...

journal_title：Nature communications

authors： Son BK,Sawaki D,Tomida S,Fujita D,Aizawa K,Aoki H,Akishita M,Manabe I,Komuro I,Friedman SL,Nagai R,Suzuki T

更新日期：2015-04-29 00:00:00

abstract：:Large Igneous Provinces (LIPs) are associated with the largest climate perturbations in Earth's history. The North Atlantic Igneous Province (NAIP) and Paleocene-Eocene Thermal Maximum (PETM) constitute an exemplar of this association. As yet we have no means to reconstruct the pacing of LIP greenhouse gas emissions f...

journal_title：Nature communications

authors： Jones SM,Hoggett M,Greene SE,Dunkley Jones T

更新日期：2019-12-05 00:00:00

abstract：:Recent studies suggest that attention samples space rhythmically through oscillatory interactions in the frontoparietal network. How these attentional fluctuations coincide with spatial exploration/displacement and exploitation/selection by a dynamic attentional spotlight under top-down control is unclear. Here, we sh...

journal_title：Nature communications

authors： Gaillard C,Ben Hadj Hassen S,Di Bello F,Bihan-Poudec Y,VanRullen R,Ben Hamed S

更新日期：2020-02-17 00:00:00

abstract：:Oocyte-specific miRNA function remains unclear in mice and worms because loss of Dgcr8 and Dicer from mouse and worm oocytes, respectively, does not yield oogenic defects. These data lead to several models: (a) miRNAs are not generated in oocytes; (b) miRNAs are generated but do not perform an oogenic function; (c) fu...

journal_title：Nature communications

authors： Minogue AL,Tackett MR,Atabakhsh E,Tejada G,Arur S

更新日期：2018-12-14 00:00:00

abstract：:Gastrin-releasing peptide (GRP) functions as a neurotransmitter for non-histaminergic itch, but its site of action (sensory neurons vs spinal cord) remains controversial. To determine the role of GRP in sensory neurons, we generated a floxed Grp mouse line. We found that conditional knockout of Grp in sensory neurons ...

journal_title：Nature communications

authors： Barry DM,Liu XT,Liu B,Liu XY,Gao F,Zeng X,Liu J,Yang Q,Wilhelm S,Yin J,Tao A,Chen ZF

更新日期：2020-03-13 00:00:00

abstract：:Cavity optomechanics allows the characterization of a vibration mode, its cooling and quantum manipulation using electromagnetic fields. Regarding nanomechanical as well as electronic properties, single wall carbon nanotubes are a prototypical experimental system. At cryogenic temperatures, as high quality factor vibr...

journal_title：Nature communications

authors： Blien S,Steger P,Hüttner N,Graaf R,Hüttel AK

更新日期：2020-04-02 00:00:00

abstract：:Toll-like receptor 7 (TLR7) senses microbial-derived RNA but can also potentially respond to self-derived RNA. To prevent autoimmune responses, TLR7 is thought to localize in endolysosomes. Contrary to this view, we show here that TLR7 is present on the cell surface of immune cells and that TLR7 responses can be inhib...

journal_title：Nature communications

authors： Kanno A,Tanimura N,Ishizaki M,Ohko K,Motoi Y,Onji M,Fukui R,Shimozato T,Yamamoto K,Shibata T,Sano S,Sugahara-Tobinai A,Takai T,Ohto U,Shimizu T,Saitoh S,Miyake K

更新日期：2015-02-04 00:00:00

abstract：:In photosystem II, light-induced water oxidation occurs at the Mn4CaO5 cluster. Here we demonstrate proton releases, dioxygen formation, and substrate water incorporation in response to Mn4CaO5 oxidation in the protein environment, using a quantum mechanical/molecular mechanical approach and molecular dynamics simulat...

journal_title：Nature communications

authors： Kawashima K,Takaoka T,Kimura H,Saito K,Ishikita H

更新日期：2018-03-28 00:00:00

abstract：:Cladodontomorph sharks are Palaeozoic stem chondrichthyans thought to go extinct at the end-Permian mass extinction. This extinction preceded the diversification of euselachians, including modern sharks. Here we describe an outer-platform cladodontomorph shark tooth assemblage from the Early Cretaceous of southern Fra...

journal_title：Nature communications

authors： Guinot G,Adnet S,Cavin L,Cappetta H

更新日期：2013-01-01 00:00:00

abstract：:Mantle plumes are thought to play a key role in transferring heat from the core-mantle boundary to the lithosphere, where it can significantly influence plate tectonics. On impinging on the lithosphere at spreading ridges or in intra-plate settings, mantle plumes may generate hotspots, large igneous provinces and henc...

journal_title：Nature communications

authors： Chang SJ,Ferreira AM,Faccenda M

更新日期：2016-02-29 00:00:00