Abstract:
:Gastrin-releasing peptide (GRP) functions as a neurotransmitter for non-histaminergic itch, but its site of action (sensory neurons vs spinal cord) remains controversial. To determine the role of GRP in sensory neurons, we generated a floxed Grp mouse line. We found that conditional knockout of Grp in sensory neurons results in attenuated non-histaminergic itch, without impairing histamine-induced itch. Using a Grp-Cre knock-in mouse line, we show that the upper epidermis of the skin is exclusively innervated by GRP fibers, whose activation via optogeneics and chemogenetics in the skin evokes itch- but not pain-related scratching or wiping behaviors. In contrast, intersectional genetic ablation of spinal Grp neurons does not affect itch nor pain transmission, demonstrating that spinal Grp neurons are dispensable for itch transmission. These data indicate that GRP is a neuropeptide in sensory neurons for non-histaminergic itch, and GRP sensory neurons are dedicated to itch transmission.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Barry DM,Liu XT,Liu B,Liu XY,Gao F,Zeng X,Liu J,Yang Q,Wilhelm S,Yin J,Tao A,Chen ZFdoi
10.1038/s41467-020-15230-ysubject
Has Abstractpub_date
2020-03-13 00:00:00pages
1397issue
1issn
2041-1723pii
10.1038/s41467-020-15230-yjournal_volume
11pub_type
杂志文章abstract::Density functional theory (DFT) is the standard formalism to study the electronic structure of matter at the atomic scale. In Kohn-Sham DFT simulations, the balance between accuracy and computational cost depends on the choice of exchange and correlation functional, which only exists in approximate form. Here, we prop...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-17265-7
更新日期:2020-07-14 00:00:00
abstract::Biodiversity-ecosystem functioning (BEF) experiments have shown that local species richness promotes ecosystem functioning and stability. Whether this also applies under real-world conditions is still debated. Here, we focus on larger scales of space, time and ecological organization. We develop a quasi-experimental d...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-14002-7
更新日期:2020-01-09 00:00:00
abstract::Lipidic cubic phase (LCP) crystallization has proven successful for high-resolution structure determination of challenging membrane proteins. Here we present a technique for extruding gel-like LCP with embedded membrane protein microcrystals, providing a continuously renewed source of material for serial femtosecond c...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4309
更新日期:2014-01-01 00:00:00
abstract::Physical properties of multi-orbital materials depend not only on the strength of the effective interactions among the valence electrons but also on their type. Strong correlations are caused by either Mott physics that captures the Coulomb repulsion among charges, or Hund physics that aligns the spins in different or...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-10257-2
更新日期:2019-06-20 00:00:00
abstract::Coherence in light-matter interaction is a necessary ingredient if light is used to control the quantum state of a material system. Coherent effects are firmly associated with isolated systems kept at low temperature. The exceedingly fast dephasing in condensed matter environments, in particular at elevated temperatur...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3953
更新日期:2013-01-01 00:00:00
abstract::Cholesterol is a key component of cell membranes with a proven modulatory role on the function and ligand-binding properties of G-protein-coupled receptors (GPCRs). Crystal structures of prototypical GPCRs such as the adenosine A2A receptor (A2AR) have confirmed that cholesterol finds stable binding sites at the recep...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms14505
更新日期:2017-02-21 00:00:00
abstract::Establishing processing-structure-property relationships for monolayer materials is crucial for a range of applications spanning optics, catalysis, electronics and energy. Presently, for molybdenum disulfide, a promising catalyst for artificial photosynthesis, considerable debate surrounds the structure/property relat...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms9311
更新日期:2015-10-07 00:00:00
abstract::Adult neural stem cells (NSCs) reside in a specialized microenvironment, the subventricular zone (SVZ), which provides them with unique signaling cues to control their basic properties and prevent their exhaustion. While the signaling mechanisms that regulate NSC lineage progression are well characterized, the molecul...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-02440-0
更新日期:2018-01-02 00:00:00
abstract::Heterostructured material systems devoid of ferroic components are presumed not to display ordering associated with ferroelectricity. In heterostructures composed of transition metal oxides, however, the disruption introduced by an interface can affect the balance of the competing interactions among electronic spins, ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2061
更新日期:2012-01-01 00:00:00
abstract::Non-linear interactions in coherent gases are not only at the origin of bright and dark solitons and superfluids; they also give rise to phenomena such as multistability, which hold great promise for the development of advanced photonic and spintronic devices. In particular, spinor multistability in strongly coupled s...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3008
更新日期:2013-01-01 00:00:00
abstract::The original version of this Article contained errors in Figs. 1a, 2a, 3a, and 4b, in which the units on the scale bars incorrectly read 'µm' rather than the correct 'nm.' This has been corrected in both the PDF and HTML versions of the Article. ...
journal_title:Nature communications
pub_type: 杂志文章,已发布勘误
doi:10.1038/s41467-018-03634-w
更新日期:2018-03-14 00:00:00
abstract::The original version of this Article omitted the Received and Accepted dates; they should have been 22nd January 2018 and 19th April 2018, respectively. This has been corrected in the PDF and HTML versions of the Article. ...
journal_title:Nature communications
pub_type: 杂志文章,已发布勘误
doi:10.1038/s41467-018-04902-5
更新日期:2018-06-13 00:00:00
abstract::Hydride transfers play a crucial role in a multitude of biological redox reactions and are mediated by flavin, deazaflavin or nicotinamide adenine dinucleotide cofactors at standard redox potentials ranging from 0 to -340 mV. 2-Naphthoyl-CoA reductase, a key enzyme of oxygen-independent bacterial naphthalene degradati...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-10078-3
更新日期:2019-05-06 00:00:00
abstract::Plant diseases caused by fungi and oomycetes pose an increasing threat to food security and ecosystem health worldwide. These filamentous pathogens, while taxonomically distinct, modulate host defense responses by secreting effectors, which are typically identified based on the presence of signal peptides. Here we sho...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms5686
更新日期:2014-08-26 00:00:00
abstract::The central melanocortin system plays a fundamental role in the control of feeding and body weight. Proopiomelanocortin (POMC) neurons in the arcuate nucleus of the hypothalamus (ARC) also regulate overall glucose homeostasis via insulin-dependent and -independent pathways. Here, we report that a subset of ARC POMC ne...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-20160-w
更新日期:2020-12-08 00:00:00
abstract::A specific bone vessel subtype, strongly positive for CD31 and endomucin (CD31hiEmcnhi), is identified as coupling angiogenesis and osteogenesis. The abundance of type CD31hiEmcnhi vessels decrease during ageing. Here we show that expression of the miR-497∼195 cluster is high in CD31hiEmcnhi endothelium but gradually ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms16003
更新日期:2017-07-07 00:00:00
abstract::Columnar joints form by cracking during cooling-induced contraction of lava, allowing hydrothermal fluid circulation. A lack of direct observations of their formation has led to ambiguity about the temperature window of jointing and its impact on fluid flow. Here we develop a novel thermo-mechanical experiment to disc...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-03842-4
更新日期:2018-04-12 00:00:00
abstract::Genetic studies have shown that obesity risk is heritable and that, of the many common variants now associated with body mass index, those in an intron of the fat mass and obesity-associated (FTO) gene have the largest effect. The size of the UK Biobank, and its joint measurement of genetic, anthropometric and lifesty...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms12724
更新日期:2016-09-06 00:00:00
abstract::Long-term depression (LTD) underlies learning and memory in various brain regions. Although postsynaptic AMPA receptor trafficking mediates LTD, its underlying molecular mechanisms remain largely unclear. Here we show that stargazin, a transmembrane AMPA receptor regulatory protein, forms a ternary complex with adapto...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3759
更新日期:2013-01-01 00:00:00
abstract::Survival in complex environments necessitates a flexible navigation system that incorporates memory of recent behavior and associations. Yet, how the hippocampal spatial circuit represents latent information independent of sensory inputs and future goals has not been determined. To address this, we image the activity ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-16825-1
更新日期:2020-06-15 00:00:00
abstract::Specialized cells in the medial entorhinal cortex (mEC), such as speed cells, head direction (HD) cells, and grid cells, are thought to support spatial navigation. To determine whether these computations are dependent on local circuits, we record neuronal activity in mEC layers II and III and optogenetically perturb l...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-06104-5
更新日期:2018-09-12 00:00:00
abstract::Understanding how cellular functions emerge from the underlying molecular mechanisms is a key challenge in biology. This will require computational models, whose predictive power is expected to increase with coverage and precision of formulation. Genome-scale models revolutionised the metabolic field and made the firs...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-08903-w
更新日期:2019-03-21 00:00:00
abstract::The removal of dying neurons by microglia has a key role during both development and in several diseases. To date, little is known about the cellular and molecular processes underlying neuronal engulfment in the brain. Here we took a live imaging approach to quantify neuronal cell death progression in embryonic zebraf...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms5046
更新日期:2014-06-05 00:00:00
abstract::Quantifying chemical compositions around nanovoids is a fundamental task for research and development of various materials. Atom probe tomography (APT) and scanning transmission electron microscopy (STEM) are currently the most suitable tools because of their ability to probe materials at the nanoscale. Both technique...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-14832-w
更新日期:2020-02-24 00:00:00
abstract::Clonal heterogeneity and evolution has major implications for disease progression and relapse in acute myeloid leukemia (AML). To model clonal dynamics in vivo, we serially transplanted 23 AML cases to immunodeficient mice and followed clonal composition for up to 15 months by whole-exome sequencing of 84 xenografts a...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-14106-0
更新日期:2020-02-05 00:00:00
abstract::Aberrant splicing is frequently found in cancer, yet the biological consequences of such alterations are mostly undefined. Here we report that the Hippo-YAP signalling, a key pathway that regulates cell proliferation and organ size, is under control of a splicing switch. We show that TEAD4, the transcription factor th...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms11840
更新日期:2016-06-13 00:00:00
abstract::The worldwide incidence of pulmonary carcinoids is increasing, but little is known about their molecular characteristics. Through machine learning and multi-omics factor analysis, we compare and contrast the genomic profiles of 116 pulmonary carcinoids (including 35 atypical), 75 large-cell neuroendocrine carcinomas (...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-11276-9
更新日期:2019-08-20 00:00:00
abstract::Synthesis of ethanol from non-petroleum carbon resources via syngas (a mixture of H2 and CO) is an important but challenging research target. The current conversion of syngas to ethanol suffers from low selectivity or multiple processes with high energy consumption. Here, we report a high-selective conversion of synga...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-14672-8
更新日期:2020-02-11 00:00:00
abstract::Scalable, integrative methods to understand mechanisms that link genetic variants with phenotypes are needed. Here we derive a mathematical expression to compute PrediXcan (a gene mapping approach) results using summary data (S-PrediXcan) and show its accuracy and general robustness to misspecified reference sets. We ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-03621-1
更新日期:2018-05-08 00:00:00
abstract::Broomcorn millet (Panicum miliaceum L.) has strong tolerance to abiotic stresses, and is probably one of the oldest crops, with its earliest cultivation that dated back to ca. ~10,000 years. We report here its genome assembly through a combination of PacBio sequencing, BioNano, and Hi-C (in vivo) mapping. The 18 super...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-07876-6
更新日期:2019-01-25 00:00:00