Distinct roles for BAI1 and TIM-4 in the engulfment of dying neurons by microglia.

abstract：:The mid-Pliocene Warm Period (mPWP) offers an opportunity to understand a warmer-than-present world and assess the predictive ability of numerical climate models. Environmental reconstruction and climate modelling are crucial for understanding the mPWP, and the synergy of these two, often disparate, fields has proven ...

journal_title：Nature communications

authors： Haywood AM,Dowsett HJ,Dolan AM

更新日期：2016-02-16 00:00:00

abstract：:Intestinal intraepithelial T cells contribute to the regulation of inflammatory responses in the intestine; however, the molecular basis for their development and maintenance is unknown. The aryl hydrocarbon receptor complexes with the aryl hydrocarbon receptor nuclear translocator (ARNT) and senses environmental fact...

journal_title：Nature communications

authors： Nakajima K,Maekawa Y,Kataoka K,Ishifune C,Nishida J,Arimochi H,Kitamura A,Yoshimoto T,Tomita S,Nagahiro S,Yasutomo K

更新日期：2013-01-01 00:00:00

abstract：:Negative gas adsorption (NGA) in ordered mesoporous solids is associated with giant contractive structural transitions traversing through metastable states. Here, by systematically downsizing the crystal dimensions of a mesoporous MOF (DUT-49) from several micrometers to less than 200 nm, counterintuitive NGA phenomen...

journal_title：Nature communications

authors： Krause S,Bon V,Senkovska I,Többens DM,Wallacher D,Pillai RS,Maurin G,Kaskel S

更新日期：2018-04-20 00:00:00

abstract：:An industrial process for the selective activation of methane under mild conditions would be highly valuable for controlling emissions to the environment and for utilizing vast new sources of natural gas. The only selective catalysts for methane activation and conversion to methanol under mild conditions are methane m...

journal_title：Nature communications

authors： Blanchette CD,Knipe JM,Stolaroff JK,DeOtte JR,Oakdale JS,Maiti A,Lenhardt JM,Sirajuddin S,Rosenzweig AC,Baker SE

更新日期：2016-06-15 00:00:00

abstract：:Th9 cells protect hosts against helminthic infection but also mediate allergic disease. Here we show that nitric oxide (NO) promotes Th9 cell polarization of murine and human CD4(+) T cells. NO de-represses the tumour suppressor gene p53 via nitrosylation of Mdm2. NO also increases p53-mediated IL-2 production, STAT5 ...

journal_title：Nature communications

authors： Niedbala W,Besnard AG,Nascimento DC,Donate PB,Sonego F,Yip E,Guabiraba R,Chang HD,Fukada SY,Salmond RJ,Schmitt E,Bopp T,Ryffel B,Liew FY

更新日期：2014-08-07 00:00:00

abstract：:The physical nature of the bacterial chromosome has important implications for its function. Using high-resolution dynamic tracking, we observe the existence of rare but ubiquitous 'rapid movements' of chromosomal loci exhibiting near-ballistic dynamics. This suggests that these movements are either driven by an activ...

journal_title：Nature communications

authors： Javer A,Kuwada NJ,Long Z,Benza VG,Dorfman KD,Wiggins PA,Cicuta P,Lagomarsino MC

更新日期：2014-05-30 00:00:00

abstract：:Regaining the function of an impaired limb is highly desirable in paralyzed individuals. One possible avenue to achieve this goal is to bridge the interrupted pathway between preserved neural structures and muscles using a brain-computer interface. Here, we demonstrate that monkeys with subcortical stroke were able to...

journal_title：Nature communications

authors： Kato K,Sawada M,Nishimura Y

更新日期：2019-10-16 00:00:00

abstract：:The possibility of measuring binding of small-molecule drugs to desired targets in live cells could provide a better understanding of drug action. However, current approaches mostly yield static data, require lysis or rely on indirect assays and thus often provide an incomplete understanding of drug action. Here, we p...

journal_title：Nature communications

authors： Dubach JM,Vinegoni C,Mazitschek R,Fumene Feruglio P,Cameron LA,Weissleder R

更新日期：2014-05-28 00:00:00

abstract：:Solution self-assembly of block copolymers into inverse bicontinuous cubic mesophases is a promising new approach for creating porous polymer films and monoliths with highly organized bicontinuous mesoporous networks. Here we report the direct self-assembly of block copolymers with branched hydrophilic blocks into lar...

journal_title：Nature communications

authors： Park C,La Y,An TH,Jeong HY,Kang S,Joo SH,Ahn H,Shin TJ,Kim KT

更新日期：2015-03-05 00:00:00

abstract：:Cholesterol is a key component of cell membranes with a proven modulatory role on the function and ligand-binding properties of G-protein-coupled receptors (GPCRs). Crystal structures of prototypical GPCRs such as the adenosine A2A receptor (A2AR) have confirmed that cholesterol finds stable binding sites at the recep...

journal_title：Nature communications

authors： Guixà-González R,Albasanz JL,Rodriguez-Espigares I,Pastor M,Sanz F,Martí-Solano M,Manna M,Martinez-Seara H,Hildebrand PW,Martín M,Selent J

更新日期：2017-02-21 00:00:00

abstract：:A non-syngas direct steam reforming route is investigated for the conversion of methanol to hydrogen and carbon dioxide over a CuZnGaO(x) catalyst at 150-200 °C. This route is in marked contrast with the conventional complex route involving steam reformation to syngas (CO/H2) at high temperature, followed by water gas...

journal_title：Nature communications

authors： Yu KM,Tong W,West A,Cheung K,Li T,Smith G,Guo Y,Tsang SC

更新日期：2012-01-01 00:00:00

abstract：:To know the properties of a particle or a wave, one should measure how its energy changes with its momentum. The relation between them is called the dispersion relation, which encodes essential information of the kinetics. In a magnet, the wave motion of atomic spins serves as an elementary excitation, called a spin w...

journal_title：Nature communications

authors： Hashimoto Y,Daimon S,Iguchi R,Oikawa Y,Shen K,Sato K,Bossini D,Tabuchi Y,Satoh T,Hillebrands B,Bauer GEW,Johansen TH,Kirilyuk A,Rasing T,Saitoh E

更新日期：2017-06-12 00:00:00

abstract：:Many applications proposed for graphene require multiple sheets be assembled into a monolithic structure. The ability to maintain structural integrity upon large deformation is essential to ensure a macroscopic material which functions reliably. However, it has remained a great challenge to achieve high elasticity in ...

journal_title：Nature communications

authors： Qiu L,Liu JZ,Chang SL,Wu Y,Li D

更新日期：2012-01-01 00:00:00

abstract：:Amontons' law defines the friction coefficient as the ratio between friction force and normal force, and assumes that both these forces depend linearly on the real contact area between the two sliding surfaces. However, experimental testing of frictional contact models has proven difficult, because few in situ experim...

journal_title：Nature communications

authors： Weber B,Suhina T,Junge T,Pastewka L,Brouwer AM,Bonn D

更新日期：2018-03-01 00:00:00

abstract：:The decoy effect is a cognitive bias documented in behavioural economics by which the presence of a third, (partly) inferior choice causes a significant shift in people's preference for other items. Here, we performed an experiment with human volunteers who played a variant of the repeated prisoner's dilemma game in w...

journal_title：Nature communications

authors： Wang Z,Jusup M,Shi L,Lee JH,Iwasa Y,Boccaletti S

更新日期：2018-07-27 00:00:00

abstract：:Highly pure semiconducting single-walled carbon nanotubes (SWNTs) are essential for the next generation of electronic devices, such as field-effect transistors and photovoltaic applications; however, contamination by metallic SWNTs reduces the efficiency of their associated devices. Here we report a simple and efficie...

journal_title：Nature communications

authors： Toshimitsu F,Nakashima N

更新日期：2014-10-03 00:00:00

abstract：:Nanostructured silicon has generated a lot of interest in the past decades as a key material for silicon-based photonics. The low absorption coefficient makes silicon nanocrystals attractive as an active medium in waveguide structures, and their third-order nonlinear optical properties are crucial for the development ...

journal_title：Nature communications

authors： Sirleto L,Ferrara MA,Nikitin T,Novikov S,Khriachtchev L

更新日期：2012-01-01 00:00:00

abstract：:The miR-200 family members have been implicated in stress responses and ovarian tumorigenesis. Here, we find that miR-200c/141 transcription is intimately linked to the transcription of the proximal upstream gene PTPN6 (SHP1) in all physiological conditions tested. PTPN6 and miR-200c/141 are transcriptionally co-regul...

journal_title：Nature communications

authors： Batista L,Bourachot B,Mateescu B,Reyal F,Mechta-Grigoriou F

更新日期：2016-01-04 00:00:00

abstract：:To expand the toolbox of imaging in living cells, we have engineered a single-chain variable fragment binding the linear HA epitope with high affinity and specificity in vivo. The resulting probe, called the HA frankenbody, can light up in multiple colors HA-tagged nuclear, cytoplasmic, membrane, and mitochondrial pro...

journal_title：Nature communications

authors： Zhao N,Kamijo K,Fox PD,Oda H,Morisaki T,Sato Y,Kimura H,Stasevich TJ

更新日期：2019-07-03 00:00:00

abstract：:Ice-shelf channels are long curvilinear tracts of thin ice found on Antarctic ice shelves. Many of them originate near the grounding line, but their formation mechanisms remain poorly understood. Here we use ice-penetrating radar data from Roi Baudouin Ice Shelf, East Antarctica, to infer that the morphology of severa...

journal_title：Nature communications

authors： Drews R,Pattyn F,Hewitt IJ,Ng FSL,Berger S,Matsuoka K,Helm V,Bergeot N,Favier L,Neckel N

更新日期：2017-05-09 00:00:00

abstract：:SIRT1, the founding member of the mammalian family of seven NAD(+)-dependent sirtuins, is composed of 747 amino acids forming a catalytic domain and extended N- and C-terminal regions. We report the design and characterization of an engineered human SIRT1 construct (mini-hSIRT1) containing the minimal structural eleme...

journal_title：Nature communications

authors： Dai H,Case AW,Riera TV,Considine T,Lee JE,Hamuro Y,Zhao H,Jiang Y,Sweitzer SM,Pietrak B,Schwartz B,Blum CA,Disch JS,Caldwell R,Szczepankiewicz B,Oalmann C,Yee Ng P,White BH,Casaubon R,Narayan R,Koppetsch K,Bourb

更新日期：2015-07-02 00:00:00

abstract：:This paper considers options for a future Indian power economy in which renewables, wind and solar, could meet 80% of anticipated 2040 power demand supplanting the country's current reliance on coal. Using a cost optimization model, here we show that renewables could provide a source of power cheaper or at least compe...

journal_title：Nature communications

authors： Lu T,Sherman P,Chen X,Chen S,Lu X,McElroy M

更新日期：2020-09-21 00:00:00

abstract：:Genome stability relies on proper coordination of mitosis and cytokinesis, where dynamic microtubules capture and faithfully segregate chromosomes into daughter cells. With a high-content RNAi imaging screen targeting more than 2,000 human lncRNAs, we identify numerous lncRNAs involved in key steps of cell division su...

journal_title：Nature communications

authors： Stojic L,Lun ATL,Mascalchi P,Ernst C,Redmond AM,Mangei J,Barr AR,Bousgouni V,Bakal C,Marioni JC,Odom DT,Gergely F

更新日期：2020-04-15 00:00:00

abstract：:Essential components of animal behaviour are modulated by dopaminergic (DA) and noradrenergic circuitry. In this study, we reveal at cellular resolution the complete set of projections ('projectome') of every single type of DA and noradrenergio neurons in the central nervous system of zebrafish larvae. The most extens...

journal_title：Nature communications

authors： Tay TL,Ronneberger O,Ryu S,Nitschke R,Driever W

更新日期：2011-01-25 00:00:00

abstract：:Long noncoding RNAs (lncRNAs) regulate gene expression by association with chromatin, but how they target chromatin remains poorly understood. We have used chromatin RNA immunoprecipitation-coupled high-throughput sequencing to identify 276 lncRNAs enriched in repressive chromatin from breast cancer cells. Using one o...

journal_title：Nature communications

authors： Mondal T,Subhash S,Vaid R,Enroth S,Uday S,Reinius B,Mitra S,Mohammed A,James AR,Hoberg E,Moustakas A,Gyllensten U,Jones SJ,Gustafsson CM,Sims AH,Westerlund F,Gorab E,Kanduri C

更新日期：2015-07-24 00:00:00

abstract：:The human pathogen Helicobacter pylori displays extensive genetic diversity. While H. pylori is known to evolve during infection, population dynamics inside the gastric environment have not been extensively investigated. Here we obtained gastric biopsies from multiple stomach regions of 16 H. pylori-infected adults, a...

journal_title：Nature communications

authors： Ailloud F,Didelot X,Woltemate S,Pfaffinger G,Overmann J,Bader RC,Schulz C,Malfertheiner P,Suerbaum S

更新日期：2019-05-22 00:00:00

abstract：:Identification of the complete set of translated genes of viruses is important to understand viral replication and pathogenesis as well as for therapeutic approaches to control viral infection. Here, we use chemical proteomics, integrating bio-orthogonal non-canonical amino acid tagging and high-resolution mass spectr...

journal_title：Nature communications

authors： Kato A,Adachi S,Kawano S,Takeshima K,Watanabe M,Kitazume S,Sato R,Kusano H,Koyanagi N,Maruzuru Y,Arii J,Hatta T,Natsume T,Kawaguchi Y

更新日期：2020-09-29 00:00:00

abstract：:Previous studies have demonstrated that aneuploidy in human embryos is surprisingly frequent with 50-80% of cleavage-stage human embryos carrying an abnormal chromosome number. Here we combine non-invasive time-lapse imaging with karyotypic reconstruction of all blastomeres in four-cell human embryos to address the hy...

journal_title：Nature communications

authors： Chavez SL,Loewke KE,Han J,Moussavi F,Colls P,Munne S,Behr B,Reijo Pera RA

更新日期：2012-01-01 00:00:00

abstract：:The scientific significance of excited-state aromaticity concerns with the elucidation of processes and properties in the excited states. Here, we focus on TMTQ, an oligomer composed of a central 1,6-methano[10]annulene and 5-dicyanomethyl-thiophene peripheries (acceptor-donor-acceptor system), and investigate a two-e...

journal_title：Nature communications

authors： Kim J,Oh J,Park S,Zafra JL,DeFrancisco JR,Casanova D,Lim M,Tovar JD,Casado J,Kim D

更新日期：2019-11-01 00:00:00

abstract：:Recent research has explored the spatiotemporal modulation of permittivity to break Lorentz reciprocity in a manner compatible with integrated-circuit fabrication. However, permittivity modulation is inherently weak and accompanied by loss due to carrier injection, particularly at higher frequencies, resulting in larg...

journal_title：Nature communications

authors： Dinc T,Tymchenko M,Nagulu A,Sounas D,Alu A,Krishnaswamy H

更新日期：2017-10-06 00:00:00