Abstract:
:Previous studies have demonstrated that aneuploidy in human embryos is surprisingly frequent with 50-80% of cleavage-stage human embryos carrying an abnormal chromosome number. Here we combine non-invasive time-lapse imaging with karyotypic reconstruction of all blastomeres in four-cell human embryos to address the hypothesis that blastomere behaviour may reflect ploidy during the first two cleavage divisions. We demonstrate that precise cell cycle parameter timing is observed in all euploid embryos to the four-cell stage, whereas only 30% of aneuploid embryos exhibit parameter values within normal timing windows. Further, we observe that the generation of human embryonic aneuploidy is complex with contribution from chromosome-containing fragments/micronuclei that frequently emerge and may persist or become reabsorbed during interphase. These findings suggest that cell cycle and fragmentation parameters of individual blastomeres are diagnostic of ploidy, amenable to automated tracking algorithms, and likely of clinical relevance in reducing transfer of embryos prone to miscarriage.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Chavez SL,Loewke KE,Han J,Moussavi F,Colls P,Munne S,Behr B,Reijo Pera RAdoi
10.1038/ncomms2249subject
Has Abstractpub_date
2012-01-01 00:00:00pages
1251issn
2041-1723pii
ncomms2249journal_volume
3pub_type
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