Abstract:
:The effective delivery of therapeutics to disease sites significantly contributes to drug efficacy, toxicity and clearance. Here we demonstrate that clinically approved iron oxide nanoparticles (Ferumoxytol) can be utilized to carry one or multiple drugs. These so called 'nanophores' retain their cargo within their polymeric coating through weak electrostatic interactions and release it in slightly acidic conditions (pH 6.8 and below). The loading of drugs increases the nanophores' transverse T2 and longitudinal T1 nuclear magnetic resonance (NMR) proton relaxation times, which is proportional to amount of carried cargo. Chemotherapy with translational nanophores is more effective than the free drug in vitro and in vivo, without subjecting the drugs or the carrier nanoparticle to any chemical modification. Evaluation of cargo incorporation and payload levels in vitro and in vivo can be assessed via benchtop magnetic relaxometers, common NMR instruments or magnetic resonance imaging scanners.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Kaittanis C,Shaffer TM,Ogirala A,Santra S,Perez JM,Chiosis G,Li Y,Josephson L,Grimm Jdoi
10.1038/ncomms4384subject
Has Abstractpub_date
2014-03-04 00:00:00pages
3384issn
2041-1723pii
ncomms4384journal_volume
5pub_type
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