The effect of crystallite size on pressure amplification in switchable porous solids.

abstract：:Human immunodeficiency virus (HIV) pre-exposure prophylaxis (PrEP) strategies with proven in vivo efficacy rely on antiretroviral drugs, creating the potential for drug resistance and complicated treatment options in individuals who become infected. Moreover, on-demand products are currently missing from the PrEP deve...

journal_title：Nature communications

authors： Derby N,Lal M,Aravantinou M,Kizima L,Barnable P,Rodriguez A,Lai M,Wesenberg A,Ugaonkar S,Levendosky K,Mizenina O,Kleinbeck K,Lifson JD,Peet MM,Lloyd Z,Benson M,Heneine W,O'Keefe BR,Robbiani M,Martinelli E,Grasperg

更新日期：2018-09-24 00:00:00

abstract：:Understanding the fundamental alterations in brain functioning that lead to psychotic disorders remains a major challenge in clinical neuroscience. In particular, it is unknown whether any state-independent biomarkers can potentially predict the onset of psychosis and distinguish patients from healthy controls, regard...

journal_title：Nature communications

authors： Cao H,Chén OY,Chung Y,Forsyth JK,McEwen SC,Gee DG,Bearden CE,Addington J,Goodyear B,Cadenhead KS,Mirzakhanian H,Cornblatt BA,Carrión RE,Mathalon DH,McGlashan TH,Perkins DO,Belger A,Seidman LJ,Thermenos H,Tsuang MT,

更新日期：2018-09-21 00:00:00

abstract：:Intramolecular photostabilization via triple-state quenching was recently revived as a tool to impart synthetic organic fluorophores with 'self-healing' properties. To date, utilization of such fluorophore derivatives is rare due to their elaborate multi-step synthesis. Here we present a general strategy to covalently...

journal_title：Nature communications

authors： van der Velde JH,Oelerich J,Huang J,Smit JH,Aminian Jazi A,Galiani S,Kolmakov K,Guoridis G,Eggeling C,Herrmann A,Roelfes G,Cordes T

更新日期：2016-01-11 00:00:00

abstract：:Non-CG methylation has been associated with stemness regulation in embryonic stem cells. By comparing differentially expressed genes affected by non-CG methylation between tumour and corresponding non-tumour tissues in oesophageal squamous cell carcinoma (OSCC), we find that Integrin α7 (ITGA7) is characterized as a p...

journal_title：Nature communications

authors： Ming XY,Fu L,Zhang LY,Qin YR,Cao TT,Chan KW,Ma S,Xie D,Guan XY

更新日期：2016-12-07 00:00:00

abstract：:Defensins are cationic antimicrobial peptides expressed throughout the plant and animal kingdoms as a first line of defense against pathogens. Membrane targeting and disruption is a crucial function of many defensins, however the precise mechanism remains unclear. Certain plant defensins form dimers that specifically ...

journal_title：Nature communications

authors： Järvå M,Lay FT,Phan TK,Humble C,Poon IKH,Bleackley MR,Anderson MA,Hulett MD,Kvansakul M

更新日期：2018-05-17 00:00:00

abstract：:The manipulation of magnetic ordering with applied electric fields is of pressing interest for new magnetoelectric devices and information storage applications. Recently, such magnetoelectric control was realized in multiferroics. However, their magnetoelectric switching is often accompanied by significant hysteresis,...

journal_title：Nature communications

authors： Oh YS,Artyukhin S,Yang JJ,Zapf V,Kim JW,Vanderbilt D,Cheong SW

更新日期：2014-01-01 00:00:00

abstract：:Spin-orbit torque has recently been intensively investigated for the purposes of manipulating the magnetization in magnetic nano-devices and understanding fundamental physics. Therefore, the search for novel materials or material combinations that exhibit a strong enough spin-torque effect has become one of the top pr...

journal_title：Nature communications

authors： Li P,Wu W,Wen Y,Zhang C,Zhang J,Zhang S,Yu Z,Yang SA,Manchon A,Zhang XX

更新日期：2018-09-28 00:00:00

abstract：:Circulating tumor cells (CTCs) have become an established biomarker for prognosis in patients with various carcinomas. However, current ex vivo CTC isolation technologies rely on small blood volumes from a single venipuncture limiting the number of captured CTCs. This produces statistical variability and inaccurate re...

journal_title：Nature communications

authors： Kim TH,Wang Y,Oliver CR,Thamm DH,Cooling L,Paoletti C,Smith KJ,Nagrath S,Hayes DF

更新日期：2019-04-01 00:00:00

abstract：:Selective thermal emission in a useful range of energies from a material operating at high temperatures is required for effective solar thermophotovoltaic energy conversion. Three-dimensional metallic photonic crystals can exhibit spectral emissivity that is modified compared with the emissivity of unstructured metals...

journal_title：Nature communications

authors： Arpin KA,Losego MD,Cloud AN,Ning H,Mallek J,Sergeant NP,Zhu L,Yu Z,Kalanyan B,Parsons GN,Girolami GS,Abelson JR,Fan S,Braun PV

更新日期：2013-01-01 00:00:00

abstract：:Long-range chromosomal interactions bring distal regulatory elements and promoters together to regulate gene expression in biological processes. By performing promoter capture Hi-C (PCHi-C) on human embryonic stem cell-derived cardiomyocytes (hESC-CMs), we show that such promoter interactions are a key mechanism by wh...

journal_title：Nature communications

authors： Choy MK,Javierre BM,Williams SG,Baross SL,Liu Y,Wingett SW,Akbarov A,Wallace C,Freire-Pritchett P,Rugg-Gunn PJ,Spivakov M,Fraser P,Keavney BD

更新日期：2018-06-28 00:00:00

abstract：:Textural properties provide information on the ingestibility, digestibility and state of ripeness or decay of sources of nutrition. Compared with our understanding of the chemosensory assessment of food, little is known about the mechanisms of texture detection. Here we show that Drosophila melanogaster can discrimina...

journal_title：Nature communications

authors： Sánchez-Alcañiz JA,Zappia G,Marion-Poll F,Benton R

更新日期：2017-01-27 00:00:00

abstract：:Scleractinian corals' microbial symbionts influence host health, yet how coral microbiomes assembled over evolution is not well understood. We survey bacterial and archaeal communities in phylogenetically diverse Australian corals representing more than 425 million years of diversification. We show that coral microbio...

journal_title：Nature communications

authors： Pollock FJ,McMinds R,Smith S,Bourne DG,Willis BL,Medina M,Thurber RV,Zaneveld JR

更新日期：2018-11-22 00:00:00

abstract：:WNTs are lipid-modified proteins that control multiple functions in development and disease via short- and long-range signaling. However, it is unclear how these hydrophobic molecules spread over long distances in the mammalian brain. Here we show that WNT5A is produced by the choroid plexus (ChP) of the developing hi...

journal_title：Nature communications

authors： Kaiser K,Gyllborg D,Procházka J,Salašová A,Kompaníková P,Molina FL,Laguna-Goya R,Radaszkiewicz T,Harnoš J,Procházková M,Potěšil D,Barker RA,Casado ÁG,Zdráhal Z,Sedláček R,Arenas E,Villaescusa JC,Bryja V

更新日期：2019-04-02 00:00:00

abstract：:Increased lipogenesis has been linked to an increased cancer risk and poor prognosis; however, the underlying mechanisms remain obscure. Here we show that phosphatidic acid phosphatase (PAP) lipin-1, which generates diglyceride precursors necessary for the synthesis of glycerolipids, interacts with and is a direct sub...

journal_title：Nature communications

authors： Song L,Liu Z,Hu HH,Yang Y,Li TY,Lin ZZ,Ye J,Chen J,Huang X,Liu DT,Zhou J,Shi Y,Zhao H,Xie C,Chen L,Song E,Lin SY,Lin SC

更新日期：2020-11-17 00:00:00

abstract：:Continuum numerical modeling of dynamic crack propagation has been a great challenge over the past decade. This is particularly the case for anticracks in porous materials, as reported in sedimentary rocks, deep earthquakes, landslides, and snow avalanches, as material inter-penetration further complicates the problem...

journal_title：Nature communications

authors： Gaume J,Gast T,Teran J,van Herwijnen A,Jiang C

更新日期：2018-08-03 00:00:00

abstract：:Metabolism is coordinated among tissues and organs via neuronal signals. Levels of circulating amino acids (AAs), which are elevated in obesity, activate the intracellular target of rapamycin complex-1 (mTORC1)/S6kinase (S6K) pathway in the liver. Here we demonstrate that hepatic AA/mTORC1/S6K signalling modulates sys...

journal_title：Nature communications

authors： Uno K,Yamada T,Ishigaki Y,Imai J,Hasegawa Y,Sawada S,Kaneko K,Ono H,Asano T,Oka Y,Katagiri H

更新日期：2015-08-13 00:00:00

abstract：:Van der Waals materials and heterostructures that manifest strongly bound exciton states at room temperature also exhibit emergent physical phenomena and are of great promise for optoelectronic applications. Here, we demonstrate that nanostructured, multilayer transition metal dichalcogenides (TMDCs) by themselves pro...

journal_title：Nature communications

authors： Zhang H,Abhiraman B,Zhang Q,Miao J,Jo K,Roccasecca S,Knight MW,Davoyan AR,Jariwala D

更新日期：2020-07-15 00:00:00

abstract：:Disordered mechanical systems, when strongly deformed, have complex configuration spaces with multiple stable states and pathways connecting them. The topology of such pathways determines which states are smoothly accessible from any part of configuration space. Controlling this topology would allow us to limit access...

journal_title：Nature communications

authors： Stern M,Jayaram V,Murugan A

更新日期：2018-10-16 00:00:00

abstract：:Cellular protein-RNA complexes assemble on nascent transcripts, but methods to observe transcription and protein binding in real time and at physiological concentrations are not available. Here, we report a single-molecule approach based on zero-mode waveguides that simultaneously tracks transcription progress and the...

journal_title：Nature communications

authors： Duss O,Stepanyuk GA,Grot A,O'Leary SE,Puglisi JD,Williamson JR

更新日期：2018-11-30 00:00:00

abstract：:Here, to overcome many limitations accompanying current available methods to detect protein-protein interactions (PPIs), we develop a live cell method called Split Intein-Mediated Protein Ligation (SIMPL). In this approach, bait and prey proteins are respectively fused to an intein N-terminal fragment (IN) and C-termi...

journal_title：Nature communications

authors： Yao Z,Aboualizadeh F,Kroll J,Akula I,Snider J,Lyakisheva A,Tang P,Kotlyar M,Jurisica I,Boxem M,Stagljar I

更新日期：2020-05-15 00:00:00

abstract：:Sphingomyelin phosphodiesterase acid-like 3b (SMPDL3b) is a lipid raft enzyme that regulates plasma membrane (PM) fluidity. Here we report that SMPDL3b excess, as observed in podocytes in diabetic kidney disease (DKD), impairs insulin receptor isoform B-dependent pro-survival insulin signaling by interfering with insu...

journal_title：Nature communications

authors： Mitrofanova A,Mallela SK,Ducasa GM,Yoo TH,Rosenfeld-Gur E,Zelnik ID,Molina J,Varona Santos J,Ge M,Sloan A,Kim JJ,Pedigo C,Bryn J,Volosenco I,Faul C,Zeidan YH,Garcia Hernandez C,Mendez AJ,Leibiger I,Burke GW,Futerm

更新日期：2019-06-19 00:00:00

abstract：:Thin films of several microns in thickness are ubiquitously used in packaging, electronics, and acoustic sensors. Here we demonstrate that natural wood can be directly converted into an ultrathin film with a record-small thickness of less than 10 μm through partial delignification followed by densification. Benefiting...

journal_title：Nature communications

authors： Gan W,Chen C,Kim HT,Lin Z,Dai J,Dong Z,Zhou Z,Ping W,He S,Xiao S,Yu M,Hu L

更新日期：2019-11-08 00:00:00

abstract：:Haematopoietic stem cells (HSCs) are produced during embryogenesis from the floor of the dorsal aorta. The localization of HSCs is dependent on the presence of instructive signals on the ventral side of the vessel. The nature of the extrinsic molecular signals that control the aortic haematopoietic niche is currently ...

journal_title：Nature communications

authors： Pouget C,Peterkin T,Simões FC,Lee Y,Traver D,Patient R

更新日期：2014-11-27 00:00:00

abstract：:The nasal cellular epigenome may serve as biomarker of airway disease and environmental response. Here we collect nasal swabs from the anterior nares of 547 children (mean-age 12.9 y), and measure DNA methylation (DNAm) with the Infinium MethylationEPIC BeadChip. We perform nasal Epigenome-Wide Association analyses (E...

journal_title：Nature communications

authors： Cardenas A,Sordillo JE,Rifas-Shiman SL,Chung W,Liang L,Coull BA,Hivert MF,Lai PS,Forno E,Celedón JC,Litonjua AA,Brennan KJ,DeMeo DL,Baccarelli AA,Oken E,Gold DR

更新日期：2019-07-12 00:00:00

abstract：:HIV can be partially contained by host immunity and understanding the basis of this may inform vaccine design. The importance of B-cell function in long-term control is poorly understood. One method of investigating this is in vivo cellular depletion. In this study, we take advantage of a unique opportunity to investi...

journal_title：Nature communications

authors： Huang KH,Bonsall D,Katzourakis A,Thomson EC,Fidler SJ,Main J,Muir D,Weber JN,Frater AJ,Phillips RE,Pybus OG,Goulder PJ,McClure MO,Cooke GS,Klenerman P

更新日期：2010-10-19 00:00:00

abstract：:During apoptosis, Bak and Bax are activated by BH3-only proteins binding to the α2-α5 hydrophobic groove; Bax is also activated via a rear pocket. Here we report that antibodies can directly activate Bak and mitochondrial Bax by binding to the α1-α2 loop. A monoclonal antibody (clone 7D10) binds close to α1 in non-act...

journal_title：Nature communications

authors： Iyer S,Anwari K,Alsop AE,Yuen WS,Huang DC,Carroll J,Smith NA,Smith BJ,Dewson G,Kluck RM

更新日期：2016-05-24 00:00:00

abstract：:Metastasis is the primary cause for mortality in breast cancer. MicroRNAs, gene expression master regulators, constitute an attractive candidate to control metastasis. Here we show that breast cancer metastasis can be prevented by miR-96 or miR-182 treatment, and decipher the mechanism of action. We found that miR-96/...

journal_title：Nature communications

authors： Gilam A,Conde J,Weissglas-Volkov D,Oliva N,Friedman E,Artzi N,Shomron N

更新日期：2016-09-19 00:00:00

abstract：:Blue/deep-blue emission is crucial for organic optoelectronics but remains a formidable challenge in organic afterglow due to the difficulties in populating and stabilizing the high-energy triplet excited states. Here, a facile strategy to realize the efficient deep-blue organic afterglow is proposed via host molecule...

journal_title：Nature communications

authors： Xu S,Wang W,Li H,Zhang J,Chen R,Wang S,Zheng C,Xing G,Song C,Huang W

更新日期：2020-09-23 00:00:00

abstract：:ADAM17, a prominent member of the 'Disintegrin and Metalloproteinase' (ADAM) family, controls vital cellular functions through cleavage of transmembrane substrates. Here we present evidence that surface exposure of phosphatidylserine (PS) is pivotal for ADAM17 to exert sheddase activity. PS exposure is tightly coupled...

journal_title：Nature communications

authors： Sommer A,Kordowski F,Büch J,Maretzky T,Evers A,Andrä J,Düsterhöft S,Michalek M,Lorenzen I,Somasundaram P,Tholey A,Sönnichsen FD,Kunzelmann K,Heinbockel L,Nehls C,Gutsmann T,Grötzinger J,Bhakdi S,Reiss K

更新日期：2016-05-10 00:00:00

abstract：:Transgenerational epigenetic inheritance refers to the transmission of epigenetic information through the germline. While it has been observed in plants, nematodes and fruit flies, its occurrence in mammals-and humans in particular-is the matter of controversial debate, mostly because the study of transgenerational ep...

journal_title：Nature communications

authors： Horsthemke B

更新日期：2018-07-30 00:00:00