Abstract:
:Understanding the fundamental alterations in brain functioning that lead to psychotic disorders remains a major challenge in clinical neuroscience. In particular, it is unknown whether any state-independent biomarkers can potentially predict the onset of psychosis and distinguish patients from healthy controls, regardless of paradigm. Here, using multi-paradigm fMRI data from the North American Prodrome Longitudinal Study consortium, we show that individuals at clinical high risk for psychosis display an intrinsic "trait-like" abnormality in brain architecture characterized as increased connectivity in the cerebello-thalamo-cortical circuitry, a pattern that is significantly more pronounced among converters compared with non-converters. This alteration is significantly correlated with disorganization symptoms and predictive of time to conversion to psychosis. Moreover, using an independent clinical sample, we demonstrate that this hyperconnectivity pattern is reliably detected and specifically present in patients with schizophrenia. These findings implicate cerebello-thalamo-cortical hyperconnectivity as a robust state-independent neural signature for psychosis prediction and characterization.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Cao H,Chén OY,Chung Y,Forsyth JK,McEwen SC,Gee DG,Bearden CE,Addington J,Goodyear B,Cadenhead KS,Mirzakhanian H,Cornblatt BA,Carrión RE,Mathalon DH,McGlashan TH,Perkins DO,Belger A,Seidman LJ,Thermenos H,Tsuang MT,doi
10.1038/s41467-018-06350-7subject
Has Abstractpub_date
2018-09-21 00:00:00pages
3836issue
1issn
2041-1723pii
10.1038/s41467-018-06350-7journal_volume
9pub_type
杂志文章abstract::Aortic dissection and intramural haematoma comprise an aortopathy involving separation of the aortic wall. Underlying mechanisms of the condition remain unclear. Here we show that granulocyte macrophage colony-stimulating factor (GM-CSF) is a triggering molecule for this condition. Transcription factor Krüppel-like fa...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms7994
更新日期:2015-04-29 00:00:00
abstract::A magnetic impurity coupled to a superconductor gives rise to a Yu-Shiba-Rusinov (YSR) state inside the superconducting energy gap. With increasing exchange coupling the excitation energy of this state eventually crosses zero and the system switches to a YSR ground state with bound quasiparticles screening the impurit...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-04683-x
更新日期:2018-06-18 00:00:00
abstract::Acid catalysis by hydronium ions is ubiquitous in aqueous-phase organic reactions. Here we show that hydronium ion catalysis, exemplified by intramolecular dehydration of cyclohexanol, is markedly influenced by steric constraints, yielding turnover rates that increase by up to two orders of magnitude in tight confines...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms15442
更新日期:2017-05-25 00:00:00
abstract::Recent advances in the understanding of spin orbital effects in ultrathin magnetic heterostructures have opened new paradigms to control magnetic moments electrically. The Dzyaloshinskii-Moriya interaction (DMI) is said to play a key role in forming a Néel-type domain wall that can be driven by the spin Hall torque. H...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms5655
更新日期:2014-08-18 00:00:00
abstract::Artificial nanoparticles accumulate a protein corona layer in biological fluids, which significantly influences their bioactivity. As nanosized obligate intracellular parasites, viruses share many biophysical properties with artificial nanoparticles in extracellular environments and here we show that respiratory syncy...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-10192-2
更新日期:2019-05-27 00:00:00
abstract::The friction between two adjacent tectonic plates under shear loading may dictate seismic activities. To advance the understanding of mechanisms underlying fault strength, we investigate the frictional characteristics of calcite in an aqueous environment. By conducting single-asperity friction experiments using an ato...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-04782-9
更新日期:2018-06-13 00:00:00
abstract::Integrating and manipulating the nano-optoelectronic properties of Van der Waals heterostructures can enable unprecedented platforms for photodetection and sensing. The main challenge of infrared photodetectors is to funnel the light into a small nanoscale active area and efficiently convert it into an electrical sign...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18544-z
更新日期:2020-09-25 00:00:00
abstract::Electron-rich dienes have revolutionized the synthesis of complex compounds since the discovery of the legendary Diels-Alder cycloaddition reaction. This highly efficient bond-forming process has served as a fundamental strategy to assemble many structurally formidable molecules. Amino silyloxy butadienes are arguably...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms7913
更新日期:2015-04-21 00:00:00
abstract::The Johnson-Kendall-Roberts theory is the basis of modern contact mechanics. It describes how two deformable objects adhere together, driven by adhesion energy and opposed by elasticity. Here we characterize the indentation of glass particles into soft, silicone substrates using confocal microscopy. We show that, wher...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3728
更新日期:2013-01-01 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Nature communications
pub_type: 已发布勘误
doi:10.1038/s41467-019-13458-x
更新日期:2019-11-26 00:00:00
abstract::Chronic kidney disease (CKD) is defined by reduced estimated glomerular filtration rate (eGFR). Previous genetic studies have implicated regulatory mechanisms contributing to CKD. Here we present epigenome-wide association studies of eGFR and CKD using whole-blood DNA methylation of 2264 ARIC Study and 2595 Framingham...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-01297-7
更新日期:2017-11-03 00:00:00
abstract::According to quantum theory, measurements generate random outcomes, in stark contrast with classical mechanics. This raises the question of whether there could exist an extension of the theory that removes this indeterminism, as suspected by Einstein, Podolsky and Rosen. Although this has been shown to be impossible, ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1416
更新日期:2011-08-02 00:00:00
abstract::Macrophages play crucial roles in host defence and tissue homoeostasis, processes in which both environmental stimuli and intracellularly generated metabolites influence activation of macrophages. Activated macrophages are classified into M1 and M2 macrophages. It remains unclear how intracellular nutrition sufficienc...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms13130
更新日期:2016-10-12 00:00:00
abstract::Stem cell transplantation is a promising strategy for therapeutic cardiac regeneration, but current therapies are limited by inefficient interaction between potentially beneficial cells (either exogenously transplanted or endogenously recruited) and the injured tissue. Here we apply targeted nanomedicine to achieve in...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms5880
更新日期:2014-09-10 00:00:00
abstract::Symbiotic associations occur in every habitat on earth, but we know very little about their evolutionary histories. Current models of trait evolution cannot adequately reconstruct the deep history of symbiotic innovation, because they assume homogenous evolutionary processes across millions of years. Here we use a rec...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms5087
更新日期:2014-06-10 00:00:00
abstract::Autophagy, activated by many stresses, plays a critical role in innate immune responses. Here we show that interferon regulatory factor 8 (IRF8) is required for the expression of autophagy-related genes in dendritic cells. Furthermore in macrophages, IRF8 is induced by multiple autophagy-inducing stresses, including I...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms7379
更新日期:2015-03-16 00:00:00
abstract::The cycling of iron and organic matter (OM) is thought to have been a major biogeochemical cycle in the early ferruginous oceans which contributed to the deposition of banded iron formations (BIF). However, BIF are deficient in OM, which is postulated to be the result of near-complete oxidation of OM during iron reduc...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-12975-z
更新日期:2019-11-04 00:00:00
abstract::The Unc-51 like autophagy activating kinase 1 (ULK1) complex plays a central role in the initiation stage of autophagy. However, the function of ULK1 in the late stage of autophagy is unknown. Here, we report that ULK1, a central kinase of the ULK1 complex involved in autophagy initiation, promotes autophagosome-lysos...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-05449-1
更新日期:2018-08-28 00:00:00
abstract::Viruses provide top-down control on microbial communities, yet their direct study in natural environments was hindered by culture limitations. The advance of bioinformatics enables cultivation-independent study of viruses. Many studies assemble new viral genomes and study viral diversity using marker genes from free v...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-09106-z
更新日期:2019-03-12 00:00:00
abstract::VRC01-class broadly neutralizing HIV-1 antibodies protect animals from experimental infection and could contribute to an effective vaccine response. Their predicted germline forms (gl) bind Env inefficiently, which may explain why they are not elicited by HIV-1 Env-immunization. Here we show that an optimized Env immu...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms10618
更新日期:2016-02-24 00:00:00
abstract::Molecules containing multiple bonds between atoms-most often in the form of olefins-are ubiquitous in nature, commerce, and science, and as such have a huge impact on everyday life. Given their prominence, over the last few decades, frequent attempts have been made to perturb the structure and reactivity of multiply-b...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-02998-3
更新日期:2018-03-22 00:00:00
abstract::Optical tracking is often combined with conventional flat panel solar cells to maximize electrical power generation over the course of a day. However, conventional trackers are complex and often require costly and cumbersome structural components to support system weight. Here we use kirigami (the art of paper cutting...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms9092
更新日期:2015-09-08 00:00:00
abstract::Proactive, that is, unsolicited, prosociality is a key component of our hyper-cooperation, which in turn has enabled the emergence of various uniquely human traits, including complex cognition, morality and cumulative culture and technology. However, the evolutionary foundation of the human prosocial sentiment remains...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms5747
更新日期:2014-08-27 00:00:00
abstract::MicroRNAs (miRNAs) loss-of-function phenotypes are mainly induced by chemically modified antisense oligonucleotides. Here we develop an alternative inhibitor for miRNAs, termed 'small RNA zipper'. It is designed to connect miRNA molecules end to end, forming a DNA-RNA duplex through a complementary interaction with hi...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms13964
更新日期:2017-01-03 00:00:00
abstract::Photothermal heating represents a major constraint that limits the performance of many nanoscale optoelectronic and optomechanical devices including nanolasers, quantum optomechanical resonators, and integrated photonic circuits. Here, we demonstrate the direct laser refrigeration of a semiconductor optomechanical res...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-16472-6
更新日期:2020-06-23 00:00:00
abstract::Metal halide perovskites feature crystalline-like electronic band structures and liquid-like physical properties. The crystal-liquid duality enables optoelectronic devices with unprecedented performance and a unique opportunity to chemically manipulate the structure with low energy input. In this work, we leverage the...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19009-z
更新日期:2020-10-16 00:00:00
abstract::Cancer cells often display altered cell-surface glycans compared to their nontransformed counterparts. However, functional contributions of glycans to cancer initiation and progression remain poorly understood. Here, from expression-based analyses across cancer lineages, we found that melanomas exhibit significant tra...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-05795-0
更新日期:2018-08-22 00:00:00
abstract::Roifman Syndrome is a rare congenital disorder characterized by growth retardation, cognitive delay, spondyloepiphyseal dysplasia and antibody deficiency. Here we utilize whole-genome sequencing of Roifman Syndrome patients to reveal compound heterozygous rare variants that disrupt highly conserved positions of the RN...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms9718
更新日期:2015-11-02 00:00:00
abstract::The proton-activated sodium channel ASIC1 belongs to the ENaC/Degenerins family of ion channels. Little is known about gating of the pore in any member of this class. Here we outline the shape of the ion pathway of ASIC1 in the open and closed conformations by measuring apparent rates of cysteine modification by thiol...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1409
更新日期:2011-07-19 00:00:00
abstract::Recently, metasurfaces composed of artificially fabricated subwavelength structures have shown remarkable potential for the manipulation of light with unprecedented functionality. Here, we first demonstrate a metasurface application to realize a compact near-eye display system for augmented reality with a wide field o...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-07011-5
更新日期:2018-11-01 00:00:00