Small RNA zippers lock miRNA molecules and block miRNA function in mammalian cells.

abstract：:The microtubule-associated protein Tau plays a central role in the pathogenesis of Alzheimer's disease. Although Tau interaction with membranes is thought to affect some of its physiological functions and its aggregation properties, the sequence determinants and the structural and functional consequences of such inter...

journal_title：Nature communications

authors： Ait-Bouziad N,Lv G,Mahul-Mellier AL,Xiao S,Zorludemir G,Eliezer D,Walz T,Lashuel HA

更新日期：2017-11-22 00:00:00

abstract：:Current-induced magnetic domain wall (DW) motion is an important operating principle of spintronic devices. Injected current generates spin torques (STs) on the DWs in two ways. One is the spin transfer from magnetic domains to the walls by the current flowing in the magnet. Current flow in attached heavy metals also ...

journal_title：Nature communications

authors： Moon KW,Kim C,Yoon J,Choi JW,Kim DO,Song KM,Kim D,Chun BS,Hwang C

更新日期：2018-09-17 00:00:00

abstract：:Efficient and low-cost electrocatalysts for the oxygen evolution reaction are essential components of renewable energy technologies, such as solar fuel synthesis and providing a hydrogen source for powering fuel cells. Here we report that the nitrogen-doped carbon materials function as the efficient oxygen evolution e...

journal_title：Nature communications

authors： Zhao Y,Nakamura R,Kamiya K,Nakanishi S,Hashimoto K

更新日期：2013-01-01 00:00:00

abstract：:Transition metal dichalcogenides have attracted research interest over the last few decades due to their interesting structural chemistry, unusual electronic properties, rich intercalation chemistry and wide spectrum of potential applications. Despite the fact that the majority of related research focuses on semicondu...

journal_title：Nature communications

authors： Qi Y,Naumov PG,Ali MN,Rajamathi CR,Schnelle W,Barkalov O,Hanfland M,Wu SC,Shekhar C,Sun Y,Süß V,Schmidt M,Schwarz U,Pippel E,Werner P,Hillebrand R,Förster T,Kampert E,Parkin S,Cava RJ,Felser C,Yan B,Medvedev S

更新日期：2016-03-14 00:00:00

abstract：:One primary reason that makes single-cell RNA-seq analysis challenging is dropouts, where the data only captures a small fraction of the transcriptome of each cell. Almost all computational algorithms developed for single-cell RNA-seq adopted gene selection, dimension reduction or imputation to address the dropouts. H...

journal_title：Nature communications

authors： Qiu P

更新日期：2020-03-03 00:00:00

abstract：:Single-celled eukaryotes (protists) are critical players in global biogeochemical cycling of nutrients and energy in the oceans. While their roles as primary producers and grazers are well appreciated, other aspects of their life histories remain obscure due to challenges in culturing and sequencing their natural dive...

journal_title：Nature communications

authors： Seeleuthner Y,Mondy S,Lombard V,Carradec Q,Pelletier E,Wessner M,Leconte J,Mangot JF,Poulain J,Labadie K,Logares R,Sunagawa S,de Berardinis V,Salanoubat M,Dimier C,Kandels-Lewis S,Picheral M,Searson S,Tara Oceans Coor

更新日期：2018-01-22 00:00:00

abstract：:Optic atrophy 1 (OPA1) is a mitochondrial inner membrane protein that has an important role in mitochondrial fusion and structural integrity. Dysfunctional OPA1 mutations cause atrophy of the optic nerve leading to blindness. Here, we show that OPA1 has an important role in the innate immune system. Using conditional ...

journal_title：Nature communications

authors： Amini P,Stojkov D,Felser A,Jackson CB,Courage C,Schaller A,Gelman L,Soriano ME,Nuoffer JM,Scorrano L,Benarafa C,Yousefi S,Simon HU

更新日期：2018-07-27 00:00:00

abstract：:Lithium- and sodium-rich layered transition-metal oxides have recently been attracting significant interest because of their large capacity achieved by additional oxygen-redox reactions. However, layered transition-metal oxides exhibit structural degradation such as cation migration, layer exfoliation or cracks upon d...

journal_title：Nature communications

authors： Mortemard de Boisse B,Reynaud M,Ma J,Kikkawa J,Nishimura SI,Casas-Cabanas M,Delmas C,Okubo M,Yamada A

更新日期：2019-05-16 00:00:00

abstract：:Human glioblastoma is the most frequent and aggressive form of brain tumour in the adult population. Proteolytic turnover of tumour suppressors by the ubiquitin-proteasome system is a mechanism that tumour cells can adopt to sustain their growth and invasiveness. However, the identity of ubiquitin-proteasome targets a...

journal_title：Nature communications

authors： Lignitto L,Arcella A,Sepe M,Rinaldi L,Delle Donne R,Gallo A,Stefan E,Bachmann VA,Oliva MA,Tiziana Storlazzi C,L'Abbate A,Brunetti A,Gargiulo S,Gramanzini M,Insabato L,Garbi C,Gottesman ME,Feliciello A

更新日期：2013-01-01 00:00:00

abstract：:In adult skin epidermis and the epithelium lining the esophagus cells are constantly shed from the tissue surface and replaced by cell division. Tracking genetically labelled cells in transgenic mice has given insight into cell behavior, but conflicting models appear consistent with the results. Here, we use an additi...

journal_title：Nature communications

authors： Piedrafita G,Kostiou V,Wabik A,Colom B,Fernandez-Antoran D,Herms A,Murai K,Hall BA,Jones PH

更新日期：2020-03-18 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature communications

authors： Temko D,Tomlinson IPM,Severini S,Schuster-Böckler B,Graham TA

更新日期：2020-04-20 00:00:00

abstract：:Neuroendocrine prostate cancer (NEPC) is an aggressive malignancy with no effective targeted therapies. The oncogenic MUC1-C protein is overexpressed in castration-resistant prostate cancer (CRPC) and NEPC, but its specific role is unknown. Here, we demonstrate that upregulation of MUC1-C in androgen-dependent PC cell...

journal_title：Nature communications

authors： Yasumizu Y,Rajabi H,Jin C,Hata T,Pitroda S,Long MD,Hagiwara M,Li W,Hu Q,Liu S,Yamashita N,Fushimi A,Kui L,Samur M,Yamamoto M,Zhang Y,Zhang N,Hong D,Maeda T,Kosaka T,Wong KK,Oya M,Kufe D

更新日期：2020-01-17 00:00:00

abstract：:Cell-cell communication and interaction is critical during fertilization and triggers free cytosolic calcium ([Ca2+]cyto) as a key signal for egg activation and a polyspermy block in animal oocytes. Fertilization in flowering plants is more complex, involving interaction of a pollen tube with egg adjoining synergid ce...

journal_title：Nature communications

authors： Denninger P,Bleckmann A,Lausser A,Vogler F,Ott T,Ehrhardt DW,Frommer WB,Sprunck S,Dresselhaus T,Grossmann G

更新日期：2014-08-22 00:00:00

abstract：:With damage tolerance rivalling advanced engineering alloys and thermoplastic forming capabilities analogous to conventional plastics, metallic glasses are emerging as a modern engineering material. Here, we take advantage of their unique electrical and rheological properties along with the classic Lorentz force conce...

journal_title：Nature communications

authors： Kaltenboeck G,Demetriou MD,Roberts S,Johnson WL

更新日期：2016-02-08 00:00:00

abstract：:Metal-halide perovskites have been widely investigated in the photovoltaic sector due to their promising optoelectronic properties and inexpensive fabrication techniques based on solution processing. Here we report the development of inorganic CsPbBr3-based photoanodes for direct photoelectrochemical oxygen evolution ...

journal_title：Nature communications

authors： Poli I,Hintermair U,Regue M,Kumar S,Sackville EV,Baker J,Watson TM,Eslava S,Cameron PJ

更新日期：2019-05-08 00:00:00

abstract：:Competing interactions in the so-called spin-ice compounds stabilize a frustrated ground state with finite zero-point entropy and, interestingly, emergent magnetic monopole excitations. The properties of these monopoles are at the focus of recent research with particular emphasis on their quantum dynamics. It is predi...

journal_title：Nature communications

authors： Grams CP,Valldor M,Garst M,Hemberger J

更新日期：2014-09-04 00:00:00

abstract：:The Mycobacterium tuberculosis (Mtb) electron transport chain (ETC) has received significant attention as a drug target, however its vulnerability may be affected by its flexibility in response to disruption. Here we determine the effect of the ETC inhibitors bedaquiline, Q203 and clofazimine on the Mtb ETC, and the v...

journal_title：Nature communications

authors： Lamprecht DA,Finin PM,Rahman MA,Cumming BM,Russell SL,Jonnala SR,Adamson JH,Steyn AJ

更新日期：2016-08-10 00:00:00

abstract：:Non-collinear spin transport is at the heart of spin or magnetization control in spintronics devices. The use of nanoscale conductors exhibiting quantum effects in transport could provide new paths for that purpose. Here we study non-collinear spin transport in a quantum dot. We use a device made out of a single-wall ...

journal_title：Nature communications

authors： Crisan AD,Datta S,Viennot JJ,Delbecq MR,Cottet A,Kontos T

更新日期：2016-01-27 00:00:00

abstract：:Gramicidin A (gA) is the simplest known natural channel, and important progress in improving conduction activity has previously been obtained with modified natural gAs. However, simple artificial systems mimicking the gA functions are unknown. Here we show that gA can be mimicked using a simple synthetic triazole or '...

journal_title：Nature communications

authors： Barboiu M,Le Duc Y,Gilles A,Cazade PA,Michau M,Marie Legrand Y,van der Lee A,Coasne B,Parvizi P,Post J,Fyles T

更新日期：2014-06-26 00:00:00

abstract：:We present Biomedisa, a free and easy-to-use open-source online platform developed for semi-automatic segmentation of large volumetric images. The segmentation is based on a smart interpolation of sparsely pre-segmented slices taking into account the complete underlying image data. Biomedisa is particularly valuable w...

journal_title：Nature communications

authors： Lösel PD,van de Kamp T,Jayme A,Ershov A,Faragó T,Pichler O,Tan Jerome N,Aadepu N,Bremer S,Chilingaryan SA,Heethoff M,Kopmann A,Odar J,Schmelzle S,Zuber M,Wittbrodt J,Baumbach T,Heuveline V

更新日期：2020-11-04 00:00:00

abstract：:The accuracy of state-of-the-art atomic clocks is derived from the insensitivity of narrow optical atomic resonances to environmental perturbations. Two such resonances in singly ionized lutetium have been identified with potentially lower sensitivities compared to other clock candidates. Here we report measurement of...

journal_title：Nature communications

authors： Arnold KJ,Kaewuam R,Roy A,Tan TR,Barrett MD

更新日期：2018-04-25 00:00:00

abstract：:The three-dimensional architecture of the genome affects genomic functions. Multiple genome architectures at different length scales, including chromatin loops, domains, compartments, and lamina- and nucleolus-associated regions, have been discovered. However, how these structures are arranged in the same cell and how...

journal_title：Nature communications

authors： Liu M,Lu Y,Yang B,Chen Y,Radda JSD,Hu M,Katz SG,Wang S

更新日期：2020-06-09 00:00:00

abstract：:Cyclophanes are a venerable class of macrocyclic and/or cage compounds that often feature high strain, unusual conformations and quite surprising properties, many of which are legendary in physical organic chemistry. However, the discovery of new, diverse cyclophanes and derivatives has been hindered by syntheses that...

journal_title：Nature communications

authors： Collins MS,Carnes ME,Nell BP,Zakharov LN,Johnson DW

更新日期：2016-04-04 00:00:00

abstract：:Pair production can be triggered by high-intensity lasers via the Breit-Wheeler process. However, the straightforward laser-laser colliding for copious numbers of pair creation requires light intensities several orders of magnitude higher than possible with the ongoing laser facilities. Despite the numerous proposed a...

journal_title：Nature communications

authors： Zhu XL,Yu TP,Sheng ZM,Yin Y,Turcu IC,Pukhov A

更新日期：2016-12-14 00:00:00

abstract：:Addressing the intrinsic charge transport limitation of metal oxides has been of significance for pursuing viable PEC water splitting photoelectrodes. Growing a photoelectrode with conductive nanoobjects embedded in the matrix is promising for enhanced charge transport but remains a challenge technically. We herein sh...

journal_title：Nature communications

authors： Jian J,Xu Y,Yang X,Liu W,Fu M,Yu H,Xu F,Feng F,Jia L,Friedrich D,van de Krol R,Wang H

更新日期：2019-06-13 00:00:00

abstract：:Autophagy, activated by many stresses, plays a critical role in innate immune responses. Here we show that interferon regulatory factor 8 (IRF8) is required for the expression of autophagy-related genes in dendritic cells. Furthermore in macrophages, IRF8 is induced by multiple autophagy-inducing stresses, including I...

journal_title：Nature communications

authors： Gupta M,Shin DM,Ramakrishna L,Goussetis DJ,Platanias LC,Xiong H,Morse HC 3rd,Ozato K

更新日期：2015-03-16 00:00:00

abstract：:Thin-film transistor (TFT)-driven full-color organic light-emitting diodes (OLEDs) with vertically stacked structures are developed herein using photolithography processes, which allow for high-resolution displays of over 2,000 pixels per inch. Vertical stacking of OLEDs by the photolithography process is technically ...

journal_title：Nature communications

authors： Choi S,Kang CM,Byun CW,Cho H,Kwon BH,Han JH,Yang JH,Shin JW,Hwang CS,Cho NS,Lee KM,Kim HO,Kim E,Yoo S,Lee H

更新日期：2020-06-01 00:00:00

abstract：:The search for a method that utilizes biological information to predict humans' place of origin has occupied scientists for millennia. Over the past four decades, scientists have employed genetic data in an effort to achieve this goal but with limited success. While biogeographical algorithms using next-generation seq...

journal_title：Nature communications

authors： Elhaik E,Tatarinova T,Chebotarev D,Piras IS,Maria Calò C,De Montis A,Atzori M,Marini M,Tofanelli S,Francalacci P,Pagani L,Tyler-Smith C,Xue Y,Cucca F,Schurr TG,Gaieski JB,Melendez C,Vilar MG,Owings AC,Gómez R,Fuji

更新日期：2014-04-29 00:00:00

abstract：:Formation of domain walls in ferroelectrics is not energetically favourable in low-dimensional systems. Instead, vortex-type structures are formed that are driven by depolarization fields occurring in such systems. Consequently, polarization vortices have only been experimentally found in systems in which these fields...

journal_title：Nature communications

authors： Peters JJP,Apachitei G,Beanland R,Alexe M,Sanchez AM

更新日期：2016-11-16 00:00:00

abstract：:Currently, there is no comprehensive framework to evaluate the evolutionary forces acting on genomic regions associated with human complex traits and contextualize the relationship between evolution and molecular function. Here, we develop an approach to test for signatures of diverse evolutionary forces on trait-asso...

journal_title：Nature communications

authors： LaBella AL,Abraham A,Pichkar Y,Fong SL,Zhang G,Muglia LJ,Abbot P,Rokas A,Capra JA

更新日期：2020-07-24 00:00:00