Neutrophil extracellular trap formation requires OPA1-dependent glycolytic ATP production.

abstract：:Primary effusion lymphoma (PEL) is caused by Kaposi's sarcoma-associated herpesvirus. Our understanding of PEL is poor and therefore treatment strategies are lacking. To address this need, we conducted genome-wide CRISPR/Cas9 knockout screens in eight PEL cell lines. Integration with data from unrelated cancers identi...

journal_title：Nature communications

authors： Manzano M,Patil A,Waldrop A,Dave SS,Behdad A,Gottwein E

更新日期：2018-08-15 00:00:00

abstract：:Lysosomes are the major degradative compartments within cells, harbouring a wide variety of hydrolytic enzymes within their lumen. Release of lysosomal hydrolases from lysosomes into the cell cytoplasm results in cell death. Here we report that damaged lysosomes undergo autophagic turnover. Using a light-induced lysos...

journal_title：Nature communications

authors： Hung YH,Chen LM,Yang JY,Yang WY

更新日期：2013-01-01 00:00:00

abstract：:A central question in stem cell biology is the relationship between stem cells and their niche. Although previous reports have uncovered how signaling molecules released by niche cells support stem cell function, the role of the extra-cellular matrix (ECM) within the niche is unclear. Here, we show that upon activatio...

journal_title：Nature communications

authors： Rayagiri SS,Ranaldi D,Raven A,Mohamad Azhar NIF,Lefebvre O,Zammit PS,Borycki AG

更新日期：2018-03-14 00:00:00

abstract：:Gastroenteritis accounts for nearly 500,000 deaths in children younger than 5 years annually. Although probiotics have been touted as having the potential to expedite diarrhea resolution, recent clinical trials question their effectiveness. A potential explanation is a shift in pathogens following the introduction of ...

journal_title：Nature communications

authors： Freedman SB,Xie J,Nettel-Aguirre A,Pang XL,Chui L,Williamson-Urquhart S,Schnadower D,Schuh S,Sherman PM,Lee BE,Gouin S,Farion KJ,Poonai N,Hurley KF,Qiu Y,Ghandi B,Lloyd C,Finkelstein Y,Pediatric Emergency Research Can

更新日期：2020-05-21 00:00:00

abstract：:N-Methyl-D-aspartate receptors (NMDARs) play critical roles in the central nervous system. Their heterotetrameric composition generates subtypes with distinct functional properties and spatio-temporal distribution in the brain, raising the possibility for subtype-specific targeting by pharmacological means for treatme...

journal_title：Nature communications

authors： Wang JX,Irvine MW,Burnell ES,Sapkota K,Thatcher RJ,Li M,Simorowski N,Volianskis A,Collingridge GL,Monaghan DT,Jane DE,Furukawa H

更新日期：2020-01-22 00:00:00

abstract：:In eukaryotes, adventitious oxidation of erythrose-4-phosphate, an intermediate of the pentose phosphate pathway (PPP), generates 4-phosphoerythronate (4PE), which inhibits 6-phosphogluconate dehydrogenase. 4PE is detoxified by metabolite-proofreading phosphatases such as yeast Pho13. Here, we report that a similar fu...

journal_title：Nature communications

authors： Sachla AJ,Helmann JD

更新日期：2019-04-04 00:00:00

abstract：:Three-dimensional (3D) assemblies based on carbon nanomaterials still lag behind their individual one-dimensional building blocks in terms of mechanical and electrical properties. Here we demonstrate a simple strategy for the fabrication of an open porous 3D self-organized double-hierarchical carbon nanotube tube stru...

journal_title：Nature communications

authors： Schütt F,Signetti S,Krüger H,Röder S,Smazna D,Kaps S,Gorb SN,Mishra YK,Pugno NM,Adelung R

更新日期：2017-10-31 00:00:00

abstract：:Protein integration into biological membranes is a vital cellular event for all organisms. We previously reported an integration factor in the inner membrane of Escherichia coli, named MPIase (membrane protein integrase). Here we show that in contrast to previously identified integration factors that are proteins, MPI...

journal_title：Nature communications

authors： Nishiyama K,Maeda M,Yanagisawa K,Nagase R,Komura H,Iwashita T,Yamagaki T,Kusumoto S,Tokuda H,Shimamoto K

更新日期：2012-01-01 00:00:00

abstract：:Neurons communicate through chemical synapses and electrical synapses (gap junctions). Although these two types of synapses often coexist between neurons, little is known about whether they interact, and whether any interactions between them are important to controlling synaptic strength and circuit functions. By stud...

journal_title：Nature communications

authors： Liu P,Chen B,Mailler R,Wang ZW

更新日期：2017-03-20 00:00:00

abstract：:Caloric restriction (CR) without malnutrition increases longevity and delays the onset of age-associated disorders in short-lived species, from unicellular organisms to laboratory mice and rats. The value of CR as a tool to understand human ageing relies on translatability of CR's effects in primates. Here we show tha...

journal_title：Nature communications

authors： Colman RJ,Beasley TM,Kemnitz JW,Johnson SC,Weindruch R,Anderson RM

更新日期：2014-04-01 00:00:00

abstract：:Polymorphism is a remarkable concept in chemistry, materials science, computer science, and biology. Whether it is the ability of a material to exist in two or more crystal structures, a single interface connecting to two different entities, or alternative phenotypes of an organism, polymorphism determines function an...

journal_title：Nature communications

authors： Li L,Salamończyk M,Shadpour S,Zhu C,Jákli A,Hegmann T

更新日期：2018-02-19 00:00:00

abstract：:Neutrophilic granulocytes are able to release their own DNA as neutrophil extracellular traps (NETs) to capture and eliminate pathogens. DNA expulsion (NETosis) has also been documented for other cells and organisms, thus highlighting the evolutionary conservation of this process. Moreover, dysregulated NETosis has be...

journal_title：Nature communications

authors： Neubert E,Meyer D,Rocca F,Günay G,Kwaczala-Tessmann A,Grandke J,Senger-Sander S,Geisler C,Egner A,Schön MP,Erpenbeck L,Kruss S

更新日期：2018-09-14 00:00:00

abstract：:Organic semiconductors enable the fabrication of a range of lightweight and mechanically flexible optoelectronic devices. Most organic semiconductor lasers, however, have remained rigid until now, predominantly due to the need for a support substrate. Here, we use a simple fabrication process to make membrane-based, s...

journal_title：Nature communications

authors： Karl M,Glackin JME,Schubert M,Kronenberg NM,Turnbull GA,Samuel IDW,Gather MC

更新日期：2018-05-01 00:00:00

abstract：:The original version of this Article contained an error in the author affiliations. Xiaochun Yu was incorrectly associated with College of Life Sciences, Hebei University, Baoding 071000 Hebei, China.This has now been corrected in both the PDF and HTML versions of the Article. ...

journal_title：Nature communications

authors： Wang J,Yuan Z,Cui Y,Xie R,Yang G,Kassab MA,Wang M,Ma Y,Wu C,Yu X,Liu X

更新日期：2019-01-08 00:00:00

abstract：:Ataxia telangiectasia is caused by mutations in ATM and represents a paradigm for cancer predisposition and neurodegenerative syndromes linked to deficiencies in the DNA-damage response. The role of ATM as a key regulator of signalling following DNA double-strand breaks (DSBs) has been dissected in extraordinary detai...

journal_title：Nature communications

authors： Álvarez-Quilón A,Serrano-Benítez A,Lieberman JA,Quintero C,Sánchez-Gutiérrez D,Escudero LM,Cortés-Ledesma F

更新日期：2014-02-27 00:00:00

abstract：:Transcranial electrical stimulation has widespread clinical and research applications, yet its effect on ongoing neural activity in humans is not well established. Previous reports argue that transcranial alternating current stimulation (tACS) can entrain and enhance neural rhythms related to memory, but the evidence ...

journal_title：Nature communications

authors： Lafon B,Henin S,Huang Y,Friedman D,Melloni L,Thesen T,Doyle W,Buzsáki G,Devinsky O,Parra LC,A Liu A

更新日期：2017-10-31 00:00:00

abstract：:Blood brain barrier (BBB) breakdown is not only a consequence of but also contributes to many neurological disorders, including stroke and Alzheimer's disease. How the basement membrane (BM) contributes to the normal functioning of the BBB remains elusive. Here we use conditional knockout mice and an acute adenovirus-...

journal_title：Nature communications

authors： Yao Y,Chen ZL,Norris EH,Strickland S

更新日期：2014-03-03 00:00:00

abstract：:The study of carrier multiplication has become an essential part of many-body physics and materials science as this multiplication directly affects nonlinear transport phenomena, and has a key role in designing efficient solar cells and electroluminescent emitters and highly sensitive photon detectors. Here we show th...

journal_title：Nature communications

authors： Hirori H,Shinokita K,Shirai M,Tani S,Kadoya Y,Tanaka K

更新日期：2011-12-20 00:00:00

abstract：:Spinel transition metal oxides (TMOs) have emerged as promising anode materials for lithium-ion batteries. It has been shown that reducing their particle size to nanoscale dimensions benefits overall electrochemical performance. Here, we use in situ transmission electron microscopy to probe the lithiation behavior of ...

journal_title：Nature communications

authors： Li J,Meng Q,Zhang Y,Peng L,Yu G,Marschilok AC,Wu L,Su D,Takeuchi KJ,Takeuchi ES,Zhu Y,Stach EA

更新日期：2019-01-09 00:00:00

abstract：:Quantized dynamics is essential for natural processes and technological applications alike. The work of Thouless on quantized particle transport in slowly varying potentials (Thouless pumping) has played a key role in understanding that such quantization may be caused not only by discrete eigenvalues of a quantum syst...

journal_title：Nature communications

authors： Fedorova Z,Qiu H,Linden S,Kroha J

更新日期：2020-07-27 00:00:00

abstract：:Traumatic brain injury (TBI) is a leading global cause of death and disability. Here we demonstrate in an experimental mouse model of TBI that mild forms of brain trauma cause severe deficits in meningeal lymphatic drainage that begin within hours and last out to at least one month post-injury. To investigate a mechan...

journal_title：Nature communications

authors： Bolte AC,Dutta AB,Hurt ME,Smirnov I,Kovacs MA,McKee CA,Ennerfelt HE,Shapiro D,Nguyen BH,Frost EL,Lammert CR,Kipnis J,Lukens JR

更新日期：2020-09-10 00:00:00

abstract：:Mountain glaciers are known to be strongly affected by global climate change. Here we compute temporally consistent changes in glacier area, surface elevation and ice mass over the entire European Alps between 2000 and 2014. We apply remote sensing techniques on an extensive database of optical and radar imagery cover...

journal_title：Nature communications

authors： Sommer C,Malz P,Seehaus TC,Lippl S,Zemp M,Braun MH

更新日期：2020-06-25 00:00:00

abstract：:Amazonian Dark Earths (ADEs) are unusually fertile soils characterised by elevated concentrations of microscopic charcoal particles, which confer their distinctive colouration. Frequent occurrences of pre-Columbian artefacts at ADE sites led to their ubiquitous classification as Anthrosols (soils of anthropic origin)....

journal_title：Nature communications

authors： Silva LCR,Corrêa RS,Wright JL,Bomfim B,Hendricks L,Gavin DG,Muniz AW,Martins GC,Motta ACV,Barbosa JZ,Melo VF,Young SD,Broadley MR,Santos RV

更新日期：2021-01-04 00:00:00

abstract：:As whole-genome sequencing for cancer genome analysis becomes a clinical tool, a full understanding of the variables affecting sequencing analysis output is required. Here using tumour-normal sample pairs from two different types of cancer, chronic lymphocytic leukaemia and medulloblastoma, we conduct a benchmarking e...

journal_title：Nature communications

authors： Alioto TS,Buchhalter I,Derdak S,Hutter B,Eldridge MD,Hovig E,Heisler LE,Beck TA,Simpson JT,Tonon L,Sertier AS,Patch AM,Jäger N,Ginsbach P,Drews R,Paramasivam N,Kabbe R,Chotewutmontri S,Diessl N,Previti C,Schmidt S

更新日期：2015-12-09 00:00:00

abstract：:All common genome-wide association (GWA) methods rely on population structure correction, to avoid false genotype-to-phenotype associations. However, population structure correction is a stringent penalization, which also impedes identification of real associations. Using recent statistical advances, we developed a ne...

journal_title：Nature communications

authors： Klasen JR,Barbez E,Meier L,Meinshausen N,Bühlmann P,Koornneef M,Busch W,Schneeberger K

更新日期：2016-11-10 00:00:00

abstract：:Autoantibodies have been associated with autoimmune diseases. However, studies have identified autoantibodies in healthy donors (HD) who do not develop autoimmune disorders. Here we provide evidence of a network of immunoglobulin G (IgG) autoantibodies targeting G protein-coupled receptors (GPCR) in HD compared to pat...

journal_title：Nature communications

authors： Cabral-Marques O,Marques A,Giil LM,De Vito R,Rademacher J,Günther J,Lange T,Humrich JY,Klapa S,Schinke S,Schimke LF,Marschner G,Pitann S,Adler S,Dechend R,Müller DN,Braicu I,Sehouli J,Schulze-Forster K,Trippel T,S

更新日期：2018-12-06 00:00:00

abstract：:Semiconductor nanowires offer the opportunity to incorporate novel structures and functionality into electronic and optoelectronic devices. A clear understanding of the nanowire growth mechanism is essential for well-controlled growth of structures with desired properties, but the understanding is currently limited by...

journal_title：Nature communications

authors： Maliakkal CB,Jacobsson D,Tornberg M,Persson AR,Johansson J,Wallenberg R,Dick KA

更新日期：2019-10-08 00:00:00

abstract：:The nitrogen-vacancy (NV) centre in diamond is a promising candidate for a solid-state qubit. However, its charge state is known to be unstable, discharging from the qubit state NV(-) into the neutral state NV(0) under various circumstances. Here we demonstrate that the charge state can be controlled by an electrolyti...

journal_title：Nature communications

authors： Grotz B,Hauf MV,Dankerl M,Naydenov B,Pezzagna S,Meijer J,Jelezko F,Wrachtrup J,Stutzmann M,Reinhard F,Garrido JA

更新日期：2012-03-06 00:00:00

abstract：:Colloidal interactions in nematic liquid crystals can be described as interactions between elastic multipoles that depend on particle shape, topology, chirality, boundary conditions and induced topological defects. Here, we describe a nematic colloidal system consisting of mesostructures of gold capable of inducing el...

journal_title：Nature communications

authors： Yuan Y,Tasinkevych M,Smalyukh II

更新日期：2020-01-10 00:00:00

abstract：:Chiral metal complexes show promise as asymmetric catalysts and optical materials. Chiral-at-metal complexes composed of achiral ligands have expanded the versatility and applicability of chiral metal complexes, especially for octahedral and half-sandwich complexes. However, Werner-type tetrahedral complexes with a st...

journal_title：Nature communications

authors： Endo K,Liu Y,Ube H,Nagata K,Shionoya M

更新日期：2020-12-09 00:00:00