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A randomized trial evaluating virus-specific effects of a combination probiotic in children with acute gastroenteritis.

Abstract：

:Gastroenteritis accounts for nearly 500,000 deaths in children younger than 5 years annually. Although probiotics have been touted as having the potential to expedite diarrhea resolution, recent clinical trials question their effectiveness. A potential explanation is a shift in pathogens following the introduction of a rotavirus vaccine. Here, we report the results of a multi-center, double-blind trial of 816 children with acute gastroenteritis who completed follow-up and provided multiple stool specimens. Participants were randomized to receive a probiotic containing Lactobacillus rhamnosus and Lactobacillus helveticus or placebo. We report no virus-specific beneficial effects attributable to the probiotic, either in reducing clinical symptoms or viral nucleic acid clearance from stool specimens collected up to 28 days following enrollment. We provide pathophysiological and microbiologic evidence to support the clinical findings and conclude that our data do not support routine probiotic administration to children with acute gastroenteritis, regardless of the infecting virus.

journal_name

Nat Commun

journal_title

Nature communications

authors

Freedman SB,Xie J,Nettel-Aguirre A,Pang XL,Chui L,Williamson-Urquhart S,Schnadower D,Schuh S,Sherman PM,Lee BE,Gouin S,Farion KJ,Poonai N,Hurley KF,Qiu Y,Ghandi B,Lloyd C,Finkelstein Y,Pediatric Emergency Research Can

doi

10.1038/s41467-020-16308-3

subject

Has Abstract

pub_date

2020-05-21 00:00:00

pages

2533

issue

1

issn

2041-1723

pii

10.1038/s41467-020-16308-3

journal_volume

11

pub_type

杂志文章,多中心研究,随机对照试验

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