Abstract:
:Lysosomes are the major degradative compartments within cells, harbouring a wide variety of hydrolytic enzymes within their lumen. Release of lysosomal hydrolases from lysosomes into the cell cytoplasm results in cell death. Here we report that damaged lysosomes undergo autophagic turnover. Using a light-induced lysosome impairing scheme that can be controlled spatially and temporally within a cell, we show that damaged lysosomes are selectively ubiquitinated, recruit autophagic proteins and are eventually incorporated into autolysosomes for degradation. We propose that autophagic removal of lysosomes, which we term lysophagy, is a surveillance mechanism that alleviates cells from the adverse effects of lysosomal damage. We envision our method to induce lysosomal damage will enable detailed molecular studies of the lysophagy pathway in the future.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Hung YH,Chen LM,Yang JY,Yang WYdoi
10.1038/ncomms3111subject
Has Abstractpub_date
2013-01-01 00:00:00pages
2111issn
2041-1723pii
ncomms3111journal_volume
4pub_type
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