Abstract:
:Azobenzene, a versatile and polymorphic molecule, has been extensively and successfully used for photoswitching applications. The debate over its photoisomerization mechanism leveraged on the computational scrutiny with ever-increasing levels of theory. However, the most resolved absorption spectrum for the transition to S1(nπ*) has not followed the computational advances and is more than half a century old. Here, using jet-cooled molecular beam and multiphoton ionization techniques we report the first high-resolution spectra of S1(nπ*) and S2(ππ*). The photophysical characterization reveals directly the structural changes upon excitation and the timescales of dynamical processes. For S1(nπ*), we find that changes in the hybridization of the nitrogen atoms are the driving force that triggers isomerization. In combination with quantum chemical calculations we conclude that photoisomerization occurs along an inversion-assisted torsional pathway with a barrier of ~2 kcal mol(-1). This methodology can be extended to photoresponsive molecular systems so far deemed non-accessible to high-resolution spectroscopy.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Tan EM,Amirjalayer S,Smolarek S,Vdovin A,Zerbetto F,Buma WJdoi
10.1038/ncomms6860subject
Has Abstractpub_date
2015-01-06 00:00:00pages
5860issn
2041-1723pii
ncomms6860journal_volume
6pub_type
杂志文章abstract::Microglia, the brain-resident macrophages, exhibit highly dynamic functions in neurodevelopment and neurodegeneration. Human microglia possess unique features as compared to mouse microglia, but our understanding of human microglial functions is largely limited by an inability to obtain human microglia under homeostat...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-15411-9
更新日期:2020-03-27 00:00:00
abstract::Breast cancer metastasis involves lymphatic dissemination in addition to hematogenous spreading. Although stromal lymphatic vessels (LVs) serve as initial metastatic routes, roles of organ-residing LVs are underinvestigated. Here we show that lymphatic endothelial cells (LECs), a component of LVs within pre-metastatic...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms5715
更新日期:2014-09-02 00:00:00
abstract::Loss of appetite or anorexia associated with inflammation impairs quality of life and increases morbidity in many diseases. However, the exact neural mechanism that mediates inflammation-associated anorexia is still poorly understood. Here we identified a population of neurons, marked by the expression of protein kina...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-10715-x
更新日期:2019-06-24 00:00:00
abstract::The complexity embedded in condensed matter fertilizes the discovery of new states of matter, enriched by ingredients like frustration. Illustrating examples in magnetic systems are Kitaev spin liquids, skyrmions phases, or spin ices. These unconventional ground states support exotic excitations, for example the magne...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-00277-1
更新日期:2017-08-08 00:00:00
abstract::Histone H2AX and MDC1 are key DNA repair and DNA-damage signalling proteins. When DNA double-strand breaks (DSBs) occur, H2AX is phosphorylated and then recruits MDC1, which in turn serves as a docking platform to promote the localization of other factors, including 53BP1, to DSB sites. Here, by using CRISPR-Cas9 engi...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-12929-5
更新日期:2019-11-15 00:00:00
abstract::The synthesis of DNA nanotubes is an important area in nanobiotechnology. Different methods to assemble DNA nanotubes have been reported, and control over the width of the nanotubes has been achieved by programmed subunits of DNA tiles. Here we report the self-assembly of DNA nanotubes with controllable diameters. The...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1535
更新日期:2011-11-15 00:00:00
abstract::To cause food-borne botulism, botulinum neurotoxin (BoNT) in the gastrointestinal lumen must traverse the intestinal epithelial barrier. However, the mechanism by which BoNT crosses the intestinal epithelial barrier remains unclear. BoNTs are produced along with one or more non-toxic components, with which they form p...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms7255
更新日期:2015-02-17 00:00:00
abstract::Monitoring the Earth's stress state plays a role in our understanding of an earthquake's mechanism and in the distribution of hazards. Crustal deformation due to the July 2019 earthquake sequence in Ridgecrest (California) that culminated in a preceding quake of magnitude (M) 6.4 and a subsequent M7.1 quake caused str...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-16867-5
更新日期:2020-06-17 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Nature communications
pub_type: 已发布勘误
doi:10.1038/s41467-020-19626-8
更新日期:2020-11-03 00:00:00
abstract::Osteoporosis is a devastating disease with an essential genetic component. GWAS have discovered genetic signals robustly associated with bone mineral density (BMD), but not the precise localization of effector genes. Here, we carry out physical and direct variant to gene mapping in human mesenchymal progenitor cell-de...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-09302-x
更新日期:2019-03-19 00:00:00
abstract::Diagnosis of disease outside of sophisticated laboratories urgently requires low-cost, user-friendly devices. Disposable, instrument-free testing devices are used for home and physician office testing, but are limited in applicability to a small class of highly abundant analytes. Direct, unambiguous visual read-out is...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms7978
更新日期:2015-04-22 00:00:00
abstract::Excessive nitrogen runoff leads to degraded water quality, harming human and ecosystem health. We examine the impact of changes in land use and land management for six combinations of socioeconomic pathways and climate outcomes, and find that societal choices will substantially impact riverine total nitrogen loading (...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-08884-w
更新日期:2019-02-26 00:00:00
abstract::Split spawning in coral populations occurs when gamete maturation and mass spawning are split over two consecutive months. While split spawning has been observed at many reefs, little is known about the frequency and significance of these events. Here we show that split spawning occurred frequently and predictably ove...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-03175-2
更新日期:2018-02-19 00:00:00
abstract::Magnetic skyrmion, a topologically stable spin-swirling object, can host emergent electromagnetism, as exemplified by the topological Hall effect and electric-current-driven skyrmion motion. To achieve efficient manipulation of nano-sized functional spin textures, it is imperative to exploit the resonant motion of sky...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3391
更新日期:2013-01-01 00:00:00
abstract::Copper levels are known to be elevated in inflamed and malignant tissues. But the mechanism underlying this selective enrichment has been elusive. In this study, we report a axis by which inflammatory cytokines, such as IL-17, drive cellular copper uptake via the induction of a metalloreductase, STEAP4. IL-17-induced ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-14698-y
更新日期:2020-02-14 00:00:00
abstract::The Middle Eocene Climatic Optimum (MECO) represents a ~500-kyr period of global warming ~40 million years ago and is associated with a rise in atmospheric CO2 concentrations, but the cause of this CO2 rise remains enigmatic. Here we show, based on osmium isotope ratios (187Os/188Os) of marine sediments and published ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-05104-9
更新日期:2018-07-23 00:00:00
abstract::The high incidence of aneuploidy in the embryo is considered the principal cause for low human fecundity. However, the prevalence of aneuploidy dramatically declines as pregnancy progresses, with the steepest drop occurring as the embryo completes implantation. Despite the fact that the plasticity of the embryo in dea...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-16796-3
更新日期:2020-06-11 00:00:00
abstract::Type 2 diabetes (T2D) results from the combined effects of genetic and environmental factors on multiple tissues over time. Of the >100 variants associated with T2D and related traits in genome-wide association studies (GWAS), >90% occur in non-coding regions, suggesting a strong regulatory component to T2D risk. Here...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms11764
更新日期:2016-06-29 00:00:00
abstract::Acoustic waves, capable of transmitting through optically opaque objects, have been widely used in biomedical imaging, industrial sensing and particle manipulation. High-fidelity wave front shaping is essential to further improve performance in these applications. An acoustic analog to the successful spatial light mod...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18347-2
更新日期:2020-09-10 00:00:00
abstract::High electron mobility is one of graphene's key properties, exploited for applications and fundamental research alike. Highest mobility values are found in heterostructures of graphene and hexagonal boron nitride, which consequently are widely used. However, surprisingly little is known about the interaction between t...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms13621
更新日期:2016-11-29 00:00:00
abstract::The ~70 km-diameter Yarrabubba impact structure in Western Australia is regarded as among Earth's oldest, but has hitherto lacked precise age constraints. Here we present U-Pb ages for impact-driven shock-recrystallised accessory minerals. Shock-recrystallised monazite yields a precise impact age of 2229 ± 5 Ma, coeva...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-13985-7
更新日期:2020-01-21 00:00:00
abstract::Amidoxime-functionalized polymeric adsorbents are the current state-of-the-art materials for collecting uranium (U) from seawater. However, marine tests show that vanadium (V) is preferentially extracted over U and many other cations. Herein, we report a complementary and comprehensive investigation integrating ab ini...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-01443-1
更新日期:2017-11-16 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Nature communications
pub_type: 杂志文章,已发布勘误
doi:10.1038/s41467-020-17555-0
更新日期:2020-07-28 00:00:00
abstract::Duchenne muscular dystrophy (DMD) is characterized by muscle degeneration and progressive weakness. There is considerable inter-patient variability in disease onset and progression, which can confound the results of clinical trials. Here we show that a common null polymorphism (R577X) in ACTN3 results in significantly...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms14143
更新日期:2017-01-31 00:00:00
abstract::Priming of the mucosal immune system during the postnatal period substantially influences host-microbial interaction and susceptibility to immune-mediated diseases in adult life. The underlying mechanisms are ill defined. Here we show that shortly after birth, CD4 T cells populate preformed lymphoid structures in the ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms8725
更新日期:2015-07-21 00:00:00
abstract::How to move efficiently is an optimal control problem, whose computational complexity grows exponentially with the horizon of the planned trajectory. Breaking a compound movement into a series of chunks, each planned over a shorter horizon can thus reduce the overall computational complexity and associated costs while...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms12176
更新日期:2016-07-11 00:00:00
abstract::The mega-diversity of herbivorous insects is attributed to their co-evolutionary associations with plants. Despite abundant studies on insect-plant interactions, we do not know whether host-plant shifts have impacted both genomic adaptation and species diversification over geological times. We show that the antagonist...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-20507-3
更新日期:2021-01-13 00:00:00
abstract::Perisomatic inhibition of pyramidal neurons is established by fast-spiking, parvalbumin-expressing interneurons (PV cells). Failure to assemble adequate perisomatic inhibition is thought to underlie the aetiology of neurological dysfunction in seizures, autism spectrum disorders and schizophrenia. Here we show that in...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms12829
更新日期:2016-09-09 00:00:00
abstract::Type I interferon (IFN) is a key driver of immunity to infections and cancer. Plasmacytoid dendritic cells (pDCs) are uniquely equipped to produce large quantities of type I IFN but the mechanisms that control this process are poorly understood. Here we report on a droplet-based microfluidic platform to investigate ty...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-05784-3
更新日期:2018-08-20 00:00:00
abstract::Programmed cell death protein-1 (PD-1)/programmed cell death ligand-1 (PD-L1) interaction plays a crucial role in tumor-associated immune escape. Here, we verify that triple-negative breast cancer (TNBC) has higher PD-L1 expression than other subtypes. We then discover that nucleophosmin (NPM1) binds to PD-L1 promoter...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-15364-z
更新日期:2020-04-03 00:00:00