A bed nucleus of stria terminalis microcircuit regulating inflammation-associated modulation of feeding.

Abstract:

:Loss of appetite or anorexia associated with inflammation impairs quality of life and increases morbidity in many diseases. However, the exact neural mechanism that mediates inflammation-associated anorexia is still poorly understood. Here we identified a population of neurons, marked by the expression of protein kinase C-delta, in the oval region of the bed nucleus of the stria terminalis (BNST), which are activated by various inflammatory signals. Silencing of these neurons attenuates the anorexia caused by these inflammatory signals. Our results demonstrate that these neurons mediate bidirectional control of general feeding behaviors. These neurons inhibit the lateral hypothalamus-projecting neurons in the ventrolateral part of BNST to regulate feeding, receive inputs from the canonical feeding regions of arcuate nucleus and parabrachial nucleus. Our data therefore define a BNST microcircuit that might coordinate canonical feeding centers to regulate food intake, which could offer therapeutic targets for feeding-related diseases such as anorexia and obesity.

journal_name

Nat Commun

journal_title

Nature communications

authors

Wang Y,Kim J,Schmit MB,Cho TS,Fang C,Cai H

doi

10.1038/s41467-019-10715-x

subject

Has Abstract

pub_date

2019-06-24 00:00:00

pages

2769

issue

1

issn

2041-1723

pii

10.1038/s41467-019-10715-x

journal_volume

10

pub_type

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