Middle Eocene greenhouse warming facilitated by diminished weathering feedback.

abstract：:Metal-organic frameworks (MOFs) are well known for their tunable structure and porosity. Many studies have shown they are promising for various important applications, for which their performance can be further enhanced by encapsulating functional species, such as luminescent guest molecules, within the frameworks. Al...

journal_title：Nature communications

authors： Sun CY,Wang XL,Zhang X,Qin C,Li P,Su ZM,Zhu DX,Shan GG,Shao KZ,Wu H,Li J

更新日期：2013-01-01 00:00:00

abstract：:Direct cross-coupling between simple arenes and heterocyclic amines under mild conditions is undoubtedly important for C-N bonds construction. Selective C(sp2)-H amination is more valuable. Herein we show a selective C(sp2)-H amination of arenes (alkyl-substituted benzenes, biphenyl and anisole derivatives) accompanie...

journal_title：Nature communications

authors： Niu L,Yi H,Wang S,Liu T,Liu J,Lei A

更新日期：2017-02-01 00:00:00

abstract：:X-linked lymphoproliferative syndrome type-2 (XLP-2) is a primary immunodeficiency disease attributed to XIAP mutation and is triggered by infection. Here, we show that mouse Xiap-/- regulatory T (Treg) cells and human XIAP-deficient Treg cells are defective in suppressive function. The Xiap-/- Treg cell defect is lin...

journal_title：Nature communications

authors： Hsieh WC,Hsu TS,Chang YJ,Lai MZ

更新日期：2018-01-31 00:00:00

abstract：:Cellobiohydrolase 1 from Trichoderma reesei (TrCel7A) processively hydrolyses cellulose into cellobiose. Although enzymatic techniques have been established as promising tools in biofuel production, a clear understanding of the motor's mechanistic action has yet to be revealed. Here, we develop an optical tweezers-bas...

journal_title：Nature communications

authors： Brady SK,Sreelatha S,Feng Y,Chundawat SP,Lang MJ

更新日期：2015-12-10 00:00:00

abstract：:Atropisomers are important organic frameworks in bioactive natural products, drugs as well as chiral catalysts. Meanwhile, silanols display unique properties compared to their alcohol analogs, however, the catalytic synthesis of atropisomers bearing silanol groups is challenging. Here, we show a rhodium-catalyzed tors...

journal_title：Nature communications

authors： Feng J,Bi X,Xue X,Li N,Shi L,Gu Z

更新日期：2020-09-07 00:00:00

abstract：:In the development of addiction, drug seeking becomes habitual and controlled by drug-associated cues, and the neural locus of control over behaviour shifts from the ventral to the dorsolateral striatum. The neural mechanisms underlying this functional transition from recreational drug use to drug-seeking habits are u...

journal_title：Nature communications

authors： Murray JE,Belin-Rauscent A,Simon M,Giuliano C,Benoit-Marand M,Everitt BJ,Belin D

更新日期：2015-12-14 00:00:00

abstract：:Cell biologists generally consider that microtubules and actin play complementary roles in long- and short-distance transport in animal cells. On the contrary, using melanosomes of melanocytes as a model, we recently discovered that the motor protein myosin-Va works with dynamic actin tracks to drive long-range organe...

journal_title：Nature communications

authors： Alzahofi N,Welz T,Robinson CL,Page EL,Briggs DA,Stainthorp AK,Reekes J,Elbe DA,Straub F,Kallemeijn WW,Tate EW,Goff PS,Sviderskaya EV,Cantero M,Montoliu L,Nedelec F,Miles AK,Bailly M,Kerkhoff E,Hume AN

更新日期：2020-07-13 00:00:00

abstract：:We trained and validated risk prediction models for the three major types of skin cancer- basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and melanoma-on a cross-sectional and longitudinal dataset of 210,000 consented research participants who responded to an online survey covering personal and family histo...

journal_title：Nature communications

authors： Fontanillas P,Alipanahi B,Furlotte NA,Johnson M,Wilson CH,23andMe Research Team.,Pitts SJ,Gentleman R,Auton A

更新日期：2021-01-08 00:00:00

abstract：:Charge transfer states play a crucial role in organic photovoltaics, mediating both photocurrent generation and recombination losses. In this work, we examine recombination losses as a function of the electron-hole spacing in fluorescent charge transfer states, including direct monitoring of both singlet and triplet c...

journal_title：Nature communications

authors： Chang W,Congreve DN,Hontz E,Bahlke ME,McMahon DP,Reineke S,Wu TC,Bulović V,Van Voorhis T,Baldo MA

更新日期：2015-03-12 00:00:00

abstract：:Receptor families of the innate immune response engage in 'cross-talk' to tailor optimal immune responses against invading pathogens. However, these responses are subject to multiple levels of regulation to keep in check aberrant inflammatory signals. Here, we describe a role for the orphan receptor interleukin-17 rec...

journal_title：Nature communications

authors： Mellett M,Atzei P,Bergin R,Horgan A,Floss T,Wurst W,Callanan JJ,Moynagh PN

更新日期：2015-03-26 00:00:00

abstract：:Homeowners around the world elevate houses to manage flood risks. Deciding how high to elevate a house poses a nontrivial decision problem. The U.S. Federal Emergency Management Agency (FEMA) recommends elevating existing houses to the Base Flood Elevation (the elevation of the 100-year flood) plus a freeboard. This r...

journal_title：Nature communications

authors： Zarekarizi M,Srikrishnan V,Keller K

更新日期：2020-10-26 00:00:00

abstract：:Recently, metasurfaces composed of artificially fabricated subwavelength structures have shown remarkable potential for the manipulation of light with unprecedented functionality. Here, we first demonstrate a metasurface application to realize a compact near-eye display system for augmented reality with a wide field o...

journal_title：Nature communications

authors： Lee GY,Hong JY,Hwang S,Moon S,Kang H,Jeon S,Kim H,Jeong JH,Lee B

更新日期：2018-11-01 00:00:00

abstract：:Microglia, the brain-resident macrophages, exhibit highly dynamic functions in neurodevelopment and neurodegeneration. Human microglia possess unique features as compared to mouse microglia, but our understanding of human microglial functions is largely limited by an inability to obtain human microglia under homeostat...

journal_title：Nature communications

authors： Xu R,Li X,Boreland AJ,Posyton A,Kwan K,Hart RP,Jiang P

更新日期：2020-03-27 00:00:00

abstract：:We have developed a single-breath-hold photoacoustic computed tomography (SBH-PACT) system to reveal detailed angiographic structures in human breasts. SBH-PACT features a deep penetration depth (4 cm in vivo) with high spatial and temporal resolutions (255 µm in-plane resolution and a 10 Hz 2D frame rate). By scannin...

journal_title：Nature communications

authors： Lin L,Hu P,Shi J,Appleton CM,Maslov K,Li L,Zhang R,Wang LV

更新日期：2018-06-15 00:00:00

abstract：:High electron mobility is one of graphene's key properties, exploited for applications and fundamental research alike. Highest mobility values are found in heterostructures of graphene and hexagonal boron nitride, which consequently are widely used. However, surprisingly little is known about the interaction between t...

journal_title：Nature communications

authors： Jobst J,van der Torren AJH,Krasovskii EE,Balgley J,Dean CR,Tromp RM,van der Molen SJ

更新日期：2016-11-29 00:00:00

abstract：:Coelacanths are known for their evolutionary conservatism, and the body plan seen in Latimeria can be traced to late Middle Devonian Diplocercides, Holopterygius and presumably Euporosteus. However, the group's early history is unclear because of an incomplete fossil record. Until now, the only Early Devonian coelacan...

journal_title：Nature communications

authors： Zhu M,Yu X,Lu J,Qiao T,Zhao W,Jia L

更新日期：2012-04-10 00:00:00

abstract：:Novel methods for information processing are highly desired in our information-driven society. Inspired by the brain's ability to process information, the recently introduced paradigm known as 'reservoir computing' shows that complex networks can efficiently perform computation. Here we introduce a novel architecture ...

journal_title：Nature communications

authors： Appeltant L,Soriano MC,Van der Sande G,Danckaert J,Massar S,Dambre J,Schrauwen B,Mirasso CR,Fischer I

更新日期：2011-09-13 00:00:00

abstract：:Columnar joints form by cracking during cooling-induced contraction of lava, allowing hydrothermal fluid circulation. A lack of direct observations of their formation has led to ambiguity about the temperature window of jointing and its impact on fluid flow. Here we develop a novel thermo-mechanical experiment to disc...

journal_title：Nature communications

authors： Lamur A,Lavallée Y,Iddon FE,Hornby AJ,Kendrick JE,von Aulock FW,Wadsworth FB

更新日期：2018-04-12 00:00:00

abstract：:Maintenance of genome integrity via repair of DNA damage is a key biological process required to suppress diseases, including Fanconi anemia (FA). We generated loss-of-function human haploid cells for FA complementation group C (FANCC), a gene encoding a component of the FA core complex, and used genome-wide CRISPR li...

journal_title：Nature communications

authors： Moder M,Velimezi G,Owusu M,Mazouzi A,Wiedner M,Ferreira da Silva J,Robinson-Garcia L,Schischlik F,Slavkovsky R,Kralovics R,Schuster M,Bock C,Ideker T,Jackson SP,Menche J,Loizou JI

更新日期：2017-11-01 00:00:00

abstract：:Tomatoes come in a multitude of shapes and flavors despite a narrow genetic pool. Here, we leverage whole-genome resequencing data available for 602 cultivated and wild accessions to determine the contribution of transposable elements (TEs) to tomato diversity. We identify 6,906 TE insertions polymorphisms (TIPs), whi...

journal_title：Nature communications

authors： Domínguez M,Dugas E,Benchouaia M,Leduque B,Jiménez-Gómez JM,Colot V,Quadrana L

更新日期：2020-08-13 00:00:00

abstract：:Conventional implementations of two-dimensional electronic spectroscopy typically spatially average over ~1010 chromophores spread over ~104 micron square area, limiting their ability to characterize spatially heterogeneous samples. Here we present a variation of two-dimensional electronic spectroscopy that is capable...

journal_title：Nature communications

authors： Tiwari V,Matutes YA,Gardiner AT,Jansen TLC,Cogdell RJ,Ogilvie JP

更新日期：2018-10-11 00:00:00

abstract：:Transition metal oxides with a perovskite crystal structure exhibit a variety of physical properties associated with the lattice. Among these materials, strontium ruthenate (SrRuO3) displays unusually strong coupling of charge, spin and lattice degrees of freedom that can give rise to the photostriction, that is, chan...

journal_title：Nature communications

authors： Wei TC,Wang HP,Liu HJ,Tsai DS,Ke JJ,Wu CL,Yin YP,Zhan Q,Lin GR,Chu YH,He JH

更新日期：2017-04-24 00:00:00

abstract：:A key question in materials science is how fast properties evolve, which relates to the kinetics of phase transformations. In metals, kinetics is primarily connected to diffusion, which for substitutional elements is enabled via mobile atomic-lattice vacancies. In fact, non-equilibrium vacancies are often required for...

journal_title：Nature communications

authors： Dumitraschkewitz P,Uggowitzer PJ,Gerstl SSA,Löffler JF,Pogatscher S

更新日期：2019-10-18 00:00:00

abstract：:The integration of β-barrel proteins into the bacterial outer membrane (OM) is catalysed by the β-barrel assembly machinery (BAM). The central BAM subunit (BamA) itself contains a β-barrel domain that is essential for OM protein biogenesis, but its mechanism of action is unknown. To elucidate its function, here we dev...

journal_title：Nature communications

authors： Doyle MT,Bernstein HD

更新日期：2019-07-26 00:00:00

abstract：:Chronic nonalcoholic steatohepatitis (NASH) is a metabolic disorder that often leads to liver fibrosis, a condition with limited therapy options. Adiponectin is an adipocytokine that regulates glucose and lipid metabolism via binding to its receptors AdipoR1 and AdipoR2, and AdipoRs signaling is reported to enhance fa...

journal_title：Nature communications

authors： Xu H,Zhao Q,Song N,Yan Z,Lin R,Wu S,Jiang L,Hong S,Xie J,Zhou H,Wang R,Jiang X

更新日期：2020-11-16 00:00:00

abstract：:Long-term depression (LTD) underlies learning and memory in various brain regions. Although postsynaptic AMPA receptor trafficking mediates LTD, its underlying molecular mechanisms remain largely unclear. Here we show that stargazin, a transmembrane AMPA receptor regulatory protein, forms a ternary complex with adapto...

journal_title：Nature communications

authors： Matsuda S,Kakegawa W,Budisantoso T,Nomura T,Kohda K,Yuzaki M

更新日期：2013-01-01 00:00:00

abstract：:Amongst the rare-earth perovskite nickelates, LaNiO3 (LNO) is an exception. While the former have insulating and antiferromagnetic ground states, LNO remains metallic and non-magnetic down to the lowest temperatures. It is believed that LNO is a strange metal, on the verge of an antiferromagnetic instability. Our work...

journal_title：Nature communications

authors： Liu C,Humbert VFC,Bretz-Sullivan TM,Wang G,Hong D,Wrobel F,Zhang J,Hoffman JD,Pearson JE,Jiang JS,Chang C,Suslov A,Mason N,Norman MR,Bhattacharya A

更新日期：2020-03-16 00:00:00

abstract：:Heterogeneous catalysis is an enabling technology that utilises transition metal nanoparticles (NPs) supported on oxides to promote chemical reactions. Structural mismatch at the NP-support interface generates lattice strain that could affect catalytic properties. However, detailed knowledge about strain in supported ...

journal_title：Nature communications

authors： Nilsson Pingel T,Jørgensen M,Yankovich AB,Grönbeck H,Olsson E

更新日期：2018-07-13 00:00:00

abstract：:Gross chromosomal rearrangements (GCRs), such as translocations, deletions or inversions, are often generated by illegitimate repair between two DNA breakages at regions with nucleotide sequences that might potentially adopt a non-B DNA conformation. We previously established a plasmid-based model system that recapitu...

journal_title：Nature communications

authors： Inagaki H,Ohye T,Kogo H,Tsutsumi M,Kato T,Tong M,Emanuel BS,Kurahashi H

更新日期：2013-01-01 00:00:00

abstract：:Phagocytosis is responsible for the elimination of particles of widely disparate sizes, from large fungi or effete cells to small bacteria. Though superficially similar, the molecular mechanisms involved differ: engulfment of large targets requires phosphoinositide 3-kinase (PI3K), while that of small ones does not. H...

journal_title：Nature communications

authors： Schlam D,Bagshaw RD,Freeman SA,Collins RF,Pawson T,Fairn GD,Grinstein S

更新日期：2015-10-14 00:00:00