Neglecting uncertainties biases house-elevation decisions to manage riverine flood risks.

abstract：:Rotational invariance strongly constrains the viscosity tensor of classical fluids. When this symmetry is broken in anisotropic materials a wide array of novel phenomena become possible. We explore electron fluid behaviors arising from the most general viscosity tensors in two and three dimensions, constrained only th...

journal_title：Nature communications

authors： Varnavides G,Jermyn AS,Anikeeva P,Felser C,Narang P

更新日期：2020-09-18 00:00:00

abstract：:The integration of β-barrel proteins into the bacterial outer membrane (OM) is catalysed by the β-barrel assembly machinery (BAM). The central BAM subunit (BamA) itself contains a β-barrel domain that is essential for OM protein biogenesis, but its mechanism of action is unknown. To elucidate its function, here we dev...

journal_title：Nature communications

authors： Doyle MT,Bernstein HD

更新日期：2019-07-26 00:00:00

abstract：:Inactivation is an intrinsic property of several voltage-dependent ion channels, closing the conduction pathway during membrane depolarization and dynamically regulating neuronal activity. BK K(+) channels undergo N-type inactivation via their β2 subunit, but the physiological significance is not clear. Here, we repor...

journal_title：Nature communications

authors： Whitt JP,Montgomery JR,Meredith AL

更新日期：2016-03-04 00:00:00

abstract：:Distinct subtypes of ionotropic glutamate receptors can segregate to specific synaptic inputs in a given neuron. Using functional mapping by focal glutamate uncaging in CA3 pyramidal cells (PCs), we observe that kainate receptors (KARs) are strictly confined to the postsynaptic elements of mossy fibre (mf) synapses an...

journal_title：Nature communications

authors： Fièvre S,Carta M,Chamma I,Labrousse V,Thoumine O,Mulle C

更新日期：2016-09-27 00:00:00

abstract：:Receptor families of the innate immune response engage in 'cross-talk' to tailor optimal immune responses against invading pathogens. However, these responses are subject to multiple levels of regulation to keep in check aberrant inflammatory signals. Here, we describe a role for the orphan receptor interleukin-17 rec...

journal_title：Nature communications

authors： Mellett M,Atzei P,Bergin R,Horgan A,Floss T,Wurst W,Callanan JJ,Moynagh PN

更新日期：2015-03-26 00:00:00

abstract：:Myelodysplastic syndromes (MDS) are uncommon in children and have a poor prognosis. In contrast to adult MDS, little is known about the genomic landscape of pediatric MDS. Here, we describe the somatic and germline changes of pediatric MDS using whole exome sequencing, targeted amplicon sequencing, and/or RNA-sequenci...

journal_title：Nature communications

authors： Schwartz JR,Ma J,Lamprecht T,Walsh M,Wang S,Bryant V,Song G,Wu G,Easton J,Kesserwan C,Nichols KE,Mullighan CG,Ribeiro RC,Klco JM

更新日期：2017-11-16 00:00:00

abstract：:The early diversification of animals (∼ 630 Ma), and their development into both motile and macroscopic forms (∼ 575-565 Ma), has been linked to stepwise increases in the oxygenation of Earth's surface environment. However, establishing such a linkage between oxygen and evolution for the later Cambrian 'explosion' (54...

journal_title：Nature communications

authors： Chen X,Ling HF,Vance D,Shields-Zhou GA,Zhu M,Poulton SW,Och LM,Jiang SY,Li D,Cremonese L,Archer C

更新日期：2015-05-18 00:00:00

abstract：:Many crystals, such as those of metals, can transform from one symmetry into another having lower free energy via a diffusionless transformation. Here we create binary colloidal crystals consisting of polymer microspheres, pulled together by DNA bridges, that induce specific, reversible attractions between two species...

journal_title：Nature communications

authors： Casey MT,Scarlett RT,Rogers WB,Jenkins I,Sinno T,Crocker JC

更新日期：2012-01-01 00:00:00

abstract：:Turn-on fluorescence imaging is routinely studied; however, turn-on chemiluminescence has been rarely explored for in vivo imaging. Herein, we report the design and validation of chemiluminescence probe ADLumin-1 as a turn-on probe for amyloid beta (Aβ) species. Two-photon imaging indicates that ADLumin-1 can efficien...

journal_title：Nature communications

authors： Yang J,Yin W,Van R,Yin K,Wang P,Zheng C,Zhu B,Ran K,Zhang C,Kumar M,Shao Y,Ran C

更新日期：2020-08-13 00:00:00

abstract：:Trafficking of mitochondria into dendrites and axons plays an important role in the physiology and pathophysiology of neurons. Mitochondrial outer membrane protein Miro and adaptor proteins TRAKs/Milton link mitochondria to molecular motors. Here we show that metaxins MTX-1 and MTX-2 contribute to mitochondrial transp...

journal_title：Nature communications

authors： Zhao Y,Song E,Wang W,Hsieh CH,Wang X,Feng W,Wang X,Shen K

更新日期：2021-01-04 00:00:00

abstract：:The dipole configuration of the Earth's magnetic field allows for the trapping of highly energetic particles, which form the radiation belts. Although significant advances have been made in understanding the acceleration mechanisms in the radiation belts, the loss processes remain poorly understood. Unique observation...

journal_title：Nature communications

authors： Shprits YY,Drozdov AY,Spasojevic M,Kellerman AC,Usanova ME,Engebretson MJ,Agapitov OV,Zhelavskaya IS,Raita TJ,Spence HE,Baker DN,Zhu H,Aseev NA

更新日期：2016-09-28 00:00:00

abstract：:Various platinum-free electrocatalysts have been explored for hydrogen evolution reaction in acidic solutions. However, in economical water-alkali electrolysers, sluggish water dissociation kinetics (Volmer step) on platinum-free electrocatalysts results in poor hydrogen-production activities. Here we report a MoNi4 e...

journal_title：Nature communications

authors： Zhang J,Wang T,Liu P,Liao Z,Liu S,Zhuang X,Chen M,Zschech E,Feng X

更新日期：2017-05-17 00:00:00

abstract：:Recent years have seen great advances in the development of synthetic self-assembling molecular systems. Designing out-of-equilibrium architectures, however, requires a more subtle control over the thermodynamics and kinetics of reactions. We propose a mechanism for enhancing the thermodynamic drive of DNA strand-disp...

journal_title：Nature communications

authors： Haley NEC,Ouldridge TE,Mullor Ruiz I,Geraldini A,Louis AA,Bath J,Turberfield AJ

更新日期：2020-05-22 00:00:00

abstract：:DNA methylation plays important roles in prokaryotes, and their genomic landscapes-prokaryotic epigenomes-have recently begun to be disclosed. However, our knowledge of prokaryotic methylation systems is focused on those of culturable microbes, which are rare in nature. Here, we used single-molecule real-time and circ...

journal_title：Nature communications

authors： Hiraoka S,Okazaki Y,Anda M,Toyoda A,Nakano SI,Iwasaki W

更新日期：2019-01-11 00:00:00

abstract：:Detection of Identical-By-Descent (IBD) segments provides a fundamental measure of genetic relatedness and plays a key role in a wide range of analyses. We develop FastSMC, an IBD detection algorithm that combines a fast heuristic search with accurate coalescent-based likelihood calculations. FastSMC enables biobank-s...

journal_title：Nature communications

authors： Nait Saada J,Kalantzis G,Shyr D,Cooper F,Robinson M,Gusev A,Palamara PF

更新日期：2020-11-30 00:00:00

abstract：:Major depressive disorder is associated with abnormalities in the brain and the immune system. Chronic stress in animals showed that epigenetic and inflammatory mechanisms play important roles in mediating resilience and susceptibility to depression. Here, through a high-throughput screening, we identify two phytochem...

journal_title：Nature communications

authors： Wang J,Hodes GE,Zhang H,Zhang S,Zhao W,Golden SA,Bi W,Menard C,Kana V,Leboeuf M,Xie M,Bregman D,Pfau ML,Flanigan ME,Esteban-Fernández A,Yemul S,Sharma A,Ho L,Dixon R,Merad M,Han MH,Russo SJ,Pasinetti GM

更新日期：2018-02-02 00:00:00

abstract：:Reduced-dimensional perovskites are attractive light-emitting materials due to their efficient luminescence, color purity, tunable bandgap, and structural diversity. A major limitation in perovskite light-emitting diodes is their limited operational stability. Here we demonstrate that rapid photodegradation arises fro...

journal_title：Nature communications

authors： Na Quan L,Ma D,Zhao Y,Voznyy O,Yuan H,Bladt E,Pan J,García de Arquer FP,Sabatini R,Piontkowski Z,Emwas AH,Todorović P,Quintero-Bermudez R,Walters G,Fan JZ,Liu M,Tan H,Saidaminov MI,Gao L,Li Y,Anjum DH,Wei N,Ta

更新日期：2020-01-10 00:00:00

abstract：:Skill learning is instantiated by changes to functional connectivity within premotor circuits, but whether the specificity of learning depends on structured changes to inhibitory circuitry remains unclear. We used slice electrophysiology to measure connectivity changes associated with song learning in the avian analog...

journal_title：Nature communications

authors： Miller MN,Cheung CYJ,Brainard MS

更新日期：2017-12-13 00:00:00

abstract：:Affiliation 4 incorrectly read 'University of the Basque Country (Ikerbasque), University of the Basque Country and Donostia International Physics Center, San Sebastian 20018, Spain.'Also, the affiliations of Ignacio Arganda-Carreras with 'IKERBASQUE, Basque Foundation for Science, Bilbao, 48013, Spain' and 'Donostia ...

journal_title：Nature communications

authors： Abdeladim L,Matho KS,Clavreul S,Mahou P,Sintes JM,Solinas X,Arganda-Carreras I,Turney SG,Lichtman JW,Chessel A,Bemelmans AP,Loulier K,Supatto W,Livet J,Beaurepaire E

更新日期：2019-05-09 00:00:00

abstract：:Missense mutations in Valosin-Containing Protein (VCP) are linked to diverse degenerative diseases including IBMPFD, amyotrophic lateral sclerosis (ALS), muscular dystrophy and Parkinson's disease. Here, we characterize a VCP-binding co-factor (SVIP) that specifically recruits VCP to lysosomes. SVIP is essential for l...

journal_title：Nature communications

authors： Johnson AE,Orr BO,Fetter RD,Moughamian AJ,Primeaux LA,Geier EG,Yokoyama JS,Miller BL,Davis GW

更新日期：2021-01-21 00:00:00

abstract：:The efficiencies of perovskite solar cells (PSCs) are now reaching such consistently high levels that scalable manufacturing at low cost is becoming critical. However, this remains challenging due to the expensive hole-transporting materials usually employed, and difficulties associated with the scalable deposition of...

journal_title：Nature communications

authors： Wu WQ,Wang Q,Fang Y,Shao Y,Tang S,Deng Y,Lu H,Liu Y,Li T,Yang Z,Gruverman A,Huang J

更新日期：2018-04-24 00:00:00

abstract：:Immune responses are crucial not only for host defence against pathogens but also for tissue maintenance and repair after injury. Lymphocytes are involved in the healing process after tissue injury, including bone fracture and muscle damage. However, the specific immune cell subsets and mediators of healing are not en...

journal_title：Nature communications

authors： Ono T,Okamoto K,Nakashima T,Nitta T,Hori S,Iwakura Y,Takayanagi H

更新日期：2016-03-11 00:00:00

abstract：:Clonal proliferation in myeloproliferative neoplasms (MPN) is driven by somatic mutations in JAK2, CALR or MPL, but the contribution of inherited factors is poorly characterized. Using a three-stage genome-wide association study of 3,437 MPN cases and 10,083 controls, we identify two SNPs with genome-wide significance...

journal_title：Nature communications

authors： Tapper W,Jones AV,Kralovics R,Harutyunyan AS,Zoi K,Leung W,Godfrey AL,Guglielmelli P,Callaway A,Ward D,Aranaz P,White HE,Waghorn K,Lin F,Chase A,Baxter EJ,Maclean C,Nangalia J,Chen E,Evans P,Short M,Jack A,Wal

更新日期：2015-04-07 00:00:00

abstract：:The dynamics of an order parameter's amplitude and phase determines the collective behaviour of novel states emerging in complex materials. Time- and momentum-resolved pump-probe spectroscopy, by virtue of measuring material properties at atomic and electronic time scales out of equilibrium, can decouple entangled deg...

journal_title：Nature communications

authors： Lee WS,Chuang YD,Moore RG,Zhu Y,Patthey L,Trigo M,Lu DH,Kirchmann PS,Krupin O,Yi M,Langner M,Huse N,Robinson JS,Chen Y,Zhou SY,Coslovich G,Huber B,Reis DA,Kaindl RA,Schoenlein RW,Doering D,Denes P,Schlotter WF

更新日期：2012-05-15 00:00:00

abstract：:Inelastic collisions involving molecular species are key to energy transfer in gaseous environments. They are commonly governed by an energy gap law, which dictates that transitions are dominated by those between initial and final states with roughly the same ro-vibrational energy. Transitions involving rotational ine...

journal_title：Nature communications

authors： Yang D,Huang J,Hu X,Guo H,Xie D

更新日期：2019-10-11 00:00:00

abstract：:Cancer cells often display altered cell-surface glycans compared to their nontransformed counterparts. However, functional contributions of glycans to cancer initiation and progression remain poorly understood. Here, from expression-based analyses across cancer lineages, we found that melanomas exhibit significant tra...

journal_title：Nature communications

authors： Sweeney JG,Liang J,Antonopoulos A,Giovannone N,Kang S,Mondala TS,Head SR,King SL,Tani Y,Brackett D,Dell A,Murphy GF,Haslam SM,Widlund HR,Dimitroff CJ

更新日期：2018-08-22 00:00:00

abstract：:Spinocerebellar ataxia type 5 (SCA5) is a neurodegenerative disease caused by mutations in the cytoskeletal protein β-III-spectrin. Previously, a SCA5 mutation resulting in a leucine-to-proline substitution (L253P) in the actin-binding domain (ABD) was shown to cause a 1000-fold increase in actin-binding affinity. How...

journal_title：Nature communications

authors： Avery AW,Fealey ME,Wang F,Orlova A,Thompson AR,Thomas DD,Hays TS,Egelman EH

更新日期：2017-11-07 00:00:00

abstract：:Rapid and accurate clinical diagnosis remains challenging. A component of diagnosis tool development is the design of effective classification models with Mass spectrometry (MS) data. Some Machine Learning approaches have been investigated but these models require time-consuming preprocessing steps to remove artifacts...

journal_title：Nature communications

authors： Seddiki K,Saudemont P,Precioso F,Ogrinc N,Wisztorski M,Salzet M,Fournier I,Droit A

更新日期：2020-11-05 00:00:00

abstract：:Owing to the significant difference in the numbers of simulated and experimentally feasible zeolite structures, several alternative strategies have been developed for zeolite synthesis. Despite their rationality and originality, most of these techniques are based on trial-and-error, which makes it difficult to predict...

journal_title：Nature communications

authors： Kasneryk V,Shamzhy M,Zhou J,Yue Q,Mazur M,Mayoral A,Luo Z,Morris RE,Čejka J,Opanasenko M

更新日期：2019-11-12 00:00:00

abstract：:Oxygen contamination is a problem which inevitably occurs during severe plastic deformation of metallic powders by exposure to air. Although this contamination can change the morphology and properties of the consolidated materials, there is a lack of detailed information about the behavior of oxygen in nanocrystalline...

journal_title：Nature communications

authors： Guo J,Haberfehlner G,Rosalie J,Li L,Duarte MJ,Kothleitner G,Dehm G,He Y,Pippan R,Zhang Z

更新日期：2018-03-05 00:00:00