Molecular determinants for the strictly compartmentalized expression of kainate receptors in CA3 pyramidal cells.

abstract：:Bone tissue, by definition, is an organic-inorganic nanocomposite, where metabolically active cells are embedded within a matrix that is heavily calcified on the nanoscale. Currently, there are no strategies that replicate these definitive characteristics of bone tissue. Here we describe a biomimetic approach where a ...

journal_title：Nature communications

authors： Thrivikraman G,Athirasala A,Gordon R,Zhang L,Bergan R,Keene DR,Jones JM,Xie H,Chen Z,Tao J,Wingender B,Gower L,Ferracane JL,Bertassoni LE

更新日期：2019-08-06 00:00:00

abstract：:Genetic factors contribute to the risk of thrombotic diseases. Recent genome wide association studies have identified genetic loci including SLC44A2 which may regulate thrombosis. Here we show that Slc44a2 controls platelet activation and thrombosis by regulating mitochondrial energetics. We find that Slc44a2 null mic...

journal_title：Nature communications

authors： Bennett JA,Mastrangelo MA,Ture SK,Smith CO,Loelius SG,Berg RA,Shi X,Burke RM,Spinelli SL,Cameron SJ,Carey TE,Brookes PS,Gerszten RE,Sabater-Lleal M,de Vries PS,Huffman JE,Smith NL,Morrell CN,Lowenstein CJ

更新日期：2020-07-13 00:00:00

abstract：:DNA N6-methyldeoxyadenosine (6mA) is a well-known prokaryotic DNA modification that has been shown to exist and play epigenetic roles in eukaryotic DNA. Here we report that 6mA accumulates up to ∼0.1-0.2% of total deoxyadenosine during early embryogenesis of vertebrates, but diminishes to the background level with the...

journal_title：Nature communications

authors： Liu J,Zhu Y,Luo GZ,Wang X,Yue Y,Wang X,Zong X,Chen K,Yin H,Fu Y,Han D,Wang Y,Chen D,He C

更新日期：2016-10-07 00:00:00

abstract：:Starting from the gas phase, small clusters can be produced and deposited with huge flexibility with regard to composition, materials choice and cluster size. Despite many advances in experimental characterization, a detailed morphology of such clusters is still lacking. Here we present an atomic scale observation as ...

journal_title：Nature communications

authors： Bals S,Van Aert S,Romero CP,Lauwaet K,Van Bael MJ,Schoeters B,Partoens B,Yücelen E,Lievens P,Van Tendeloo G

更新日期：2012-06-12 00:00:00

abstract：:Small interfering RNAs (siRNAs) conjugated to a trivalent N-acetylgalactosamine (GalNAc) ligand are being evaluated in investigational clinical studies for a variety of indications. The typical development candidate selection process includes evaluation of the most active compounds for toxicity in rats at pharmacologi...

journal_title：Nature communications

authors： Janas MM,Schlegel MK,Harbison CE,Yilmaz VO,Jiang Y,Parmar R,Zlatev I,Castoreno A,Xu H,Shulga-Morskaya S,Rajeev KG,Manoharan M,Keirstead ND,Maier MA,Jadhav V

更新日期：2018-02-19 00:00:00

abstract：:Heterozygous germline mutations in BRCA2 predispose to breast and ovarian cancer. Contrary to non-cancerous cells, where BRCA2 deletion causes cell cycle arrest or cell death, tumors carrying BRCA2 inactivation continue to proliferate. Here we set out to investigate adaptation to loss of BRCA2 focusing on genome-wide ...

journal_title：Nature communications

authors： Reisländer T,Lombardi EP,Groelly FJ,Miar A,Porru M,Di Vito S,Wright B,Lockstone H,Biroccio A,Harris A,Londoño-Vallejo A,Tarsounas M

更新日期：2019-07-17 00:00:00

abstract：:BRCA2 is essential for maintaining genomic integrity. BRCA2-deficient primary cells are either not viable or exhibit severe proliferation defects. Yet, BRCA2 deficiency contributes to tumorigenesis. It is believed that mutations in genes such as TRP53 allow BRCA2 heterozygous cells to overcome growth arrest when they ...

journal_title：Nature communications

authors： Biswas K,Philip S,Yadav A,Martin BK,Burkett S,Singh V,Babbar A,North SL,Chang S,Sharan SK

更新日期：2018-02-07 00:00:00

abstract：:The cellular and molecular basis of stromal cell recruitment, activation and crosstalk in carcinomas is poorly understood, limiting the development of targeted anti-stromal therapies. In mouse models of triple negative breast cancer (TNBC), Hedgehog ligand produced by neoplastic cells reprograms cancer-associated fibr...

journal_title：Nature communications

authors： Cazet AS,Hui MN,Elsworth BL,Wu SZ,Roden D,Chan CL,Skhinas JN,Collot R,Yang J,Harvey K,Johan MZ,Cooper C,Nair R,Herrmann D,McFarland A,Deng N,Ruiz-Borrego M,Rojo F,Trigo JM,Bezares S,Caballero R,Lim E,Timpson P

更新日期：2018-07-24 00:00:00

abstract：:The myogenic regulatory factor MRF4 is highly expressed in adult skeletal muscle but its function is unknown. Here we show that Mrf4 knockdown in adult muscle induces hypertrophy and prevents denervation-induced atrophy. This effect is accompanied by increased protein synthesis and widespread activation of muscle-spec...

journal_title：Nature communications

authors： Moretti I,Ciciliot S,Dyar KA,Abraham R,Murgia M,Agatea L,Akimoto T,Bicciato S,Forcato M,Pierre P,Uhlenhaut NH,Rigby PW,Carvajal JJ,Blaauw B,Calabria E,Schiaffino S

更新日期：2016-08-03 00:00:00

abstract：:Substance abuse disorders are linked to alteration of circadian rhythms, although the molecular and neuronal pathways implicated have not been fully elucidated. Addictive drugs, such as cocaine, induce a rapid increase of dopamine levels in the brain. Here, we show that acute administration of cocaine triggers reprogr...

journal_title：Nature communications

authors： Brami-Cherrier K,Lewis RG,Cervantes M,Liu Y,Tognini P,Baldi P,Sassone-Corsi P,Borrelli E

更新日期：2020-09-07 00:00:00

abstract：:Perovskite light emitting diodes suffer from poor operational stability, exhibiting a rapid decay of external quantum efficiency within minutes to hours after turn-on. To address this issue, we explore surface treatment of perovskite films with phenylalkylammonium iodide molecules of varying alkyl chain lengths. Combi...

journal_title：Nature communications

authors： Guo Y,Apergi S,Li N,Chen M,Yin C,Yuan Z,Gao F,Xie F,Brocks G,Tao S,Zhao N

更新日期：2021-01-28 00:00:00

abstract：:Topologically nontrivial materials host protected edge states associated with the bulk band inversion through the bulk-edge correspondence. Manipulating such edge states is highly desired for developing new functions and devices practically using their dissipation-less nature and spin-momentum locking. Here we introdu...

journal_title：Nature communications

authors： Mitsuishi N,Sugita Y,Bahramy MS,Kamitani M,Sonobe T,Sakano M,Shimojima T,Takahashi H,Sakai H,Horiba K,Kumigashira H,Taguchi K,Miyamoto K,Okuda T,Ishiwata S,Motome Y,Ishizaka K

更新日期：2020-05-18 00:00:00

abstract：:A key element enabling the microelectronic technology advances of the past decades has been the conceptualization of complex circuits with versatile functionalities as being composed of the proper combination of basic 'lumped' circuit elements (for example, inductors and capacitors). In contrast, modern nanophotonic s...

journal_title：Nature communications

authors： Shi J,Monticone F,Elias S,Wu Y,Ratchford D,Li X,Alù A

更新日期：2014-05-29 00:00:00

abstract：:Memories of experiences that occur around the same time are linked together by a shared temporal context, represented by shared patterns of neural activity. However, shared temporal context may be problematic for selective retrieval of specific memories. Here, we examine intracranial EEG (iEEG) in the human temporal l...

journal_title：Nature communications

authors： El-Kalliny MM,Wittig JH Jr,Sheehan TC,Sreekumar V,Inati SK,Zaghloul KA

更新日期：2019-01-14 00:00:00

abstract：:Liquid phase separation into two or more coexisting phases has emerged as a new paradigm for understanding subcellular organization, prebiotic life, and the origins of disease. The design principles underlying biomolecular phase separation have the potential to drive the development of novel liquid-based organelles an...

journal_title：Nature communications

authors： Fisher RS,Elbaum-Garfinkle S

更新日期：2020-09-15 00:00:00

abstract：:CD1 proteins are expressed on dendritic cells, where they display lipid antigens to T-cell receptors (TCRs). Here we describe T-cell autoreactivity towards ubiquitous human membrane phospholipids presented by CD1b. These T-cells discriminate between two major types of lipids, sphingolipids and phospholipids, but were ...

journal_title：Nature communications

authors： Shahine A,Reinink P,Reijneveld JF,Gras S,Holzheimer M,Cheng TY,Minnaard AJ,Altman JD,Lenz S,Prandi J,Kubler-Kielb J,Moody DB,Rossjohn J,Van Rhijn I

更新日期：2019-01-04 00:00:00

abstract：:Decoherence originates from the leakage of quantum information into external degrees of freedom. For a qubit, the two main decoherence channels are relaxation and dephasing. Here, we report an experiment on a superconducting qubit where we retrieve part of the lost information in both of these channels. We demonstrate...

journal_title：Nature communications

authors： Ficheux Q,Jezouin S,Leghtas Z,Huard B

更新日期：2018-05-15 00:00:00

abstract：:Foxg constitutes a regulatory loop with Fgf8 and plays an important role in the development of anterior placodes and the telencephalon in vertebrate embryos. Ascidians, which belong to Tunicata, the sister group of vertebrates, develop a primitive placode-like structure at the anterior boundary of the neural plate, bu...

journal_title：Nature communications

authors： Liu B,Satou Y

更新日期：2019-10-29 00:00:00

abstract：:Split spawning in coral populations occurs when gamete maturation and mass spawning are split over two consecutive months. While split spawning has been observed at many reefs, little is known about the frequency and significance of these events. Here we show that split spawning occurred frequently and predictably ove...

journal_title：Nature communications

authors： Foster T,Heyward AJ,Gilmour JP

更新日期：2018-02-19 00:00:00

abstract：:Adeno-associated virus (AAV) capsid engineering is an emerging approach to advance gene therapy. However, a systematic analysis on how each capsid amino acid contributes to multiple functions remains challenging. Here we show proof-of-principle and successful application of a novel approach, termed AAV Barcode-Seq, th...

journal_title：Nature communications

authors： Adachi K,Enoki T,Kawano Y,Veraz M,Nakai H

更新日期：2014-01-01 00:00:00

abstract：:As whole-genome sequencing for cancer genome analysis becomes a clinical tool, a full understanding of the variables affecting sequencing analysis output is required. Here using tumour-normal sample pairs from two different types of cancer, chronic lymphocytic leukaemia and medulloblastoma, we conduct a benchmarking e...

journal_title：Nature communications

authors： Alioto TS,Buchhalter I,Derdak S,Hutter B,Eldridge MD,Hovig E,Heisler LE,Beck TA,Simpson JT,Tonon L,Sertier AS,Patch AM,Jäger N,Ginsbach P,Drews R,Paramasivam N,Kabbe R,Chotewutmontri S,Diessl N,Previti C,Schmidt S

更新日期：2015-12-09 00:00:00

abstract：:Experimental data accumulated over more than 120 years show not only that diffusion coefficients of impurities ordinarily obey the Arrhenius law in crystalline solids, but also that diffusion pre-exponential factors measured in a same solid increase exponentially with activation energies. This so-called compensation e...

journal_title：Nature communications

authors： Gelin S,Champagne-Ruel A,Mousseau N

更新日期：2020-08-07 00:00:00

abstract：:To fully exploit the microbial genome resources, a high-throughput experimental platform is needed to associate genes with phenotypes at the genome level. We present here a novel method that enables investigation of the cellular consequences of repressing individual transcripts based on the CRISPR interference (CRISPR...

journal_title：Nature communications

authors： Wang T,Guan C,Guo J,Liu B,Wu Y,Xie Z,Zhang C,Xing XH

更新日期：2018-06-26 00:00:00

abstract：:Cosmic rays interact with the Earth's atmosphere to produce 14C, which can be absorbed by trees. Therefore, rapid increases of 14C in tree rings can be used to probe previous cosmic-ray events. By this method, three 14C rapidly increasing events have been found. Plausible causes of these events include large solar pro...

journal_title：Nature communications

authors： Wang FY,Yu H,Zou YC,Dai ZG,Cheng KS

更新日期：2017-11-14 00:00:00

abstract：:The insulin/IGF-1 signalling pathway is a key regulator of metabolism and the rate of ageing. We previously documented that systemic inactivation of phosphoinositide 3-kinase (PI3K) p110α, the principal PI3K isoform that positively regulates insulin signalling, results in a beneficial metabolic effect in aged mice. He...

journal_title：Nature communications

authors： Araiz C,Yan A,Bettedi L,Samuelson I,Virtue S,McGavigan AK,Dani C,Vidal-Puig A,Foukas LC

更新日期：2019-04-04 00:00:00

abstract：:Recent years have seen great advances in the development of synthetic self-assembling molecular systems. Designing out-of-equilibrium architectures, however, requires a more subtle control over the thermodynamics and kinetics of reactions. We propose a mechanism for enhancing the thermodynamic drive of DNA strand-disp...

journal_title：Nature communications

authors： Haley NEC,Ouldridge TE,Mullor Ruiz I,Geraldini A,Louis AA,Bath J,Turberfield AJ

更新日期：2020-05-22 00:00:00

abstract：:Many microorganisms, with phytoplankton and zooplankton as prominent examples, display phototactic behaviour, that is, the ability to perform directed motion within a light gradient. Here we experimentally demonstrate that sensing of light gradients can also be achieved in a system of synthetic photo-activated micropa...

journal_title：Nature communications

authors： Lozano C,Ten Hagen B,Löwen H,Bechinger C

更新日期：2016-09-30 00:00:00

abstract：:Two-dimensional electron systems have attracted attention as thermoelectric materials, which can directly convert waste heat into electricity. It has been theoretically predicted that thermoelectric power factor can be largely enhanced when the two-dimensional electron layer is far narrower than the de Broglie wavelen...

journal_title：Nature communications

authors： Zhang Y,Feng B,Hayashi H,Chang CP,Sheu YM,Tanaka I,Ikuhara Y,Ohta H

更新日期：2018-06-20 00:00:00

abstract：:Island systems generally have fewer species than continental areas due to their small size and geographical isolation. Low island diversity reduces the possibility of exportation of island lineages and island systems are not thought to have a major influence on the build-up of continental diversity. However, the view ...

journal_title：Nature communications

authors： Jønsson KA,Holt BG

更新日期：2015-10-05 00:00:00

abstract：:Activation of autophagy and elevation of glutamine synthesis represent key adaptations to maintain amino acid balance during starvation. In this study, we investigate the role of autophagy and glutamine on the regulation of mTORC1, a critical kinase that regulates cell growth and proliferation. We report that suppleme...

journal_title：Nature communications

authors： Tan HWS,Sim AYL,Long YC

更新日期：2017-08-24 00:00:00