Abstract:
:Turn-on fluorescence imaging is routinely studied; however, turn-on chemiluminescence has been rarely explored for in vivo imaging. Herein, we report the design and validation of chemiluminescence probe ADLumin-1 as a turn-on probe for amyloid beta (Aβ) species. Two-photon imaging indicates that ADLumin-1 can efficiently cross the blood-brain barrier and provides excellent contrast for Aβ plaques and cerebral amyloid angiopathy. In vivo brain imaging shows that the chemiluminescence signal of ADLumin-1 from 5-month-old transgenic 5xFAD mice is 1.80-fold higher than that from the age-matched wild-type mice. Moreover, we demonstrate that it is feasible to further dually-amplify signal via chemiluminescence resonance energy transfer (DAS-CRET) using two non-conjugated smart probes (ADLumin-1 and CRANAD-3) in solutions, brain homogenates, and in vivo whole brain imaging. Our results show that DAS-CRET can provide a 2.25-fold margin between 5-month-old 5xFAD mice and wild type mice. We believe that our strategy could be extended to other aggregating-prone proteins.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Yang J,Yin W,Van R,Yin K,Wang P,Zheng C,Zhu B,Ran K,Zhang C,Kumar M,Shao Y,Ran Cdoi
10.1038/s41467-020-17783-4subject
Has Abstractpub_date
2020-08-13 00:00:00pages
4052issue
1issn
2041-1723pii
10.1038/s41467-020-17783-4journal_volume
11pub_type
杂志文章abstract::Estimates of recent biodiversity change remain inconsistent, debated, and infrequently assessed for their functional implications. Here, we report that spatial scale and type of biodiversity measurement influence evidence of temporal biodiversity change. We show a pervasive scale dependence of temporal trends in taxon...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-04889-z
更新日期:2018-07-02 00:00:00
abstract::Thanks to the nature of strong programmability, field-programmable gate arrays (FPGAs) have been playing a significant role in signal processing and control. With the explosive growth in digital data, big data analytics becomes an important emerging field, in which FPGAs are a major player. However, the computational ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-14249-0
更新日期:2020-01-21 00:00:00
abstract::The original version of this Article contained errors in Fig. 3. In panel a, bars from a chart depicting the percentage of antibody-positive individuals in non-infectious and infectious groups were inadvertently included in place of bars depicting the percentage of infectious individuals, as described in the Article a...
journal_title:Nature communications
pub_type: 杂志文章,已发布勘误
doi:10.1038/s41467-018-03769-w
更新日期:2018-04-11 00:00:00
abstract::Mitochondria and peroxisomes proliferate by division. During division, a part of their membrane is pinched off by constriction of the ring-shaped mitochondrial division (MD) and peroxisome-dividing (POD) machinery. This constriction is mediated by a dynamin-like GTPase Dnm1 that requires a large amount of GTP as an en...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-07009-z
更新日期:2018-11-06 00:00:00
abstract::Most tumor cells take up more glucose than normal cells. Splicing dysregulation is one of the molecular hallmarks of cancer. However, the role of splicing factor in glucose metabolism and tumor development remains poorly defined. Here, we show that upon glucose intake, the splicing factor SRSF5 is specifically induced...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-04815-3
更新日期:2018-06-25 00:00:00
abstract::Artificial particle ices are model systems of constrained, interacting particles. They have been introduced theoretically to study ice-manifolds emergent from frustration, along with domain wall and grain boundary dynamics, doping, pinning-depinning, controlled transport of topological defects, avalanches, and memory ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-06631-1
更新日期:2018-10-08 00:00:00
abstract::Although a hydrophobic microtexture at a solid surface most often reflects rain owing to the presence of entrapped air within the texture, it is much more challenging to repel hot water. As it contacts a colder material, hot water generates condensation within the cavities at the solid surface, which eventually builds...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-09456-8
更新日期:2019-03-29 00:00:00
abstract::Generation of coherent light with desirable amplitude and phase profiles throughout the optical spectrum is a key issue in optical technologies. Nonlinear wavefront shaping offers an exceptional way to achieve this goal by converting an incident light beam into the beam (or beams) of different frequency with spatially...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-11114-y
更新日期:2019-07-19 00:00:00
abstract::Syngnathid fish (seahorses, pipefish and sea dragons) are slow swimmers yet capture evasive prey (copepods) using a technique known as the 'pivot' feeding, which involves rapid movement to overcome prey escape capabilities. However, this feeding mode functions only at short range and requires approaching very closely ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3840
更新日期:2013-01-01 00:00:00
abstract::Inflammasomes regulate innate immune responses by facilitating maturation of inflammatory cytokines, interleukin (IL)-1β and IL-18. NACHT, LRR and PYD domains-containing protein 7 (NALP7) is one inflammasome constituent, but little is known about its cellular handling. Here we show a mechanism for NALP7 protein stabil...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms15203
更新日期:2017-05-11 00:00:00
abstract::Primitive carbonaceous chondrites contain a large array of organic compounds dominated by insoluble organic matter (IOM). A striking feature of this IOM is the systematic enrichment in deuterium compared with the solar hydrogen reservoir. This enrichment has been taken as a sign of low-temperature ion-molecule or gas-...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms9567
更新日期:2015-10-13 00:00:00
abstract::Coelacanths are known for their evolutionary conservatism, and the body plan seen in Latimeria can be traced to late Middle Devonian Diplocercides, Holopterygius and presumably Euporosteus. However, the group's early history is unclear because of an incomplete fossil record. Until now, the only Early Devonian coelacan...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1764
更新日期:2012-04-10 00:00:00
abstract::Intracellular traffic between compartments of the secretory and endocytic pathways is mediated by vesicle-based carriers. The proteomes of carriers destined for many organelles are ill-defined because the vesicular intermediates are transient, low-abundance and difficult to purify. Here, we combine vesicle relocalisat...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19840-4
更新日期:2020-11-25 00:00:00
abstract::Manipulation of nonlinear waves in artificial periodic structures leads to spectacular spatial features, such as generation of gap solitons or onset of the Mott insulator phase transition. Cavity exciton-polaritons are strongly interacting quasiparticles offering large possibilities for potential optical technologies....
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2760
更新日期:2013-01-01 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Nature communications
pub_type: 已发布勘误
doi:10.1038/s41467-020-14339-4
更新日期:2020-01-24 00:00:00
abstract::Pentatricopeptide repeat (PPR) proteins control diverse aspects of RNA metabolism in eukaryotic cells. Although recent computational and structural studies have provided insights into RNA recognition by PPR proteins, their highly insoluble nature and inconsistencies between predicted and observed modes of RNA binding ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms6729
更新日期:2014-12-17 00:00:00
abstract::Maternal glucose levels during pregnancy impact the developing fetus, affecting metabolic health both early and later on in life. Both genetic and environmental factors influence maternal metabolism, but little is known about the genetic mechanisms that alter glucose metabolism during pregnancy. Here, we report that h...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms7069
更新日期:2015-02-04 00:00:00
abstract::β-Adrenergic receptor (β-AR) signaling is a pathway controlling adaptive thermogenesis in brown or beige adipocytes. Here we investigate the biological roles of the transcription factor Foxp1 in brown/beige adipocyte differentiation and thermogenesis. Adipose-specific deletion of Foxp1 leads to an increase of brown ad...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-12988-8
更新日期:2019-11-07 00:00:00
abstract::Ultrashort optical pulses propagating in a dissipative nonlinear system can interact and bind stably, forming optical soliton molecules. Soliton molecules in ultrafast lasers are under intense research focus and present striking analogies with their matter molecules counterparts. The recent development of real-time sp...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-08755-4
更新日期:2019-02-19 00:00:00
abstract::Longevity is influenced by genetic and environmental factors, but the underlying mechanisms remain elusive. Here, we functionally characterise a Drosophila small nucleolar RNA (snoRNA), named jouvence whose loss of function reduces lifespan. The genomic region of jouvence rescues the longevity in mutant, while its ove...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-14784-1
更新日期:2020-02-20 00:00:00
abstract::The HIRA histone chaperone complex deposits the histone variant H3.3 onto chromatin in a DNA synthesis-independent manner. It comprises three identified subunits, HIRA, UBN1 and CABIN1, however the functional oligomerization state of the complex has not been investigated. Here we use biochemical and crystallographic a...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-05581-y
更新日期:2018-08-06 00:00:00
abstract::Stimuli-responsive behaviors of flexible metal-organic frameworks (MOFs) make these materials promising in a wide variety of applications such as gas separation, drug delivery, and molecular sensing. Considerable efforts have been made over the last decade to understand the structural changes of flexible MOFs in respo...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-08939-y
更新日期:2019-03-01 00:00:00
abstract::The ultrafast dynamics of hot carriers in graphene are key to both understanding of fundamental carrier-carrier interactions and carrier-phonon relaxation processes in two-dimensional materials, and understanding of the physics underlying novel high-speed electronic and optoelectronic devices. Many recent experiments ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms11617
更新日期:2016-05-25 00:00:00
abstract::Semiconducting two-dimensional transition metal dichalcogenides are emerging as top candidates for post-silicon electronics. While most of them exhibit isotropic behaviour, lowering the lattice symmetry could induce anisotropic properties, which are both scientifically interesting and potentially useful. Here we prese...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms7991
更新日期:2015-05-07 00:00:00
abstract::How do descending inputs from the brain control leg motor circuits to change how an animal walks? Conceptually, descending neurons are thought to function either as command-type neurons, in which a single type of descending neuron exerts a high-level control to elicit a coordinated change in motor output, or through a...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19936-x
更新日期:2020-12-02 00:00:00
abstract::Astrocytes are implicated in modulation of neuronal excitability and synaptic function, but it remains unknown if these glial cells can directly control activities of motor circuits to influence complex behaviors in vivo. This study focused on the vital respiratory rhythm-generating circuits of the preBötzinger comple...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-02723-6
更新日期:2018-01-25 00:00:00
abstract::Despite the pursuit of quantum advantages in various applications, the power of quantum computers in executing neural network has mostly remained unknown, primarily due to a missing tool that effectively designs a neural network suitable for quantum circuit. Here, we present a neural network and quantum circuit co-des...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-20729-5
更新日期:2021-01-25 00:00:00
abstract::Non-linear interactions in coherent gases are not only at the origin of bright and dark solitons and superfluids; they also give rise to phenomena such as multistability, which hold great promise for the development of advanced photonic and spintronic devices. In particular, spinor multistability in strongly coupled s...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3008
更新日期:2013-01-01 00:00:00
abstract::Co-expression analysis is widely used to predict gene function and to identify functionally related gene sets. However, co-expression analysis using human cancer transcriptomic data is confounded by somatic copy number alterations (SCNA), which produce co-expression signatures based on physical proximity rather than b...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-02181-0
更新日期:2017-12-19 00:00:00
abstract::The original version of this Article contained an error in the third sentence of the penultimate paragraph of the 'Definition of the harmonic phase' section of the Results, which incorrectly read 'In the Coulomb phase the tensor S αβ (q) has one zero and two degenerate eigenvalues and it may be represented by an infin...
journal_title:Nature communications
pub_type: 杂志文章,已发布勘误
doi:10.1038/s41467-018-03815-7
更新日期:2018-04-16 00:00:00