Abstract：
:β-Adrenergic receptor (β-AR) signaling is a pathway controlling adaptive thermogenesis in brown or beige adipocytes. Here we investigate the biological roles of the transcription factor Foxp1 in brown/beige adipocyte differentiation and thermogenesis. Adipose-specific deletion of Foxp1 leads to an increase of brown adipose activity and browning program of white adipose tissues. The Foxp1-deficient mice show an augmented energy expenditure and are protected from diet-induced obesity and insulin resistance. Consistently, overexpression of Foxp1 in adipocytes impairs adaptive thermogenesis and promotes diet-induced obesity. A robust change in abundance of the β3-adrenergic receptor (β3-AR) is observed in brown/beige adipocytes from both lines of mice. Molecularly, Foxp1 directly represses β3-AR transcription and regulates its desensitization behavior. Taken together, our findings reveal Foxp1 as a master transcriptional repressor of brown/beige adipocyte differentiation and thermogenesis, and provide an important clue for its targeting and treatment of obesity.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Liu P,Huang S,Ling S,Xu S,Wang F,Zhang W,Zhou R,He L,Xia X,Yao Z,Fan Y,Wang N,Hu C,Zhao X,Tucker HO,Wang J,Guo Xdoi
10.1038/s41467-019-12988-8subject
Has Abstractpub_date
2019-11-07 00:00:00pages
5070issue
1issn
2041-1723pii
10.1038/s41467-019-12988-8journal_volume
10pub_type
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