Autophagy is a gatekeeper of hepatic differentiation and carcinogenesis by controlling the degradation of Yap.

abstract：:Dendrite growth threatens the safety of batteries by piercing the ion-transporting separators between the cathode and anode. Finding a dendrite-suppressing material that combines high modulus and high ionic conductance has long been considered a major technological and materials science challenge. Here we demonstrate ...

journal_title：Nature communications

authors： Tung SO,Ho S,Yang M,Zhang R,Kotov NA

更新日期：2015-01-27 00:00:00

abstract：:Gene regulation and metabolism are two fundamental processes that coordinate the self-renewal and differentiation of neural precursor cells (NPCs) in the developing mammalian brain. However, little is known about how metabolic signals instruct gene expression to control NPC homeostasis. Here, we show that methylglyoxa...

journal_title：Nature communications

authors： Rodrigues DC,Harvey EM,Suraj R,Erickson SL,Mohammad L,Ren M,Liu H,He G,Kaplan DR,Ellis J,Yang G

更新日期：2020-04-24 00:00:00

abstract：:Chikungunya virus (CHIKV) is a globally spreading alphavirus against which there is no commercially available vaccine or therapy. Here we use a genome-wide siRNA screen to identify 156 proviral and 41 antiviral host factors affecting CHIKV replication. We analyse the cellular pathways in which human proviral genes are...

journal_title：Nature communications

authors： Karlas A,Berre S,Couderc T,Varjak M,Braun P,Meyer M,Gangneux N,Karo-Astover L,Weege F,Raftery M,Schönrich G,Klemm U,Wurzlbauer A,Bracher F,Merits A,Meyer TF,Lecuit M

更新日期：2016-05-12 00:00:00

abstract：:The original version of this Article contained errors in Fig. 2, Fig. 3a-c and Supplementary Fig. 2. In Fig. 2g and Supplementary Fig. 2, the band structure plot calculated from density function theory (DFT) had a missing band of mainly z2 character that starts at about - 0.25 eV at the Y point and disperses downwards...

journal_title：Nature communications

authors： Li H,Zhou X,Nummy T,Zhang J,Pardo V,Pickett WE,Mitchell JF,Dessau DS

更新日期：2018-05-11 00:00:00

abstract：:The original version of this Article contained an error in the spelling of the author Dan Credgington, which was incorrectly given as Dan Credington. This has now been corrected in both the PDF and HTML versions of the Article. ...

journal_title：Nature communications

authors： Ban M,Zou Y,Rivett JPH,Yang Y,Thomas TH,Tan Y,Song T,Gao X,Credgington D,Deschler F,Sirringhaus H,Sun B

更新日期：2019-02-22 00:00:00

abstract：:Loss of seed dispersal is a key agronomical trait targeted by ancient human selection and has been regarded as a milestone of crop domestication. In this study, in the legume crop soybean Glycine max (L.) Merr. which provides vegetable oils and proteins for humans, we show that the key cellular feature of the shatteri...

journal_title：Nature communications

authors： Dong Y,Yang X,Liu J,Wang BH,Liu BL,Wang YZ

更新日期：2014-01-01 00:00:00

abstract：:Highly specific Cas9 nucleases derived from SpCas9 are valuable tools for genome editing, but their wide applications are hampered by a lack of knowledge governing guide RNA (gRNA) activity. Here, we perform a genome-scale screen to measure gRNA activity for two highly specific SpCas9 variants (eSpCas9(1.1) and SpCas9...

journal_title：Nature communications

authors： Wang D,Zhang C,Wang B,Li B,Wang Q,Liu D,Wang H,Zhou Y,Shi L,Lan F,Wang Y

更新日期：2019-09-19 00:00:00

abstract：:Topological insulators are a new class of materials that exhibit robust and scatter-free transport along their edges - independently of the fine details of the system and of the edge - due to topological protection. To classify the topological character of two-dimensional systems without additional symmetries, one com...

journal_title：Nature communications

authors： Maczewsky LJ,Zeuner JM,Nolte S,Szameit A

更新日期：2017-01-04 00:00:00

abstract：:Brain oscillations reflect pattern formation of cell assemblies' activity, which is often disturbed in neurological and psychiatric diseases like depression, schizophrenia and stroke. In the neurobiological analysis and treatment of these conditions, transcranial electric currents applied to the brain proved beneficia...

journal_title：Nature communications

authors： Soekadar SR,Witkowski M,Cossio EG,Birbaumer N,Robinson SE,Cohen LG

更新日期：2013-01-01 00:00:00

abstract：:Integrating and manipulating the nano-optoelectronic properties of Van der Waals heterostructures can enable unprecedented platforms for photodetection and sensing. The main challenge of infrared photodetectors is to funnel the light into a small nanoscale active area and efficiently convert it into an electrical sign...

journal_title：Nature communications

authors： Castilla S,Vangelidis I,Pusapati VV,Goldstein J,Autore M,Slipchenko T,Rajendran K,Kim S,Watanabe K,Taniguchi T,Martín-Moreno L,Englund D,Tielrooij KJ,Hillenbrand R,Lidorikis E,Koppens FHL

更新日期：2020-09-25 00:00:00

abstract：:The ventral striatum has long been proposed as an integrator of biologically significant associative information to drive actions. Although inputs from the amygdala and hippocampus have been much studied, the role of prominent inputs from orbitofrontal cortex (OFC) are less well understood. Here, we recorded single-un...

journal_title：Nature communications

authors： Cooch NK,Stalnaker TA,Wied HM,Bali-Chaudhary S,McDannald MA,Liu TL,Schoenbaum G

更新日期：2015-05-21 00:00:00

abstract：:The quiescent centre (QC) in the Arabidopsis root apical meristem is essential for stem cell organization. Here we show that the loss of REPRESSOR OF WUSCHEL1 (ROW1), a PHD domain-containing protein, leads to QC failure, defects in cell differentiation and ectopic expression of WUSCHEL-RELATED HOMEOBOX 5 (WOX5) in cel...

journal_title：Nature communications

authors： Zhang Y,Jiao Y,Liu Z,Zhu YX

更新日期：2015-01-29 00:00:00

abstract：:Electron motion in chemical bonds occurs on an attosecond timescale. This ultrafast motion can be driven by strong laser fields. Ultrashort asymmetric laser pulses are known to direct electrons to a certain direction. But do symmetric laser pulses destroy symmetry in breaking chemical bonds? Here we answer this questi...

journal_title：Nature communications

authors： Wu J,Magrakvelidze M,Schmidt LP,Kunitski M,Pfeifer T,Schöffler M,Pitzer M,Richter M,Voss S,Sann H,Kim H,Lower J,Jahnke T,Czasch A,Thumm U,Dörner R

更新日期：2013-01-01 00:00:00

abstract：:G protein-coupled receptors (GPCRs) constitute a large family of receptors that activate intracellular signaling pathways upon detecting specific extracellular ligands. While many aspects of GPCR signaling have been uncovered through decades of studies, some fundamental properties, like its channel capacity-a measure ...

journal_title：Nature communications

authors： Keshelava A,Solis GP,Hersch M,Koval A,Kryuchkov M,Bergmann S,Katanaev VL

更新日期：2018-02-28 00:00:00

abstract：:A collective order of spin and charge degrees of freedom into stripes has been predicted to be a possible ground state of hole-doped CuO(2) planes, which are the building blocks of high-temperature superconductors. In fact, stripe-like spin and charge order has been observed in various layered cuprate systems. For the...

journal_title：Nature communications

authors： Wu HH,Buchholz M,Trabant C,Chang CF,Komarek AC,Heigl F,Zimmermann MV,Cwik M,Nakamura F,Braden M,Schüßler-Langeheine C

更新日期：2012-01-01 00:00:00

abstract：:The success of protein evolution campaigns is strongly dependent on the sequence context in which mutations are introduced, stemming from pervasive non-additive interactions between a protein's amino acids ('intra-gene epistasis'). Our limited understanding of such epistasis hinders the correct prediction of the funct...

journal_title：Nature communications

authors： Zurek PJ,Knyphausen P,Neufeld K,Pushpanath A,Hollfelder F

更新日期：2020-11-26 00:00:00

abstract：:Environmental challenges to plants typically entail retardation of vegetative growth and delay or cessation of flowering. Here we report a link between the flowering time regulator, GIGANTEA (GI), and adaptation to salt stress that is mechanistically based on GI degradation under saline conditions, thus retarding flow...

journal_title：Nature communications

authors： Kim WY,Ali Z,Park HJ,Park SJ,Cha JY,Perez-Hormaeche J,Quintero FJ,Shin G,Kim MR,Qiang Z,Ning L,Park HC,Lee SY,Bressan RA,Pardo JM,Bohnert HJ,Yun DJ

更新日期：2013-01-01 00:00:00

abstract：:Lean body mass, consisting mostly of skeletal muscle, is important for healthy aging. We performed a genome-wide association study for whole body (20 cohorts of European ancestry with n = 38,292) and appendicular (arms and legs) lean body mass (n = 28,330) measured using dual energy X-ray absorptiometry or bioelectric...

journal_title：Nature communications

authors： Zillikens MC,Demissie S,Hsu YH,Yerges-Armstrong LM,Chou WC,Stolk L,Livshits G,Broer L,Johnson T,Koller DL,Kutalik Z,Luan J,Malkin I,Ried JS,Smith AV,Thorleifsson G,Vandenput L,Hua Zhao J,Zhang W,Aghdassi A,Åkesson

更新日期：2017-07-19 00:00:00

abstract：:Individual cells in clonal populations often respond differently to environmental changes; for binary phenotypes, such as cell death, this can be measured as a fractional response. These types of responses have been attributed to cell-intrinsic stochastic processes and variable abundances of biochemical constituents, ...

journal_title：Nature communications

authors： Santos LC,Vogel R,Chipuk JE,Birtwistle MR,Stolovitzky G,Meyer P

更新日期：2019-03-21 00:00:00

abstract：:Cell-to-cell variability plays a critical role in cellular responses and decision-making in a population, and transcriptional bursting has been broadly studied by experimental and theoretical approaches as the potential source of cell-to-cell variability. Although molecular mechanisms of transcriptional bursting have ...

journal_title：Nature communications

authors： Fujita K,Iwaki M,Yanagida T

更新日期：2016-12-07 00:00:00

abstract：:Molecularly defined subclassification is associated with phenotypic malignancy of glioblastoma (GBM). However, current understanding of the molecular basis of subclass conversion that is often involved in GBM recurrence remain rudimentary at best. Here we report that canonical Wnt signalling that is active in proneura...

journal_title：Nature communications

authors： Huang T,Alvarez AA,Pangeni RP,Horbinski CM,Lu S,Kim SH,James CD,J Raizer J,A Kessler J,Brenann CW,Sulman EP,Finocchiaro G,Tan M,Nishikawa R,Lu X,Nakano I,Hu B,Cheng SY

更新日期：2016-10-04 00:00:00

abstract：:Molecular spins have become key enablers for exploring magnetic interactions, quantum information processes and many-body effects in metals. Metal-organic molecules, in particular, let the spin state of the core metal ion to be modified according to its organic environment, allowing localized magnetic moments to emerg...

journal_title：Nature communications

authors： Atxabal A,Ribeiro M,Parui S,Urreta L,Sagasta E,Sun X,Llopis R,Casanova F,Hueso LE

更新日期：2016-12-12 00:00:00

abstract：:Explaining trait differences between individuals is a core and challenging aim of life sciences. Here, we introduce a powerful framework for complete decomposition of trait variation into its underlying genetic causes in diploid model organisms. We sequence and systematically pair the recombinant gametes of two interc...

journal_title：Nature communications

authors： Hallin J,Märtens K,Young AI,Zackrisson M,Salinas F,Parts L,Warringer J,Liti G

更新日期：2016-11-02 00:00:00

abstract：:Ellagitannins are a family of polyphenols containing more than 1,000 natural products. Nearly 40% of these compounds contain a highly oxygenated diaryl ether that is one of the most critical elements to their structural diversity. Here, we report a unified strategy for the synthesis of highly oxygenated diaryl ethers ...

journal_title：Nature communications

authors： Hirokane T,Hirata Y,Ishimoto T,Nishii K,Yamada H

更新日期：2014-03-24 00:00:00

abstract：:Non-covalent π-π interactions are central to chemical and biological processes, yet the full understanding of their origin that would unite the simplicity of empirical approaches with the accuracy of quantum calculations is still missing. Here we employ a quantum-mechanical Hamiltonian model for van der Waals interact...

journal_title：Nature communications

authors： Hermann J,Alfè D,Tkatchenko A

更新日期：2017-02-07 00:00:00

abstract：:16p11.2 and 22q11.2 Copy Number Variants (CNVs) confer high risk for Autism Spectrum Disorder (ASD), schizophrenia (SZ), and Attention-Deficit-Hyperactivity-Disorder (ADHD), but their impact on functional connectivity (FC) remains unclear. Here we report an analysis of resting-state FC using magnetic resonance imaging...

journal_title：Nature communications

authors： Moreau CA,Urchs SGW,Kuldeep K,Orban P,Schramm C,Dumas G,Labbe A,Huguet G,Douard E,Quirion PO,Lin A,Kushan L,Grot S,Luck D,Mendrek A,Potvin S,Stip E,Bourgeron T,Evans AC,Bearden CE,Bellec P,Jacquemont S

更新日期：2020-10-19 00:00:00

abstract：:Exposure to extreme events is a major concern in coastal regions where growing human populations and stressed natural ecosystems are at significant risk to such phenomena. However, the complex sequence of processes that transform an event from notable to extreme can be challenging to identify and hence, limit forecast...

journal_title：Nature communications

authors： Dzwonkowski B,Coogan J,Fournier S,Lockridge G,Park K,Lee T

更新日期：2020-09-22 00:00:00

abstract：:Neuropeptides have central roles in the regulation of homoeostatic behaviours such as sleep and feeding. Caenorhabditis elegans displays sleep-like quiescence of locomotion and feeding during a larval transition stage called lethargus and feeds during active larval and adult stages. Here we show that the neuropeptide ...

journal_title：Nature communications

authors： Nelson MD,Trojanowski NF,George-Raizen JB,Smith CJ,Yu CC,Fang-Yen C,Raizen DM

更新日期：2013-01-01 00:00:00

abstract：:Bacterial infections and antibiotic resistance, particularly by Gram-negative pathogens, have become a global healthcare crisis. We report the design of a class of cationic antimicrobial polymers that cluster local facial amphiphilicity from repeating units to enhance interactions with bacterial membranes without requ...

journal_title：Nature communications

authors： Rahman MA,Bam M,Luat E,Jui MS,Ganewatta MS,Shokfai T,Nagarkatti M,Decho AW,Tang C

更新日期：2018-12-07 00:00:00

abstract：:Imaging of nuclear structures within intact eukaryotic nuclei is imperative to understand the effect of chromatin folding on genome function. Recent developments of super-resolution fluorescence microscopy techniques combine high specificity, sensitivity, and less-invasive sample preparation procedures with the sub-di...

journal_title：Nature communications

authors： Sarmento MJ,Oneto M,Pelicci S,Pesce L,Scipioni L,Faretta M,Furia L,Dellino GI,Pelicci PG,Bianchini P,Diaspro A,Lanzanò L

更新日期：2018-08-24 00:00:00