Postnatal β-cell maturation is associated with islet-specific microRNA changes induced by nutrient shifts at weaning.

Abstract:

:Glucose-induced insulin secretion is an essential function of pancreatic β-cells that is partially lost in individuals affected by Type 2 diabetes. This unique property of β-cells is acquired through a poorly understood postnatal maturation process involving major modifications in gene expression programs. Here we show that β-cell maturation is associated with changes in microRNA expression induced by the nutritional transition that occurs at weaning. When mimicked in newborn islet cells, modifications in the level of specific microRNAs result in a switch in the expression of metabolic enzymes and cause the acquisition of glucose-induced insulin release. Our data suggest microRNAs have a central role in postnatal β-cell maturation and in the determination of adult functional β-cell mass. A better understanding of the events governing β-cell maturation may help understand why some individuals are predisposed to developing diabetes and could lead to new strategies for the treatment of this common metabolic disease.

journal_name

Nat Commun

journal_title

Nature communications

authors

Jacovetti C,Matkovich SJ,Rodriguez-Trejo A,Guay C,Regazzi R

doi

10.1038/ncomms9084

subject

Has Abstract

pub_date

2015-09-02 00:00:00

pages

8084

issn

2041-1723

pii

ncomms9084

journal_volume

6

pub_type

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