Abstract:
:Glucose-induced insulin secretion is an essential function of pancreatic β-cells that is partially lost in individuals affected by Type 2 diabetes. This unique property of β-cells is acquired through a poorly understood postnatal maturation process involving major modifications in gene expression programs. Here we show that β-cell maturation is associated with changes in microRNA expression induced by the nutritional transition that occurs at weaning. When mimicked in newborn islet cells, modifications in the level of specific microRNAs result in a switch in the expression of metabolic enzymes and cause the acquisition of glucose-induced insulin release. Our data suggest microRNAs have a central role in postnatal β-cell maturation and in the determination of adult functional β-cell mass. A better understanding of the events governing β-cell maturation may help understand why some individuals are predisposed to developing diabetes and could lead to new strategies for the treatment of this common metabolic disease.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Jacovetti C,Matkovich SJ,Rodriguez-Trejo A,Guay C,Regazzi Rdoi
10.1038/ncomms9084subject
Has Abstractpub_date
2015-09-02 00:00:00pages
8084issn
2041-1723pii
ncomms9084journal_volume
6pub_type
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