Abstract：
:Auditory cortex neurons nonlinearly integrate synaptic inputs from the thalamus and cortex, and generate spiking outputs for simple and complex sounds. Directly comparing synaptic and spiking activity can determine whether this input-output transformation is stimulus-dependent. We employ in vivo whole-cell recordings in the mouse primary auditory cortex, using pure tones and broadband dynamic moving ripple stimuli, to examine properties of functional integration in tonal (TRFs) and spectrotemporal (STRFs) receptive fields. Spectral tuning in STRFs derived from synaptic, subthreshold and spiking responses proves to be substantially more selective than for TRFs. We describe diverse spectral and temporal modulation preferences and distinct nonlinearities, and their modifications between the input and output stages of neural processing. These results characterize specific processing differences at the level of synaptic convergence, integration and spike generation resulting in stimulus-dependent transformation patterns in the primary auditory cortex.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Kim KX,Atencio CA,Schreiner CEdoi
10.1038/s41467-020-14835-7subject
Has Abstractpub_date
2020-02-27 00:00:00pages
1102issue
1issn
2041-1723pii
10.1038/s41467-020-14835-7journal_volume
11pub_type
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